O-superfamily conotoxin peptides

ABSTRACT

The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present application is related to U.S. provisional patent applications Serial No. 60/173,754 filed Dec. 30, 1999, Serial No. 60/214,263 filed Jun. 26, 2000, Serial No. 60/219,440 filed Jul. 20, 2000 and Serial No. 60/243,412 filed Oct. 27, 2000.

[0002] This invention was made with Government support under Grant No. PO1 GM48677 awarded by the National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Md. The United States Government has certain rights in the invention.

BACKGROUND OF THE INVENTION

[0003] The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include three disulfide bonds.

[0004] The publications and other materials used herein to illuminate the background of the invention, and in particular, cases to provide additional details respecting the practice, are incorporated by reference, and for convenience are referenced in the following text by author and date and are listed alphabetically by author in the appended bibliography.

[0005] Conus is a genus of predatory marine gastropods (snails) which envenomate their prey. Venomous cone snails use a highly developed apparatus to deliver their cocktail of toxic conotoxins into their prey. In fish-eating species such as Conus magus the cone detects the presence of the fish using chemosensors in its siphon. When close enough the cone extends its proboscis and impales the fish with a hollow harpoon-like tooth containing venom. This immobilizes the fish and enables the cone snail to wind it into its mouth via the tooth held at the end of its proboscis. For general information on Conus and their venom see the website address http://grimwade.biochem.unimelb.edu.au/cone/referenc.htrnl. Prey capture is accomplished through a sophisticated arsenal of peptides which target specific ion channel and receptor subtypes. Each Conus species venom appears to contain a unique set of 50-200 peptides. The composition of the venom differs greatly between species and between individual snails within each species, each optimally evolved to paralyse it's prey. The active components of the venom are small peptides toxins, typically 10-30 amino acid residues in length and are typically highly constrained peptides due to their high density of disulphide bonds.

[0006] The venoms consist of a large number of different peptide components that when separated exhibit a range of biological activities: when injected into mice they elicit a range of physiological responses from shaking to depression. The paralytic components of the venom that have been the focus of recent investigation are the α-, ω- and μ-conotoxins. All of these conotoxins act by preventing neuronal communication, but each targets a different aspect of the process to achieve this. The α-conotoxins target nicotinic ligand gated channels, the μ-conotoxins target the voltage-gated sodium channels and the ω-conotoxins target the voltage-gated calcium channels (Olivera et al., 1985; Olivera et al., 1990). For example a linkage has been established between α-, αA- & ψ-conotoxins and the nicotinic ligand-gated ion channel; ω-conotoxins and the voltage-gated calcium channel; μ-conotoxins and the voltage-gated sodium channel; δ-conotoxins and the voltage-gated sodium channel; κ-conotoxins and the voltage-gated potassium channel; conantokins and the ligand-gated glutamate (NMDA) channel. Five δ-conotoxins have been described: GmVIA (U.S. Pat. No. 5,719,264); PVIA (U.S. Pat. No. 5,739,276); TxVIA (Hillyard et al., 1989; Fainzilber et al., 1991); TxVIB (Fainzilber et al., 1991); NgVIA (Fainzilber et al., 1995); and TxIIA (Nakamura et al., 1996). For a partial list of Conus peptides and their amino acid sequences see the website address http://pir.georgetown.edu.

[0007] However, the structure and function of only a small minority of these peptides have been determined to date. For peptides where function has been determined, three classes of targets have been elucidated: voltage-gated ion channels; ligand-gated ion channels, and G-protein-linked receptors.

[0008] Conus peptides which target voltage-gated ion channels include those that delay the inactivation of sodium channels, as well as blockers specific for sodium channels, calcium channels and potassium channels. Peptides that target ligand-gated ion channels include antagonists of NMDA and serotonin receptors, as well as competitive and noncompetitive nicotinic receptor antagonists. Peptides which act on G-protein receptors include neurotensin and vasopressin receptor agonists. The unprecedented pharmaceutical selectivity of conotoxins is at least in part defined by a specific disulfide bond frameworks combined with hypervariable amino acids within disulfide loops (for a review see McIntosh et al., 1998).

[0009] Potassium channels comprise a large and diverse group of proteins that, through maintenance of the cellular membrane potential, are fundamental in normal biological function. These channels are vital in controlling the resting membrane potential in excitable cells and can be broadly sub-divided into three classes: voltage-gated K⁺ channels, Ca²⁺ activated K⁺ channels and ATP-sensitive K⁺ channels. Many disorders are associated with abnormal flow of potassium ions through these channels. The identification of agents which would regulate the flow of potassium ions through each of these channel types would be useful in treating disorders associated with such abnormal flow.

[0010] It is desired to identify additional conotoxin peptides having activities of the above conopeptides, as well as conotoxin peptides having additional activities.

SUMMARY OF THE INVENTION

[0011] The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include three disulfide bonds. The O-superfamily conotoxins include ω-conotxins, κ-conotoxins, δ-conotoxins, μO-conotoxins and GS conotoxin.

[0012] Thus, in one embodiment, the present invention is directed to the conotoxin peptides set forth in Table 2 and the corresponding peptides set forth in Table 1.

[0013] In a second embodiment, the present invention is directed to all of the propeptides and nucleic acid sequences encoding the propeptides or peptides set forth in Table 1.

[0014] In a third embodiment, the present invention is directed to derivatives or pharmaceutically acceptable salts of the conotoxin peptides disclosed herein. Examples of derivatives include peptides in which the Arg residues may be substituted by Lys, ornithine, homoargine, nor-Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any synthetic basic amino acid; the Lys residues may be substituted by Arg, ornithine, homoargine, nor-Lys, or any synthetic basic amino acid; the Tyr residues may be substituted with ¹²⁵I-Tyr, meta-Tyr, ortho-Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr, nitro-Tyr or any synthetic hydroxy containing amino acid; the Ser residues may be substituted with Thr or any synthetic hydroxylated amino acid; the Thr residues may be substituted with Ser or any synthetic hydroxylated amino acid; the Phe residues may be substituted with any synthetic aromatic amino acid; the Trp residues may be substituted with Trp (D), neo-Trp, halo-Trp (D or L) or any aromatic synthetic amino acid; and the Asn, Ser, Thr or Hyp residues may be glycosylated. The halogen may be iodo, chloro, fluoro or bromo; preferably iodo for halogen substituted-Tyr and bromo for halogen-substituted Trp. The Tyr residues may also be substituted with the 3-hydroxyl or 2-hydroxyl isomers (meta-Tyr or ortho-Tyr, respectively) and corresponding O-sulpho- and O-phospho-derivatives. The acidic amino acid residues may be substituted with any synthetic acidic amino acid, e.g., tetrazolyl derivatives of Gly and Ala. The aliphatic amino acids may be substituted by synthetic derivatives bearing non-natural aliphatic branched or linear side chains C_(n)H_(2n+2) up to and including n=8. The Leu residues may be substituted with Leu (D). The Glu residues may be substituted with Gla. The Gla residues may be substituted with Glu. The Met residues may be substituted with norleucine (Nle). The Cys residues may be in D or L configuration and may optionally be substituted with homocysteine (D or L).

[0015] Examples of synthetic aromatic amino acid include, but are not limited to, nitro-Phe, 4-substituted-Phe wherein the substituent is C₁-C₃ alkyl, carboxyl, hyrdroxymethyl, sulphomethyl, halo, phenyl, —CHO, —CN, —SO₃H and —NHAc. Examples of synthetic hydroxy containing amino acid, include, but are not limited to, such as 4-hydroxymethyl-Phe, 4-hydroxyphenyl-Gly, 2,6-dimethyl-Tyr and 5-amino-Tyr. Examples of synthetic basic amino acids include, but are not limited to, N-1-(2-pyrazolinyl)-Arg, 2-(4-piperidinyl)-Gly, 2-(4-piperidinyl)-Ala, 2-[3-(2S)pyrrolidininyl)-Gly and 2-[3-(2S)pyrrolidininyl)-Ala. These and other synthetic basic amino acids, synthetic hydroxy containing amino acids or synthetic aromatic amino acids are described in Building Block Index, Version 3.0 (1999 Catalog, pages 4-47 for hydroxy containing amino acids and aromatic amino acids and pages 66-87 for basic amino acids; see also http://www.amino-acids.com), incorporated herein by reference, by and available from RSP Amino Acid Analogues, Inc., Worcester, Mass. The residues containing protecting groups are deprotected using conventional techniques. Examples of synthetic acid amino acids include those derivatives bearing acidic functionality, including carboxyl, phosphate, sulfonate and synthetic tetrazolyl derivatives such as described by Omstein et al. (1993) and in U.S. Pat. No. 5,331,001, each incorporated herein by reference.

[0016] Optionally, in the peptides of the present invention, the Asn residues may be modified to contain an N-glycan and the Ser, Thr and Hyp residues may be modified to contain an O-glycan (e.g., g-N, g-S, g-T and g-Hyp). In accordance with the present invention, a glycan shall mean any N—, S— or O-linked mono-, di-, tri-, poly- or oligosaccharide that can be attached to any hydroxy, amino or thiol group of natural or modified amino acids by synthetic or enzymatic methodologies known in the art. The monosaccharides making up the glycan can include D-allose, D-altrose, D-glucose, D-mannose, D-gulose, D-idose, D-galactose, D-talose, D-galactosamine, D-glucosamine, D-N-acetyl-glucosamine (GIcNAc), D-N-acetyl-galactosamine (GalNAc), D-fucose or D-arabinose. These saccharides may be structurally modified, e.g., with one or more O-sulfate, O-phosphate, O-acetyl or acidic groups, such as sialic acid, including combinations thereof. The gylcan may also include similar polyhydroxy groups, such as D-penicillamine 2,5 and halogenated derivatives thereof or polypropylene glycol derivatives. The glycosidic linkage is beta and 1-4 or 1-3, preferably 1-3. The linkage between the glycan and the amino acid may be alpha or beta, preferably alpha and is 1-.

[0017] Core O-glycans have been described by Van de Steen et al. (1998), incorporated herein by reference. Mucin type O-linked oligosaccharides are attached to Ser or Thr (or other hydroxylated residues of the present peptides) by a GalNAc residue. The monosaccharide building blocks and the linkage attached to this first GaINAc residue define the “core glycans,” of which eight have been identified. The type of glycosidic linkage (orientation and connectivities) are defined for each core glycan. Suitable glycans and glycan analogs are described further in U.S. Ser. No. 09/420,797 filed Oct. 19, 1999 and in PCT Application No. PCT/US99/24380 filed Oct. 19, 1999 (PCT Published Application No. WO 00/23092), each incorporated herein by reference. A preferred glycan is Gal(β1→3)GalNAc(α1→).

[0018] Optionally, in the peptides of general formula I and the specific peptides described herein, pairs of Cys residues may be replaced pairwise with isoteric lactam or ester-thioether replacements, such as Ser/(Glu or Asp), Lys/(Glu or Asp), Cys/(Glu or Asp) or Cys/Ala combinations. Sequential coupling by known methods (Barnay et al., 2000; Hruby et al., 1994; Bitan et al., 1997) allows replacement of native Cys bridges with lactam bridges. Thioether analogs may be readily synthesized using halo-Ala residues commercially available from RSP Amino Acid Analogues.

[0019] The present invention is further directed to derivatives of the above peptides and peptide derivatives which are acylic permutations in which the cyclic permutants retain the native bridging pattern of native toxin. See, Craik et al. (2001).

[0020] In a fourth embodiment, the present invention is directed to uses of the conotoxin peptides described herein. In one aspect of this embodiment, members of the O-Superfamily conotoxins disclosed herein or a pharmaceutically acceptable salt or solvate thereof are used for regulating the flow of sodium ions through Na⁺ channels. Disorders which can be treated using these conopeptides include multiple sclerosis, other demyelinating diseases (such as acute dissenmiated encephalomyelitis, optic neuromyelitis, adrenoleukodystrophy, acute transverse myelitis, progressive multifocal leukoencephalopathy), sub-acute sclerosing panencephalomyelitis (SSPE), metachromatic leukodystrophy, Pelizaeus-Merzbacher disease, spinal cord injury, botulinum toxin poisoning, Huntington's chorea, compression and entrapment neurophathies (such as carpal tunnel syndrome, ulnar nerve palsy), cardiovascular disorders (such as cardiac arrhythmias, congestive heart failure), reactive gliosis, hyperglycemia, immunosuppression, cocaine addiction, cancer, cognitive dysfunction, disorders resulting from defects in neurotransmitter release (such as Eaton-Lambert syndrome), and reversal of the actions of curare and other neuromuscular blocking drugs.

[0021] In a second apsect of this embodiment, a method of treating disorders associated with voltage gated ion channel disorders in a subject is provided which comprises administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a member of the O-Superfamily contoxins described herein or a pharmaceutically acceptable salt or solvate thereof. Thus, these peptides can be used to treat neurologic disorders, such as anticonvulsant agents, or as neuroprotective agents, such as for treating stroke, or as cardiovascular agents or for the management of pain. These peptides can further be used to treat spasticity, spinal cord injury or upper motor neuron syndrome.

[0022] In a third aspect of this embodiment, a method of reducing/alleviating/decreasing the perception of pain by a subject or for inducing analgesia, particularly local analgesia, in a subject is provided which comprises administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a member of the O-Superfamily contoxins described herein or a pharmaceutically acceptable salt or solvate thereof.

[0023] In a fourth aspect of this embodiment, a method for activating (i.e., opening) ATP-sensitive K⁺ channels in a subject is provided which comprises administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a member of the O-Superfamily contoxins described herein or a pharmaceutically acceptable salt or solvate thereof.

[0024] In a fifth aspect of this embodiment, a method of treating disorders and conditions associated with proton-gated ion channels in a subject comprising administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a member of the O-Superfamily conotoxins described herein or a pharmaceutically acceptable salt or solvate thereof.

[0025] Another embodiment of the invention contemplates a method of identifying compounds that mimic the therapeutic activity of the instant peptide, comprising the steps of: (a) conducting a biological assay on a test compound to determine the therapeutic activity; and (b) comparing the results obtained from the biological assay of the test compound to the results obtained from the biological assay of the peptide. The peptide is labeled with any conventional label, preferably a radioiodine on an available Tyr. Thus, the invention is also directed to radioiodinated O-Superfamily conotoxins.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

[0026] The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include three disulfide bonds.

[0027] The present invention, in another aspect, relates to a pharmaceutical composition comprising an effective amount of an O-Superfamily conotoxin peptide, a mutein thereof, an analog thereof, an active fragment thereof or pharmaceutically acceptable salts.

[0028] In one embodiment, such a pharmaceutical composition comprises a member of the O-Superfamily conotoxins described herein which has the capability of delaying inactivation of sodium channels. The activity of δ-conotoxin peptides, members of the O-Superfamily, on sodium channels is described in U.S. Pat. No. 5,739,276, incorporated herein by reference. The treatment of disorders according to this embodiment comprises the step of administering to such a living animal body, including a human, in need thereof a therapeutically effective amount of a pharmaceutical composition of the present invention.

[0029] Sodium channels comprise a large and diverse group of proteins that, through maintenance of the cellular membrane potential, are fundamental in normal biological function. The therapeutic applications for compounds that regulate the flow of sodium ions through Na⁺ channels are far-reaching and include treatments of a wide range of disease and injury states. Disorders which can be treated using these conopeptides include multiple sclerosis, other demyelinating diseases (such as acute dissenmiated encephalomyelitis, optic neuromyelitis, adrenoleukodystrophy, acute transverse myelitis, progressive multifocal leukoencephalopathy), sub-acute sclerosing panencephalomyelitis (SSPE), metachromatic leukodystrophy, Pelizaeus-Merzbacher disease, spinal cord injury, botulinum toxin poisoning, Huntington's chorea, compression and entrapment neurophathies (such as carpal tunnel syndrome, ulnar nerve palsy), cardiovascular disorders (such as cardiac arrhythmias, congestive heart failure), reactive gliosis, hyperglycemia, immunosuppression, cocaine addiction, cancer, cognitive dysfunction, disorders resulting from defects in neurotransmitter release (such as Eaton-Lambert syndrome), and reversal of the actions of curare and other neuromuscular blocking drugs.

[0030] In a second embodiment, such a pharmaceutical composition comprises a member of the O-Superfamily conotoxins described herein which has the capability of acting at voltage gated ion channels, particularly calcium channels, and are thus useful for treating a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the partial or complete blockade of voltage gated ion channels of the central nervous system. The activity of ω-conotoxin peptides, members of the O-Superfamily, on calcium channels is described in U.S. Pat. Nos. 5,587,454; 5,559,095 and 5,824,645, incorporated herein by reference. The treatment according to this embodiment comprises the step of administering to such a living animal body, including a human, in need thereof a therapeutically effective amount of a pharmaceutical composition of the present invention.

[0031] Voltage-gated calcium channels are present in neurons, and in cardiac, smooth, and skeletal muscle and other excitable cells, and are known to play a variety of roles in membrane excitability, muscle contraction, and cellular secretion, such as in synaptic transmission (McCleskey). In neuronal cells, voltage-gated calcium channels have been classified by their electrophysiological as well as by their biochemical (binding) properties. Six classes of physiologically distinct calcium channels have been identified to date, namely the T, L, N, P, Q, and R-type channels.

[0032] It is well known that an accumulation of calcium (calcium overload) in the brain is seen after anoxia, ischemia, migraine and other hyperactivity periods of the brain, such as after epileptic convulsions. An uncontrolled high concentration of calcium in the cells of the central nervous system (CNS) is known to cause most of the degenerative changes connected with the above diseases. Compounds which can block the calcium channels of brain cells are therefore useful in the treatment of stroke, anoxia, ischemia, migraine, psychosis, or epilepsy, any other convulsive disorder and in the prevention of the degenerative changes connected with the same.

[0033] Compounds blocking the so called L-type calcium channels in the CNS are useful for the treatment of the above disorders by directly blocking the calcium uptake in the CNS. Further, it is well known that the so called N- and P-types of calcium channels, as well as possibly other types of calcium channels, are involved in the regulation of neurotransmitter release. Compounds blocking the N- and/or P-types of calcium channels indirectly and very powerfully prevent calcium overload in the CNS after the hyperactivity periods of the brain as described above by inhibiting the enhanced neurotransmitter release seen after such hyperactivity periods of the CNS, and especially the neurotoxic, enhanced glutamate release after such hyperactivity periods of the CNS. Furthermore, blockers of the N- and/or P-types of calcium channels, as dependent upon the selectivity of the compound in question, inhibit the release of various other neurotransmitters such as aspartate, GABA, glycine, dopamine, serotonin and noradrenaline.

[0034] Thus, the pharmaceutical compositions comprising a member of the O-Superfamily conotoxins of the present invention are useful as neuroprotectants, cardiovascular agents, anticonvulsants, analgesics or adjuvants to general anesthetics. A “neurological disorder or disease” is a disorder or disease of the nervous system including, but not limited to, global and focal ischemic and hemorrhagic stroke, head trauma, spinal cord injury, hypoxia-induced nerve cell damage as in cardiac arrest or neonatal distress or epilepsy. In addition, a “neurological disorder or disease” is a disease state and condition in which a neuroprotectant, anticonvulsant, analgesic and/or as an adjunct in general anesthesia may be indicated, useful, recommended or prescribed.

[0035] More specifically, the present invention is directed to the use of a member of the O-Superfamily conotoxins for the treatment and alleviation of epilepsy and as a general anticonvulsant agent. The present invention is also directed to the use of these compounds for reducing neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, cerebrovascular accident, brain or spinal cord trauma, myocardial infarct, physical trauma, drowning, suffocation, perinatal asphyxia, or hypoglycemic events. The present invention is further directed to the use of O-superfamily-conotoxin peptides for treating pain, including acute and chronic pain, such migraine, nociceptive and neuropathic pain. These peptides can further be used to treat spasticity, spinal cord injury or upper motor neuron syndrome. Other uses of these compounds are described in U.S. Pat. No. 5,859,186, incorporated herein by reference.

[0036] A “neuroprotectant” is a compound capable of preventing the neuronal death associated with a neurological disorder or disease. An “anticonvulsant” is a compound capable of reducing convulsions produced by conditions such as simple partial seizures, complex partial seizures, status epilepticus, and trauma-induced seizures such as occur following head injury, including head surgery. An “analgesic” is a compound capable of relieving pain by altering perception of nociceptive stimuli without producing anesthesia or loss of consciousness. A “muscle relaxant” is a compound that reduces muscular tension. A “adjunct in general anesthesia” is a compound useful in conjunction with anesthetic agents in producing the loss of ability to perceive pain associated with the loss of consciousness.

[0037] The invention relates as well to methods useful for treatment of neurological disorders and diseases, including, but not limited to, global and focal ischemic and hemorrhagic stroke, head trauma, spinal cord injury, hypoxia-induced nerve cell damage such as in cardiac arrest or neonatal distress, epilepsy or other convulsive disorders without undesirable side effects.

[0038] Thus, in one aspect, the invention provides a method of reducing/alleviating/decreasing the perception of pain by a subject or for inducing analgesia in a subject comprising administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a member of the O-Superfamily conotoxins of the present invention or a pharmaceutically acceptable salt or solvate thereof. The pain may be acute, persistent, inflammatory or neuropathic pain.

[0039] In a second aspect, the invention provides a method of treating stroke, head or spinal cord trauma or injury, anoxia, hypoxia-induced nerve cell damage, ischemia, migraine, psychosis, anxiety, schizophrenia, inflammation, movement disorder, epilepsy, any other convulsive disorder or in the prevention of the degenerative changes connected with the same in a subject comprising administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a member of the O-Superfamily conotoxins of the present invention or a pharmaceutically acceptable salt or solvate thereof.

[0040] In a third embodiment, such a pharmaceutical composition comprises a member of the O-Superfamily conotoxins described herein which is useful as a local anesthetic for treating pain. These conopeptides have long lasting anesthetic activity and are particularly useful for spinal anesthesia, either administered acutely for post-operative pain or via an intrathecal pump for severe chronic pain situations or for treatment of pain in epithelial tissue. The activity of μO-conotoxin peptides, members of the O-Superfamily, on sodium channels is described in U.S. patent application Ser. No. 09/590,386 (International Application No. PCT/US00/15779) filed on Jun. 9, 2000, incorporated herein by reference. The treatment according to this embodiment comprises the step of administering to such a living animal body, including a human, in need thereof a therapeutically effective amount of a pharmaceutical composition of the present invention.

[0041] More specifically, in one aspect, the pain results from surgical or medical procedures, and a member of the O-Superfamily conotoxins as described herein is administered to the central nervous system (CNS), e.g. to the spine for spinal analgesia. In a second aspect, the pain is in an epithelial tissue region associated with damage or loss of epithelial tissue as a result of, for example, plastic surgery, canker sores, burns, sore throats, genital lesions, upper or lower gastrointestinal bronchoscopy or endoscopy, intubation, dermatologic abrasions or chemical skin peels, and a member of the O-Superfamily conotoxins as described herein is administered to alleviate the associated pain.

[0042] In a fourth embodiment, such a pharmaceutical composition comprises a member of the O-Superfamily conotoxins which has the capability of activating (i.e., opening) ATP-sensitive K⁻ channels, and is thus useful for for treating a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the activation of ATP-sensitive K⁺ channels. The activity of κ-conotoxin peptides, members of the O-Superfamily, on sodium channels is described in U.S. patent application Ser. No. ______ (International Application No. PCT/US00/25827) filed on Sep. 21, 2000, incorporated herein by reference. The treatment according to this embodiment comprises the step of administering to such a living animal body, including a human, in need thereof a therapeutically effective amount of a pharmaceutical composition of the present invention. Thus the invention provides a method for treating cardiac ischemia, neuronal ischemia, ocular ischemia or asthma in a subject comprising administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a member of the O-Superfamily conotoxins described herein or a pharmaceutically acceptable salt or solvate thereof.

[0043] In a fifth embodiment, such a pharmaceutical composition comprises a member of the O-Superfamily conotoxins which has the capability of acting on proton gated ion channels, and ise thus useful for treating a disorder, disease or condition of a living animal body, including a human, which disorder, disease or condition is responsive to the partial or complete blockade of proton-gated ion channels. Since, these members of the O-Superfamily antagonize the proton-gated ion channel, they are useful as analgesics, especially for pain associated with inflammation, hematomas, cardiac or muscle ischemia, or cancer. Thus, in one aspect of the present invention, the peptides and derivatives disclosed herein are useful as analgesics, i.e., for the reduction in the perception of pain or the induction of analgesia. The treatment according to this embodiment comprises the step of administering to such a living animal body, including a human, in need thereof a therapeutically effective amount of a pharmaceutical composition of the present invention.

[0044] The conotoxin peptides of the present invention are identified by isolation from Conus venom. Alternatively, the conotoxin peptides of the present invention are identified using recombinant DNA techniques by screening cDNA libraries of various Conus species using conventional techniques, such as the use of reverse-transcriptase polymerase chain reaction (RT-PCR) or the use of degenerate probes. Primers for RT-PCR are based on conserved sequences in the signal sequence and 3′ untranslated region of the conotoxin peptides genes isolated using degenerate probes. Clones which hybridize to degenerate probes are analyzed to identify those which meet minimal size requirements, i.e., clones having approximately 300 nucleotides (for a propeptide), as determined using PCR primers which flank the cDNA cloning sites for the specific CDNA library being examined. These minimal-sized clones and the clones produced by RT-PCR are then sequenced. The sequences are then examined for the presence of a peptide having the characteristics noted above for the O-Superfamily conotoxin peptides.

[0045] The conotoxin peptides described herein are sufficiently small to be chemically synthesized. General chemical syntheses for preparing the foregoing conotoxin peptides are described hereinafter. Various ones of the conotoxin peptides can also be obtained by isolation and purification from specific Conus species using the technique described in U.S. Pat. Nos. 4,447,356 (Olivera et al., 1984); 5,514,774; 5,719,264; and 5,591,821, as well as in PCT published application WO 98/03189, the disclosures of which are incorporated herein by reference.

[0046] Although the conotoxin peptides of the present invention can be obtained by purification from cone snails, because the amounts of conotoxin peptides obtainable from individual snails are very small, the desired substantially pure conotoxin peptides are best practically obtained in commercially valuable amounts by chemical synthesis using solid-phase strategy. For example, the yield from a single cone snail may be about 10 micrograms or less of conotoxin peptide. By “substantially pure” is meant that the peptide is present in the substantial absence of other biological molecules of the same type; it is preferably present in an amount of at least about 85% purity and preferably at least about 95% purity. Chemical synthesis of biologically active conotoxin peptides depends of course upon correct determination of the amino acid sequence.

[0047] The conotoxin peptides can also be produced by recombinant DNA techniques well known in the art. Such techniques are described by Sambrook et al. (1989). A gene of interest (i.e., a gene that encodes a suitable conotoxin peptide) can be inserted into a cloning site of a suitable expression vector by using standard techniques. These techniques are well known to those skilled in the art. The expression vector containing the gene of interest may then be used to transfect the desired cell line. Standard transfection techniques such as calcium phosphate co-precipitation, DEAE-dextran transfection or electroporation may be utilized. A wide variety of host/expression vector combinations may be used to express a gene encoding a conotoxin peptide of interest. Such combinations are well known to a skilled artisan. The peptides produced in this manner are isolated, reduced if necessary, and oxidized to form the correct disulfide bonds.

[0048] One method of forming disulfide bonds in the conotoxin peptides of the present invention is the air oxidation of the linear peptides for prolonged periods under cold room temperatures or at room temperature. This procedure results in the creation of a substantial amount of the bioactive, disulfide-linked peptides. The oxidized peptides are fractionated using reverse-phase high performance liquid chromatography (HPLC) or the like, to separate peptides having different linked configurations. Thereafter, either by comparing these fractions with the elution of the native material or by using a simple assay, the particular fraction having the correct linkage for maximum biological potency is easily determined. However, because of the dilution resulting from the presence of other fractions of less biopotency, a somewhat higher dosage may be required.

[0049] The peptides are synthesized by a suitable method, such as by exclusively solid-phase techniques, by partial solid-phase techniques, by fragment condensation or by classical solution couplings.

[0050] In conventional solution phase peptide synthesis, the peptide chain can be prepared by a series of coupling reactions in which constituent amino acids are added to the growing peptide chain in the desired sequence. Use of various coupling reagents, e.g., dicyclohexylcarbodiimide or diisopropylcarbonyldimidazole, various active esters, e.g., esters of N-hydroxyphthalimide or N-hydroxy-succinimide, and the various cleavage reagents, to carry out reaction in solution, with subsequent isolation and purification of intermediates, is well known classical peptide methodology. Classical solution synthesis is described in detail in the treatise, “Methoden der Organischen Chemie (Houben-Weyl): Synthese von Peptiden,” (1974). Techniques of exclusively solid-phase synthesis are set forth in the textbook, “Solid-Phase Peptide Synthesis,” (Stewart and Young, 1969), and are exemplified by the disclosure of U.S. Pat. No. 4,105,603 (Vale et al., 1978). The fragment condensation method of synthesis is exemplified in U.S. Pat. No. 3,972,859 (1976). Other available syntheses are exemplified by U.S. Pat. Nos. 3,842,067 (1974) and 3,862,925 (1975). The synthesis of peptides containing γ-carboxyglutamic acid residues is exemplified by Rivier et al. (1987), Nishiuchi et al. (1993) and Zhou et al. (1996).

[0051] Common to such chemical syntheses is the protection of the labile side chain groups of the various amino acid moieties with suitable protecting groups which will prevent a chemical reaction from occurring at that site until the group is ultimately removed. Usually also common is the protection of an α-amino group on an amino acid or a fragment while that entity reacts at the carboxyl group, followed by the selective removal of the α-amino protecting group to allow subsequent reaction to take place at that location. Accordingly, it is common that, as a step in such a synthesis, an intermediate compound is produced which includes each of the amino acid residues located in its desired sequence in the peptide chain with appropriate side-chain protecting groups linked to various ones of the residues having labile side chains.

[0052] As far as the selection of a side chain amino protecting group is concerned, generally one is chosen which is not removed during deprotection of the α-amino groups during the synthesis. However, for some amino acids, e.g., His, protection is not generally necessary. In selecting a particular side chain protecting group to be used in the synthesis of the peptides, the following general rules are followed: (a) the protecting group preferably retains its protecting properties and is not split off under coupling conditions, (b) the protecting group should be stable under the reaction conditions selected for removing the α-amino protecting group at each step of the synthesis, and (c) the side chain protecting group must be removable, upon the completion of the synthesis containing the desired amino acid sequence, under reaction conditions that will not undesirably alter the peptide chain.

[0053] It should be possible to prepare many, or even all, of these peptides using recombinant DNA technology. However, when peptides are not so prepared, they are preferably prepared using the Merrifield solid-phase synthesis, although other equivalent chemical syntheses known in the art can also be used as previously mentioned. Solid-phase synthesis is commenced from the C-terminus of the peptide by coupling a protected α-amino acid to a suitable resin. Such a starting material can be prepared by attaching an a-anino-protected amino acid by an ester linkage to a chloromethylated resin or a hydroxymethyl resin, or by an amide bond to a benzhydrylamine (BHA) resin or para-methylbenzhydrylamine (MBHA) resin. Preparation of the hydroxymethyl resin is described by Bodansky et al. (1966). Chloromethylated resins are commercially available from Bio Rad Laboratories (Richmond, Calif.) and from Lab. Systems, Inc. The preparation of such a resin is described by Stewart and Young (1969). BHA and MBHA resin supports are commercially available, and are generally used when the desired polypeptide being synthesized has an unsubstituted amide at the C-terminus. Thus, solid resin supports may be any of those known in the art, such as one having the formulae —O—CH₂-resin support, —NH-BHA resin support, or —NH-MBHA resin support. When the unsubstituted amide is desired, use of a BHA or MBHA resin is preferred, because cleavage directly gives the amide. In case the N-methyl amide is desired, it can be generated from an N-methyl BHA resin. Should other substituted amides be desired, the teaching of U.S. Pat. No. 4,569,967 (Kornreich et al., 1986) can be used, or should still other groups than the free acid be desired at the C-terminus, it may be preferable to synthesize the peptide using classical methods as set forth in the Houben-Weyl text (1974).

[0054] The C-terminal amino acid, protected by Boc or Fmoc and by a side-chain protecting group, if appropriate, can be first coupled to a chloromethylated resin according to the procedure set forth in K. Horiki et al. (1978), using KF in DMF at about 60° C. for 24 hours with stirring, when a peptide having free acid at the C-terminus is to be synthesized. Following the coupling of the BOC-protected amino acid to the resin support, the α-amino protecting group is removed, as by using trifluoroacetic acid (TFA) in methylene chloride or TFA alone. The deprotection is carried out at a temperature between about 0° C. and room temperature. Other standard cleaving reagents, such as HCl in dioxane, and conditions for removal of specific α-amino protecting groups may be used as described in Schroder & Lubke (1965).

[0055] After removal of the α-amino-protecting group, the remaining α-amino- and side chain-protected amino acids are coupled step-wise in the desired order to obtain the intermediate compound defined hereinbefore, or as an alternative to adding each amino acid separately in the synthesis, some of them may be coupled to one another prior to addition to the solid phase reactor. Selection of an appropriate coupling reagent is within the skill of the art. Particularly suitable as a coupling reagent is N,N′-dicyclohexylcarbodiimide (DCC, DIC, HBTU, HATU, TBTU in the presence of HOBt or HOAt).

[0056] The activating reagents used in the solid phase synthesis of the peptides are well known in the peptide art. Examples of suitable activating reagents are carbodiimides, such as N,N′-diisopropylcarbodiimide and N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide. Other activating reagents and their use in peptide coupling are described by Schroder & Lubke (1965) and Kapoor (1970).

[0057] Each protected amino acid or amino acid sequence is introduced into the solid-phase reactor in about a twofold or more excess, and the coupling may be carried out in a medium of dimethylformamide (DMF): CH₂Cl₂ (1:1) or in DMF or CH₂Cl₂ alone. In cases where intermediate coupling occurs, the coupling procedure is repeated before removal of the α-amino protecting group prior to the coupling of the next amino acid. The success of the coupling reaction at each stage of the synthesis, if performed manually, is preferably monitored by the ninhydrin reaction, as described by Kaiser et al. (1970). Coupling reactions can be performed automatically, as on a Beckman 990 automatic synthesizer, using a program such as that reported in Rivier et al. (1978).

[0058] After the desired amino acid sequence has been completed, the intermediate peptide can be removed from the resin support by treatment with a reagent, such as liquid hydrogen fluoride or TFA (if using Fmoc chemistry), which not only cleaves the peptide from the resin but also cleaves all remaining side chain protecting groups and also the α-amino protecting group at the N-terminus if it was not previously removed to obtain the peptide in the form of the free acid. If Met is present in the sequence, the Boc protecting group is preferably first removed using trifluoroacetic acid (TFA)/ethanedithiol prior to cleaving the peptide from the resin with HF to eliminate potential S-alkylation. When using hydrogen fluoride or TFA for cleaving, one or more scavengers such as anisole, cresol, dimethyl sulfide and methylethyl sulfide are included in the reaction vessel.

[0059] Cyclization of the linear peptide is preferably affected, as opposed to cyclizing the peptide while a part of the peptido-resin, to create bonds between Cys residues. To effect such a disulfide cyclizing linkage, fully protected peptide can be cleaved from a hydroxymethylated resin or a chloromethylated resin support by ammonolysis, as is well known in the art, to yield the fully protected amide intermediate, which is thereafter suitably cyclized and deprotected. Alternatively, deprotection, as well as cleavage of the peptide from the above resins or a benzhydrylamine (BHA) resin or a methylbenzhydrylamine (MBHA), can take place at 0° C. with hydrofluoric acid (HF) or TFA, followed by oxidation as described above.

[0060] The peptides are also synthesized using an automatic synthesizer. Amino acids are sequentially coupled to an MBHA Rink resin (typically 100 mg of resin) beginning at the C-terminus using an Advanced Chemtech 357 Automatic Peptide Synthesizer. Couplings are carried out using 1,3-diisopropylcarbodimide in N-methylpyrrolidinone (NMP) or by 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) and diethylisopro- pylethylamine (DIEA). The FMOC protecting group is removed by treatment with a 20% solution of piperidine in dimethylformamide (DMF). Resins are subsequently washed with DMF (twice), followed by methanol and NMP.

[0061] Muteins, analogs or active fragments, of the foregoing tconotoxin peptides are also contemplated here. See, e.g., Hammerland et al, Eur. J. Pharmacol., 226, pp. 239-244 (1992). Derivative muteins, analogs or active fragments of the conotoxin peptides may be synthesized according to known techniques, including conservative amino acid substitutions, such as outlined in U.S. Pat. No. 5,545,723 (see particularly col. 2, line 50—col. 3, line 8); U.S. Pat. No. 5,534,615 (see particularly col. 19, line 45—col. 22, line 33); and U.S. Pat. No. 5,364,769 (see particularly col. 4, line 55—col. 7, line 26), each herein incorporated by reference.

[0062] Pharmaceutical compositions containing a compound of the present invention or its pharmaceutically acceptable salts or solvates as the active ingredient can be prepared according to conventional pharmaceutical compounding techniques. See, for example, Remington's Pharmaceutical Sciences, 18th Ed. (1990, Mack Publishing Co., Easton, Pa.). Typically, an antagonistic amount of the active ingredient will be admixed with a pharmaceutically acceptable carrier. The carrier may take a wide variety of forms depending on the form of preparation desired for administration, e.g., intravenous, oral or parenteral. The compositions may further contain antioxidizing agents, stabilizing agents, preservatives and the like. For examples of delivery methods see U.S. Pat. No. 5,844,077, incorporated herein by reference.

[0063] “Pharmaceutical composition” means physically discrete coherent portions suitable for medical administration. “Pharmaceutical composition in dosage unit form” means physically discrete coherent units suitable for medical administration, each containing a daily dose or a multiple (up to four times) or a sub-multiple (down to a fortieth) of a daily dose of the active compound in association with a carrier and/or enclosed within an envelope. Whether the composition contains a daily dose, or for example, a half, a third or a quarter of a daily dose, will depend on whether the pharmaceutical composition is to be administered once or, for example, twice, three times or four times a day, respectively.

[0064] The term “salt”, as used herein, denotes acidic and/or basic salts, formed with inorganic or organic acids and/or bases, preferably basic salts. While pharmaceutically acceptable salts are preferred, particularly when employing the compounds of the invention as medicaments, other salts find utility, for example, in processing these compounds, or where non-medicament-type uses are contemplated. Salts of these compounds may be prepared by art-recognized techniques.

[0065] Examples of such pharmaceutically acceptable salts include, but are not limited to, inorganic and organic addition salts, such as hydrochloride, sulphates, nitrates or phosphates and acetates, trifluoroacetates, propionates, succinates, benzoates, citrates, tartrates, fumarates, maleates, methane-sulfonates, isothionates, theophylline acetates, salicylates, respectively, or the like. Lower alkyl quaternary ammonium salts and the like are suitable, as well.

[0066] As used herein, the term “pharmaceutically acceptable” carrier means a non-toxic, inert solid, semi-solid liquid filler, diluent, encapsulating material, formulation auxiliary of any type, or simply a sterile aqueous medium, such as saline. Some examples of the materials that can serve as pharmaceutically acceptable carriers are sugars, such as lactose, glucose and sucrose, starches such as corn starch and potato starch, cellulose and its derivatives such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt, gelatin, talc; excipients such as cocoa butter and suppository waxes; oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols, such as propylene glycol, polyols such as glycerin, sorbitol, mannitol and polyethylene glycol; esters such as ethyl oleate and ethyl laurate, agar; buffering agents such as magnesium hydroxide and aluminum hydroxide; alginic acid; pyrogen-free water; isotonic saline, Ringer's solution; ethyl alcohol and phosphate buffer solutions, as well as other non-toxic compatible substances used in pharmaceutical formulations.

[0067] Wetting agents, emulsifiers and lubricants such as sodium lauryl sulfate and magnesium stearate, as well as coloring agents, releasing agents, coating agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants can also be present in the composition, according to the judgment of the formulator. Examples of pharmaceutically acceptable antioxidants include, but are not limited to, water soluble antioxidants such as ascorbic acid, cysteine hydrochloride, sodium bisulfite, sodium metabisulfite, sodium sulfite, and the like; oil soluble antioxidants, such as ascorbyl palmitate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), lecithin, propyl gallate, aloha-tocopherol and the like; and the metal chelating agents such as citric acid, ethylenediamine tetraacetic acid (EDTA), sorbitol, tartaric acid, phosphoric acid and the like.

[0068] For oral administration, the compounds can be formulated into solid or liquid preparations such as capsules, pills, tablets, lozenges, melts, powders, suspensions or emulsions. In preparing the compositions in oral dosage form, any of the usual pharmaceutical media may be employed, such as, for example, water, glycols, oils, alcohols, flavoring agents, preservatives, coloring agents, suspending agents, and the like in the case of oral liquid preparations (such as, for example, suspensions, elixirs and solutions); or carriers such as starches, sugars, diluents, granulating agents, lubricants, binders, disintegrating agents and the like in the case of oral solid preparations (such as, for example, powders, capsules and tablets). Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit form, in which case solid pharmaceutical carriers are obviously employed. If desired, tablets may be sugar-coated or enteric-coated by standard techniques. The active agent can be encapsulated to make it stable to passage through the gastrointestinal tract while at the same time allowing for passage across the blood brain barrier. See for example, WO 96/11698.

[0069] For parenteral administration, the compound may be dissolved in a pharmaceutical carrier and administered as either a solution or a suspension. Illustrative of suitable carriers are water, saline, dextrose solutions, fructose solutions, ethanol, or oils of animal, vegetative or synthetic origin. The carrier may also contain other ingredients, for example, preservatives, suspending agents, solubilizing agents, buffers and the like. When the compounds are being administered intrathecally, they may also be dissolved in cerebrospinal fluid.

[0070] A variety of administration routes are available. The particular mode selected will depend of course, upon the particular drug selected, the severity of the disease state being treated and the dosage required for therapeutic efficacy. The methods of this invention, generally speaking, may be practiced using any mode of administration that is medically acceptable, meaning any mode that produces effective levels of the active compounds without causing clinically unacceptable adverse effects. Such modes of administration include oral, rectal, sublingual, topical, nasal, transdermal or parenteral routes. The term “parenteral” includes subcutaneous, intravenous, epidural, irrigation, intramuscular, release pumps, or infusion.

[0071] For example, administration of the active agent according to this invention may be achieved using any suitable delivery means, including:

[0072] (a) pump (see, e.g., Luer & Hatton (1993), Zimm et al. (1984) and Ettinger et al. (1978));

[0073] (b), microencapsulation (see, e.g., U.S. Pat. Nos. 4,352,883; 4,353,888; and 5,084,350);

[0074] (c) continuous release polymer implants (see, e.g., U.S. Pat. No. 4,883,666);

[0075] (d) macroencapsulation (see, e.g., U.S. Pat. Nos. 5,284,761, 5,158,881, 4,976,859 and 4,968,733 and published PCT patent applications WO92/19195, WO 95/05452);

[0076] (e) naked or unencapsulated cell grafts to the CNS (see, e.g., U.S. Pat. Nos. 5,082,670 and 5,618,531);

[0077] (f) injection, either subcutaneously, intravenously, intra-arterially, intramuscularly, or to other suitable site; or

[0078] (g) oral administration, in capsule, liquid, tablet, pill, or prolonged release formulation.

[0079] In one embodiment of this invention, an active agent is delivered directly into the CNS, preferably to the brain ventricles, brain parenchyma, the intrathecal space or other suitable CNS location, most preferably intrathecally. This administration is preferably by a pump.

[0080] Alternatively, targeting therapies may be used to deliver the active agent more specifically to certain types of cell, by the use of targeting systems such as antibodies or cell specific ligands. Targeting may be desirable for a variety of reasons, e.g. if the agent is unacceptably toxic, or if it would otherwise require too high a dosage, or if it would not otherwise be able to enter the target cells.

[0081] The active agents, which are peptides, can also be administered in a cell based delivery system in which a DNA sequence encoding an active agent is introduced into cells designed for implantation in the body of the patient, especially in the spinal cord region. Suitable delivery systems are described in U.S. Pat. No. 5,550,050 and published PCT Application Nos. WO 92/19195, WO 94/25503, WO 95/01203, WO 95/05452, WO 96/02286, WO 96/02646, WO 96/40871, WO 96/40959 and WO 97/12635. Suitable DNA sequences can be prepared synthetically for each active agent on the basis of the developed sequences and the known genetic code.

[0082] The active agent is preferably administered in a therapeutically effective amount. By a “therapeutically effective amount” or simply “effective amount” of an active compound is meant a sufficient amount of the compound to treat the desired condition at a reasonable benefit/risk ratio applicable to any medical treatment. The actual amount administered, and the rate and time-course of administration, will depend on the nature and severity of the condition being treated. Prescription of treatment, e.g. decisions on dosage, timing, etc., is within the responsibility of general practitioners or specialists, and typically takes account of the disorder to be treated, the condition of the individual patient, the site of delivery, the method of administration and other factors known to practitioners. Examples of techniques and protocols can be found in Remington's Pharmaceutical Sciences.

[0083] Dosage may be adjusted appropriately to achieve desired drug levels, locally or systemically. Typically the active agents of the present invention exhibit their effect at a dosage range from about 0.001 mg/kg to about 250 mg/kg, preferably from about 0.01 mg/kg to about 100 mg/kg of the active ingredient, more preferably from a bout 0.05 mg/kg to about 75 mg/kg. A suitable dose can be administered in multiple sub-doses per day. Typically, a dose or sub-dose may contain from about 0.1 mg to about 500 mg of the active ingredient per unit dosage form. A more preferred dosage will contain from about 0.5 mg to about 100 mg of active ingredient per unit dosage form. Dosages are generally initiated at lower levels and increased until desired effects are achieved. In the event that the response in a subject is insufficient at such doses, even higher doses (or effective higher doses by a different, more localized delivery route) may be employed to the extent that patient tolerance permits. Continuous dosing over, for example 24 hours or multiple doses per day are contemplated to achieve appropriate systemic levels of compounds.

[0084] For the treatment of pain, if the route of administration is directly to the CNS, the dosage contemplated is from about 1 ng to about 100 mg per day, preferably from about 100 ng to about 10 mg per day, more preferably from about 1 μg to about 100 μg per day. If administered peripherally, the dosage contemplated is somewhat higher, from about 100 ng to about 1000 mg per day, preferably from about 10 μg to about 100 mg per day, more preferably from about 100 μg to about 10 mg per day. If the conopeptide is delivered by continuous infusion (e.g., by pump delivery, biodegradable polymer delivery or cell-based delivery), then a lower dosage is contemplated than for bolus delivery.

[0085] Advantageously, the compositions are formulated as dosage units, each unit being adapted to supply a fixed dose of active ingredients. Tablets, coated tablets, capsules, ampoules and suppositories are examples of dosage forms according to the invention.

[0086] It is only necessary that the active ingredient constitute an effective amount, i.e., such that a suitable effective dosage will be consistent with the dosage form employed in single or multiple unit doses. The exact individual dosages, as well as daily dosages, are determined according to standard medical principles under the direction of a physician or veterinarian for use humans or animals.

[0087] The pharmaceutical compositions will generally contain from about 0.0001 to 99 wt. %, preferably about 0.001 to 50 wt. %, more preferably about 0.01 to 10 wt. % of the active ingredient by weight of the total composition. In addition to the active agent, the pharmaceutical compositions and medicaments can also contain other pharmaceutically active compounds. Examples of other pharmaceutically active compounds include, but are not limited to, analgesic agents, cytokines and therapeutic agents in all of the major areas of clinical medicine. When used with other pharmaceutically active compounds, the conotoxin peptides of the present invention may be delivered in the form of drug cocktails. A cocktail is a mixture of any one of the compounds useful with this invention with another drug or agent. In this embodiment, a common administration vehicle (e.g., pill, tablet, implant, pump, injectable solution, etc.) would contain both the instant composition in combination supplementary potentiating agent. The individual drugs of the cocktail are each administered in therapeutically effective amounts. A therapeutically effective amount will be determined by the parameters described above; but, in any event, is that amount which establishes a level of the drugs in the area of body where the drugs are required for a period of time which is effective in attaining the desired effects.

[0088] The practice of the present invention employs, unless otherwise indicated, conventional techniques of chemistry, molecular biology, microbiology, recombinant DNA, genetics, immunology, cell biology, cell culture and transgenic biology, which are within the skill of the art. See, e.g., Maniatis et al., 1982; Sambrook et al., 1989; Ausubel et al., 1992; Glover, 1985; Anand, 1992; Guthrie and Fink, 1991; Harlow and Lane, 1988; Jakoby and Pastan, 1979; Nucleic Acid Hybridization (B. D. Hames & S. J. Higgins eds. 1984); Transcription And Translation (B. D. Hames & S. J. Higgins eds. 1984); Culture Of Animal Cells (R. I. Freshney, Alan R. Liss, Inc., 1987); Immobilized Cells And Enzymes (IRL Press, 1986); B. Perbal, A Practical Guide To Molecular Cloning (1984); the treatise, Methods In Enzymology (Academic Press, Inc., N.Y.); Gene Transfer Vectors For Mammalian Cells (J. H. Miller and M. P. Calos eds., 1987, Cold Spring Harbor Laboratory); Methods In Enzymology, Vols. 154 and 155 (Wu et al. eds.), Immunochemical Methods In Cell And Molecular Biology (Mayer and Walker, eds., Academic Press, London, 1987); Handbook Of Experimental Immunology, Volumes I-IV (D. M. Weir and C. C. Blackwell, eds., 1986); Riott, Essential Immunology, 6th Edition, Blackwell Scientific Publications, Oxford, 1988; Hogan et al., Manipulating the Mouse Embryo, (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1986).

EXAMPLES

[0089] The present invention is described by reference to the following Examples, which are offered by way of illustration and are not intended to limit the invention in any manner. Standard techniques well known in the art or the techniques specifically described below were utilized.

Example 1 Isolation of O-Superfamily Conotoxins

[0090] Crude venom was extracted from venom ducts (Cruz et al., 1976), and the components were purified as previously described (Cartier et al., 1996). The crude extract from venom ducts was purified by reverse phase liquid chromatography (RPLC) using a Vydac C₁₈ semi-preparative column (10×250 mm). Further purification of bioactive peaks was done on a Vydac C₁₈ analytical column (4.6×220 mm). The effluents were monitored at 220 nm. Peaks were collected, and aliquots were assayed for activity.

[0091] The amino acid sequence of the purified peptides were determined by standard methods. The purified peptides were reduced and alkylated prior to sequencing by automated Edman degradation on an Applied Biosystems 477A Protein Sequencer with a 120A Analyzer (DNA/Peptide Facility, University of Utah) (Martinez et al., 1995; Shon et al., 1994).

[0092] In accordance with this method, peptides δ-GmVIA, δ-PVIA, δ-SVIE, δ-SVIE [D1E], δ-NgVIA, δ-TxVIA and Israel TxVIA were obtained.

Example 2 Synthesis of Conopeptides

[0093] The synthesis of conopeptides, either the mature toxins or the precursor peptides, was separately performed using conventional protection chemistry as described by Cartier et al. (1996). Briefly, the linear chains were built on Rink amide resin by Fmoc procedures with 2-(1H-benzotriol-1-yl)-1,1,3,3,-tetramethyluronium tetrafluoroborated coupling using an ABI model 430A peptide sythesizer with amino acid derivatives purchased from Bachem (Torrence Calif.). Orthogonal protection was used on cysteines: two cysteines were protected as the stable Cys(S-acetamidomethyl), while the other two cysteines were protected as the acid-labile Cys(S-trityl). After removal of the terminal Fmoc protecting group and cleavage of the peptides from the resins, the released peptides were precipitated by filtering the reaction mixture into −10° C. methyl t-butyl ether, which removed the protecting groups except the Cys(S-acetamidomethyl). The peptides were dissolved in 0.1% TFA and 60% acetonitrile and purified by RPLC on a Vydac C₁₈ preparative column (22×250 mm) and eluted at a flow rate of 20 mL/min with a gradient of acetonitrile in 0.1% TFA.

[0094] The disulfide bridges in the three conopeptides were formed as described in Cartier et al. (1996). Briefly, the disulfide bridges between one pair of cysteines were formed by air oxidation which was judged to be complete by analytical RPLC. The monocyclic peptides were purified by RPLC on a Vydac C₁₈ prepartive column (22×250 mm) and eluted with a gradient of acetonitrile in 0.1% TFA. Removal of S-acetamidomethyl groups and closure of the disulfide bridge between the other pair of cysteines was carried out simultaneously be iodine oxidation. The cyclic peptides were purified by RPLC on a Vydac C₁₈ prepartive column (22×250 mm) and eluted with a gradient of acetonitrile in 0.1% TFA.

Example 3 Isolation of DNA Encoding O-Superfamily Conotoxins

[0095] DNA coding for conotoxins described herein was isolated and cloned in accordance with conventional techniques using general procedures well known in the art, such as described in Olivera et al. (1996). Alternatively, cDNA libraries was prepared from Conus venom duct using conventional techniques. DNA from single clones was amplified by conventional techniques using primers which correspond approximately to the M13 universal priming site and the M13 reverse universal priming site. Clones having a size of approximately 300-500 nucleotides were sequenced and screened for similarity in sequence to known O-Superfamily conotoxins, including the δ-conotoxins isolated in Example 1. The DNA sequences, encoded propeptide sequences and sequences of the mature toxins are set forth in the attached Table 1. DNA sequences coding for the mature toxin can also be prepared on the basis of the DNA sequences set forth on these pages. An alignment of the conotoxins is set forth in Table 2. TABLE 1 Sequences of Mature O-Superfamily Conotoxins, Propeptides and DNA Encoding Propeptides Name:      δ-GmVIA Species:   gloriamaris Isolated:  Yes Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:1) GTCACGGCTGATGACTCCGGAAATGGAATGGAGATTCTTTTTCCGAAGGCGGGTCA CGAAATGGAGAACCTCGAAGTCTCTAATCGGGTCAAGCCGTGCCGTAAAGAAGGTC AACTTTGTGATCCGATATTTCAAAACTGCTGCCGTGGCTGGAATTGCGTTCTTTTCTG CGTCTGAAACTACCGTGATGTCTTCTCTCCCCTC Translation: MKLTCMMIVAVLFLTAWTFVTADDSGNGMEILFPKAGHEMENLEVSNRVKPCRKEGQ (SEQ ID NO:2) LCDPIFQNCCRGWNCVLFCV Toxin Sequence: Val-Lys-Xaa3-Cys-Arg-Lys-Xaal-Gly-Gln-Leu-Cys-Asp-Xaa3-Ile-Phe-Gln-Asn-Cys-Cys-Arg- (SEQ ID NO:3) Gly-Xaa4-Asn-Cys-Val-Leu-Phe-Cys-Val-{circumflex over ( )} Name:       δ-GmVIA [F15Y] Species:    gloriamaris Toxin Sequence: Val-Lys-Xaa3-Cys-Arg-Lys-Xaal-Gly-Gln-Leu-Cys-Asp-Xaa3-Ile-Xaa5-Gln-Asn-Cys-Cys- (SEQ ID NO:4) Arg-Gly-Xaa4-Asn-Cys-Val-Leu-Phe-Cys-Val-{circumflex over ( )} Name:       δ-GmVIA [F27Y] Species:    gloriamaris Isolated:   No Toxin Sequence: Val-Lys-Xaa3-Cys-Arg-Lys-Xaal-Gly-Gln-Leu-Cys-Asp-Xaa3-Ile-Phe-Gln-Asn-Cys-Cys-Arg- (SEQ ID NO:5) Gly-Xaa4-Asn-Cys-Val-Leu-Xaa5-Cys-Val-{circumflex over ( )} Name:      Omaria9 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: GAAGCTGGTACGCCTGCAGGTACCGGTCCGGAATTCCCGGGTCGACATCATCATCA (SEQ ID NO:6) TCGATCCATCTGTCCATCCATCCATTCATTCATTCGCTGCCAGACTATAATAAACATT CAAGTCTCTCTTTCTTTTTGTGTCTGACAGATCGATCAGGATGTGCCGTAGAGAAGC TCAACTTTGTGATCCGATTTTTCAAAACTGCTGCCATGGCTTGTTTTGCGTTTTGGTC TGCGTCTAAAACTACCGTGATGTCTTCTCCTCCCCTCTAGTAGTAGTAGGCGGCCGC TCTAGAGGATCCAAGCTTACGTACGCGTGCATGCGACGTCATAGCTCTTCTATAGTG TCACCTAAATTCAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAACCCT GGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGCGTAAT AGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGAATGGCGA ATGGGACGCGCCCTGTAGCGGCGCATTAT Translation: SIRMCRREAQLCDPIFQNCCHGLFCVLVCV (SEQ ID NO:7) Toxin Sequence: Met-Cys-Arg-Arg-Xaa1-Ala-Gln-Leu-Cys-Asp-Xaa3-Ile-Phe-Gln-Asn-Cys-Cys-His-Gly-Leu- (SEQ ID NO:8) Phe-Cys-Val-Leu-Val-Cys-Val-{circumflex over ( )} Name:      Tx6.11 Species:    textile Isolated:  No Cloned:    Yes DNA Sequence: GGCATTACCTAAAACATCACCAAGATGAAACTGACGTGCATGATGATCGTTGCTGT (SEQ ID NO:9) GCTGTTCTTGACCGCCTGGACATTCGTCACGGCTGATGACTCCAGAAATGGAATGGA GAATCTTTTTCCGAAGGCAGGTCACGAAATGGAGAACCTCGAAGACTCTAAACACA GGCACCAGGAGAGACCGGACACCGGCGACAAAGAAGAGATGCTGCTACAGAGACA GGTCAAGCCGTGTCGTAAAGAACATCAACTTTGTGATCTGATTTTTCAAAACTGCTG CCGTGGCTGGTATTGCGTTGTTCTGTCTTGCACTTGAAAGCTACCTGATGTGTTCTAC TCCCATC Translation: MKLTCMMIVAVLFLTAWTFVTADDSRNGMENLFPKAGHEMENLEDSKHRHQERPDTG (SEQ ID NO:10) DKEEMLLQRQVKPCRKEHQLCDLIFQNCCRGWYCVVLSCT Toxin Sequence: Xaa2-Val-Lys-Xaa3-Cys-Arg-Lys-Xaa1-His-Gln-Leu-Cys-Asp-Leu-Ile-Phe-Gln-Asn-Cys-Cys- (SEQ ID NO:11) Arg-Gly-Xaa4-Xaa5-Cys-Val-Val-Leu-Ser-Cys-Thr-{circumflex over ( )} Name:      Om6.6 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCCTGATGATCGTTGCCGTGCTGTCCTTGACCGGCTGGACATTC (SEQ ID NO:12) GTCACGGCTGATGACTCTGGAAATGGATTGGGGAATCTTTTTTCGAATGCACATCAC GAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGCGTTCCACACGAGGG CCCTTGTAATTGGCTTACACAAAACTGCTGCAGTGGTTATAATTGCATCATTTTTTTC TGCCTATAAAACTACCGTGATGTCTTCTCTTCCCCTC Translation: MKLTCLMIVAVLSLTGWTFVTADDSGNGLGNLFSNAHHEMKNPEASKLNKRCVPHEG (SEQ ID NO:13) PCNWLTQNCCSGYNCIIFFCL Toxin Sequence: Cys-Val-Xaa3-His-Xaa1-Gly-Xaa3-Cys-Asn-Xaa4-Leu-Thr-Gln-Asn-Cys-Cys-Ser-Gly-Xaa5- (SEQ ID NO:14) Asn-Cys-Ile-Phe-Phe-Cys-Leu-{circumflex over ( )} Name:      Da6.2 Species:   dalli Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCCTGCTGATCATTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:15) GTCACGGCTGATGACTCCGGAAATGGAATGGAGAATCTTTTTCCGAAGGCACGTCA CGAAATGGAGAACCTCGAAGACTCTAAACACAGGCACCAGGAGAGACCGGACACG GGCGACAAAGAAGAGATGCTGCTACAGAGACAGGTCAAGCCGTGTCGTAAAGAAC ATCAACTTTGTGATCTGATTTTTCAAAACTGCTGCCGTGGCTGGTATTGCTTGCTTCG TCCTTGCATCTGAAACTACCGTGATGTCTTCTCTCCCATC Translation: MKLTCLLIIAVLFLTAWTFVTADDSGNGMENLFPKARHEMENLEDSKHRHQERPDTGD (SEQ ID NO:16) KEEMLLQRQVKPCRKEHQLCDLIFQNCCRGWYCLLRPCI Toxin Sequence: Xaa2-Val-Lys-Xaa3-Cys-Arg-Lys-Xaa1-His-Gln-Leu-Cys-Asp-Leu-Ile-Phe-Gln-Asn-Cys-Cys- (SEQ ID NO:17) Arg-Gly-Xaa4-Xaa5-Cys-Leu-Leu-Arg-Xaa3-Cys-Ile-{circumflex over ( )} Name:      Da6.6 Species:   dalli Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTATGCTGATCATTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:18) GTCACGGCTGATGACTCCGGAAATGGAATGGAGAATCTTTTTCCGAAGGCACGTCA CGAAATGGAGAACCTCGAAGACTCTAAACACAGGCACCAGGAGAGACCGGACACG GGCGACAAAGAAGAGATGCTGCTACAGAGACGGGTCAAGCCGTGCAGTGAAGAAG GTCAACTTTGTGATCCACTTTCTCAAAACTGCTGCCGTGGCTGGCATTGCGTTCTTGT CTCTTGCGTCTGAAACTACCGTGATGTCTTCTCTCCCATC Translation: MKLTCMLIIAVLFLTAWTFVTADDSGNGMENLFPKARHEMENLEDSKHRHQERPDTGD (SEQ ID NO:19) KEEMLLQRRVKPCSEEGQLCDPLSQNCCRGWHCVLVSCV Toxin Sequence: Val-Lys-Xaa3-Cys-Ser-Xaa1-Xaa1-Gly-Gln-Leu-Cys-Asp-Xaa3-Leu-Ser-Gln-Asn-Cys-Cys- (SEQ ID NO:20) Arg-Gly-Xaa4-His-Cys-Val-Leu-Val-Ser-Cys-Val-{circumflex over ( )} Name:      δ-TxVIA Species:   textile Isolated:  Yes Cloned:    Yes DNA Sequence: AAACATCGCCAAGATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGAC (SEQ ID NO:21) CGCCTGGACATTTGCCACGGCTGATGACCCCAGAAATGGATTGGGGAATCTTTTTTC GAATGCACATCACGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGGT GCAAACAAAGCGGTGAAATGTGTAATTTGTTAGACCAAAACTGCTGCGACGGCTAT TGCATAGTACTTGTCTGCACATAAAACTGCCGTGATGTCTTCTCTTCCCCTCTGTGCT ACCTGGCTTGATCTTTGATTGGCGCGTGTCGTTCACTGGTTATGAACCCCCCCCCCC CCCCCCCCCCCCCCCTTCCGGCTCTCTGGAGGCCTCGGGGGTTCAACATCCAATAA AGTGACAG Translation: MRLTCMMIVAVLFLTAWTFATADDPRNCLGNLFSNAHHEMKNEASKLNKRWCKQS (SEQ ID NO:22) GEMCNLLDQNCCDGYCIVLVCT Toxin Sequence: Xaa4-Cys-Lys-Gln-Ser-Gly-Xaa1-Met-Cys-Asn-Leu-Leu-Asp-Gln-Asn-Cys-Cys-Asp-Gly- (SEQ ID NO:23) Xaa5-Cys-Ile-Val-Leu-Val-Cys-Thr-{circumflex over ( )} Name:       δ-TxVIA [M8J] Species:    textile Toxin Sequence: Xaa4-Cys-Lys-Gln-Ser-Gly-Xaa1-Xaa6-Cys-Asn-Leu-Leu-Asp-Gln-Asn-Cys-Cys-Asp-Gly- (SEQ ID NO:24) Xaa5-Cys-Ile-Val-Leu-Val-Cys-Thr-{circumflex over ( )} Name:      M6.4 Species:   magus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:25) GCCACGGCTGATGACCCCAGAAATGGATTGGGGAATCTTTTTTCGAATGCACATCAC GAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGGTGCAAACAAAGCG GTGAAATGTGTAATTTGTTAGACCAAAACTGCTGCGACGGCTATTGCATAGTACTTG TCTGCACATAAAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTAWTFATADDPRNGLGNLFSNAHHEMKNPEASKLNKRWCKQSG EMCNLLDQNCCDGYCIVLVCT Toxin Sequence: Xaa4-Cys-Lys-Gln-Ser-Gly-Xaa1-Met-Cys-Asn-Leu-Leu-Asp-Gln-Asn-Cys-Cys-Asp-Gly- (SEQ ID NO:27) Xaa5-Cys-Ile-Val-Leu-Val-Cys-Thr-{circumflex over ( )} Name:       Israel TxIA Species:    textile Isolated:   Yes Cloned:     No Toxin Sequence: Xaa4-Cys-Lys-Gln-Ser-Gly-Xaa1-Met-Cys-Asn-Leu-Leu-Asp-Gln-Asn-Cys-Cys-Asp-Gly- (SEQ ID NO:28) Xaa5-Cys-Ile-Phe-Val-Cys-Thr-{circumflex over ( )} Name:      Di6.2 Species:   distans Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCCTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:29) GCCACGGCTGATGACCCCAGAAATGGATTGGGGAATCTTTTTTCGAATGCACATCAC GAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGGTGCAAACAAAGCG GTGAAATGTGTAATTTGTTAGACCAAAACTGCTGCGACGGCTATTGCATAGTACTTG TCTGCACATAAAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCLMIVAVLFLTAWTFATADDPRNGLGNLFSNAHHEMKNPEASKLNKRWECKQSG (SEQ ID NO:30) EMCNLLDQNCCDGYCIVLVCT Toxin Sequence: Xaa4-Cys-Lys-Gln-Ser-Gly-Xaa1-Met-Cys-Asn-Leu-Leu-Asp-Gln-Asn-Cys-Cys-Asp-Gly- (SEQ ID NO:31) Xaa5-Cys-Ile-Val-Leu-Val-Cys-Thr-{circumflex over ( )} Name:      Af6.9 Species:   ammiralis Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:32) GCCACGGCTGATGACCCCAGAAATGGATTGGGGAATCTTTTTTCGAATGCACATCAC GAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGGTGCAAACAAAGCG GTGAAATGTGTAATTTGTTAGACCAAAACTGCTGCGAGGGCTATTGCATAGTACTTG TCTGCACATAAAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTAWTFATADDPRNGLGNLFSNAHHEMKNPEASKLNKRWCKQSG (SEQ ID NO:33) EMCNLLDQNCCEGYCIVLVCT Toxin Sequence: Xaa4-Cys-Lys-Gln-Ser-Gly-Xaa1-Met-Cys-Asn-Leu-Leu-Asp-Gln-Asn-Cys-Cys-Xaa1-Gly- (SEQ ID NO:34) Xaa5-Cys-Ile-Val-Leu-Val-Cys-Thr-{circumflex over ( )} Name:      Da6.4 Species:   dalli Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:35) GCCACGGCTGATGACCCCAGAAATGGATTGGAGAATCTTTTTTTGAAGGCACATCA CGAAATGAACCCCGAAGCCTCTAAGTTGAATGAGAGGTGCCTTGGTGGTGGTGAAG TTTGTGATATCTTTTTTCCACAATGCTGTGGCTATTGCATTCTTCTTTTCTGCACATAA AACTACCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTAWTFATADDPRNGLENLFLKAHHPEASKLNERCLGGGEV (SEQ ID NO:36) CDIFFPQCCGYCILLFCT Toxin Sequence: Cys-Leu-Gly-Gly-Gly-Xaa1-Val-Cys-Asp-Ile-Phe-Phe-Xaa3-Gln-Cys-Cys-Gly-Xaa5-Cys-Ile- (SEQ ID NO:37) Leu-Leu-Phe-Cys-Thr-{circumflex over ( )} Name:      Gm6.5 Species:   gloriamaris Isolated:  No Cloned:    Yes DNA Sequence: GCTTGCACGGTGAATTTGGCTTCACAGTTTTCCACTGTCGTCTTTGGCATCATCTGAA (SEQ ID NO:38) ACATCGCCAAGATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCG CCTGGACATTTGCCACGGCTGATGACCCCAGAAATGGATTGGGGAATATTTTTTCGA ATGCACATCACGAAATGAAGAATCCCGAAGCCTCTAAATTGAACAAGAGGTGCCGT CTAGGGGCTGAAAGTTGTGATGTAATTTCACAAAACTGCTGCCAAGGCACGTGCGT TTTTTTCTGCTTACCATGATGTCTTCTATTCTCCTCTGTGCTACCTGGCTTGATCTTTC ATTAGCGCGTGCCTTTCACTGGTTATGAACCCCCTGATCCGACTCTCTGGCAGCCTC GGGGGTTCAACATCCAAATAAAACGACAGCACAATGACAAA Translation: MKLTCMMIVAVLFLTAWTFATADDPRNGLGNIFSNAHHEMKNPEASKLNKRCRLGAE (SEQ ID NO:39) SCDVISQNCCQGTCVFFCLP Toxin Sequence: Cys-Arg-Leu-Gly-Ala-Xaa1-Ser-Cys-Asp-Val-Ile-Ser-Gln-Asn-Cys-Cys-Gln-Gly-Thr-Cys-Val- (SEQ ID NO:40) Phe-Phe-Cys-Leu-Xaa3-{circumflex over ( )} Name:      Gm6.6 Species:   gloriamaris Isolated:  No Cloned:    Yes DNA Sequence: GGATCCTTGCACGGTGAATTTGGCTTCACAGTTTTCCACTGTCGTCTTTCGCATCATC (SEQ ID NO:41) CAAAACATCACCAAGATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTG ACCGCCTGGACATTCGCCACGGCTGATGACCCCAGAAATGGATTGGAGAAACTTTT TTCGAATACACATCACGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGT GCAAACAAGCTGATGAATCTTGTAATGTATTTTCACTTGACTGCTGCACCGGCTTAT GCTTGGGATTCTGCGTATCGTGATGTCTTCTACTCCCCTCTGTgCTACCTGGCTTGAT CTTTGATTGGCGTGTGCCTTTCATTGGTTATGAACCCCCCTGATCCGATTCTTTGGCG GCCTCGGGGGTTCAACATCCAAATAAAGCGACAGCACAATAAAAAA Translation: MKLTCMMIVAVLFLTAWTFATADDPRNGLEKLFSNTHHEMKNPEASKLNKRCKQADE (SEQ ID NO:42) SCNVFSLDCCTGLCLGFCVS Toxin Sequence: Cys-Lys-Gln-Ala-Asp-Xaa1-Ser-Cys-Asn-Val-Phe-Ser-Leu-Asp-Cys-Cys-Thr-Gly-Leu-Cys- (SEQ ID NO:43) Leu-Gly-Phe-Cys-Val-Ser-{circumflex over ( )} Name:      Gm6.3 Species:   gloriamaris Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCACCTGGACATTC (SEQ ID NO:44) GCCACGGCCATCACCAGGAATGGATTGGGGAATCTTTTTCCGAAGAATCATCACGA AATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGCGTTCCATACGAGGGCC CTTGTAATTGGCTTACACAAAACTGCTGCGATGAGCTATGCGTATTTTTCTGCCTAT AAAACTAGCCTGATGT Translation: MKLTCMMIVAVLFLTTWTFATAITRNGLGNLFPKNHHEMKNPEASKLNKRCVPYEGPC (SEQ ID NO:45) NWLTQNCCDELCVFFCL Toxin Sequence: Cys-Val-Xaa3-Xaa5-Xaa1-Gly-Xaa3-Cys-Asn-Xaa4-Leu-Thr-Gln-Asn-Cys-Cys-Asp-Xaa1- (SEQ ID NO:46) Leu-Cys-Val-Phe-Phe-Cys-Leu-{circumflex over ( )} Name:      M6.5 Species:   magus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTCTTCTTGACCGTCTGGACATTC (SEQ ID NO:47) GCCACGGCTGATGACTCCGGAAATGGATTGGAGAAACTTTTTTCGAATGCACATCA CGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGCAAACAAGCTGAT GAACCTTGTGATGTATTTTCACTTGAATGCTGCACCGGCATATGTCTTGGATTCTGC ACGTGGTGATGTCTTCCCTCCCCTC Translation: MKLTCVMIVAVLFLTVWTFATADDSGNGLEKLFSNAHHEMKNPEASKLNKRCKQADE (SEQ ID NO:48) PCDVFSLECCTGICLGFCTW Toxin Sequence: Cys-Lys-Gln-Ala-Asp-Xaa1-Xaa3-Cys-Asp-Val-Phe-Ser-Leu-Xaa1-Cys-Cys-Thr-Gly-Ile-Cys- (SEQ ID NO:49) Leu-Gly-Phe-Cys-Thr-Xaa4-{circumflex over ( )} Name:      Tx6.2 Species:   textile Isolated:  No Cloned:    Yes DNA Sequence: GCCTTGCACGGTGAATTTGGCTTCATAGTTTTCCACTGTCGTCTTTGGCATCATCCAA (SEQ ID NO:50) AACATCACCAAGATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACC GCCTGGACATTCGCCACGGCTGATGACTCCAGCAATGGATTGGAGAATCTTTTTTTG AAGGCACATCACGAAATGAACCCCGAAGCCTCTAAGTTGAACGAGAGGTGCCTTGA TGCTGGTGAAGTTTGTGATATTTTTTTTCCAACATGCTGCGGCTATTGCATTCTTCTT TTCTGCGCATAAAACTACCGTGATGTCTTCTACTCCCCTCTGTGCTACCTGGCTTGAT CTTTGATTGGCGCGTACCCTTCACTGGTTATGAAACCCCTGATCCAGCTCTCTGGAG GCCTCGGGGGTTCAACATCCAAATAAAGCGACA Translation: MKLTCMMIVAVLFLTAWTFATADDSSNGLENLFLKAHHEMNPEASKLNERCLDAGEV (SEQ ID NO:51) CDIFFPTCCGYCILLFCA Toxin Sequence: Cys-Leu-Asp-Ala-Gly-Xaa1-Val-Cys-Asp-Ile-Phe-Phe-Xaa3-Thr-Cys-Cys-Gly-Xaa5-Cys-Ile- (SEQ ID NO:52) Leu-Leu-Phe-Cys-Ala-{circumflex over ( )} Name:       KK-1 Species:    textile Toxin Sequence: Cys-Ile-Xaa1-Gln-Phe-Asp-Xaa3-Cys-Xaa1-Met-Ile-Arg-His-Thr-Cys-Cys-Val-Gly-Val-Cys- (SEQ ID NO:53) Phe-Leu-Met-Ala-Cys-Ile-{circumflex over ( )} Name:       KK-2 Species:    textile Toxin Sequence: Cys-Ala-Xaa3-Phe-Leu-His-Xaa3-Cys-Thr-Phe-Phe-Phe-Xaa3-Asn-Cys-Cys-Asn-Ser-Xaa5- (SEQ ID NO:54) Cys-Val-Gln-Phe-Ile-{circumflex over ( )} Name:      Om6.1 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:55) GCCACGGCTGATGACCCCAGAAATGGATTGGAGAATTTTTTTTCGAAGACACAACA CGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGCCTAGCAGAACATG AAACTTGTAATATATTTACACAAAACTGCTGCGAAGGCGTGTGCATTTTTATCTGCG TACAAGCTCCAGAGTGATGTCTTCTCCTCCCCTC Translation: MKLTCMMIVAVLFLTAWTFATADDPRNGLENFFSKTQHEMKNPEASKLNKRCLAEHE (SEQ ID NO:56) TCNIFTQNCCEGVCIFICVQAPE Toxin Sequence: Cys-Leu-Ala-Xaa1-His-Xaa1-Thr-Cys-Asn-Ile-Phe-Thr-Gln-Asn-Cys-Cys-Xaa1-Gly-Val-Cys- (SEQ ID NO:57) Ile-Phe-Ile-Cys-Val-Gln-Ala-Xaa3-Xaa1-{circumflex over ( )} Name:      Om6.3 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACTGTCATGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:58) GCCACGGCTGAAGACCCCAGACATGGATTGGAGAATCTTTTTTCGAAGGCACATCA CGAAATGAAGAACCCTGAAGACTCTAAATTGGACAAGAGGTGCATTCCACATTTTG ACCCTTGTGACCCGATACGCCACACCTGCTGCTTTGGCCTGTGCCTACTAATAGCCT GCATCTAAAACTGCCGTGATGTCTTCTCTCCCATC Translation: MKLTVMMIVAVLFLTAWTFATAEDPRHGLENLFSKAHHEMKNPEDSKLDKRCIPHEDP (SEQ ID NO:59) CDPIRHTCCFGLCLLIACI Toxin Sequence: Cys-Ile-Xaa3-His-Phe-Asp-Xaa3-Cys-Asp-Xaa3-Ile-Arg-His-Thr-Cys-Cys-Phe-Gly-Leu-Cys- (SEQ ID NO:60) Leu-Leu-Lle-Ala-Cys-Ile-{circumflex over ( )} Name:      Om6.4 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGACCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:61) GTCACGGCTGAAGACCCCAGAGATGGATTGAAGAATCTTTTATCAAATGCACATAA CGAAATGAAGAACCCCGAAGCCTCTACATTGAACGAGAGGTGCCTTGGGTTTGGTG AAGCTTGTCTTATACTTTATTCAGACTGCTGCGGCTATTGCGTTGGTGCTATCTGCCT ATAAAACTACCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMTVAVLFLTAWTFVTAEDPRDGLKNLLSNAHNEMKNPEASTLNERCLGFGE (SEQ ID NO:62) ACLILYSDCCGYCVGAICL Toxin Sequence: Cys-Leu-Gly-Phe-Gly-Xaa1-Ala-Cys-Leu-Ile-Leu-Xaa5-Ser-Asp-Cys-Cys-Gly-Xaa5-Cys-Val- (SEQ ID NO:63) Gly-Ala-Ile-Cys-Leu-{circumflex over ( )} Name:      Au6.1 Species:   aulicus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:64) GCCACGGCTGATGACCCCAGAAATGGATTGGAGAATCTTTTTTCGAAGACACAACA CAAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGCAAAGCAGAAAAT GAACTTTGTAATATATTTATACAAAACTGCTGCGACGGGACGTGCCTTCTTATCTGC ATACAAAATCCACAGTGATGTCTTCTCTCCTACCCTC Translation: MKLTCVMIVAVLFLTAWTFATADDPRNGLENLFSKTQHKMKNPEASKLNKRCKAENE (SEQ ID NO:65) LCNIFIQNCCDGTCLLICIQNPQ Toxin Sequence: Cys-Lys-Ala-Xaa1-Asn-Xaa1-Leu-Cys-Asn-Ile-Phe-Ile-Gln-Asn-Cys-Cys-Asp-Gly-Thr-Cys- (SEQ ID NO:66) Leu-Leu-Ile-Cys-Ile-Cln-Asn-Xaa3-Gln-{circumflex over ( )} Name:      Au6.2 Species:   aulicus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:67) GCCACGGCTGATGACCCCAGAAATGGATTGGATAATCGTTTTTCGAAGGCACGTCA CGAAATGAATAACCGCAGAGCCTCTAAATTGAACAAGAGGTGCCTTGAGTTTGGTG AACTTTGTAATTTTTTTTTCCCAACCTGCTGCGGCTATTGCGTTCTTCTTGTCTGCCTA TAAACTACCGTGATGTCTTCTCTTCCCCTC Translation: MKLTCVMIVAVLFLTAWTFATADDPRNGLDNRFSKARHEMNNRRASKLNKRCLEFGE (SEQ ID NO:68) LCNFFFPTCCGYCVLLVCL Toxin Sequence: Cys-Leu-Xaa1-Phe-Gly-Xaa1-Leu-Cys-Asn-Phe-Phe-Phe-Xaa3-Thr-Cys-Cys-Gly-Xaa5-Cys- (SEQ ID NO:69) Val-Leu-Leu-Val-Cys-Leu-{circumflex over ( )} Name:      Da6.5 Species:   dalli Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:70) GTCATGGCTGATGACTCCGGAAATGGATTGGAAAATCTGTTTTCGAAGGCACATCA CGAAATGAAGAACCCTGAAGCCTCTAAATTGAACAAGAGGTGCGCTCAAAGCAGTG AATTATGTGATGCGCTGGACTCAGACTGCTGCAGTGGTGTTTGCATGGTATTTTTCT GCCTATAAAACTGCCGTGATGTCTTCTCTATCCCCTC Translation: MKLTCVMIVAVLFLTAWTFVMADDSGNGLENLFSKAHHEMKNPEASKLNKRCAQSSE (SEQ ID NO:71) LCDALDSDCCSGVCMVFFCL Toxin Sequence: Cys-Ala-Gln-Ser-Ser-Xaa1-Leu-Cys-Asp-Ala-Leu-Asp-Ser-Asp-Cys-Cys-Ser-Gly-Val-Cys- (SEQ ID NO:72) Met-Val-Phe-Phe-Cys-Leu-{circumflex over ( )} Name:      Di6.4 Species:   distans Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGACCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:73) GTCACGGCTGAAGACCCCAGAGATGGATTGAGGAATCTTTTATCGAATGCACGTCA TGAAATGAAGAACCCCGAAGCCTCTAAATTGAACGAGAGGTGCCTTGGGTTTGGTG AAGCTTGTCTTATGCTTTATTCAGACTGCTGCAGCTATTGCGTTGGTGCTGTCTGCCT ATAAAACTACCGTGATGTCTTCTACTCCCATC Translation: MKLTCVMTVAVLFLTAWTFVTAEDPRDGLRNLLSNARHEMKNPEASKLNERCLGFGE (SEQ ID NO:74) ACLMLYSDCCSYCVGAVCL Toxin Sequence: Cys-Leu-Gly-Phe-Gly-Xaa1-Ala-Cys-Leu-Met-Leu-Xaa5-Ser-Asp-Cys-Cys-Ser-Xaa5-Cys-Val- (SEQ ID NO:75) Gly-Ala-Val-Cys-Leu-{circumflex over ( )} Name:      Pn6.2 Species:   pennaceus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCCTGATGACCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:76) GCCACGGCTGAAGACCCCAGAAATGGATTGGAGAATCTTTTTTCGAAGGCACATCA CGAAATGAAGAACCCTGAAGACTCTAAATTGGACAAGAGGTGCGTTAAATATCTTG ACCCTTGTGACATGTTACGCCACACCTGCTGCTTTGGCCTGTGCGTACTAATAGCCT GCATCTAAAACTGCCGTGATGTCTTCTACTCCCATC Translation: MKLTCLMTVAVLFLTAWTFATAEDPRNGLENLFSKAHHEMKNPEDSKLDKRCVKYLD (SEQ ID NO:77) PCDMLRHTCCFGLCVLIACI Toxin Sequence: Cys-Val-Lys-Xaa5-Leu-Asp-Xaa3-Cys-Asp-Met-Leu-Arg-His-Thr-Cys-Cys-Phe-Gly-Leu-Cys- (SEQ ID NO:78) Val-Leu-Ile-Ala-Cys-Ile-{circumflex over ( )} Name:      Pn6.3 Species:   pennaceus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:79) GCCACGGCTGATGACCCCAGAAATGGATTGGGGAATCTTTTTTCGAATGCACATCAC GAAATGAAGAACCCCGAAGCTTCTAAATTGAACGAGAGGTGCCTTGGGTTTGGTGA AGTTTGCAATTTCTTTTTTCCAAACTGCTGCAGCTATTGCGTTGCTCTTGTCTGCCTA TAAAACTACCGTGATGTCTTCTATTCCCCTC Translation: MKLTCVMIVAVLFLTAWTFATADDPRNGLGNLFSNAHHEMKNPEASKLNERCLGFGE (SEQ ID NO:80) VCKFFFPNCCSYCVALVCL Toxin Sequence: Cys-Leu-Gly-Phe-Gly-Xaa1-Val-Cys-Asn-Phe-Phe-Phe-Xaa3-Asn-Cys-Cys-Ser-Xaa5-Cys-Val- (SEQ ID NO:81) Ala-Leu-Val-Cys-Leu-{circumflex over ( )} Name:      Pn6.4 Species:   pennaceus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGCTCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:82) GCCACGGCTGATGACTCCAGCAATGGACTGGAGAATCTTTTTTCGAAGGCACATCA CGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGCATTCCACAATTTG ATCCTTGTGACATGGTACGTCACACTTGCTGCAAAGGGTTGTGCGTACTAATAGCCT GCTCTAAAACTGCGTGATGTCTTCATCTCCCCTC Translation: MKLTCVMLVAVLFLTAWTFATADDSSNGLENLFSKAHHEMKNPEASKLNKRCIPQFDP (SEQ ID NO:83) CDMVRHTCCKGLCVLIACSKTA Toxin Sequence: Cys-Ile-Xaa3-Gln-Phe-Asp-Xaa3-Cys-Asp-Met-Val-Arg-His-Thr-Cys-Cys-Lys-Gly-Leu-Cys- (SEQ ID NO:84) Val-Leu-Ile-Ala-Cys-Ser-Lys-Thr-Ala-{circumflex over ( )} Name:      Pn6.7 Species:   pennaceus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCTTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:85) GCCACGGCTGATGACCCCAGAAATGGATTGGAGAATTTTTTTTCGAAGACACAACA CGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGCAAAGCAGAAAGT GAAGCTTGTAATATAATTACACAAAACTGCTGCGACGGCAAGTGCCTTTTTTTCTGC ATACAAATTCCAGAGTGATGTCTTCTCCTCCCATC Translation: MKLTCLMIVAVLFLTAWTFATADDPRNGLENFFSKTQHEMKNPEASKLNKRCKAESEA (SEQ ID NO:86) CNIITQNCCDGKCLFFCIQIPE Toxin Sequence: Cys-Lys-Ala-Xaa1-Ser-Xaa1-Ala-Cys-Asn-Ile-Ile-Thr-Gln-Asn-Cys-Cys-Asp-Gly-Lys-Cys- Leu-Phe-Phe-Cys-Ile-Gln-Ile-Xaa3-Xaa1-{circumflex over ( )} Name:      Omaria3 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: GGTCGACATCATCATCATCATCGATCCATCTGTCCATCCATCCATTCATTCATTCGCT (SEQ ID NO:88) GCCAGACTGTCATAAATATTCGAGTCTCTCCTTCTGTTTGTATCTGACAGATTGAAC AAGAGGTGCATTGACGGTGGTGAAATTTGTGATATTTTTTTTCCAAACTGCTGCAGT GGGTGGTGCATTATTCTCGTCTGCGCATGAAACTACCGTGATGTCTTCTACTCCCCTC TAGTAGTAGTAGGCGGCCGCTCTAGAGGATCCAAGCTTACGTACGCGTGCATGCGA CGTCATAGCTCTTCTATAGTGTCACCTAAATTCAATTCACTGGCCGTCGTTTTACAAC GTCGTGACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCC CTTTCGCCAGCTGGCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCAACAGT TTGCGCAGCCTGAATGGCGAATGGGACGCGCCCTGTAGCGGCGCATTAAGCGCGGC GGGTGTGGTGGGTaCGCGCAGCGTGACCGGTACACTTGCCAGCGCCCTAGCGCCCGC TCCTTTTGCTTTCTTCCCTTCCTTTCTCGCCACCGTTCgCCCGGGGTTTTCCCGTCaAG CTC Translation: LNKRCIDGGEICDIFFPNCCSGWCIILVCA (SEQ ID NO:89) Toxin Sequence: Cys-Ile-Asp-Gly-Gly-Xaa1-Ile-Cys-Asp-Ile-Phe-Phe-Xaa3-Asn-Cys-Cys-Ser-Gly-Xaa4-Cys- (SEQ ID NO:90) Ile-Ile-Leu-ValCys-Ala-{circumflex over ( )} Name:      Omaria1 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: GGTCGACATCATCATCATCGATCCATCTGTCCATCCATCCATTCATTCATTCGCTGCC (SEQ ID NO:91) AGACTGTCATAAATATTCGAGTCTCTCCTTCTGTTTGTATCTGACAGATTGAACAAG AGGTGCCTTGACGGTGGTGAAATTTGTGGTATTTTGTTTCCAAGCTGCTGCAGTGGG TGGTGCATTGTTCTCGTCTGCGCATGAAACTACCGTGATGTCTTCTACTCCCCTCTAG TAGTAGTAGGCGGCCGCTCTAGAGGATCCAAGCTTACGTACGCGTGCATGCGACGT CATAGCTCTTCTATAGTGTCACCTAAATTCAATTCACTGGCCGTCGTTTTACAACGTC GTGACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTT TCGCCAGCTGGCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAAGTT GCGCAGCCTGAATGGCGAATGGGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGG GTGTGGTGGTTACGCGCACCGTGACCGCTACACTTGCCAGCGCCCTAGCCGCCCGCT CCTTTCGCTTTCTTCCCTTcCTTTCTCGCACGTTCGGCCGGCTTTCCCCGTCAAGCTCT AAATCGGGGGCTTCCCTTTTA Translation: LNKRCLDGGEICGILFPSCCSGWCIVLVCA (SEQ ID NO:92) Toxin Sequence: Cys-Leu-Asp-Gly-Gly-Xaa1-Ile-Cys-Gly-Ile-Leu-Phe-Xaa3-Ser-Cys-Cys-Ser-Gly-Xaa4-Cys- (SEQ ID NO:93) Ile-Val-Leu-ValCycs-Ala-{circumflex over ( )} Name:      Marm7 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: GGTCGACATCATCATCATCGATCCATCTGTCCATCCATCCATCCATTCATTCGCTGCC (SEQ ID NO:94) AGACTGTAATAAATATTCGAGTCTCTCTTTCTGTTTGTATCTGACAGATTGAACAAG AGGTGCCTTGAGTTTGGTGAAGTTTGTAATTTTTTTTTCCCAACCTGCTGCGGCTATT GCGTTCTTCTTGTCTGCCTATAAAACTACCGTGATGTCTTCTACTCCCCTCTAGTAGT AGTAGGCGGCCGCTCTAGAGGATCCAAGCTTACGTACGCGTGCATGCGACGTCATA GCTCTTCTATAGTGTCACCTAAATTCAATTCACTGGCCGTCGTTTTACAACGTCGTGA CTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGC CAGCTGGCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCA GCCTGAATGGCGAATGGGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTG GTGGTTACGCGCAGCGTGACCGCTACACTTGCAGCGCCCTAGCGCCCGCTCCTTTCG CTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAA Translation: LNKRCLEFGEVCNFFFPTCCGYCVLLVCL (SEQ ID NO:95) Toxin Sequence: Cys-Leu-Xaa1-Phe-Gly-Xaa1-Val-Cys-Asn-Phe-Phe-Phe-Xaa3-Thr-Cys-Cys-Gly-Xaa5-Cys- (SEQ ID NO:96) Val-Leu-Leu-Val-Cys-Leu-{circumflex over ( )} Name:      Marm12 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: GAAAGCTGGTACGCCTGCAGGTACCGGTCCGGAATTCCCGGGTCGACATCATCATC (SEQ ID NO:97) ATCATCGATCCATCTGTCCATCCATCCATTCATTCATTCGCTGCCAGACTGTAATAA ATATTCGAGTTTCTCCTTCTGTTTGTATCTGACAGGTTGAACAAGAGGTGCCAAGAG TTCGGTGAAGTTTGTAATTTTTTTTTCCCAGACTGCTGCGGCTATTGCGTTCTTTTAC TCTGCATATAAAACTACCGTGATGTCTTCTCTTCCCATCTAGTAGTAGTAGTAGTAG TAGGCGGCCGCTCTAGAGGATCCAAGCTTACGTACGCGTGCATGCGACGTCATAGC TCTTCTATAGTGTCACCTAAATTCAATTCACTGGCCGTCGTTTTACAACCGTCGTGAC TGGGAAAACCCTGGCGTTCCCAACTTAATTCGCCTTGCAGCACAT Translation: LNKRCQEFGEVCNFFFPDCCGYCVLLLCI (SEQ ID NO:98) Toxin Sequence: Cys-Gln-Xaa1-Phe-Gly-Xaa1-Val-Cys-Asn-Phe-Phe-Phe-Xaa3-Asp-Cys-Cys-Gly-Xaa5-Cys- (SEQ ID NO:99) Val-Leu-Leu-Leu-Cys-Ile-{circumflex over ( )} Name:      Omaria7 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: TTTTGAAGCNGGTACGCCTGCAGGTACCGGTCCGGAATTCCCGGGTCGACATCATCA (SEQ ID NO:100) TCATCATCGATCCATCTGTCCATCCATCCATTCATTCATTCGCTACCAGACTGTAATA AATATTCGGGTCTCTCTTTCTGTTTGTATCTGACAGATTGGACAAGAGGTGCATTCC ACATTTTGACCCTTGTGACCCGATACGCCACACCTGCTGCTTTGGCCTGTGCCTACT AATAGCCTGCATCTAAAACTGCCGTGATGTCTTCTCCTCCCCTCTAGTAGTAGTAGG CGGCCGCTCTAGAGGATCCAAGCTTACGTACGCGTGCATGCGACGTCATAGCTCTTC TATAGTGTCACCTAAATTCAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGA AAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTG GCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGA ATGGCGAATGGGACGCGCCCTGTAGCGGCGCT Translation: LDKRCIPHFDPCDPIRHTCCFGLCLLIACI (SEQ ID NO:101) Toxin Sequence: Cys-Ile-Xaa3-His-Phe-Asp-Xaa3-Cys-Asp-Xaa3-Ile-Arg-His-Thr-Cys-Cys-Phe-Gly-Leu-Cys- (SEQ ID NO:102) Leu-Leu-Ile-Ala-Cys-Ile-{circumflex over ( )} Name:      Omaria11 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: GGTACGCCTGCAGGTACCGGTCCGGAATTCCCGGGTCGACATCATCATCATCGATCC (SEQ ID NO:103) ATCTGTCCATCCATCCATTCTTTCATTTGCTGCCAGACTGTAATAAATATTCGAGTCT CTCTTTCTGTTTGTATCTGACAGATTGAACAAGAGGTGCCTTGAGTTTGGTGAAGTT TGTAATTTTTTTTTCCCAACCTGCTGCGGCTATTGCGTTCTTCTTGTCTGCCTATAAA ACTACCGTGATGTCTTCTCTTCCCCTCTAGTAGTAGTAGGCGGCCGCTCTAGAGGAT CCAAGCTTACGTACGCGTGCATGCGACGTCATAGCTCTTCTATAGTGTCACCTAAAT TCAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAACCCTGGCGTTACCC AACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGCGTAATAGCGAAGAGG CCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGAATGGCGAATGGGACGCG CCCTGTAGCGGCGCATTAAG Translation: LNKRCLEFGEVCNFFFPTCCGYCVLLVCL (SEQ ID NO:104) Toxin Sequence: Cys-Leu-Xaa1-Phe-Gly-Xaa1-Val-Cys-Asn-Phe-Phe-Phe-Xaa3-Thr-Cys-Cys-Gly-Xaa5-Cys- (SEQ ID NO:105) Val-Leu-Leu-Val-Cys-Leu-{circumflex over ( )} Name:      O6.5 Species:   obseurus Isolated:  No Cloned:    Yes DNA Sequence: cgatccatctgtccatccatccattcgttcgttcgctgccaaactgtaataaataaccgagtctctctgtttgtatctgacagATC (SEQ ID NO:106) GAAAAAGCAATGCCGTCAAAATGGTGAAGTGTGTGATGCGAATTTGGCACACTGCTGCAGT GGCCCGTGTTTTCTCTTCTGTCTAAACCAGCCGTGATGTCTTCTACTCCCCTC Translation: VSDRSKKQCRQNGEVCDANLAHCCSGPCFLFCLNQP (SEQ ID NO:107) Toxin Sequence: Ser-Lys-Lys-Gln-Cys-Arg-Gln-Asn-Gly-Xaa1-Val-Cys-Asp-Ala-Asn-Leu-Ala-His-Cys-Cys- (SEQ ID NO:108) Ser-Gly-Xaa3-Cys-Phe-Leu-Phe-Cys-Leu-Asn-Gln-Xaa3-{circumflex over ( )} Name:      Af6.8 Species:   ammiralis Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCATTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:109) GCCACGGCTGATGACTCCGGAAATGGATTGGAAAATCTTTTTTCGAAGGCACATCA CGAAATGAAGAACCCCAAAGCCTCTAAATTGAACAAGAGGTGCACTCAAAGCGGTG AACTTTGTGATGTGATAGACCCAGACTGCTGCAATAATTTTTGCATTATATTTTTCTG CATATAAAACTGCCGTGATGTCTTCTACTCCCCTC Translation: MKLTCVMIIAVLFLTAWTFATADDSGNGLENLFSKAHHEMKNPKASKLNKRCTQSGEL (SEQ ID NO:110) CDVIDPDCCNNFCIIFFCI Toxin Sequence: Cys-Thr-Gln-Ser-Gly-Xaa1-Leu-Cys-Asp-Val-Ile-Asp-Xaa3-Asp-Cys-Cys-Asn-Asn-Phe-Cys- (SEQ ID NO:111) Ile-Ile-Phe-Phe-Cys-Ile-{circumflex over ( )} Name:      KK-2A Species:   textile Isolated:  No Cloned:    Yes DNA Sequence: GGCATTACCTAAAACATCACCAAAATGAAACTGACGTGCATGATGATCGTTGCTGT (SEQ ID NO:112) GCTGTTCTTGACCGCCTGGACATTCGCCACGGCTGATGACTCCGGAAATGGATTGGA GAAACTTTTTTCGAATGCACATCACGAAATGAAGAACCCCGAAGCCTCTAATTTGA ACAAGAGGTGCGCTCCTTTTCTTCACCTTTGTACCTTTTTCTTCCCAAACTGCTGCAA CGGCTATTGCGTTCAATTTATCTGCCTATAAAACTACTGTGATGTCTTCTATTCCCCTC Translation: MKLTCMMIVAVLFLTAWTFATADDSGNGLEKLFSNAHHEMKNPEASNLNKRCAYFLH (SEQ ID NO:113) LCTFFFPNCCNGYCVQFICL Toxin Sequence: Cys-Ala-Xaa3-Phe-Leu-His-Leu-Cys-Thr-Phe-Phe-Phe-Xaa3-Asn-Cys-Cys-Asn-Gly-Xaa5-Cys- (SEQ ID NO:114) Val-Gln-Phe-Ile-Cys-Leu-{circumflex over ( )} Name:      KKM1 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCTAGCACAGTGAATTTGGCTTCACAGTTTTCCACTGTCGTCTTTGGCATCATC (SEQ ID NO:115) CAAAACATCACCAAGATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTG ACCGCCTGGACATTTGCCACGGCTGATGACCCCAGANATGGATTGGAGAATCTTTTT TCGAAGGCACATCACGAAATGAAGAACCCCAAAGACTCTAAATTGAACAAGAGGT GCCTTGACGCTGGTGAAATGTGTGATCTTTTTAATTCAAAATGCTGCAGTGGGTGGT GCATTATTCTCTTCTGCGCATAAAACTACCGTGATGTCTTCTACTCCCCTCTGTGCTA CCTGGCTTGATCTTTGATTGGCGCGTGCCCTTCACTGGTTATGAACCCCCCTGATCC GACTCTCTGGCGGCCTCGGGGGTTCAACATCCAAATAAAGCCGACACGATACTGAC GTAGAAAAAAAAAAAAAAAAAAAAAAAAA Translation: MKLTCMMIVAVLFLTAWTFATADDPRNGLENLFSKAHHEMKNPKDSKLKRCLDAGE (SEQ ID NO:116) MCDLFNSKCCSGWCIILFCA Toxin Sequence: Cys-Leu-Asp-Ala-Gly-Xaa1-Met-Cys-Asp-Leu-Phe-Asn-Ser-Lys-Cys-Cys-Ser-Gly-Xaa4-Cys- (SEQ ID NO:117) Ile-Ile-Leu-Phe-Cys-Ala-{circumflex over ( )} Name:      KKM4 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: GCCGAAAACATCACCAAGATGAAACTGACGAGCATGATGATCGTTGCTGTGCTGTT (SEQ ID NO:118) CTTGACCGCCTGGACATTCGTCACGGCTGACGACTCCGGAAATGGATTGGAGAATC TTTTTTCGAAGGCACATCACGAGATGAAGAACCCCAAAGACTCTAAATTGAACAAG AGGTGCCTTGACGGTGGTGAAATTTGTGGTATTTTGTTTCCAAGCTGCTGCAGTGGG TGGTGCATTGTTCTCGTCTGCGCATGAAACTACCGTGATGTCTTCTACTCCCCTCTGT GCTACCTGGCTTGATCTTTGATTGGCGCGTGCCCTTCACTGGTTATGAACCCCCCTG ATCCGACTCTCTGGCGGCCTCGGGGGTTCAACATCCAAATAAAGCGACACGACAAT GACAAAAAAAAAAAAAAAAAAAAAAAAAAAA Translation: MKLTSMMIVAVLFLTAWTFVTADDSGNGLENLFSKAHHEMKNPKDSKLNKRCLDGGE (SEQ ID NO:119) ICGILFPSCCSGWCIVLVCA Toxin Sequence: Cys-Leu-Asp-Gly-Gly-Xaa1-Ile-Cys-Gly-Ile-Leu-Phe-Xaa3-Ser-Cys-Cys-Ser-Gly-Xaa4-Cys- (SEQ ID NO:120) Ile-Val-Leu-Val-Cys-Ala-{circumflex over ( )} Name:      KKM5 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: GCTAGCACAGTGAATTTGGCTTCACAGTTTTCCACTGTCGTCTTTGGCATCATCCAA (SEQ ID NO:121) AACATCACCAAGATGAAACTGACGTGCATGATGATCGAAGCAGAGCTGTTCTTGAC CGCCTGGACATTTGCCACGGCTGATGACCCCAGAAATGGATTGGAGAATCTTTTTTC GAAGGCACATCACGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGC CCTAACACTGGTGAATTATGTGATGTGGTTGAACAAAACTGCTGCTATACCTATTGC TTTATTGTAGTCTGCCCTATATAACTACCGTGATGTCTTCTACTCCCCTCTGTGCTGC CTGGCTTGATCTTTGATTGGCGCGTGCCCTTCACTGGTTATGAACCCCCCTGATCCG ACTCTCTTGCGGCCTCAGGGGTTCAACATCCAAATAAAGCGACACGAAAATGAAAA AAAAAAAAAAAAAAAAA Translation: MKLTCMMIEAELFLTAWTFATADDPRNGLENLFSKAHHEMKNPEASKLNKRCPNTGEL (SEQ ID NO:122) CDVVEQNCCYTYCFIVVCPI Toxin Sequence: Cys-Xaa3-Asn-Thr-Gly-Xaa1-Leu-Cys-Asp-Val-Val-Xaa1-Gln-Asn-Cys-Cys-Xaa5-Thr-Xaa5- (SEQ ID NO:123) Cys-Phe-Ile-Val-Val-Cys-Xaa3-Ile-{circumflex over ( )} Name:      KKM6 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: TTGCACGGTGAATTTCGCTTATATTTTTCTACTGTCGTCTTTGGCATCATCCAAAACA (SEQ ID NO:124) TCACCAAGATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCGCCT GGACATTCGTCACGGCTGTGCCTCACTCCAGCGATGTATTGGAGAATCTTTATCTGA AGGCACTTCACGAAACGGAAAACCACGAAGCCTCTAAATTGAACGTGAGAGACGA CGAGTGCGAACCTCCTGGAGATTTTTGTGGCTTTTTTAAAATTGGGCCGCCTTGCTG CAGTGGCTGGTGCTTCCTCTGGTGCGCCTAAAACTGCCGTGATGTCTTCTATTCCCCT CTGTGCTACCTGGCTTGATCTTTGATTGGCGCGTGCCCTTCAGTGGTTATGAACCCCC CTGATCCGACTCTCTGGGGGCCTCGGGGGTTCAACATCCAAATAAAGCTGACAACA CAATAAAAAAAAAA Translation: MKLTCMMIVAVLFLTAWTFVTAVPHSSDVLENLYLKALHETENHEASKLNVRDDECEP (SEQ ID NO:125) PGDFCGFFKIGPPCCSGWCFLWCA Toxin Sequence: Asp-Asp-Xaa1-Cys-Xaa1-Xaa3-Xaa3-Gly-Asp-Phe-Cys-Gly-Phe-Phe-Lys-Ile-Gly-Xaa3-Xaa3- (SEQ ID NO:126) Cys-Cys-Ser-Gly-Xaa4-Cys-Phe-Leu-Xaa4-Cys-Ala-{circumflex over ( )} Name:      C. striatus S2 Species:   striatus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:127) GTCACGGCTGTGCCTCACTCCAGCGATGCATTGGAGAATCTTTATCTGAAGGCACTT CACGAAACGGAAAACCACGAAGCCTCTAAATTGAACGTGAGAGACGACGAGTGCG AACCTCCTGGAGATTTTTGTGGCTTTTTTAAAATTGGGCCGCCTTGCTGCAGTGGCT GGTGCTTCCTCTGGTGCGCATAAAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTAWTFVTAVPHSSDALENLYLKALHETENHEASKLNVRDDDCEP (SEQ ID NO:128) PGDFCGFFKIGPPCCSGWCFLWCA Toxin Sequence: Asp-Asp-Xaa1-Cys-Xaa1-Xaa3-Xaa3-Gly-Asp-Phe-Cys-Gly-Phe-Phe-Lys-Ile-Gly-Xaa3-Xaa3- (SEQ ID NO:129) Cys-Cys-Ser-Gly-Xaa4-Cys-Phe-Leu-Xaa4-Cys-Ala-{circumflex over ( )} Name:      Om6.5 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:130) GTCACGGCTGTGCCTCACTCCAGCAATGCATTGGAAAATCTTTATCTGAAGGCACGT CACGAAATGGAAAACCCCGAAGCCTCTAAATTGAACACGAGAGACGACGATTGCG AACCTCCTGGAAATTTTTGTGGCATGATAAAAATTGGGCCGCCTTGCTGCAGTGGCT GGTGCTTTTTCGCCTGCGCCTAAAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTAWTFVTAVPHSSNALENLYLKARHEMENPEASKLNTRDDDCEP (SEQ ID NO:131) PGNFCGMIKIGPPCCSGWCFFACA Toxin Sequence: Asp-Asp-Asp-Cys-Xaa1-Xaa3-Xaa3-Gly-Asn-Phe-Cys-Gly-Met-Ile-Lys-Ile-Gly-Xaa3-Xaa3- (SEQ ID NO:132) Cys-Cys-Ser-Gly-Xaa4-Cys-Phe-Phe-Ala-Cys-Ala-{circumflex over ( )} Name:      Au6.3 Species:   aulicus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCCTGATGATAGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:133) GTCACGGCTGTGCCTCACTCCAGCAATGCATTGGAGAATCTTTATCTGAAGGCACGT CACGAAATGGAAAACCCCGAAGCCTCTAAATTGAACACGAGAGACTACGATTGCGA ACCTCCTGGAAATTTTTGTGGCATGATAAAAATTGGGCCGCCTTGCTGCAGTGGCTG GTGCTTTTTCGCCTGCGCCTAAAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCLMIVAVLFLTAWTFVTAVPHSSNALENLYLKARHEMENPEASKLNTRDYDCEP (SEQ ID NO:134) PGNFCGMIKIGPPCCSGWCFFACA Toxin Sequence: Asp-Xaa5-Asp-Cys-Xaa1-Xaa3-Xaa3-Gly-Asn-Phe-Cys-Gly-Met-Ile-Lys-Ile-Gly-Xaa3-Xaa3- (SEQ ID NO:135) Cys-Cys-Ser-Gly-Xaa4-Cys-Phe-Phe-Ala-Cys-Ala-{circumflex over ( )} Name:      Marm9 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: GGTCGACATCATCATCATCATCGATCCATCTGTCCATCCATCTATTCATTCATTCGTG (SEQ ID NO:136) GCCAAACTGTAATAAATAATGCAAGTCTCTCTTTCTGTTTGTATCTGACAGATTGAA CACGAGAGACGACGATTGCGAACCTCCTGGAAATTTTTGTGGCATGATAAAAATTG GGCCGCCTTGCTGCAGTGGCTGGTGCTTTTTCGCCTGCGCCTAAAACTGCCGTGATG TCTTCTCTTCCCCTCTAGTAGTAGTAGGCGGCCGCTCTAGAGGATCCAAGCTTACGT ACGCGTGCATGCGACGTCATAGCTCTTCTATAGTGTCACCTAAATTCAATTCACTGG CCGTCGTTTTACAACGTCGTGACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCC TTGCAGCACATCCCCCTTTCGCCAGCTGGCGTAATAGCGAAGAGGCCCGCACCGAT CGCCCTTCCCAACAGTTGCGCAGCCTGAATGGCGAATGGGACGCGCCCTGTAGCGG CGCATTAAGCGCGGCGGGTGTGGTGGTTACGCCGCAGCCGTGACCCGCTACACTTG CCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCTTCCTTTCTCGCCACGTTCGCC GGCTTTTCCCGTCAAGCTCTAAATCGGGGGCTCCTTTAGGGTCCGATTTAAGTGCTT TAC Translation: LNTRDDDCEPPGNFCGMIKIGPPCCSGWCFFACA (SEQ ID NO:137) Toxin Sequence: Asp-Asp-Asp-Cys-Xaa1-Xaa3-Xaa3-Gly-Asn-Phe-Cys-Gly-Met-Ile-Lys-Ile-Gly-Xaa3-Xaa3- (SEQ ID NO:138) Cys-Cys-Ser-Gly-Xaa4-Cys-Phe-Phe-Ala-Cys-Ala-{circumflex over ( )} Name:      Rg6.4 Species:   regius Isolated:  No Cloned:    Yes DNA Sequence: TTGAACCAGAGAGACTGCCTTAGTAAAAACGCTTTCTGTGCCTGGCCGATACTTGGA (SEQ ID NO:139) CCACTGTGCTGCAGTGGCTGGTGCTTATACGTCTGCATGTAAAACTGCCGTGATGTC TTCTATCCCCTC Translation: LNQRDCLSKNAFCAWPILGPLCCSGWCLYVCM (SEQ ID NO:140) Toxin Sequence: Asp-Cys-Leu-Ser-Lys-Asn-Ala-Phe-Cys-Ala-Xaa4-Xaa3-Ile-Leu-Gly-Xaa3-Leu-Cys-Cys-Ser- (SEQ ID NO:141) Gly-Xaa4-Cys-Leu-Xaa5-Val-Cys-Met-{circumflex over ( )} Name:      R6.5 Species:   radiatus Isolated:  No Cloned:    Yes DNA Sequence: ATTGAACAAGAAAGGTGATGACTGCCTTGCTGTTAAAAAAAATTGTGGCTTTCCAA (SEQ ID NO:142) AACTTGGAGGGCCATGCTGCAGTGGCTTGTGCTTTTTCGTCTGCGCCTAAAACTGCC GTGATGTCTTCTCCTCCCCT Translation: LNKKGDDCLAVKKNCGFPKLGGPCCSGLCFFVCA (SEQ ID NO:143) Toxin Sequence: Gly-Asp-Asp-Cys-Leu-Ala-Val-Lys-Lys-Asn-Cys-Gly-Phe-Xaa3-Lys-Leu-Gly-Gly-Xaa3-Cys- (SEQ ID NO:144) Cys-Ser-Gly-Leu-Cys-Phe-Phe-Val-Cys-Ala-{circumflex over ( )} Name:      Rg6.2 Species:   regius Isolated:  No Cloned:    Yes DNA Sequence: TTGAATCAGAGCGACTGCCTTCCTAGAGACACATTCTGTGCCTTGCCGCAACTTGGA (SEQ ID NO:145) CTACTGTGCTGCAGTGGCCGGTGCTTACTCTTCTGCGTGTAAAACTGCCGTGATGTC TTCTCCTCCCCTC Translation: LNQSDCLPRDTFCALPQLGLLCCSGRCLLFCV (SEQ ID NO:146) Toxin Sequence: Asp-Cys-Leu-Xaa3-Arg-Asp-Thr-Phe-Cys-Ala-Leu-Xaa3-Gln-Leu-Gly-Leu-Leu-Cys-Cys-Ser- (SEQ ID NO:147) Gly-Arg-Cys-Leu-Leu-Phe-Cys-Val-{circumflex over ( )} Name:      A6.5 Species:   aurisiacus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGACCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:148) GTCACGGCTGATGACTCCAGAAATGGACTGAAGAATCTTTTTCCGAAGGCACGTCA TGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGAGATGGGTGCTCTAATG CTGGTGCATTTTGTGGCATCCATCCAGGACTCTGCTGCAGCGAGATTTGCATTGTTT GGTGCACATGAGTCGTATTCTGCTGGTACATTTTGTGGCTTCAACGGAGGACTCTGC TGCAGCAACCTTTGCTTATTTTTCGTGTGCTTAACATATTCGTGATGTCTTCTACTCC CATC Translation: MKLTCVMTVAVLFLTAWTFVTADDSRNGLKNLFPKARHEMKNPEASKLNKRDGCSNA (SEQ ID NO:149) GAFCGIHPGLCCSEICIVWCT Toxin Sequence: Asp-Gly-Cys-Ser-Asn-Ala-Gly-Ala-Phe-Cys-Gly-Ile-His-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1-Ile- (SEQ ID NO:150) Cys-Ile-Val-Xaa4-Cys-Thr-{circumflex over ( )} Name:      6-P VIA Species:   purpurascens Isolated:  Yes Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACTGCCTGGACATTC (SEQ ID NO:151) GTCACGGCTGATGACTCCAAAAATGGACTGGAGAATCATTTTTGGAAGGCACGTGA CGAAATGAAGAACCGCGAAGCCTCTAAATTGGACAAAAAGGAAGCCTGCTATGCGC CTGGTACTTTTTGTGGCATAAAGCCCGGGCTATGCTGCAGTGAGTTTTGTCTCCCGG GCGTCTGCTTCGGTGGTTAACTGCCGTGATGTCTTCTACTCCCCTCTGTGCTACCTGG CTTGATCTTTGATCGGCGTGTGCCCTTCACTGGTTATGAACCCACTGATCTTACCTCT CTTGAAGGACCTCTGGGGTCCAGCATCCAAATAAGCGACATCCCAATGAAAAAAAA AAAAAAAAAAAAAA Translation: MKLTCVMIVAVLFLTAWTFVTADDSKNGLENHFWKARDEMKNREASKLDKKEACYA (SEQ ID NO:152) PGTFCGIKPGLCCSEFCLPGVCFGG Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Ala-Xaa3-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:153) Xaa1-Phe-Cys-Leu-Xaa3-Gly-Val-Cys-Phe-Gly-# Name:       δ-PVIA-OH Species:    purpurascens Isolated:   Yes Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Ala-Xaa3-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:153) Xaa1-Phe-Cys-Leu-Xaa3-Gly-Val-Cys-Phe-Gly-{circumflex over ( )} Name:       6-PVIA[F9A] Species:    purpurascens Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Ala-Xaa3-Gly-Thr-Ala-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:154) Xaa1-Phe-Cys-Leu-Xaa3-Gly-Val-Cys-Phe-Gly-{circumflex over ( )} Name:       δ-PVIA[I12A] Species:    purpurascens Isolated: Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Ala-Xaa3-Gly-Thr-Phe-Cys-Gly-Ala-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:155) Xaa1-Phe-Cys-Leu-Xaa3-Gly-Val-Cys-Phe-Gly-{circumflex over ( )} Name:       δ-PVIA[T8A] Species:    purpurascens Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Ala-Xaa3-Gly-Ala-Phe-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:156) Xaa1-Phe-Cys-Leu-Xaa3-Gly-Val-Cys-Phe-Gly-{circumflex over ( )} Name:      M6.3 Species:   magus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACCACGTGGACATTC (SEQ ID NO:157) GTCACGGCTGATGACTCCAGATATGGATTGAAGAATCTTTTTCCGAAGGCACGTCAT GAAATGAAGAACCCTGAAGCCTCTAAATTGAACAAGAGAGATGGGTGCTATAATGC TGGTACATTTTGTGGCATCCGTCCAGGACTCTGCTGCAGCGAGTTTTGCTTTTTATGG TGCATAACATTTGTTGATTCTGGCTAACAGTGTGCGTTGGTTAGTGTCTTCTCCTCCC CTC Translation: MKLTCVMIVAVLFLTTWTFVTADDSRYGLKNLFPKARHEMKNPEASKLNKRDGCYNA (SEQ ID NO:158) GTFCGIRPGLCCSEFCFLWCITFVDSG Toxin Sequence: Asp-Gly-Cys-Xaa5-Asn-Ala-Gly-Thr-Phe-Cys-Gly-Ile-Arg-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1- (SEQ ID NO:159) Phe-Cys-Phe-Leu-Xaa4-Cys-Ile-Thr-Phe-Val-Asp-Ser-# Name:      M6.6 Species:   magus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACCACCTGGACATTC (SEQ ID NO:160) GTCACGGCTGATGACTCCAGATATGGATTGAAGAATCTTTTTCCGAAGGCACGTCAT GAAATGAAGAACCCTGAAGCCTCTAAATTGAACAAGAGAGATGAATGCTATCCTCC TGGTACATTTTGTGGCATCAAACCAGGACTTTGCTGCAGCGCGATATGCTTATCGTT TGTCTGCATATCATTTGATTTTTGATTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTTWTFVTADDSRYGLKNLFPKARHEMKNPEASKLNKRDECYPP (SEQ ID NO:161) GTFCGIKPGLCCSAICLSFVCISFDF Toxin Sequence: Asp-Xaa1-Cys-Xaa5-Xaa3-Xaa3-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:162) Ala-Ile-Cys-Leu-Ser-Phe-Val-Cys-Ile-Ser-Phe-Asp-Phe-{circumflex over ( )} Name:      M6.7 Species:   magus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTACTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:163) GTCACGGCTGATGACTCCAGATATGGACTGAAGGATCTGTTTCCGAAGGAACGTCA TGAAATGAAGAACCCCGAAGCCTCTAAATTGAACCAGAGAGAAGCCTGCTATAATG CTGGTTCATTTTGTGGCATCCATCCAGGACTCTGCTGCAGCGAGTTTTGCATTCTTTG GTGCATAACATTTGTTGATTCTGGCTAACTGTGTGCGTTGGTTGATGTCTTCTCCTCC CATC Translation: MKLTCVMIVAVLFLTAWTFVTADDSRYGLKDLFPKERHEMKNPEASKLNQREACYNA (SEQ ID NO:164) GSFCGIHPGLCCSEFCILWCITFVDSG Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Asn-Ala-Gly-Ser-Phe-Cys-Gly-Ile-His-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1- (SEQ ID NO:165) Phe-Cys-Ile-Leu-Xaa4-Cys-Ile-Thr-Phe-Val-Asp-Ser-# Name:      M6.8 Species:   magus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTACTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:166) GTCACGGCTGATGACTCCAGATATGGACTGAAGGATCTGTTTCCGAAGGAACGTCA TGAAATGAAGAACCCCGAAGCCTCTAAATTGAACCAGAGAGAAGCCTGCTATAATG CTGGTACATTTTGTGGCATCAAACCAGGACTTTGCTGCAGCGCGATATGCTTATCGT TTGTCTGCATATCATTTGATTTTTGATTGATGTCTTCTCCTCCCCTC Translation: MKLTCMMIVAVLFLTAWTFVTADDSRYGLKDLFPKERHEMKNPEASKLNQREACYNA (SEQ ID NO:167) GTFCGIKPGLCCSAICLSFVCISFDF Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Asn-Ala-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser-Ala (SEQ ID NO:168) Ile-Cys-Leu-Ser-Phe-Val-Cys-Ile-Ser-Phe-Asp-Phe- Name:      E6.4 Species:   ermineus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACTGCCTGGACATTC (SEQ ID NO:169) GTCACGGCTGATGACTCCAAAAATGGACTGGAGAATCATTTTTGGAAGGCACGTGA CGAAATGAAGAACCGCGAAGCCTCTAAATTGGACAAAAAGGAAGCCTGCTATCCGC CTGGTACTTTTTGTGGCATAAAGCCCGGGCTATGCTGCAGTGAGTTGTGTTTACCGG CCGTCTGCGTCGGTGGTTAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTAWTFVTADDSKNGLENHFWKARDEMKNREASKLDKKEACYP (SEQ ID NO:170) PGTFCGIKPGLCCSELCLPAVCVGG Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Xaa3-Xaa3-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:171) Xaa1-Leu-Cys-Leu-Xaa3-Ala-Val-Cys-Val-Gly-# Name:      P6.4 Speciet:   purpurascens Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACTGCCTGGACATTC (SEQ ID NO:172) GTCACGGCTGATGACTCCAAAAATGGACTGGAGAATCATTTTTGGAAGGCACGTGA CGAAATGAAGAACCGCGAAGCCTCTAAATTGGACAAAAAGGAAGCCTGCTATCCGC CTGGTACTTTTTGTGGCATAAAGCCCGGGCTATGCTGCAGTGAGTTGTGTTTACCGG CCGTCTGCGTCGGTGGTTAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCMMIVAVLFLTAWTFVTADDSKNGLENHFWKARDEMKNREASKLDKKEACYP (SEQ ID NO:173) PGTFCGIKPGLCCSELCLPAVCVGG Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Xaa3-Xaa3-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:174) Xaa1-Leu-Cys-Leu-Xaa3-Ala-Val-Cys-Val-Gly-# Name:      δ-SVIE[D1E] Species:   striatus Isolated:  Yes Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACCACTTGGACATTC (SEQ ID NO:175) GTCACGGCTGATGACTCCAGATATGGATTGAAGAATCTTTTTCCGAAGGCACGTCAT GAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGAGAAGGGTGCTCTAGTG GTGGTACATTTTGTGGCATCCATCCAGGACTCTGCTGCAGCGAGTTTTGCTTTCTTTG GTGCATAACATTTATTGATTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTTWTFVTADDSRYGLKNLFPKARHEMKNPEASKLNKREGCSSG (SEQ ID NO:176) GTFCGIHPGLCCSEFCFLWCITFID Toxin Sequence: Xaa1-Gly-Cys-Ser-Ser-Gly-Gly-Thr-Phe-Cys-Gly-Ile-His-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1- (SEQ ID NO:177) Phe-Cys-Phe-Leu-Xaa4-Cys-Ile-Thr-Phe-Ile-Asp-{circumflex over ( )} Name:      δ-SVIE Species:   striatus Isolated:  Yes Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACCACTTGGACATTC (SEQ ID NO:178) GTCACGGCTGATGACTCCAGATATGGATTGAAGAATCTTTTTCCGAAGGCACGTCAT GAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGAGATGGGTGCTCTAGTGG TGGTACATTTTGTGGCATCCATCCAGGACTCTGCTGCAGCGAGTTTTGCTTTCTTTGG TGCATAACATTTATTGATTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTTWTFVTADDSRYGLKNLFPKARHEMKNPEASKLNKRDGCSSG (SEQ ID NO:179) GTFCGIHPGLCCSEFCFLWCITFID Toxin Sequence: Asp-Gly-Cys-Ser-Ser-Gly-Gly-Thr-Phe-Cys-Gly-Ile-His-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1- (SEQ ID NO:180) Phe-Cys-Phe-Leu-Xaa4-Cys-Ile-Thr-Phe-Ile-Asp-{circumflex over ( )} Name:       δ-NgVIA Species:    striolatus Isolated:   Yes Toxin Sequence: Ser-Lys-Cys-Phe-Ser-Xaa3-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser-Val- (SEQ ID NO:181) Arg-Cys-Phe-Ser-Leu-Phe-Cys-Ile-Ser-Phe-Xaa1-{circumflex over ( )} Name:      C6.2 Species:   catus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:182) GTCACGGCTGATGACTCCAGAAATGGACTGAAGAATCTTTTTCCGAAGGCACGTCA TGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGATATGGGTGCTCTAATG CTGGTGCATTTTGTGGCATCCATCCAGGACTCTGCTGCAGCGAGCTTTGCCTGGTTT GGTGCACATGAGTGCTATTCTTCTGGTACATTTTGTGGCTTCAACGGAGGACTCTGC TGCAGCAACCTTTGCTTATTTTCGTGTGCTTAACATTTCGTGATGTCTTCTCTATTCC CCTC Translation: MKLTCMMIVAVLFLTAWTFVTADDSRNGLKNLFPKARHEMKNPEASKLNKRYGCSNA (SEQ ID NO:183) GAFCGIHPGLCCSELCLVWCT Toxin Sequence: Xaa5-Gly-Cys-Ser-Asn-Ala-Gly-Ala-Phe-Cys-Gly-Ile-His-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1- (SEQ ID NO:184) Leu-Cys-Leu-Val-Xaa4-Cys-Thr-{circumflex over ( )} Name:      C6.3 Species:   catus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTATGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:185) GTCACGGCTGATGACTCCAGATATGGACTGAAGAATCTTTTTCCGAAGGCACGTCAT GAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGATATGGGTGCTCTAATGC TGGTGCATTTTGTGGCATCCATCCAGGACTCTGCTGCAGCGAGCTTTGCCTGGGTTG GTGCACATGAGTGCTATTCTACTGGTACATTTTGTGGCTTCAACGGAGGACTCTGCT GCAGCAACCTTTGCTTATTTTCGTGTGCTTAACATTTCGTGATGTCTTCTCTATTCCC CTC Translation: MKLTCMMIVAVLFLTAWTFVTADDSRYGLKLNLFPKARHEMKNPEASKLNKRYGCSNA (SEQ ID NO:186) GAFCGIHPGLCCSELCLGWCT Toxin Sequence: Xaa5-Gly-Cys-Ser-Asn-Ala-Gly-Ala-Phe-Cys-Gly-Ile-His-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1- (SEQ ID NO:187) Leu-Cys-Leu-Gly-Xaa4-Cys-Thr-{circumflex over ( )} Name:      Di6.3 Species:   distans Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTCTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:188) GTCACGGCTGATGACTCCAGAAATGGATTGGAGAATCTCTCTCCGAAGGCACCTCA CGAAATGAAGAACCCCGAAGCCTCTAAATCGAACAAGAGATATGAGTGCTATCTAC TGGTACATTTTTGTGGCATCAACGGAGGACTCTGCTGCAGCAACCTTTGCTTATTTTT CGTGTGCTTAACATTTTCGTGATGTCTTCTCCTCCCATC Translation: MKLTCLMIVAVLFLTAWTFVTADDSRNGLENLSPKAPHEMKNPEASKSNKRYECYLLV (SEQ ID NO:189) HFCGINGGLCCSNLCLFFVCLTFS Toxin Sequence: Xaa5-Xaa1-Cys-Xaa5-Leu-Leu-Val-His-Phe-Cys-Gly-Ile-Asn-Gly-Gly-Leu-Cys-Cys-Ser-Asn- (SEQ ID NO:190) Leu-Cys-Leu-Phe-Phe-Val-Cys-Leu-Thr-Phe-Ser-{circumflex over ( )} Name:      Rg6.1 Species:   regius Isolated:  No Cloned:    Yes DNA Sequence: TTGAGCAAGAGAGACTGCCTTCCTGACTACACGATTTGTGCCTTCAATATGGGTCTG (SEQ ID NO:191) TGCTGCAGCGACAAGTGCATGCTCGTCTGCCTGCCGTGATGTCTTCTCCTCCCCTC Translation: LSKRDCLPDYTICAFNMGLCCSDKCMLVCLP (SEQ ID NO:192) Toxin Sequence: Asp-Cys-Leu-Xaa3-Asp-Xaa5-Thr-Ile-Cys-Ala-Phe-Asn-Met-Gly-Leu-Cys-Cys-Ser-Asp-Lys- (SEQ ID NO:193) Cys-Met-Leu-Val-Cys-Leu-Xaa3-{circumflex over ( )} Name:      Rg6.3 Species:   regius Isolated:  No Cloned:    Yes DNA Sequence: TTGAACAAGAGAATCATCTGCTTTCCTGACTACATGTTTTGTGGCGTCKAATGTGTTTC (SEQ ID NO:194) TGTGCTGCAGTGGCAACTGCCTTCTCATCTGCGTGCCGTGATGTCTTCTACTCCCCTC Translation: LNKRIICEPDYMFCGVNVFLCCSGNCLLICVP (SEQ ID NO:195) Toxin Sequence: Ile-Ile-Cys-Phe-Xaa3-Asp-Xaa5-Met-Phe-Cys-Gly-Val-Asn-Val-Phe-Leu-Cys-Cys-Ser-Gly- (SEQ ID NO:196) Asn-Cys-Leu-Leu-Ile-Cys-Val-Xaa3-{circumflex over ( )} Name:      Gm6.2 Species:   gloriamaris Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:197) GTCACGGCTGTGCCTCACTCCAGCAATGCGTTGGAGAATCTTTATCTGAAGGCACAT CATGAAATGAACAACCCCGAAGACTCTGAATTGAACAAGAGGTGCTATGATGGTGG GACAGGTTGTGACTCTGGAAACCAATGCTGCAGTGGCTGGTGCATTTTCGCCTGCCT CTAAAACTGTCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCMMIVAVLFLTAWTFVTAVPHSSNALENLYLKAHHEMNNPEDSELNKRCYDGG (SEQ ID NO:198) TGCDSGNQCCSGWCIFACL Toxin Sequence: Cys-Xaa5-Asp-Gly-Gly-Thr-Gly-Cys-Asp-Ser-Gly-Asn-Gln-Cys-Cys-Ser-Gly-Xaa4-Cys-Ile- (SEQ ID NO:199) Phe-Ala-Cys-Leu-{circumflex over ( )} Name:      Da6.1 Species:   dalli Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATTATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:200) GTCACGGCTGTGCCTCACTCCAGCAATGCGTTGGAGAATCTTTATCTGAAGGCACAT CATGAAATGAACAACCCCGAGGACTCTGAATTGAACAAGAGGTGCTATGATGGTGG GACAGGTTGTGACTCTGGAAACCAATGCTGCAGTGGCTGGTGCATTTTCGTCTGCCT CTAAAACTGCCGTGATGTCTTCTCTCCCATC Translation: MKLTCIMIVAVLFLTAWTFVTAVPHSSNALENLYLKAHHEMNNPEDSELNKRCYDGGT (SEQ ID NO:201) GCDSGNQCCSGWCIFVCL Toxin Sequence: Cys-Xaa5-Asp-Gly-Gly-Thr-Gly-Cys-Asp-Ser-Gly-Asn-Gln-Cys-Cys-Ser-Gly-Xaa4-Cys-Ile- (SEQ ID NO:202) Phe-Val-Cys-Leu-{circumflex over ( )} Name:      Pn6.6 Species:   pennaceus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACAGTC (SEQ ID NO:203) GTCACGGCTGTGCCTCACTCCAACAAGCGGTTGGCGAATCTTTATCTGAAGGCACGT CACGAAATGAAAAACCCCGAAGCCTCTAATGTGGACAAGAGGTGCTTTGAGAGTTG GGTAGCTTGTGAGTCTCCAAAACGATGCTGCAGTCACGTGTGCCTTTTCGTCTGCAC CTGAAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCVMIVAVLFLTAWTVVTAVPHSNKRLANLYLKARHEMKNPEASNVDKRCFESW (SEQ ID NO:204) VACESPKRCCSHVCLFVCT Toxin Sequence: Cys-Phe-Xaa1-Ser-Xaa4-Val-Ala-Cys-Xaa1-Ser-Xaa3-Lys-Arg-Cys-Cys-Ser-His-Val-Cys-Leu- (SEQ ID NO:205) Phe-Val-Cys-Thr-{circumflex over ( )} Name:      Di6.5 Species:   distans Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTATGTTGATCATCGCTGTGCTGTTCCTGACGGCCTGTCAACTC (SEQ ID NO:206) TCTACAAATGCGAGTTACGCCAGAAGTAAGCAGAAGCATCGTGTTCTGAGGTCGAC TGACAAAAACTCCAAGTTGACCCAGCGTTGCAATGAAGCTCAAGAACATTGCACTC AAAATCCTGACTGCTGCAGTGAGTCTTGCAATAAGTTTGTCGGCAGATGCTTGTCAG ACTGATCTGATGTCTTCTCCTCCCATC Translation: MKLTCMLIIAVLFLTACQLSTNASYARSKQKHRVLRSTDKNSKLTQRCNEAQEHCTQN (SEQ ID NO:207) PDCCSESCNKFVGRCLSD Toxin Sequence: Cys-Asn-Xaa1-Ala-Gln-Xaa1-His-Cys-Thr-Gln-Asn-Xaa3-Asp-Cys-Cys-Ser-Xaa1-Ser-Cys- (SEQ ID NO:208) Asn-Lys-Phe-Val-Gly-Arg-Cys-Leu-Ser-Asp-{circumflex over ( )} Name:      Af6.10 Species:   ammiralis Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCCTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:209) GTCACGGCTGTGCCTGACTCCAGCAATGCGTTGGAGAATCTTTATCTGAAGGCACAT CATGAAATGAACAACCCCGAAGACTCTGAATTGAACAAGAGGTGCTATGATGGTGG GACAAGTTGTAACACTGGAAACCAATGCTGCAGTGGCTGGTGCATTTTCCTCTGCCT CTAAAACTGCCGTGATGTCTTCTCTTCCCCTC Translation: MKLTCLMIVAVLFLTAWTFVTAVPDSSNALENLYLKAHHEMNNPEDSELNKRCYDGG (SEQ ID NO:210) TSCNTGNQCCSGWCIFLCL Toxin Sequence: Cys-Xaa5-Asp-Gly-Gly-Thr-Ser-Cys-Asn-Thr-Gly-Asn-Gln-Cys-Cys-Ser-Gly-Xaa4-Cys-Ile- (SEQ ID NO:211) Phe-Leu-Cys-Leu-{circumflex over ( )} Name:      Tx6.1O Species:   textile Isolated:  No Cloned:    Yes DNA Sequence: GGCATTACCTAAAACATCACCAAGATGAAACTGACGTGCATGATGATCGTTGCTGT (SEQ ID NO:212) GCTGTTCTTGACCGCCTGGACATTCGTCACGGCTGCGCCTCACTCCAGCAATGCGTT GGAGAATCTTTATCTGAAGGCACATCATGAAATGAACAACCCCGAAGCCTCTGAAT TGAACAAGAGGTGCTATGATAGTGGGACAAGTTGTAACACTGGAAACCAATGCTGC AGTGGCTGGTGCATTTTCGTCTCTTGCCTCTAAAACTACCGTGATGTCTTCTCCTCCC CTC Translation: MKLTCMMIVAVLFLTAWTFVTAAPHSSNALELYLKAHHEMNNPEASELNKRCYDSG (SEQ ID NO:213) TSCNTGNQCCSGWCIFVSCL Toxin Sequence: Cys-Xaa5-Asp-Ser-Gly-Thr-Cys-Asn-Thr-Gly-Asn-Cyc-Cys-Ser-Gly-Xaa4-Cys-Ile- (SEQ ID NO:214) Phe-Val-Ser-Cys-Leu-{circumflex over ( )} Name:      Gm6.4 Species:   gloriamaris Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCCTGACAGCCTGGACGCTA (SEQ ID NO:215) GTCATGGCTGATGACTCCAACAATGGACTGGCGAATCTTTTTTCGAAATCACGTGAC GAAATGGAGGACCCCGAAGCTTCTAAATTGGAGAAAAGGGATTGCCAAGCACTATG GGATTATTGTCCAGTACCGCTCTTGTCATCGGGTGATTGCTGCTATGGCTTAATCTGT GGCCCTTTCGTCTGCATTGGATGGTGATGTCTTCTACTCCCATC Translation: MKLTCMMIVAVLFLTAWTLVMADDSNNGLANLFSKSRDEMEDPEASKLEKRDCQAL WDYCPVPLLSSGDCCYGLICGPFVCIGW Toxin Sequence: Asp-Cys-Gln-Ala-Leu-Xaa4-Asp-Xaa5-Cys-Xaa3-Val-Xaa3-Leu-Leu-Ser-Ser-Gly-Asp-Cys- (SEQ ID NO:217) Cys-Xaa5-Gly-Leu-Ile-Cys-Gly-Xaa3-Phe-Val-Cys-Ile-Gly-Xaa4-{circumflex over ( )} Name:      Om6.2 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCCTGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:218) GTCATGGCTGATGACTCCAACAATGGACTGGCAAATCTTTTCTCGAAATCACGTGAC GAAATGGAGGATACCGATCCTTCTAAATTGGAGAACAGAAAAACTTGCCAAAGAAG GTGGGATTTTTGTCCAGGATCGCTCGTTGGAGTGATAACTTGCTGCGGTGGCTTAAT CTGTTTTCTGTTCTTCTGCGTTTGATAGTGATGCTCTTCTCCTCCCCT Translation: MKLTCLMIVAVLFLTAWTFVMADDSNNGLANLFSKSRDEMEDTDPSKLENRKTCQRR (SEQ ID NO:219) WDFCPGSLVGVITCCGGLICFLFFCV Toxin Sequence: Lys-Thr-Cys-Gln-Arg-Arg-Xaa4-Asp-Phe-Cys-Xaa3-Gly-Ser-Leu-Val-Gly-Val-Ile-Thr-Cys- (SEQ ID NO:220) Cys-Gly-Gly-Leu-Ile-Cys-Phe-Leu-Phe-Phe-Cys-Val-{circumflex over ( )} Name:      Da6.3 Species:   dalli Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTGTGATGATCGTTGCTGTGCTGTTCCTGACAGCCTGGACGCTA (SEQ ID NO:221) GTCATGGCTGATGACTCCAACAATGGACTGGCGAATCTTTTTTCGAAATTACGTGAC GAAATGGAGGACCCCGAAGGTTCTAAATTGGAGAAAAAGGATTGCCAAGAAAAAT GGGATTATTGTCCAGTACCGTTCTTGGGATCGAGGTATTGCTGCGATGGCTTTATCT GTCCATCTTTCTTCTGCGCTTGATAGTGATGTCTTCTCTATTCCCCTC Translation: MKLTCVMIVAVLFLTAWTLVMADDSNNGLANLFSKLRDEMEDPEGSKLEKKDCQEK (SEQ ID NO:222) WDYCPVPFLGSRYCCDGFICPSFFCA Toxin Sequence: Asp-Cys-Gln-Xaa1-Lys-Xaa4-Asp-Xaa5-Cys-Xaa3-Val-Xaa3-Phe-Leu-Gly-Ser-Arg-Xaa5-Cys- (SEQ ID NO:223) Cys-Asp-Gly-Phe-Ile-Cys-Xaa3-Ser-Phe-Phe-Cys-Ala-{circumflex over ( )} Name:      Da6.7 Species:   dalli Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGTTGTTCCTGACAGCCTGGACGCTA (SEQ ID NO:224) GTCATGGCTGATGACTCCAACAATGGACTGGCGAATCATTTTTGGKAATCACGTGAC GAAATGGAGGACCCTGAAGCTTCTAAATTGGAGAAAAGGGATTGCCAAGGCGAAT GGAGTTTTGTATAGTACCGGTCCTTGGATTTGTGTATTGCTGCCCCTGGCTTATCTGT GGCCCTTTCGTCTGCGTTGATATCTGATGTCTTCTATCCCCTC Translation: MKLTCVMIVAVLFLTAWTLVMADDSNNGLANHFWKSRDEMEDPEASKLEKRDCQGE (SEQ ID NO:225) WEFCIVPVLGFVYCCPWLICGPFVCVDI Toxin Sequence: Asp-Cys-Gln-Gly-Xaa1-Xaa4-Xaa1-Phe-Cys-Ile-Val-Xaa3-Val-Leu-Gly-Phe-Val-Xaa5-Cys- (SEQ ID NO:226) Cyd-Xaa3-Xaa4-Leu-Ile-Cys-Gly-Xaa3-Phe-Val-Cys-Val-Asp-Ile-{circumflex over ( )} Name:      Pn6.5 Species:   pennaceus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCCTGATGATCATTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:227) GTCATGGCTGATGACCCCAGAGATGAACCGGAGGCACGTGACGAAATGAACCCCGC AGCCTCTAAATTGAACGAGAGAGGCTGCCTTGAAGTTGATTATTTTTGCGGCATACC GTTTGTGAACAACGGGCTATGCTGCAGTGGCAATTGTGTTTTTGTCTGCACACCCCA AGGGAAGTAAAACTGCTGTGATGTCTTCTCTTCCCATC Translation: MKLTCLMIIAVLFLTAWTFVMADDPRDEPEARDEMNPAASKLNERGCLEVDYFCGIPF (SEQ ID NO:228) VNNGLCCSGNCVFVCTPQGK Toxin Sequence: Gly-Cys-Leu-Xaa1-Val-Asp-Xaa5-Phe-Cys-Gly-Ile-Xaa3-Phe-Val-Asn-Asn-Gly-Leu-Cys-Cys- (SEQ ID NO:229) Ser-Gly-Asn-Cys-Val-Phe-Val-Cys-Thr-Xaa3-Gln-# Name:      Marm6 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: GGTCGACATCATCATCATCGATCCATCTGTCCATCCATCTGTCCATCCATCCATTCAT (SEQ ID NO:230) TCATTCACTGCCAAACTGTCATAAATATTTGAGTCTCTCTTTCTGTTTTTATCTGACA GATTGAACGAGAGAGACTGCCTTAATGTTGATTATTTTTGCGGCATACCGTTTGTGA ACAACGGGCTATGCTGCAGTGGCAATTGTGTTTTTGTCTGCACACCCCAAGGGAAGT AAAACTGCCGTGATGTCTTCTCTTCCCCTCTAGTAGTAGTAGGCGGCCGCTCTAGAG GATCCAAGCTTACGTACGCGTGCATGCGACGTCATAGCTCTTCTATAGTGTCACCTA AATTCAATTCACTGGCCGTCCGTTTTACAACGTCGTGACTGGGAAAACCCTGGCGTT ACCCAACTTAATCGCCTTGCAGCACAT Translation: NERDCLNVDYFCGIPFVNNGLCCSGNCVFVCTPQGK (SEQ ID NO:231) Toxin Sequence: Cys-Leu-Asn-Val-Asp-Xaa5-Phe-Cys-Gly-Ile-Xaa3-Phe-Val-Asn-Asn-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:232) Gly-Asn-Cys-Val-Phe-Val-Cys-Thr-Xaa3-Gln-# Name:      Marm15 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: TCGACATCATCATCATCGATCCATCTGTCCATCCATCCATTCATTCATTCGCTGCCAA (SEQ ID NO:233) ACTGTCATAAATATTTGAGTCTCTCTTTCTGTTTTTATCTGACAGATTGGACAAGAGA GAGTGCCTGGAAGCTGATTATTATTGCGTCTTACCGTTTGTGGGCAAcGGGATGTGC TGCAGTGGCATTTGTGTTTTTGTCTGCATAGCCC Translation: LDKRECLEADYYCVLPFVGNGMCCSGICVFVCIAQRFKTV (SEQ ID NO:234) Toxin Sequence: Xaa1-Cys-Leu-Xaa1-Ala-Asp-Xaa5-Xaa5-Cys-Val-Leu-Xaa3-Phe-Val-Gly-Asn-Gly-Met-Cys- (SEQ ID NO:235) Cys-Ser-Gly-Ile-Cys-Val-Phe-Val-Cys-Ile-Ala-Gln-Arg-Phe-Lys-Thr-Val-{circumflex over ( )} Name:      Marm10 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: GTACCGGTCCGGAATTCCCGGGTCGACATCATCATCATCGATCCATCTGTCCATCCA (SEQ ID NO:236) TCCATCCATTCATTCATTCGCTGCCAAACTGTCATAAACATTTGAGTCTCTCTTTCTG TTTTTATCTGACAGATTGAACGAGAGAGACTGCCTTGAACCTGATTATGTTTGCGGC ATACCGTTTGTGTTCAACGGGCTATGCTGCAGTGGAATTTGTGTTTTTATCTGCATAG CCCAAAAGTATTAAAACGCCGTGATGTCTTCTATTCCCATCTAGTAGTAGTAGGCGG CCGCTCTAGAGGATCCAAGCTTACGTACGCGTGCATGCGACGTCATAGCTCTTCTAT AGTGTCACCTAAATTCAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAA CCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGCG TAATAGCCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGAAT GGCGAATGGGG Translation: LNERDCLEPDYVCGIPFVFNGLCCSGICVFICIAQKY (SEQ ID NO:237) Toxin Sequence: Asp-Cys-Leu-Xaa1-Xaa3-Asp-Xaa5-Val-Cys-Gly-Ile-Xaa3-Phe-Val-Phe-Asn-Gly-Leu-Cys- (SEQ ID NO:238) Cys-Ser-Gly-Ile-Cys-Val-Phe-Ile-Cys-Ile-Ala-Gln-Lys-Xaa5-{circumflex over ( )} Name:      Marm14 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: GGTACGCCTGCAGGTACCGGTCCGGAATTCCCGGGTCGACATCATCATCATCATCGA (SEQ ID NO:239) TCCATCTGTCCATCCATCTATTCATTCATTCGCTGTCAAACTGTAATACATATTAGAA TCTCTCTTTCTGTTTGTATCTGACAGATTGGAGAAAAGGGCGTGCAGCAAAAAATGG GAATATTGTATAGTACCGATCCTTGGATTCGTATATTGCTGCCCTGGCTTAATCTGTG GTCCTTTCGTCTGCGTTTGATAGTGATGTCTTCTCCTCCCATCTAGTAGTAGTAGGCG GCCGCTCTAGAGGATCCAAGCTTACGTACGCGTGCATGCGACGTCATAGCTCTTCTA TAGTGTCACCTAAATTCAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAA ACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGC GTAATAAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGAA TGGCGAAATGGGACGCGCCCTG Translation: LEKRACSKKWEYCIVPILGFVYCCPGLICGPFVCV (SEQ ID NO:240) Toxin Sequence: Ala-Cys-Ser-Lys-Lys-Xaa4-Xaa1-Xaa5-Cys-Ile-Val-Xaa3-Ile-Leu-Gly-Phe-Val-Xaa5-Cys-Cys- (SEQ ID NO:241) Xaa3-Gly-Leu-Ile-Cys-Gly-Xaa3-Phe-Val-Cys-Val-{circumflex over ( )} Name:      Omaria14 Species:   omaria Isolated:  No Cloned:    Yes DNA Sequence: AAAGCCGGTACGCCTGCAGGTACCGGTCCGGAATTCCCGGGTCGACATCATCATCA (SEQ ID NO:242) TCATCGATCCATCTGTCCATCCATCCATTCATTCATTCACTGCCACTGTCATAAAT ATTTGAGTCTCTCTTTCTGTTTTTATCTGACAGATTGAACGAGAGAGACTGCCTTAAT GTTGATTATTTTTGTGGCATACCGTTTGTGAACAACGGGCTATGCTGCAGTGGCAAT TGTGTTTTTTGTCTGCACACCCCAAGGGAAGTAAAACTGCCGTGATGTCTTCTCTTCC CCTCTAGTAGTAGTAGGCGGCCGCTCTAGAGGATCCAAGCTTACGTACGCGTGCAT GCGACGTCATAGCTCTTCTATAGTGTCACCTAAATTCAATTCACTGGCCGTCGTTTTA CAACGTCGTGACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACAT CCCCCTTTCGCCAGCTGGCGTAATAGCGAAGAGCCCGCACCGATCGCCCTTCCCA ACAGTTGCGCAGCCTGAATGGCGAATGGGACGCGCCCT Translation: LNERDCLNVDYFCGIPFVNNGLCCSGNCVFCLHTPREVKLP (SEQ ID NO:243) Toxin Sequence: Asp-Cys-Leu-Asn-Val-Asp-Xaa5-Phe-Cys-Gly-Ile-Xaa3-Phe-Val-Asn-Asn-Gly-Leu-Cys-Cys- (SEQ ID NO:244) Ser-Gly-Asn-Cys-Val-Phe-Cys-Leu-His-Thr-Xaa3-Arg-Xaa1-Val-Lys-Leu-Xaa3-{circumflex over ( )} Name:      06.4 Species:   obscurus Isolated:  No Cloned:    Yes DNA Sequence: cgatccatctgtccatccatccattcattcattcattgccaaactgtaacaaatattcaagtctctctttctgtttgtgtctgaca (SEQ ID NO:245) gATCGAAACGGTGCCTTGTTTACGGTACACCTTGTGACTGGCTGACCATTGCGGGTATGGAGTGC TGCAGTAAAAAGTGCTTTATGATGTGCTGGTAAAACTGCCGTGATGTCTTCTACTCC CCTC Translation: RSKRCLVYGTPCDWLTIAGMECCSKKCFMMCW (SEQ ID NO:246) Toxin Sequence: Cys-Leu-Val-Xaa5-Gly-Thr-Xaa3-Cys-Asp-Xaa4-Leu-Thr-Ile-Ala-Gly-Met-Xaa1-Cys-Cys-Ser- (SEQ ID NO:247) Lys-Lys-Cys-Phe-Met-Met-Cys-Xaa4-{circumflex over ( )} Name:      R6.4 Species:   radiatus Isolated:  No Cloned:    Yes DNA Sequence: ATTGAACCAGAGAGACTGCCATGAAGTTGGTGAATTTTGTGGCTTACCGTTAATAAA (SEQ ID NO:248) GAACGGGCTATGCTGCAGTCAGATTTGTTTAGGTGTCTGCGCAAAGTGTTTTAAAA CTGCCGTGATGTCTTCTACTCCCAT Translation: LNQRDCHEVGEFCGLPLIKNGLCCSQICLGVCAKVF (SEQ ID NO:249) Toxin Sequence: Asp-Cys-His-Xaa1-Val-Gly-Xaa1-Phe-Cys-Gly-Leu-Xaa3-Leu-Ile-Lys-Asn-Gly-Leu-Cys-Cys- (SEQ ID NO:250) Ser-Gln-Ile-Cys-Leu-Gly-Val-Cys-Ala-Lys-Val-Phe-{circumflex over ( )} Name:      R6.6 Species:   radiatus Isolated:  No Cloned:    Yes DNA Sequence: ATTAGACAAGAAAGAGTGCACTGCCAATGGTGAATTTTGTGGCATATCGGTCTTTGG (SEQ ID NO:251) AAGCTACCTATGCTGCAGTGGCCGGTGTGTATTCGTCTGCATCTAGTTGAACTGCCG TGATGTCTTCTACTCCCCT Translation: LDKKECTANGEFCGISVFGSYLCCSGRCVFVCI (SEQ ID NO:252) Toxin Sequence: Xaa1-Cys-Thr-Ala-Asn-Gly-Xaa1-Phe-Cys-Gly-Ile-Ser-Val-Phe-Gly-Ser-Xaa5-Leu-Cys-Cys- (SEQ ID NO:253) Ser-Gly-Arg-Cys-Val-Phe-Val-Cys-Ile-{circumflex over ( )} Name:      R6.7 Species:   radiatus Isolated:  No Cloned:    Yes DNA Sequence: ATTGGACAAGAAAGAGTGCACTACCAATGGTGAATTTTGTGGCATATCGGTCTTTGC (SEQ ID NO:254) AAGCTTCCTATGCTGCAGTGGCCTGTGTGTATTCGTCTGCATCTAGCTGAACTGCCG TGATGTCTTCTCTTCCCCT Translation: LDKKECTTNGEFCGISVFASFLCCSGLCVFVCI (SEQ ID NO:255) Toxin Sequence: Xaa1-Cys-Thr-Thr-Asn-Gly-Xaa1-Phe-Cys-Gly-Ile-Ser-Val-Phe-Ala-Ser-Phe-Leu-Cys-Cys- (SEQ ID NO:256) Ser-Gly-Leu-Cys-Val-Phe-Val-Cycs-Ile-{circumflex over ( )} Name:      R6.8 Species:   radiatus Isolated:  No Cloned:    Yes DNA Sequence: ATTGGACAAGAGAAAATGCTTTCCCAAAAATCATTTTTGTGGCTTTGTGGTGATGCT (SEQ ID NO:257) GAACTACCTATGCTGCAGTGGCCGGTGTATATTCGTCTGCGTCTAGTTGAACTGCCG TGATGTCTTCTACTCCCAT Translation: LDKRKCFPKNHFCGFVVMLNYLCCSGRCIFVCV (SEQ ID NO:258) Toxin Sequence: Lys-Cys-Phe-Xaa3-Lys-Asn-His-Phe-Cys-Gly-Phe-Val-Val-Met-Leu-Asn-Xaa5-Leu-Cys-Cys- (SEQ ID NO:259) Ser-Gly-Arg-Cys-Ile-Phe-Val-Cys-Val-{circumflex over ( )} Name:      Rg6.5 Species:   regius Isolated:  No Cloned:    Yes DNA Sequence: TTGAACAAGAGAAGCTGCCTTCCTCTAGACTGGTTTTGTGGCTTCAATATAATTGGA (SEQ ID NO:260) GCGTTTCTGTGCTGTAGTGGCTACTGCCTTGTCGTCTGCATGTAAAACTGCCGTGAT GTCTTCTCCTCCCCTC Translation: LNKRSCLPLDWFCGFNIIGAFLCCSGYCLVVCM (SEQ ID NO:261) Toxin Sequence: Ser-Cys-Leu-Xaa3-Leu-Asp-Xaa4-Phe-Cys-Gly-Phe-Asn-Ile-Ile-Gly-Ala-Phe-Leu-Cys-Cys- (SEQ ID NO:262) Ser-Gly-Xaa5-Cys-Leu-Val-Val-Cys-Met-{circumflex over ( )} Name:      De6.2 Species:   delessertii Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTCTGCTGATCGTTGCTGTGCTGGTCTTGGCAGCCTGTCAGTTC ATCGTAGCTGGCGACTCGAGTGATGGCCAGGAGAATCCTGCTCTGAGGTCACCTAG CGATTCCTCTGGGAAAATGTCATCAATGAAGCGCTTCCAGACACGGCTGATGGTGG GGCAATCTGCATCGAAAAGACCAAGCAAGAGGGACTGCATCCCCGGCGGCGAAAA TTGTGATGTATTCCGACCATACCGGTGCTGCAGTGGATATTGCATACTACTCCTTTG CGCATGATAAAGCTGCCTTGATGTCTTCTCCTCCCCTC (SEQ ID NO:263) Translation: MKLTCLLIVAVLVLAACQIVAGDSSDGQENPALRSPSDSSGKMSSMKRFQTRLMVGQ (SEQ ID NO:264) SASKRPSKRDCJPGGENCDVFRPYRCCSGYCILLLCA Toxin Sequence: Asp-Cys-Ile-Xaa3-Gly-Gly-Xaa1-Asn-Cys-Asp-Val-Phe-Arg-Xaa3-Xaa5-Arg-Cys-Cys-Ser- (SEQ ID NO:265) Gly-Xaa5-Cys-Ile-Leu-Leu-Leu-Cys-Ala-{circumflex over ( )} Name:      Striat2l Species:   striatus Isolated:  No Cloned:    Yes DNA Sequence: GCTGGTTCGCCTGCAGGTACCGGTCCGGAATTCCCGGGTCGACATCATCATCATCGA (SEQ ID NO:266) TCCATCTGTCCATCCATCTATTCATTCATTCATTCGCTGCCAAACTGTATTAAATATT CAAGTCTCTCTTTCTGTTTGTGTCTAACAGATTGAGATGGTGCATTCCTAGTGGTGA ACTTTGTTTCCGCTCGGATCACATAGGATGCTGCAGTGGCAAGTGCGCATTCGTCTG CTTGTAAAACTGCCGTGATGTCTTCTCCTCCCATCTAGTAGTAGTAGGCGGCCGCTC TAGAGGATCCAAGCTTACGTACGCGTGCATGCGACGTCATAGCTCTTCTATAGTGTC ACCTAAATTCAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAACCCTGG CGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGCGTAATAG CGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTTGCGCAGCCTGAATGGCGAA TGGGACGCGCCCTGTAGCGGCGCATTAAACCGCGGCGGGTGTGGGTGGGTTACGCC CACGTGACCCGCTACACTTGCCAGCGCCCTANCGCCCCGCTCCTTTCGCTTTCTTTCC CTTCCTTTCTCGNCACGTTTCGGCCGNTTTTCCCCGTCAAGCTCTTAAATCGGGGGG CTTCCCTTTAAGGGTTNCCGAATTANTGCTTTACCGGNACCCTTGACCCCCAAAAAA ACTTGGANTAAGGGGNGATGGNTCNCGTAANTGGGGGCCATCNCCCCTGAANAGA ACGGTTTTTCNCCCCTTTTGACNGTTGGGNGTTCCNCGGTTTTTAAAAAANGGGACC TTTTNTTTCCAAAACTGGGAANANACCTAAACCCTATTTTTGGGGCTATTTTTTTGAN TTTNAAANGGGATTTTGCCCCATTTTNGGCCCTNTTGGGGTAAAAAAAAGAGCCGG TTTTAAAAAAAATTTTACCCCAAATTTTAACAAAAATTTTTT Translation: LRWCIPSGELCFRSDHIGCCSGKCAFVCL (SEQ ID NO:267) Toxin Sequence: Leu-Arg-Xaa4-Cys-Ile-Xaa3-Ser-Gly-Xaa1-Leu-Cys-Phe-Arg-Ser-Asp-His-Ile-Gly-Cys-Cys- (SEQ ID NO:268) Ser-Gly-Lys-Cys-Ala-Phe-Val-Cys-Leu-{circumflex over ( )} Name:      δStriatus 26 Species:   striatus Isolated:  No Cloned:    Yes DNA Sequence: TTGAGATGGTGCATTCCTAGTGGTGATCTTTGTTTCCGCTCGGATCACATAGGATGC (SEQ ID NO:269) TGCAGTGGCAAGTGCGCATTCGTCTGCTTGTAA Translation: LRWCIPSGDLCFRSDHIGCCSGKCAFVCL (SEQ ID NO:270) Toxin Sequence: Xaa4-Cys-Ile-Xaa3-Ser-Gly-Asp-Leu-Cys-Phe-Arg-Ser-Asp-His-Ile-Gly-Cys-Cys-Ser-Gly-Lys- (SEQ ID NO:271) Cys-Ala-Phe-Val-Cys-Leu-{circumflex over ( )} Name:      δStriatus 106 Species:   striatus Isolated:  No Cloned:    Yes DNA Sequence: TTGAGATGGTGCATTCCTAGTGGTGATCTTTGTTTCCGCTCGGATCACATACAATGC (SEQ ID NO:272) TGCAGTGGCAAGTGCGCATTCGTCTGCTTGTAA Translation: LRWCIPSGDLCFRSDHIQCCSGKCAFVCL (SEQ ID NO:273) Toxin Sequence: Xaa4-Cys-Ile-Xaa3-Ser-Gly-Asp-Leu-Cys-Phe-Arg-Ser-Asp-His-Ile-Gln-Cys-Cys-Ser-Gly-Lys- (SEQ ID NO:274) Cys-Ala-Phe-Val-Cys-Leu-{circumflex over ( )} Name:      06.3 Species:   obscurus Isolated:  No Cloned:    Yes DNA Sequence: cgatccatctgtccatccatccattcagtcattcgctgccaaactgtaacaaatattcaagtcttgctttctgtttgtgtctgaca (SEQ ID NO:275) gATTGAGATGGTGCGTTCCTAGCGGTGAAGTTTGTCGCCGCTATGAATTCGTGGGATGCTGCAG TGGCAAGTGCTTCTTCGTCTGCTCGTAAAACTGTTGTGATGTCTTCTCCTCCCCTC Translation: VSDRLRWCVPSGEVCRRYEFVGCCSGKCFFVCS (SEQ ID NO:276) Toxin Sequence: Leu-Arg-Xaa4-Cys-vaL-Xaa3-Ser-Gly-Xaa1-Val-Cys-Arg-Arg-Xaa5-Xaa1-Phe-Val-Gly-Cys- (SEQ ID NO:277) Cys-Ser-Gly-Lys-Cys-Phe-Phe-Val-Cys-Ser-{circumflex over ( )} Name:      R6.3 Species:   radiatus Isolated:  No Cloned:    Yes DNA Sequence: ctctctctctctctgctggacaggTCGACTCGCTGCTTGCCTGACGGAACGTCTTGCCTTTTTAGTA (SEQ ID NO:278) GGATCAGATGCTGCGGTACTTGCAGTTCAATCTTAAAGTCATGTGTGAGCTGATCCG GCGGTTGATCTTCCTCCCTCTGTGCTCCATCCTTTTCTGCCTGAGTCCTCCTTACCTG AGAGTGGTCATGAACCACTCATCACCTACTCCTCTGGAGGCTTCAGAGGAGCTACAT TGAAATAAAAGCCGCATTGC Translation: RSTRCLPDGTSCLFSRIRCCGTCSSILKSCVS (SEQ ID NO:279) Toxin Sequence: Cys-Leu-Xaa3-Asp-Gly-Thr-Ser-Cys-Leu-Phe-Ser-Arg-Ile-Arg-Cys-Cys-Gly-Thr-Cycs-Ser-Ser- (SEQ ID NO:280) Ile-Leu-Lys-Ser-CysVal-Ser-{circumflex over ( )} Name:      G6.3 Species:   geographus Isolated:  No Cloned:    Yes DNA Sequence: GGATCTTGCACGGTGAATTTCGCTTCATATTTTTCTACTGTCGTCTTTGGCATCATCC (SEQ ID NO:281) AAAACATCACCAAGATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGA CCGCCTGGACATTCGTCACGGCTGTGCCTCACTCCAGCGATGTATTGGAGAATCTTT ATCTGAAGGCACTTCACGAAACGGAAAACCACGAAGCCTCTAAATTGAACGTGAGA GACGACGAGTGCGAACCTCCTGGAGATTTTTGTGGCTTTTTTAAAATTGGGCCGCCT TGCTGCAGTGGCTGGTGCTTCCTCTGGTGCGCCTAAAACTGCCGTGATGTCTTCTATT CCCCTCTGTGCTACCTGGCTTGATCTTTGATTGGCGCGTGCCCTTCAGTGGTTATGAA CCCCCCTGAGCCGACTCTCTGGGGGCCTCGGGGGTTCAACATCCAAATAAAGCGAC AACACAATCACAAGTAAAAAA Translation: MKLTCMMIVAVLFLTAWTFVTAVPHSSDVLENLYLKALHETENHEASKLNVRDDECEP (SEQ ID NO:282) PGDFCGFFKIGPPCCSGWCFLWCA Toxin Sequence: Asp-Asp-Xaa1-Cys-Xaa1-Xaa3-Xaa3-Gly-Asp-Phe-Cys-Gly-Phe-Phe-Lys-Ile-G1y-Xaa3-Xaa3- (SEQ ID NO:283) Cys-Cys-Ser-Gly-Xaa4-Cys-Phe-Leu-Xaa4-Cys-Ala-{circumflex over ( )} Name:      Tx6.8 Species:   textile Isolated:  No Cloned:    Yes DNA Sequence: GCTGCAGGTCGACTCTAGAGGCGTTGGAGAATCTTTATCTGAAGGCACATCATGAA (SEQ ID NO:284) ATGAACAACCCCGAAGACTCTGAATTGAACAAGAGGTGCTATGATAGTGGGACAAAG TTGTAACACTGGAAACCAATGCTGCAGTGGCTGGTGCATTTTCGTCTGCCTCTAAAA CTGCCGTGATGTCTTCTACTCCCCTCTGTGCTACCTACCTGGCTTGATCTTTGATTGG CGCGTGCCCTTCACTGGTTATGAACCCCTCTGATCCGACTCTCTGGGGGCCTCGGGG ATCCAACATCAAAATANAGCGACAGCACAATCAC Translation: CRSTLEALENLYLKAHHEMNPEDSELNKRCYDSGTSCNTGNQCCSGWCIFVCL (SEQ ID NO:285) Toxin Sequence: Cys-Xaa5-Asp-Ser-Gly-Thr-Ser-Cys-Asn-Thr-Gly-Asn-Gln-Cys-Cys-Ser-Gly-Xaa4-Cys-Ile- (SEQ ID NO:286) ------------------------------- Phe-Val-Cys-Leu-{circumflex over ( )} Name:      Qc6.1 Species:   quercinus Isolated:  No Cloned:    Yes DNA Sequence: GCTTCGTATTTCTCCGCTGTCTTCCTTGGCATCACCCAAAACATCACCAAGATGAAA (SEQ ID NO:287) CTGACGTGCATGATGATCGTTGCTCTGCTGTTCTTGACCGCCTGGACATTCGTCACG GCTGTTGACTCCAAAAATGAACTGGAGaACAGAGGAGGATGGGGGCAGGCACGAG GATGGGGGAAACTTTTTCCGATGGCACGCGACGAAATGAAAAACAGCGAAGTCTCT AAATTGGACAATAAGAGAAGTGCGCTGCAGCCGGTGAAGCTTGCGTAATACCTAT CATTGGaAACGTATTTTGCTGCAAAGGCTACTGtCTTTTCGTCTGCATTAGTTAAACT GCTGTGATGCCTTCTACTCACCTCTGTGCTACCTGGCTTGATCTTTGATTGGCGTGTGC CCTTCACTGGTTATGAgCTCGTCTGAtCCTACTCTCTGGAGACCTCTGTGGTCCAACAt CCaAATAAAGCGGcATCCCAATC Translation: MKLTCMMIVALLFLTAWTFVTAVDSKNELENRGGWGQAGGWGKLFPMARDEMKNSE (SEQ ID NO:288) VSKLDNKRKCAAAGEACVIPIIGNVFCCKGYCLFVCIS Toxin Sequence: Cys-Ala-Ala-Ala-Gly-Xaa1-Ala-Cys-Val-Ile-Xaa3-Ile-Ile-Gly-Asn-Val-Phe-Cys-Cys-Lys-Gly- (SEQ ID NO:289) Xaa5-Cys-Leu-Phe-Val-Cys-Ile-Ser-{circumflex over ( )} ------------------------------- Name:      Lp6.5 Species:   leopardus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGGTGATCGTTGCTGTGCTGTTCTTGACCGCCTGGATATTC (SEQ ID NO:290) ATCACGGCTGATGACTCCACAATGGACTGGAGAATCGTTTTAGGAAGGCACGTGA CAACATGAAGAACGCCAAGCCTCTACATTAGCCGAGAAGAAAGCGTGTGTTGAAC TTGGTGAGATTTGTGCCACAGGCTTCTTCCTAGACGAGGAATGCTGCACTGGTTCAT GCCATGTCTTCTGCGTACTATAGTTAAACTGCTGTGATGTCTTCTTCTCTCCTCCGTG CTACCTGGCTTGATCTTTGATTGGTGCCTGTCCTTCAGTGGTTGTGAAACCCTCTGAT CCTACTCTCTGGACGCCTCTGAGGCCCAACATCCAAATAAAGCGACATCCTAATGCC AAAAAAAAAAA Translation: MKLTCVVIVAVLKLTAWIFITADDSTNGLENRFKARDNMKNAKASTLAEKKACVELG (SEQ ID NO:291) EICATGFFLDEECCTGSCHVFCVL Toxin Sequence: Ala-Cys-Val-Xaa1-Leu-Gly-Xaa1-Ile-Cys-Ala-Thr-Gly-Phe-Phe-Leu-Asp-Xaa1-Xaa1-Cys-Cys- (SEQ ID NO:292) Thr-Gly-Ser-Cys-His-Val-Phe-Cys-Val-Leu-{circumflex over ( )} ------------------------------- Name:      Mr6.4 Species:   marmoreus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGGTGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTT (SEQ ID NO:293) GCCACGGCTGATGACCCCAGAATGGATTGGAGAATCTTTTTTCGAAGGCACATCA AATTATGTGATGTGGTTGAACAAAACTGCTGCTATACCTATTGCTTTATTGTAGTCT AATTATGTGATGTGGTTGAACAAAACTGCTGCTATACCTATTGCTTTATTGTAGTCT GCCTATAAAACTACCGTGATGTCTTCTACTCCCCTCTGTGCTGCCTGGCTTGATCTTT GATTGGCGCGTGCCCTTCACTGGTTATGACCCCCCTGATCCGACCTCTGGGG Translation: MKLTCVVIVAVLFLTAWTFATADDPRNGLENLFSKAHHEMKNPEASKLNKRCPNTGEL (SEQ ID NO:294) CDVVEQNCCYTYCFIVVCL Toxin Sequence: Cys-Xaa3-Asn-Thr-Gly-Xaa1-Leu-Cys-Asp-Val-Val-Xaa1-Gln-Asn-Cys-Cys-Xaa5-Thr-Xaa5- (SEQ ID NO:295) Cys-Phe-Ile-Val-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Qc6.2 Species:   quercinus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGTATGGTGATCGTTGCTGTGCTATTCTTGACCGCCTCG (SEQ ID NO:296) GCTGATGACTCCAGAAATGGATTCGAGAATCGAAATGGAGAACGCGAAACGAAAACG AAATGAAGAACCTCGAAGCCTCTAAATTGAACAGGAGAGACGGCGATTGCGTTGAT GGTGGTGAATTTTGTGGCTTTCCGAAAATTGGAGGGCCATGCTGTAGTGGCTGGTGC TTTTTCGTCTGCTTATAAAACTGCCATGATGTCTTCTACCCCCCTCTGTGCTACCTGA CTTGATCTTTGATTGGCGTGTGCCCTTCACTGGTTATGAACCCCTCTGATCCGACTCT CTGGAGGCCTGGGGGGTCCAACATCCK&ATAAAGCGACAGCAAAAAAAAAAAAAA AAAAAA Translation: MKLTCMVIVAVLFTASADDSRNGFENRNGERNENEMKNLEASKLNRRDGDCVDGGE (SEQ ID NO:297) FCGFPKIGGPCCSGWCFFVCL Toxin Sequence: Asp-Gly-Asp-Cys-Val-Asp-Gly-Gly-Xaa1-Phe-Cys-Gly-Phe-Xaa3-Lys-Ile-Gly-Gly-Xaa3-Cys- (SEQ ID NO:298) Cys-Ser-Gly-Xaa4-Cys-Phe-Phe-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Qc6.3 Species:   quercinus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCGTGGTGATCGTTGCTGTGCTATTCTTGACCGCCTTG (SEQ ID NO:299) GCTGATGACTCCAGAAATGGATTGGAGAATCGAAATGAACAAGAACGAAACGAAA ACGAAATGAGGGACCGCCGGGACTGCCAAGATAGTGGTGTAGTTTGTGGCTTTCCG AAACCTGAACCACACTGCTGCAGTGGCTGGTGCCTTTTCGTCTGCGCCTAAAACTGC CGTGATGTCAAATAAAGCGACAGACAATNAAAAAAAAAAAAAAAAAAAA Translation: MKLTCVVIVAVLFLTALADDSRNGLENRNEQERNENEMRDRRDCQDSGVVCGFPKPEP (SEQ ID NO:300) HCCSGWCLFVCA Toxin Sequence: Asp-Cys-Gln-Asp-Ser-Gly-Va1-Val-Cys-Gly-Phe-Xaa3-Lys-Xaa3-Xaa1-Xaa3-His-Cys-Cys- (SEQ ID NO:301) Ser-Gly-Xaa4-Cys-Leu-Phe-Val-Cys-Ala-{circumflex over ( )} ------------------------------- Name:      Ar6.5 Species:   arenatus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGTGTGGTGATCGTTGCTGTGCTGTTCTTGACCGCCTGG (SEQ ID NO:302) ACATTCGTCACGGCTGACTCCATACGTGCACTGGAGGATTTTTTTGCGAAGGCACGT GACGAAATGGAAAACAGCGGAGCTTCTCCATTGAACGAGAGAGACTGCCGACCTGT AGGTCAATATTGTGGCATACCGTATAAGCACAACTGGCGATGCTGCAGTCAGCTTTG TGCAATTATCTGTGTTTCCTAACCCCTCTGATCCTACTCTCTGAAGACCTCCCGGATT CAACATCCAAATAAAGCGACATCCCGATNAAAAAAAANGAAAAAAAAAAAAAAAAAAA Translation: MKLTCVVIVAVLFLTAWTFVTADSIRALEDFFAEKARDEMENSGASPLNERDCRPVGQY (SEQ ID NO:303) CGIPYKHNWRCCSQLCAIICVS Toxin Sequence: Asp-Cys-Arg-Xaa3-Val-Gly-Gln-Xaa5-Cys-Gly-Ile-Xaa3-Xaa5-Lys-His-Asn-Xaa4-Arg-Cys- (SEQ ID NO:304) Cys-Ser-Gln-Leu-Cys-Ala-Ile-Ile-Cys-Val-Ser-{circumflex over ( )} ------------------------------- Name:      Ar6.11 Species:   arenatus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGTGTGGTGATCGTTGTTGTGCTGTTCTTGACCGCCTGG (SEQ ID NO:305) ACATTCGTCAAGGCTGATGACTCCATAAATGGATTGGAGAATCTTTTTCCGAAGGCA CGTCACGAAATGAAGAACCCCGAAGCCTCTAAATTGAACGAGAGGTGCCTTGAAAA GGGTGTACTTTGTGATCCGAGTGCTGGAAACTGCTGTAGTGGCGAATGCGTTTTAGT CTGCCTCTAAAACTACCGTGATGTCTTCTACTCCCATCTGTGCTACCCCTCGAG Translation: MKLTCVVIVVVLFLTAWTFVKADDSINGLENLFPKARHEMKNPEASKLNERCLELGVL (SEQ ID NO:306) CDPSAGNCCSGECVLVCL Toxin Sequence: Cys-Leu-Xaa1-Lys-Gly-Val-Leu-Cys-Asp-Xaa3-Ser-Ala-Gly-Asn-Cys-Cys-Ser-Gly-Xaa1-Cys- (SEQ ID NO:307) Val-Leu-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Ar6.12 Species:   arenatus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCATGGTGATCGTTACTGTGTTGTTCTTGACCGCCTGG (SEQ ID NO:308) ACATTCGTCACGGCTGATGACTCCAGAAATGAATTGGAGAATCTTTTTCTGAAGGCA TATCACGAAATGAACTCCGAAGCCTCTAAATTGGACAAGAAAGAGTGCGTTGCTGG TAGTCACTTTTGTGGTTTTCCGAAAATTGGAGGGCCATGCTGCAGTGGCTGGTGCTT TTTCGTCTGCTTGTAAACCTGCCGTGATGTCTTCTACTCCCATCTGTGCTACCCCTCG AG Translation: MKLTCMVIVTVLFLTAWTFVTADDSRNELENLFKAYHEMNSEASKLDKKECVAGSHF (SEQ ID NO:309) CGFPKIGGPCCSGWCFFVCL Toxin Sequence: Xaa1-Cys-Val-Ala-Gly-Ser-His-Phe-Cys-Gly-Phe-Xaa3-Lys-Ile-Gly-Gly-Xaa3-Cys-Cys-Ser- (SEQ ID NO:310) Gly-Xaa4-Cys-Phe-Phe-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Ts6.2 Species:   tessulatus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGTGTGGTGATCGTTGCTGTGATGTTCTTGACCGCCTGG (SEQ ID NO:311) ACATTCATCACGGCTGATGACTCCATAAATGGACTGGAGGATAGAGGCATATGGGG GGAACCTTTGTCGAAGGCACGTGACGAATGAACCCCGAAGTCTCTAAACGGGATT GCTGGCCTCAATATTGGTTTTGTGGCCTACAGAGGGGATGCTGCCCAGGGACTACTT GCTTCTTCCTTTGCTTTTAGTGATCTCTTCGACTCCCTTCTGTGCTACCTGGCTTGACC TTTGATTGGCGCGTGCCCTTCACTGGTTATAAACCCCTCTGTTCCTCCTCTCTGGACG CTTCGGGGTGTCCAGCATCCMATKAAGCGACGTCCCCAAAAAAAAAAAAAAAAA AA Translation: MKLTCVVIVAVMFLTAWTFITADDSINGLEDRGIWGEPLSKARDEMNPEVSKRDCWPQ (SEQ ID NO:312) YWFCGLQRGCCPGTTCFFLCF Toxin Sequence: Asp-Cys-Xaa4-Xaa3-Gln-Xaa5-Xaa4-Phe-Cys-Gly-Leu-Gln-Arg-Gly-Cycs-Cycs-Xaa3-Gly-Thr- (SEQ ID NO:313) Thr-Cys-Phe-Phe-Leu-Cys-Phe-{circumflex over ( )} ------------------------------- Name:      Ts6.4 Species:   tessulatus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCGTGGTGGTCGTTGCTGTGCTGTTCTTGAACGCCTGG (SEQ ID NO:314) ACATTCGCCACGGCTGTTGACTCCAACATGCACTGGCGKAACTTTTTATGAAGGCA CGTGACGAAATGTATAACCCCGATGCCACTAAATTGGACGATAAGAGATGGTGCGC TTTAGATGGTGAACTTTGTATCATACCGGTCATTGGGTCCATATTTTGCTGCCATGGC ATATGTATGATCTACTGCGTCTAGTTGAACTGCCGTGATGTCTTCTACTCCCCTCTGT GCTACCCCTGGTTTGATCTTTGATTGCCCTGTGCCCTTCACTGATTATGAATCCCTCT GATCCTACTCTCTGAAGACCTCTTGGGGTCCAACATCCAAATAAAGCGACATCCCAA AAAAAAAAAAAAAAAAAA Translation: MKLTCVVVVAVLFLNAWTFATAVDSKHALAKLFMKARDEMTNPDATKLDDKRWCA (SEQ ID NO:315) LDGELCIIPVIGSIFCCHGICMIYCV Toxin Sequence: Xaa4-Cys-Ala-Leu-Asp-Gly-Xaa1-Leu-Cys-Ile-Ile-Xaa3-Val-Ile-Gly-Ser-Ile-Phe-Cys-Cys- (SEQ ID NO:316) His-Gly-Ile-Cys-Met-Ile-Xaa5-Cys-Val-{circumflex over ( )} ------------------------------- Name:      Im6.1 Species:   imperialis Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCGTGGTGTTCGTTGCTGTGCCGTTCTTGACCGCCTCG (SEQ ID NO:317) GTATTCATCACGGCTGATGACTCCAGAAATGGAATCGAGAATCTTCCTCGGATGAG ACGTCACGAAATGAAGAACCCCAAAGCCTCTAAGTTGAACAAGAGACAGTGCCGTG TAGAAGGTGAAATTTGTGGCATGCTGTTTGAAGCACAATGCTGCGATGGCTGGTGCT TTTTCGTCTGCATGTAAAACTGCCGTGATGTCTTCTACTCTCCTCTGTGCTACCTGCC CTGATCTTTGATTGGCTCGCGCCCTTCATTGGTTATGAACCCCTCTGATCCTACTCTC TGGAGGCCTCAGGGGTCCAGCATCTAAATAAAGCGACATCACAATCAAAAAAAAA AAAAAAAAAAAA Translation: MKLTCVVFVAVPFLTASVFITADDSRNGIENLPRMRRHEMKNPKASKLNKRQCRVEGEI (SEQ ID NO:318) CGMLFEAQCCDGWCFFVCM Toxin Sequence: Xaa2-Cys-Arg-Val-Xaa1-Gly-Xaa1-Ile-Cys-Gly-Met-Leu-Phe-Xaa1-Ala-Gln-Cys-Cys-Asp- (SEQ ID NO:319) Gly-Xaa4-Cys-Phe-Phe-Val-Cys-Met-{circumflex over ( )} Name:      Ca6.5 Species:   caracteristicus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGTGTGGTGATCGTTGCTGTGCTGTTCTTGACCGCCTGG (SEQ ID NO:320) ACATTCGTCACGGCTGATGACTCCAGAAATGGATTGGAGAATCTTTTTCCGAAGGCA CGTCACGAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGGTGCGTTGACCC TGGTGAATTTTGTGGTCCGGGATTTGGAGATTGCTGCACTGGCTTCTGCCTTTTAGTC TGCATCTAAAACTGCCGTGATGTCTTCTACTCCCATCTGTGCTACCCCTCGAG Translation: MKLTCVVIVAVLFLTAWTFVTADDSRNGLENLFPKARHEMKNPEASKLNKRCVDPGEF (SEQ ID NO:321) CGPGFGDCCTGFCLLVCI Toxin Sequence: Cys-Val-Asp-Xaa3-Gly-Xaa1-Phe-Cys-Gly-Xaa3-Gly-Phe-Gly-Asp-Cys-Cys-Thr-Gly-Phe-Cys- (SEQ ID NO:322) Leu-Leu-Val-Cys-Ile-{circumflex over ( )} ------------------------------- Name:      Mf6.2 Species:   miliaris Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCGTGGTGATCGTTGCTGTGTTGTTCTTGACCGCCTGG (SEQ ID NO:323) ACATTCGTCATGGCTGATGACTCCAGAAATGATTTGGAGAATCTTTTTCTGAAGCA CGTCATGAAATGAAGAACCCCGAAGCTTCTAAATTGAACAAGAGATGCCTTCCAAA TGGTGTACTTTGTGATCTGGGATCTCCACCATACTGCTGCAGTGGCTGGTGCGCGAT CGTCGTCTGCATCTAAAACTGTCGTCATGTCTTCTACTCCCATCTGTGCTACCCCTCG AG Translation: MKLTCVVIVAVLFLTAWTFVMADDSRNDLENLFLKARHEMKNPEASKLNKRCLPNGV (SEQ ID NO:324) LCDLGSPPYCCSGWCAIVVCI Toxin Sequence: Cys-Leu-Xaa3-Asn-Gly-Val-Leu-Cys-Asp-Leu-Gly-Ser-Xaa3-Xaa3-Xaa5-Cys-Cys-Ser-Gly- (SEQ ID NO:325) Xaa4-Cys-Ala-Ila-Ile-Val-Val-Cys-Ile-{circumflex over ( )} ------------------------------- Name:      Ak6.1 Species:   atlanticus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCGTGGTGATCGTTGCTGTGCTGTTCTTGACCGCCTGG (SEQ ID NO:326) ACATTCGTCACGGCTGATGACTCCATAAATGGGTTGGAGAATCTTTTTCCGAAGGCA CGTCACGAAATGAGGAAACCCGAAGCCTCTAGATCGAGAGGGAGGTGCCGTCCTCG TGGTATGTTCTGTGGCTTTCCGAAACCTGGACCATACTGCTGCAATGGCTGGTGCTT TTTCGTCTGCATCTAAAACTGCCGTGATGTGTTCTACTCCCATCTGTGCTACCCCTCG AG Translation: MKLTCVVIVAVLFLTAWTFVTADDSINGLENLFPKARHEMRKPEASRSRGRCRPRGMF (SEQ ID NO:327) CGFPKPGPYCCNGWCFFVCI Toxin Sequence: Cys-Arg-Xaa3-Arg-Gly-Met-Phe-Cys-Gly-Phe-Xaa3-Lys-Xaa3-Gly-Xaa5-Cys-Cys-Asn- (SEQ ID NO:328) Gly-Xaa4-Cys-Phe-Phe-Val-Cys-Ile-{circumflex over ( )} ------------------------------- Name:      Lv6.1 Species:   lividus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCGTGGTGATCGTTGCTGTGCTGTTCTTGACCGCCTGG (SEQ ID NO:329) ACATTTGCCACGGCTGATGACCCCAGAAATGGATTGGAGAATCTTTTTTCGAAGGCA CATCACGAAATGAAGAACCCCGAAGCCTCTAAATTGACAAGAGGTGCCCTAACAC TGGTGAATTATGTGATGTGGTTGAACAAAACTGCTGCTATACCTATTGCTTTATTGT AGTCTGCCTATAAAACTACCGTGATGTCTTCTACTCCCATCTGTGCTACCCCTCGAG Translation: MKLTCVVIVAVLFLTAWTFATADDPRNGLENLFSKAHEMKNPEASKLNKRCPNTGEL (SEQ ID NO:330) CDVVEQNCCYTYCFIVVCL Toxin Sequence: Cys-Xaa3-Asn-Thr-Gly-Xaa1-Leu-Cys-Asp-Val-Val-Xaa1-Gln-Asn-Cys-Cys-Xaa5-Thr-Xaa5- (SEQ ID NO:331) Cys-Phe-Ile-Val-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Pu6.3 Species:   pulicarius Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCATGGTGATCGTTGCTGTGCTGTTCTTGACCGCCTGG (SEQ ID NO:332) ACATTCGTCAAGGCTGATGACTCCAGAAATGGATTGGAGAATCTTTTTCCGAAGGC ACGTCACGAAATGAAGAACTCCAAAGCCCTCTAAATTAAACAAGAGGTGCGTTGAAG ATGGTGATTTTTGTGGTCCGGGATATGAAGAGTGCTGCAGTGGCTTCTGCCTTTACG TCTGCATCTAAAACTGCCGTGATGTCTTCTACTCCCATCTGTGCTACCCCTCGAG Translation: MKLTCMVIVAVLFTAWTFVKADDSRNGLENLFPKARHEMKNSKASKLNKRCVEDGD (SEQ ID NO:333) FCGPGYEECCSGFCLYVCI Toxin Sequence: Cys-Val-Xaa1-Asp-Gly-Asp-Phe-Cys-Gly-Xaa3-Gly-Xaa5-Xaa1-Xaa1-Cys-Cys-Ser-Gly-Phe- (SEQ ID NO:334) Cys-Leu-Xaa5-Val-Cys-Ile-{circumflex over ( )} ------------------------------- Name:      Ge6.1 Species:   generalis Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGTGTGGTGATCGTTGCTGTGCTATTCTTGACCGCCTGG (SEQ ID NO:335) ACATTCGTCACGGCTGATGACACCAGATATAACTGGAGAATCCTTTTCTGAAGGC ACGCAACGAACTGCAGAAACACGAAGCCTCTCAACTGAACGAGAGAGGCTGCCTTG ACCCAGGTTACTTCTGTGGGACGCCGTTTCTTGGAGCATACTGCTGCGGTGGCATTT GCCTTATTGTCTGCATAGAAACGTAAAGGCTTGATGTCTTCTACTCCCATCTGTGCT ACCCCTCGAG Translation: MKLTCVVIVAVLFLTAWTFVTADDTRYKLENPFLKARNELQKHEASQLNERGCLDPGY (SEQ ID NO:336) FCGTPFLGAYCCGGICLIVCIET Toxin Sequence: Gly-Cys-Leu-Asp-Xaa3-Gly-Xaa5-Phe-Cys-Gly-Thr-Xaa3-Phe-Leu-Gly-Ala-Xaa5-Cys-Cys- (SEQ ID NO:337) Gly-Gly-Ile-Cys-Leu-Ile-Val-Cys-Ile-Xaa1-Thr-{circumflex over ( )} ------------------------------- Name:      Ep6.1 Species:   episcopatus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCGTGGTGATCGTTGCTGTGCTGTTCTTGACCGCCTGG (SEQ ID NO:338) ACATTTGCCACGGCTGATGACCCCAGAAATGGATTGGGGAATCTTTTTTCGAATGTA CATCACGAAATGAAGAACCTCGAAGACTCTAAATTGGACAAGAAGTGCCTTGGGTT TGGTGAAGCTTGTCTTATGCTTTATTCAGACTGCTGCAGCTATTGCGTTGCTCTTGTC TGCCTATAAAACTACCGTGACGTCTTCTACTCCCCTCTGTGCTACCTGGCTTGATCTT TGATTGGCGTGTGCGCTTCACTGGTTATGAACCCCTCTGATCCTACTCTCTGAAGAC CTCTGGGGTCCAACATCCAAATAAAGCGACATCACAAAAAAAAAAAAAAAAAAAA AA Translation: MKLTCVVIVAVLFLTAWTFATADDPRNGLGNLFSNVHHEMKNLEDSKLDKKCLGFGE (SEQ ID NO:339) ACLMLYSDCCSYCVALVCL Toxin Sequence: Cys-Leu-Gly-Phe-Gly-Xaa1-Ala-Cys-Leu-Met-Leu-Xaa5-Ser-Asp-Cys-Cys-Ser-Xaa5-Cys-Val- (SEQ ID NO:340) Ala-Leu-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Ep6.2 Species:   episcopatus Isolated:  No Cloned:    Yes DNA Sequence: GGATCCATGAAACTGACGTGCGTGGTGATCATTGCTGTGCTGTTCTTGACCGCCTGG (SEQ ID NO:341) ACATTCGTCATGGCTGATGACCCCAGAGATGAACCGGAGGCACGTGACGAAATGAA CCCCGCAGCCTCTAAATTGAACGAGAGAGGCTGCCTTGCAGTTGATTATTTTTGCGG CATACCGTTTGTGAGCAACGGGCTATGCTGCAGTGGCAATTGTGTTTTTGTCTGCAC ACCCCAAGGGAAGTAAAACTGCCGTGACGTCTTCTACTCCCCTCTGTGCTACCTGGC TTGATCTTTGATTGGCGTGTGCACTTCACTGGTTATGAACCCCTCTGATCCTACTCTC TGAAGACCTCTGGGGTCCAACATCCAAATAAAGCGACATCCCAAAAAAAAAAAAA AAAAAAA Translation: MKLTCVVIIAVLFLTAWTFVMADDPRDEPEARDEMNPAASKLNERGCLAVDYFCGIPF (SEQ ID NO:342) VSNGLCCSGNCVFVCTPQGK Toxin Sequence: Gly-Cys-Leu-Ala-Val-Asp-Xaa5-Phe-Cys-Gly-Ile-Xaa3-Phe-Val-Ser-Asn-Gly-Leu-Cys-Cys- (SEQ ID NO:343) Ser-Gly-Asn-Cys-Val-Phe-Val-Cys-Thr-Xaa3-Gln-# ------------------------------- Name:      Ac6.1 Species:   achatinus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCTCTGTCCTCCATCTATTATTATTCGCTGCCAAACTGTGTTAAATATTCAAGT (SEQ ID NO:344) CTCTCTTTCTGTTTGTGTCTAACAGGTTGAGATGGTGCATTCCTAGAGGTGATCTTTG TTTCCCCTCGGATCGCATACAATGCTGCAGTGGCAAGTGCACATTCGTCTGCATGTA AAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: LRWCIPRGDLCFPSDRIQCCSGKCTFVCM (SEQ ID NO:345) Toxin Sequence: Xaa4-Cys-Ile-Xaa3-Arg-Gly-Asp-Leu-Cys-Phe-Xaa3-Ser-Asp-Arg-Ile-Gln-Cys-Ser-Gly- (SEQ ID NO:346) Lys-Cys-Thr-Phe-Val-Cys-Met-{circumflex over ( )} ------------------------------- Name:      Ac6.2 Species:   achatinus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCTCTGTCCTCCTCCTTCATTCATTCGCTGCCAAACTGTATTAAATATTCGAAT (SEQ ID NO:347) CTCTCTTTCTGTTTGTGTCTGACAGATTGAGAGGGTGCGTTCCTAGTGGTGAAATTTG TTACTTCATGGATCACATAGGATGCTGCAGTGGCAAGTGCACATTCGTCTGCATGTA AAACTGCCGTGATGTCTTCTCCTCCCATC Translation: LRGCVPSGEICYFMDHIGCCSGKCTFVCM (SEQ ID NO:348) Toxin Sequence: Gly-Cys-Val-Xaa3-Ser-Gly-Xaa1-Ile-Cys-Xaa5-Phe-Met-Asp-His-Ile-Gly-Cys-Cys-Ser-Gly- (SEQ ID NO:349) Lys-Cys-Thr-Phe-Val-Cys-Met-{circumflex over ( )} ------------------------------- Name:      Bu6.7 Species:   bullatus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTACTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:350) GTCAGGCTGATGACTCCACATATGGATTGAAGAATCTTTTGCCGAACGGACGTCAT GAAATGATGAACCCCGAAGCCCCTAAATTGAACAAGAAAGATGAATGCTCTGCTCC TGGTGCATTTTGTCTCATCAGGCCAGGACTCTGCTGCAGCGAGTTCTGCTTCTTTGCG TGTTTTTAGTGACGGTTGATGTCTTCTACTCCCCTC Translation: MKLTCVMIVTVLFLTAWTFVTADDSTYGLKNLLPNGRHEMMNPEAPKLNKKDECSAP (SEQ ID NO:351) GAFCLIRPGLCCSEFCFFACF Toxin Sequence: Asp-Xaa1-Cys-Ser-Ala-Xaa3-Gly-Ala-Phe-Cys-Leu-Ile-Arg-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1- (SEQ ID NO:352) Phe-Cys-Phe-Phe-Ala-Cys-Phe-{circumflex over ( )} ------------------------------- Name:      Bu6.8 Species:   bullatus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTACTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:353) GTCACGGCTGATGACTCCAGAGACGCTCCGGATAGTGCAGAAGGATGGGAGAAACT TTTCTCGGAGGCACGTGACGAAATGAAGAACCGCAAAGACTTTGAATTGAGAGGGT GCCTTCCTAGGTGGGAATTTTGTCCCATCTTTAAAAAAAACGATTGCTGCAGTGGCA TATGCATAAGCATCTGCTTGTAAAACTCCGTGATGTCTTCTCTTCCCATC Translation: MKLTCVMIVTVLFLTAWTFVTADDSRDAPDSAEGWEKLFSEARDEMKNRKDFELRGC (SEQ ID NO:354) LPRWEFCPIFKKNDCCSGICISICL Toxin Sequence: Gly-Cys-Leu-Xaa3-Arg-Xaa4-Xaa1-Phe-Cys-Xaa3-Ile-Phe-Lys-Lys-Asn-Asp-Cys-Cys-Ser- (SEQ ID NO:355) Gly-Ile-Cys-Ile-Ser-Ile-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Sx6.4 Species:   striolatus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATTGTTGCTGTGCTGTTCTTGACCGCCTGGATATTT (SEQ ID NO:356) GTAATGGCTGATGACTCCAGAAATGGATTGGAGAATCTTCCTCAGACTACACGTCA CGAAATGAAGAACCCCGAAGCCTCTAAATTGAACCAGACAGACTGCCTTGCTAAAG ACGCTTTCTGTGCCTGGCCGATACTTGGACCACTGTGCTGCAGTCGCTTGTGCTTAT ACGTCTGCATGtaaAACTGCCGTGATGTCTTCTACTCCCCTC Translation: MKLTCMMIVAVLFLTAWIFVMADDSRNGIENLPQTTRHEMKNPEASKLNQTDCLAKD (SEQ ID NO:357) AFCAWPILGPLCCSRLCLYVCM Toxin Sequence: Asp-Cys-Leu-Ala-Lys-Asp-Ala-Phe-Cys-Ala-Xaa4-Xaa3-Ile-Leu-Gly-Xaa3-Leu-Cys-Cys-Ser- (SEQ ID NO:358) Arg-Leu-Cys-Leu-Xaa5-Val-Cys-Met-{circumflex over ( )} ------------------------------- Name:      Cn6.9 Species:   consors Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:359) GTCACGGCTGATGACTCCAGAAATGGATTGGAGAATCTTTCTCCGAAGGCACGTCA CGAAATGAAGAACCCCGAAGCCTCTAAATCGAACAAGAGATATGAGTGCTATTCTA CTGGTACATTTTGTGGCATCAACGGAGGACTCTGCTGCAGCAACCTTTGCTTATTTTT CGTGTGCTTAACATTTTCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCMMIVAVLFLTAWTFVTADDSRNGLENLSPKARHEMKNPEASKSNKRYECYST (SEQ ID NO:360) GTFCGINGGLCCSNLCLFFVCLTFS Toxin Sequence: Xaa5-Xaa1-Cys-Xaa5-Ser-Thr-Gly-Thr-Phe-Cys-Gly-Ile-Asn-Gly-Gly-Leu-Cys-Cys-Ser-Asn- (SEQ ID NO:361) Leu-Cys-Leu-Phe-Phe-Val-Cys-Leu-Thr-Phe-Ser-{circumflex over ( )} ------------------------------- Name:      Cn6.10 Species:   consors Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCCTGATGATCGTTGCTGTGCTGTTCTTGACCACCTGGACATTC (SEQ ID NO:362) GTCACGGCTGATGACTCCAGATATGGATTGAAGAATCTTTTTCCGAAGGCACGTCAT GAAATGAAGAACCCTGAAGCCTCTAAATTGAACAAGAGAGATGGGTGCTATAATGC TGGTACATTTTGTGGCATCCGTCCAGGACTCTGCTGCAGCGAGTTTTGCTTTTTATGG TGCATAACATTTGTTGATTCTGGCTAACAGTGTGCGTTGGTTGATGTCTTCTACTCCC CTC Translation: MKLTCLMIVAVLFLTTWTFVTADDSRYGLKNLFPKARHMKNPEASKLNKRDGCYNA (SEQ ID NO:363) GTFCGIRPGLCCSEFCFLWCITFVDSG Toxin Sequence: Asp-Gly-Cys-Xaa5-Asn-Ala-Gly-Thr-Phe-Cys-Gly-Ile-Arg-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1- (SEQ ID NO:364) Phe-Cys-Phe-Leu-Xaa4-Cys-Ile-Thr-Phe-Val-Asp-Ser-# ------------------------------- Name:      Cr6.6 Species:   circumcisus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCATCTGTCCATCCATCTATTCATTCATTCGCTGCCAAACTGTATTAAATATTC AAGTCTCTCTTTCTGTTTGTGTCTAACAGATTGAGTAGGTGCATTCCTAGTGGTGATC TTTGTTTCCCCTCGGATCACATACAATGCTGCAATGCCAAGTGCGCATTCGTCTGCTT GTAAAACTGCCGTGATGTCTTCTCTTCCCTC (SEQ ID NO:365) Translation: NRLSRCIPSGDLCFPSDHIQCCNAKCAFVCL (SEQ ID NO:366) Toxin Sequence: Cys-Ile-Xaa3-Ser-Gly-Asp-Leu-Cys-Phe-Xaa3-Ser-Asp-His-Ile-Gln-Cys-Cys-Asn-Ala-Lys- (SEQ ID NO:367) Cys-Ala-Phe-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Cr6.5 Species:   circumcisus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCATCTGTCCATCCATCTATTCATTCATTCGCTGTCAAACTGTATTAAATATTC (SEQ ID NO:368) AAGTCTCTCTTTCTGTTTGTGTCTAACAGATTGAGTTGGTGCATTCCTAGTGGTGATC TTTGTTTCCCCTCGGATCACATACAATGCTGCAGTGCCAAGTGCGCATTCGTCTGCTT GTAAAACTGCCGTGATGTCTTCTACTCCCCTC Translation: NRLSWCIPSGDLCFPSDHIQCCSAKCAFVCL (SEQ ID NO:369) Toxin Sequence: Xaa4-Cys-Ile-Xaa3-Ser-Gly-Asp-Leu-Cys-Phe-Xaa3-Ser-Asp-His-Ile-Gln-Cys-Cys-Ser-Ala- (SEQ ID NO:370) Lys-Cys-Ala-Phe-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Cr6.5A Species:   circumoisus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCATCTGTCCATCCATCTATTCATTCATTCGCTGTCAAACTGTATTAAATATTC (SEQ ID NO:371) AAGTCTCTCTTTCTGTTTGTGTCTAACAGATTGAGTAGGTGCATTCCTAGTGGTGATC TTTGTTTCCCCTCGGATCACATACAATGCTGCAGTGCCAAGTGCGCATTCGTCTGCTT GTAAAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: NRLSRCIPSGDLCFPSDHIQCCSAKCAFVCL (SEQ ID NO:372) Toxin Sequence: Cys-Ile-Xaa3-Ser-Gly-Asp-Leu-Cys-Phe-Xaa3-Ser-Asp-His-Ile-Gln-Cys-Cys-Ser-Ala-Lys-Cys- (SEQ ID NO:373) Ala-Phe-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Cr6.6A Species:   circumcisus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCATCTGTCCATCCATCTATTCATTCATTCGCTGCCAAACTGTATTAAATATTC (SEQ ID NO:374) AAGTCTCTCTTTCTGTTTGTGTCTAACAGATTGAGTAGGTGCATTCCTAGTGGTGATC TTTGTTTCCCCTCGGATCACATACAATGCTGCAATGCCGAGTGCGCATTCGTCTGCTT GTAAAACTGCCGTGATGTCTTCTCCTCCCCTC Translation: NRLSRCIPSGDLCFPSDHIQCCNAECAFVCL (SEQ ID NO:375) Toxin Sequence: Cys-Ile-Xaa3-Ser-Gly-Asp-Leu-Cys-Phe-Xaa3-Ser-Asp-His-Ile-Gln-Cys-Cys-Asn-Ala-Xaa1- (SEQ ID NO:376) Cys-Ala-Phe-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Cr6.5B Species:   circumcisus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCATCTGTCCATCCATCTATTCATTCATTCGCTGTCAAACTGTATTAAATATTC (SEQ ID NO:377) AAGTCTCTCTTTCTGTTTGTGTCTAACAGATTGAGTTGGTGCATTCCTAGTGGTGATC TTTGTTTCCCCTCGGATCACATACGATGCTGCAGTGCCAAGTGCGCATTCGTCTGCTT GTAAAACTGCCGTGATGTCTTCTCTTCCCATC Translation: NRLSWCIPSGDLCFPSDHIRCCSAKCAFVCL (SEQ ID NO:378) Toxin Sequence: Xaa4-Cys-Ile-Xaa3-Ser-Gly-Asp-Leu-Cys-Phe-Xaa3-Ser-Asp-His-Ile-Arg-Cys-Cys-Ser-Ala- (SEQ ID NO:379) Lys-Cys-Ala-Phe-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Cr6.6B Species:   circumcisus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCATCTGTCCATCCATCTATTCATTCATTCGCTGCCACTGTATTAAATATTC (SEQ ID NO:380) AAGTCTCTCTTTCTGTTTGTGTCTAACAGATTGAGTAGGTGCATTCCTAGTGGTGATC TTTGTTTCCCCTCGGATCACATACAATGCTGCAATGCCAAGTGCGCATTCGCCTGCT TGTAAAACTGCCGTGATGTCTTCTCTTCCCCTC Translation: NRLSRCIPSGDLCFPSDHIQCCNAKCAFACL (SEQ ID NO:381) Toxin Sequence: Cys-Ile-Xaa3-Ser-Gly-Asp-Leu-Cys-Phe-Xaa3-Ser-Asp-His-Ile-Gln-Cys-Cys-Asn-Ala-Lys- (SEQ ID NO:382) Cys-Ala-Phe-Ala-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Cr6.6C Species:   circumoisus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCATCTGTCCATCCATCTATTCATTCATTCGCTGCCAAACTGTATTAAATATTC (SEQ ID NO:383) AAGTCTCTCTTTCTGTTTGTGTCTAACAGATTGAGTTGGTGCATTCCTAGTGGTGATC TTTGTTTCCCCTCGGATCACATACAATGCTGCAATGCCAAGTGCGCATTCGTCTGCTT GTAAAACTGCCGTGATGTCTTCTACTCCCCTC Translation: NRLSWCIPSGDLCFPSDHIQCCNAKCAFVCL (SEQ ID NO:384) Toxin Sequence: Xaa4-Cys-Ile-Xaa3-Ser-Gly-Asp-Leu-Cys-Phe-Xaa3-Ser-Asp-His-Ile-Gln-Cys-Cys-Asn-Ala- (SEQ ID NO:385) Lys-Cys-Ala-Phe-Val-Cys-Leu-{circumflex over ( )} ------------------------------- Name:      Cr6.7 Species:   circumcisus Isolated:  No Cloned:    Yes DNA Sequence: CGATCCTCTGTCCTCCTCTATTATTATTCGCTGCCAACTGTATTAAATATTCAAGTCT (SEQ ID NO:386) CTCTTTCTGTTTGTGTCTAACAGATTGAGTTGGTGCATTCCTACTGGTGATCTTTGTT TCCCCTCGGATCACATACAATGCTGCAGTGGCAAGTGCACATTCGTCTGCATGTAAA ACTGCCGTGATGTCTTCTCCTCCCCTC Translation: NRLSWCIPTGDLCFPSDHIQCCSGKCTFVCM (SEQ ID NO:387) Toxin Sequence: Xaa4-Cys-Ile-Xaa3-Thr-Gly-Asp-Leu-Cys-Phe-Xaa3-Ser-Asp-His-Ile-Gln-Cys-Cys-Ser-Gly- (SEQ ID NO:388) Lys-Cys-Thr-Phe-Val-Cys-Met-{circumflex over ( )} ------------------------------- Name:      Mn6.3 Species:   monachus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:389) GTCACGGCTGATGACTCCAGAAATGGATTGGAGAATCTTTCTCCGAAGGCACGTCA CGAAATGAAGAACCCCGAAGCCTCTAAATCGAACAAGAGATATGAGTGCTATTCTA CTGGTACATTTTGTGGCATCAACGGAGGACTCTGCTGCAGCAACCTTTGCTTATTTTT CGTGTGCTTAACATTTTCGTGATGTCTTCTCCTCCCCTC Translation: MKLTCMMIVAVLFLTAWTFVTADDSRNGLENLSPKARHEMKNPEASKSNKRYECYST (SEQ ID NO:390) GTFCGINGGLCCSNLCLFFVCLTFS Toxin Sequence: Xaa5-Xaa1-Cys-Xaa5-Ser-Thr-Gly-Thr-Phe-Cys-Gly-Ile-Asn-Gly-Gly-Leu-Cys-Cys-Ser-Asn- (SEQ ID NO:391) Leu-Cys-Leu-Phe-Phe-Val-Cys-Leu-Thr-Phe-Ser-{circumflex over ( )} ------------------------------- Name:      Sm6.5 Species:   stercusmuscarum Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATGATGATCGTTGCTGTGCTGTTCTTGACCGCCTGGACATTC (SEQ ID NO:392) GTCACAGCTGATGACTCCATAAATGGACCGGAGAATAGACGAATATGGGAGAAACT TTTGTTGAAGGCACGTGACGAAATGAAGAACCCCGAAGCCTCTCAATTGAGATGGT GCATTCCTAGTGGTGAACTTTGTTTCCGCTCGGATCACATACAATGCTGCAGTGCCA AGTGCGCATTCGTCTGCTTGTAAAACTACCGTGATGTCTTCTCCTCCCATC Translation: MKLTCMMIVAVLFLTAWTFVTADDSINGPENRRIWEKLLLKARDEMKNPEASQLRWCI (SEQ ID NO:393) PSGELCFRSDHIQCCSAKCAFVCL Toxin Sequence: Xaa4-Cys-Ile-Xaa3-Ser-Gly-Xaa1-Leu-Cys-Phe-Arg-Ser-Asp-His-Ile-Gln-Cys-Cys-Ser-Ala- (SEQ ID NO:394) Lys-Cys-Ala-Phe-Val-Cycs-Leu-{circumflex over ( )} ------------------------------- Name:      Sm6.6 Species:   stercusmuscarum Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTGTGATGATCGTTGCTGTGCTGTTCTTGATCGCCTGGACATTC (SEQ ID NO:395) GTCACGGCTGATGACTCCAGAAATGGATTGAAGAATCTTTTTCCGAAGGCACGTCAT GAAATGAAGAACCCCGAAGCCTCTAAATTGAACAAGAGAGATGGGTGCTCTAGTGG TGGTACATTTTGTGGCATCCGTCCAGGACTCTGCTGCAGCGAGTTTTGCTTTCTTTGG TGCATAACATTTATTGATTGATGTCTTCTATTCCCCTC Translation: MKLTCVMIVAVLFLIAWTFVTADDSRNGLKNLFPKARHEMKNPEASKLNKRDGCSSGG (SEQ ID NO:396) TFCGIRPGLCCSEFCFLWCITFID Toxin Sequence: Asp-Gly-Cys-Ser-Ser-Gly-Gly-Thr-Phe-Cys-Gly-Ile-Arg-Xaa3-Gly-Leu-Cys-Cys-Ser-Xaa1- (SEQ ID NO:397) Phe-Cys-Phe-Leu-Xaa4-Cys-Ile-Thr-Phe-Ile-Asp-{circumflex over ( )} ------------------------------- Name:      Sx6.5 Species:   striolatus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCATAATGACCGTTGCTGTGCTGTTCTTGACCGCTTGGACATTC (SEQ ID NO:398) GTCACGGCTGATGACTCCAGAAATGCATTGGAGAATCTTCTTCTGAAGACACGTCA CGAAGTGGAAAACCCCAAAGCCTCTAGGTCGGGCGGTAGGTGCCGTCCTGGTGGTA CGGTTTGTGGCTTTCCGAAACCTGGACCATACTGCTGCAGTGGCTGGTGCTTTTTTGT CTGCGCCTAAACCTGCCGTGATGTCTTCTCCTCCCATC Translation: MKLTCIMTVAVLFLTAWTFVTADDSRNGLENLLLKTRIHEVENPKASRSGGRCRGGTV (SEQ ID NO:399) CGFPKPGPYCCSGWCFFVCA Toxin Sequence: Cys-Arg-Xaa3-Gly-Gly-Thr-Val-Cys-Gly-Phe-Xaa3-Lys-Xaa3-Gly-Xaa3-Xaa5-Cys-Cys-Ser- (SEQ ID NO:400) Gly-Xaa4-Cys-Phe-Phe-Val-Cycs-Ala-{circumflex over ( )} ------------------------------- Name:      Sx6.6 Species:   striolatus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGCGTGATGATCGTTGCTGTGCTGTTCTTGACTGCCTGGACATTC (SEQ ID NO:401) GTCACGGCTGATGACTCCAAAAATGGACTGGAGAATCATTTTTGGAAGGCACGTGA CGAAATGAAGAACCGCGAAGCCTCTAAATTGGACAAAAAGGAAGCCTGCTATCCGC CTGGTACTTTTTGTGGCATAAAGCCCGGGCTATGCTGCAGTGAGTTGTGTTTACCGG CCGTCTGCGTCGGTGGTTAACTGCCGTGATGTCTTCTATTCCCCTC Translation: MKLTCVMIVAVLFLTAWTFVTADDSKNGLENHFWKARDEMKNREASKLDKKEACYP (SEQ ID NO:402) PGTFCGIKPGLCCSELCLPAVCVGG Toxin Sequence: Xaa1-Ala-Cys-Xaa5-Xaa3-Xaa3-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa3-Gly-Leu-Cys-Cys-Ser- (SEQ ID NO:403) Xaa1-Leu-Cys-Leu-Xaa3-Ala-Val-Cys-Val-Gly-# ------------------------------- Name:      Sx6.7 Species:   striolatus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTCTGATGGCTGTTGCTGTGCTGTTCTTGACCGCCCGGACATTC (SEQ ID NO:404) GTCACGGCTGATGACTCCAGAAATGGATTGGAGAATCTTTCTCCGAAGGCACGTCA CGAAATGAAGAACCCCGAAGCCTCTAAATCGAACAAGAGATATGAGTGCTATTCTA CTGGTACATTTTGTGGCATCAACGGAGGACTCTGCTGCAGCAACCTTTGCTTATTTTT CGTGTGCTTAACATTTTCGTGATGTCTTCTATCCCCTC Translation: MKLTCLMAVAVLFLTARTFVTADDSRNGLENLSPKARHMKNPEASKSNKRYECYST (SEQ ID NO:405) GTFCGTNGGLCCSNLCLFFVCLTFS Toxin Sequence: Xaa5-Xaa1-Cys-Xaa5-Ser-Thr-Gly-Thr-Phe-Cys-Gly-Ile-Asn-Gly-Gly-Leu-Cys-Cys-Ser-Asn- (SEQ ID NO:406) Leu-Cys-Leu-Phe-Phe-Val-Cys-Leu-Thr-Phe-Ser-{circumflex over ( )} ------------------------------- Name:      Sx6.8 Species:   striolatus Isolated:  No Cloned:    Yes DNA Sequence: ATGAAACTGACGTGTATGGTGATCGTCGCCGTGCTGCTCCTGACGACCTGTCATCTC (SEQ ID NO:407) ATCACAGCTGATGACTCCAGAGGTACGCAGAAGCATCGTTCCCTGAGGTCGACTAC CAAAGTCTCCAAGTCGACTAGCTGCATGAAAGCCGGGTCTTATTGCGTCGCTACTAC GAGAATCTGCTGCGGTTATTGCGCTTATTTCGGCAAAATATGTATTGGCTATCCCAA AAACTGATCCTCCCCCTACTGTGCTCTATCCTTTTCTGCCTGATGTCTTCTCCTCCCC TC Translation: MKLTCMVIVAVLLLTTCHLITADDSRGTQKHRSLRSTTKVSKSTSCMKAGSYCVATTRI (SEQ ID NO:408) CCGYCAYFGKICIGYPKN Toxin Sequence: Ser-Thr-Ser-Cys-Met-Lys-Ala-Gly-Ser-Xaa5-Cys-Val-Ala-Thr-Thr-Arg-Ile-Cys-Cys-Gly-Xaa5- (SEQ ID NO:409) Cys-Ala-Xaa5-Phe-Gly-Lys-Ile-Cys-Ile-Gly-Xaa5-Xaa3-Lys-Asn-{circumflex over ( )}

[0096] TABLE 2 Alignment of Conotoxin Peptide Sequences δ-GmVIA [F15Y] -VKPCRKEGQLCDPIYQN---C CRGWNC--VLF-CV{circumflex over ( )} (SEQ ID NO:4) δ-GmVIA [F27Y] -VKPCRKEGQLCDPIFQN---CCRGWNC--VLY-CV{circumflex over ( )} (SEQ ID NO:5) Omaria9 M---CRREAQLCDPIFQN---CCHGLFC--VLV-CV{circumflex over ( )} (SEQ ID NO:8) Tx6.11 QVKPCRKEHQLCDLIFQN---CCRGWYC--VVLSCT{circumflex over ( )} (SEQ ID NO:11) Om6.6 ----CVPHEGPCNWLTQN---CCSGYNC--IIFFCL{circumflex over ( )} (SEQ ID NO:14) Da6.2 QVKPCRKEHQLCDLIFQN---CCRGWYC--LLRPCI{circumflex over ( )} (SEQ ID NO:17) Da6.6 -VKPCSEEGQLCDPLSQN---CCRGWHC--VLVSCV{circumflex over ( )} (SEQ ID NO:22) δ-TxVIA [M8J] W---CKQSGEXCNLLDQN---CCDGY-C--IVLVCT{circumflex over ( )} (SEQ ID NO:24) Da6.4 ----CLGGGEVCDIFFPQ---CC-GY-C--ILLFCT{circumflex over ( )} (SEQ ID NO:37) GmG.5 ----CRLGAESCDVISQN---CCQGT-C--VFF-CLP{circumflex over ( )} (SEQ ID NO:40) Gm6.6 ----CKQADESCNVFSLD----CCTGL-C--LGF-CVS{circumflex over ( )} (SEQ ID NO:43) Gm6.3 ----CVPYEOPCNWLTQN----CCDEL-C--VFF-CL{circumflex over ( )} (SEQ ID NO:46) M6.5 ----CKQADEPCDVFSLE---CCTGI-C--LGF-CTW{circumflex over ( )} (SEQ ID NO:49) Tx6.2 ----CLDAGEVCDIFFPT---CC-GY-C--ILLFCA{circumflex over ( )} (SEQ ID NO:52) Om6.1 ----CLAEHETCNIFTQN---CCEGV-C--IFI-CVQAPE{circumflex over ( )} (SEQ ID NO:57) Om6.3 ----CIPHFDPCDPIRHT---CCFGL-C--LLIACI{circumflex over ( )} (SEQ ID NO:60) Om6.4 ----CLGFGEACLILYSD---CC-GY-C--VGAICL{circumflex over ( )} (SEQ ID NO:63) Au6.1 ----CKAENELCNIFIQN---CCDGT-C--LLI-CIQNPQ{circumflex over ( )} (SEQ ID NO:66) Au6.2 ----CLEFGELCNFFFPT---CC-GY-C--VLLVCL{circumflex over ( )} (SEQ ID NO:69) Da6.5 ----CAQSSELCDALDSD---CCSGV-C--MVFFCL{circumflex over ( )} (SEQ ID NO:72) Di6.4 ----CLGFGEACLMLYSD---CC-SY-C--VGAVCL{circumflex over ( )} (SEQ ID NO:75) Pn6.2 ----CVKYLDPCDMLRHT---CCFGL-C--VLIACI{circumflex over ( )} (SEQ ID NO:78) Pn6.3 ----CLGFGEVCNFFFPN---CC-SY-C--VALVCL{circumflex over ( )} (SEQ ID NO:81) Pn6.4 ----CIPQFDPCDMVRHT---CCKGL-C--VLIACSKTA{circumflex over ( )} (SEQ ID NO:84) Pn6.7 ----CKAESEACNIITQN---CCDGK-C--LFF-CIQIPE{circumflex over ( )} (SEQ ID NO:87) Omaria3 ----CIDGGEICDIFFPN---CCSGW-C--IILVCA{circumflex over ( )} (SEQ ID NO:90) Omaria1 ----CLDGGEICGILFPS---CCSGW-C--IVLVCA{circumflex over ( )} (SEQ ID NO:93) Marm7 ----CLEFGEVCNFFFPT---CC-GY-C--VLLVCL{circumflex over ( )} (SEQ ID NO:96) Marm12 ----CQEFGEVCNFFFPD---CC-GY-C--VLLLCI{circumflex over ( )} (SEQ ID NO:99) Omaria7 ----CIPHFDPCDPIRHT---CCFGL-C--LLIACI{circumflex over ( )} (SEQ ID NO:102) Omaria11 ----CLEFGEVCNFFFPT---CC-GY-C--VLLVCL{circumflex over ( )} (SEQ ID NO:105) O6.5 SKKQCRQNGEVCDANLAH---CCSGP-C--FLF-CLNQP{circumflex over ( )} (SEQ ID NO:108) Af6.8 ----CTQSGELCDVIDPD---CCNNF-C--IIFFCI{circumflex over ( )} (SEQ ID NO:111) KK-2A ----CAPFLHLCTFFFPN---CCNGY-C--VQFICL{circumflex over ( )} (SEQ ID NO:114) KKM1 ----CLDAGEMCDLFNSK---CCSGW-C--IILFCA{circumflex over ( )} (SEQ ID NO:117) KKM4 ----CLDGGEICGILFPS---CCSGW-C--IVLVCA{circumflex over ( )} (SEQ ID NO:120) KKM5 ----CPNTGELCDVVEQN---CCYTY-C--FIVVCPI{circumflex over ( )} (SEQ ID NO:123) KKM6 -DDECEPPGDFCGFFKIGP-PCCSGW-C--FLW-CA{circumflex over ( )} (SEQ ID NO:126) C. striatus S2 -DDECEPPGDFCGFFKIGP-PCCSCW-C--FLW-CA{circumflex over ( )} (SEQ ID NO:129) Om6.5 -DDDCEPPGNFCGMIKIGP-PCCSGW-C--FFA-CA{circumflex over ( )} (SEQ ID NO:132) Au6.3 -DYDCEPPCNFCGMIKIGP-PCCSGW-C--FFA-CA{circumflex over ( )} (SEQ ID NO:135) Marm9 -DDDCEPPGNFCGMIKIGP-PCCSGW-C--FFA-CA{circumflex over ( )} (SEQ ID NO:138) Rg6.4 -D--CLSKNAFCAWPILGP-LCCSGW-C--LYV-CM{circumflex over ( )} (SEQ ID NO:141) R6.5 -GDDCLAVKKNCGFPKLGG-PCCSGL-C--FFV-CA{circumflex over ( )} (SEQ ID NO:144) Rg6.2 D--CLPRDTFCALPQLGL-LCCSGR-C--LLF-CV{circumflex over ( )} (SEQ ID NO:147) A6.5 -DG-CSNAGAFCG---IHPGLCCSEI-C--IVW-CT{circumflex over ( )} (SEQ ID NO:150) δ-PVIA[F9A] -EA-CYAOGTACG---IKOGLCCSEF-C--LPGVCFG{circumflex over ( )} (SEQ ID NO:154) δ-PVIA[I12A] -EA-CYAOGTFCG---AKOGLCCSEF-C--LPGVCFG{circumflex over ( )} (SEQ ID NO:155) δ-PVIA[TS8] -EA-CYAOGAFCG---IKOGLCCSEF-C--LPGVCFG{circumflex over ( )} (SEQ ID NO:156) M6.3 -DG-CYNAGTFCG---IRPGLCCSEF-C--FLW-CITFVDS# (SEQ ID NO:159) M6.6 -DE-CYPPGTFCG---IKPGLCCSAI-C--LSFVCISF-DF{circumflex over ( )} (SEQ ID NO:162) M6.7 -EA-CYNAGSFCG---IHPGLCCSEF-C--ILW-CITFVDS# (SEQ ID NO:165) M6.8 -EA-CYNAGTFCG---IKPGLCCSAI-C--LSFVCTSF-DF{circumflex over ( )} (SEQ ID NO:168) E6.4 -EA-CYPPGTFCG---IKPGLCCSEL-C--LPAVCVG# (SEQ ID NO:171) P6.4 -EA-CYPPCTPCG---IKPGLCCSEL-C--LPAVCVG# (SEQ ID NO:174) δ-SVIE [D1E] -EG-CSSOGTFCG---IHOGLCCSEP-C--FLW-CITFID{circumflex over ( )} (SEQ ID NO:177) δ-SVIE -DG-CSSGGTFCG---IHOGLCCSEF-C--FLW-CITFID{circumflex over ( )} (SEQ ID NO:180) C6.2 -YG-CSNAGAFCG---IHPGLCCSEL-C--LVW-CT{circumflex over ( )} (SEQ ID NO:184) C6.3 -YG-CSNAGAFCG---IHPGLCCSEL-C--LGW-CT{circumflex over ( )} (SEQ ID NO:187) Di6.3 -YE-CYLLVHFCG---INGGLCCSNL-C--LFFVCLTFS{circumflex over ( )} (SEQ ID NO:190) Rg6.1 -D--CLPDYTICA---FNMGLCCSDK-C--MLV-CLP{circumflex over ( )} (SEQ ID NO:193) Rg6.3 -II-CFPDYMFCG---VNVFLCCSGN-C--LLI-CVP{circumflex over ( )} (SEQ ID NO:196) Gm6.2 ----CYDGGTGCD----SGNQCCSGW-C--IFA-CL{circumflex over ( )} (SEQ ID NO:199) Da6.1 ----CYDGGTGCD----SGNQCCSGW-C--IFV-CL{circumflex over ( )} (SEQ ID NO:202) Pn6.6 ----CFESWVACE----SPKRCCSHV-C--LFV-CT{circumflex over ( )} (SEQ ID NO:205) Di6.5 ----CNEAQEHCT----QNPDCCSES-CNKFVGRCLS--D{circumflex over ( )} (SEQ ID NO:208) Af6.10 ----CYDGGTSCN----TGNQCCSGW-C--IFL-CL{circumflex over ( )} (SEQ ID NO:211) Tx6.10 ----CYDSGTSCN----TGNQCCSGW-C--IFVSCL{circumflex over ( )} (SEQ ID NO:214) Gm6.4 -D--CQALWDYCPVPLLSSGDCCYGLIC--GPFVCIGW{circumflex over ( )} (SEQ ID NO:217) Om6.2 KT--CQRRWDFCPGSLVGVITCCGGLIC--FLFFCV{circumflex over ( )} (SEQ ID NO:220) Da6.3 -D--CQEKWDYCPVPFLGSRYCCDGFIC--PSFFCA{circumflex over ( )} (SEQ ID NO:223) Da6.7 -D--CQCEWEFCIVPVLGPVYCCPWLIC--GPFVCVDI{circumflex over ( )} (SEQ ID NO:226) Pn6.5 -G--CLEVDYFCGIPFVNNGLCCSGN-C--VFV-C--TPQ# (SEQ ID NO:229) Marm6 ----CLNVDYFCGIPFVNNGLCCSGN-C--VFV-C--TPQ# (SEQ ID NO:232) Marm15 -E--CLEADYYCVLPFVGNGMCCSGI-C--VFV-CIAQRFKTV{circumflex over ( )} (SEQ ID NO:235) Marm10 -D--CLEPDYVCGIPFVFNGLCCSOI-C--VFI-CIAQKY{circumflex over ( )} (SEQ ID NO:238) Marm14 -A--CSKKWEYCIVPILGFVYCCPGLIC--GPFVCV{circumflex over ( )} (SEQ ID NO:241) Omaria14 -D--CLNVDYFCGIPFVNNGLCCSGN-C--VF--CLHTPREVKLP{circumflex over ( )} (SEQ ID NO:244) O6.4 ----CLVYGTPCDWLTIAGMECCSKK-C--FMM-CW{circumflex over ( )} (SEQ ID NO:247) R6.4 -D--CHEVGEPCGLPLIKNGLCCSQI-C--LGV-CAKVF{circumflex over ( )} (SEQ ID NO:250) R6.6 -E--CTANGEFCGISVFGSYLCCSGR-C--VFV-CI{circumflex over ( )} (SEQ ID NO:253) R6.7 -E--CTTNGEFCGISVFASFLCCSGL-C--VFV-CI{circumflex over ( )} (SEQ ID NO:256) R6.8 -K--CFPKNHFCGFVVMLNYLCCSGR-C--IFV-CV{circumflex over ( )} (SEQ ID NO:259) Rg6.5 -S--CLPLDWFCGFNIIGAFLCCSGY-C--LVV-CM{circumflex over ( )} (SEQ ID NO:262) De6.2 -D--CIPGGENC--DVFRPYRCCSGY-C--ILLLCA{circumflex over ( )} (SEQ ID NO:265) Striat21 -LRWCIPSGELC--FRSDHIGCCSGK-C--AFV-CL{circumflex over ( )} (SEQ ID NO:268) δStriatus 26 ---WCIPSGDLC--FRSDHIGCCSGK-C--AFV-CL{circumflex over ( )} (SEQ ID NO:271) δStriatus 106 ---WCIPSGDLC--FRSDHIQCCSGK-C--AFV-CL{circumflex over ( )} (SEQ ID NO:274) O6.3 -LRWCVPSGEVC--RRYEFVGCCSGK-C--FFV-CS{circumflex over ( )} (SEQ ID NO:277) R6.3 ----CLPDGTSC---LFSRIRCC-GT-CSSILKSCVS{circumflex over ( )} (SEQ ID NO:280) Ak6.1 (F763) ----CRPRGMFCGFPKPGPY-CCNGW-CF--FV-CI{circumflex over ( )} (SEQ ID NO:328) Ar6.11 (G21) ----CLEKGVLCD--PSAGN-CCSGE-CV--LV-CL{circumflex over ( )} (SEQ ID NO:307) Ar6.12 (G20) -E--CVAGSHFCGFPKIGGP-CCSGW-CF--FV-CL{circumflex over ( )} (SEQ ID NO:310) Ar6.5 (F008) -D---CRPVGQYCGIPYKHNWRCCSQL-CA--II-CVS{circumflex over ( )} (SEQ ID NO:304) Ca6.5 (G211) ----CVDPGEFCG--PGFGD-CCTGF-CL--LV-CI{circumflex over ( )} (SEQ ID NO:322) Ep6.1 (J425) ----CLGFGEACL--MLYSD--CCS-Y-CV-ALV-CL{circumflex over ( )} (SEQ ID NO:340) Ep6.2 (J424) -G--CLAVDYFCGIPFVSNOLCCSON-CV--FV-CTPQ# (SEQ ID NO:343) G6.3 -DDECEPPGDPCGFPKIGPP-CCSGW-CF--LW-CA{circumflex over ( )} (SEQ ID NO:283) Ge6.1 (G18) -G--CLDPGYFCGTPFLGAY-CCGGI-CL--IV-CIET{circumflex over ( )} (SEQ ID NO:337) Im6.1 (F076) Q---CRVEGEICGML-FEAQ-CCDGW-CF--FV-CM{circumflex over ( )} (SEQ ID NO:319) Lp6.5 (A667) -A--CVELGEICATGFFLDEECCTGS-CH--VF--CVL{circumflex over ( )} (SEQ ID NO:292) Lv6.1 (F775) ----CPNTGELCDV--VEQN-CCYTY-CF-IVV-CL{circumflex over ( )} (SEQ ID NO:331) Mf6.2 (G218) ----CLPNGVLCDL--GSPPYCCSGW-CA-IVV-CI{circumflex over ( )} (SEQ ID NO:325) Mr6.4 (A666) ----CPNTGELCDV--VEQN-CCYTY-CF-IVV-CL{circumflex over ( )} (SEQ ID NO:295) Pu6.3 (F770) ----CVEDGDFCG--PGYEE-CCSGP-CL--YV-CI{circumflex over ( )} (SEQ ID NO:334) Qc6.1 ----CAAAGEACVIPIIGNVFCCKGY-CL--FV-CIS{circumflex over ( )} (SEQ ID NO:289) Qc6.2 (F024) -DGDCVDGGEFCGFPKIGGP-CCSGW-CF--FV-CL{circumflex over ( )} (SEQ ID NO:298) Qc6.3 (F026) -D--CQDSGVVCGFPKPEPH-CCSGW-CL--FV-CA{circumflex over ( )} (SEQ ID NO:301) Ts6.2 (F078) -D--CWPQYWFCGLQRG----CCPGTTCF--FL-CF{circumflex over ( )} (SEQ ID NO:313) Ts6.4 (F080) ---WCALDGELCIIPV1GSIFCCHGI-CM--IY-CV{circumflex over ( )} (SEQ ID NO:316) Tx6.8 -----CYDSGTSC---NTGNQ-CCSGW-CI--FV-CL{circumflex over ( )} (SEQ ID NO:286) Ac6.1 W---CIPRGDLC-FPSDRIQ-CCSGK-CTF---VCM{circumflex over ( )} (SEQ ID NO:346) Ac6.2 -G--CVPSCEIC-YFMDHTC-CCSGK-CTF---VCM{circumflex over ( )} (SEQ ID NO:349) Bu6.7 -DE-CSAPGAFCL--IRPGL-CCSEF-C-FF--ACF{circumflex over ( )} (SEQ ID NO:352) Bu6.8 -G--CLPRWEFC-PIFKKND--CCSGI-CIS---ICL{circumflex over (’)} (SEQ ID NO:355) Cn6.10 -DG-CYNAGTFCG--IRPGL-CCSEF-C-FL--WCITFVDS# (SEQ ID NO:364) Cn6.9 -YE-CYSTGTFCG--INGGL-CCSNL-CLFF--VCLTFS{circumflex over ( )} (SEQ ID NO:361) Cr6.5 W---CIPSGDLC-FPSDHIQ-CCSAK-CAF---VCL{circumflex over ( )} (SEQ ID NO:370) Cr6.5A ----CIPSGDLC-FPSDHIQ-CCSAK-CAF---VCL{circumflex over ( )} (SEQ ID NO:373) Cr6.6 ----CIPSGDLC-FPSDHIQ-CCNAK-CAF---VCL{circumflex over ( )} (SEQ ID NO:367) Cr6.6A ----CIPSGDLC-FPSDHIQ-CCNAE-CAF---VCL{circumflex over ( )} (SEQ ID NO:376) Cr6.5B W---CIPSGDLC-FPSDHIR-CCSAK-CAF---VCL{circumflex over ( )} (SEQ ID NO:379) Cr6.6B ----CIPSCDLC-FPSDHIQ-CCNAK-CAF---ACL{circumflex over ( )} (SEQ ID NO:382) Cr6.6C W---CIPSCDLC-FPSDHIQ-CCNAK-CAF---VCL{circumflex over ( )} (SEQ ID NO:285) Cr6.7 W---CIPTGDLC-FPSDSIQ-CCSGK-CTF---VCM{circumflex over ( )} (SEQ ID NO:368) Mn6.3 -YE-CYSTGTFCG--INGGL-CCSNL-CLFF--VCLTFS{circumflex over ( )} (SEQ ID NO:391) Sm6.5 W---CIPSGELC-FRSDHIQ-CCSAK-CAF---VCL{circumflex over ( )} (SEQ ID NO:394) Sm6.6 -DC-CSSGGTFCG--IRPGL-CCSEF-C-FL--WCITFID{circumflex over ( )} (SEQ ID NO:397) Sx6.4 -D--CLAKDAFCAWPILGPL-CCSRL-CLY---VCM{circumflex over ( )} (SEQ ID NO:358) Sx6.5 ----CRPGGIVCGFPKPGPY-CCSGW-CFF---VCA{circumflex over ( )} (SEQ ID NO:400) Sx6.6 -EA-CYPPGTFCG--IKPGL-CCSEL-CLPA--VCVG# (SEQ ID NO:403) Sx6.7 -YE-CYSTGTFCG--INGGL-CCSNL-CLFF--VCLTFS{circumflex over ( )} (SEQ ID NO:406) Sx6.8 STS-CMKAGSYCVATTR--I-CC-GY-CAYFGKICIGYPKN{circumflex over ( )} (SEQ ID NO:409)

[0097] It will be appreciated that the methods and compositions of the instant invention can be incorporated in the form of a variety of embodiments, only a few of which are disclosed herein. It will be apparent to the artisan that other embodiments exist and do not depart from the spirit of the invention. Thus, the described embodiments are illustrative and should not be construed as restrictive.

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[0146] U.S. Pat. No. 5,514,774.

[0147] U.S. Pat. No. 5,531,001.

[0148] U.S. Pat. No. 5,534,615.

[0149] U.S. Pat. No. 5,364,769.

[0150] U.S. Pat. No. 5,545,723.

[0151] U.S. Pat. No. 5,550,050.

[0152] U.S. Pat. No. 5,591,821.

[0153] U.S. Pat. No. 5,719,264.

[0154] U.S. Pat. No. 5,844,077.

[0155] PCT Published Application WO 92/19195.

[0156] PCT Published Application WO 94/25503.

[0157] PCT Published Application WO 95/01203.

[0158] PCT Published Application WO 95/05452.

[0159] PCT Published Application WO 96/02286.

[0160] PCT Published Application WO 96/02646.

[0161] PCT Published Application WO 96/11698.

[0162] PCT Published Application WO 96/40871.

[0163] PCT Published Application WO 96/40959.

[0164] PCT Published Application WO 97/12635.

[0165] PCT Published Application WO 98/03189.

[0166] PCT Published Application WO 00/23092.

0 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 409 <210> SEQ ID NO 1 <211> LENGTH: 261 <212> TYPE: DNA <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(231) <400> SEQUENCE: 1 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc gga aat gga atg gag att ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn Gly Met Glu Ile Leu 20 25 30 ttt ccg aag gcg ggt cac gaa atg gag aac ctc gaa gtc tct aat cgg 144 Phe Pro Lys Ala Gly His Glu Met Glu Asn Leu Glu Val Ser Asn Arg 35 40 45 gtc aag ccg tgc cgt aaa gaa ggt caa ctt tgt gat ccg ata ttt caa 192 Val Lys Pro Cys Arg Lys Glu Gly Gln Leu Cys Asp Pro Ile Phe Gln 50 55 60 aac tgc tgc cgt ggc tgg aat tgc gtt ctt ttc tgc gtc tgaaactacc 241 Asn Cys Cys Arg Gly Trp Asn Cys Val Leu Phe Cys Val 65 70 75 gtgatgtctt ctctcccctc 261 <210> SEQ ID NO 2 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 2 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn Gly Met Glu Ile Leu 20 25 30 Phe Pro Lys Ala Gly His Glu Met Glu Asn Leu Glu Val Ser Asn Arg 35 40 45 Val Lys Pro Cys Arg Lys Glu Gly Gln Leu Cys Asp Pro Ile Phe Gln 50 55 60 Asn Cys Cys Arg Gly Trp Asn Cys Val Leu Phe Cys Val 65 70 75 <210> SEQ ID NO 3 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 3 and 13 may be pro or hydroxy-Pro; Xaa at residu e 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 22 may be Trp or bromo-Trp <400> SEQUENCE: 3 Val Lys Xaa Cys Arg Lys Xaa Gly Gln Leu Cys Asp Xaa Ile Phe Gln 1 5 10 15 Asn Cys Cys Arg Gly Xaa Asn Cys Val Leu Phe Cys Val 20 25 <210> SEQ ID NO 4 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 3 and 13 may be pro or hydroxy-Pro; Xaa at residu e 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 15 may be Tyr , 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospn o-Tyr; Xaa at residue 22 may be Trp or bromo-Trp <400> SEQUENCE: 4 Val Lys Xaa Cys Arg Lys Xaa Gly Gln Leu Cys Asp Xaa Ile Xaa Gln 1 5 10 15 Asn Cys Cys Arg Gly Xaa Asn Cys Val Leu Phe Cys Val 20 25 <210> SEQ ID NO 5 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 3 and 13 may be pro or hydroxy-Pro; Xaa at residu e 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 22 may be Trp or bromo-Trp; Xaa at residue 27 may be Tyr, 125-I-Tyr, mono-iodo -Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospno-Tyr <400> SEQUENCE: 5 Val Lys Xaa Cys Arg Lys Xaa Gly Gln Leu Cys Asp Xaa Ile Phe Gln 1 5 10 15 Asn Cys Cys Arg Gly Xaa Asn Cys Val Leu Xaa Cys Val 20 25 <210> SEQ ID NO 6 <211> LENGTH: 542 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (146)..(235) <400> SEQUENCE: 6 gaagctggta cgcctgcagg taccggtccg gaattcccgg gtcgacatca tcatcatcga 60 tccatctgtc catccatcca ttcattcatt cgctgccaga ctataataaa cattcaagtc 120 tctctttctt tttgtgtctg acaga tcg atc agg atg tgc cgt aga gaa gct 172 Ser Ile Arg Met Cys Arg Arg Glu Ala 1 5 caa ctt tgt gat ccg att ttt caa aac tgc tgc cat ggc ttg ttt tgc 220 Gln Leu Cys Asp Pro Ile Phe Gln Asn Cys Cys His Gly Leu Phe Cys 10 15 20 25 gtt ttg gtc tgc gtc taaaactacc gtgatgtctt ctcctcccct ctagtagtag 275 Val Leu Val Cys Val 30 taggcggccg ctctagagga tccaagctta cgtacgcgtg catgcgacgt catagctctt 335 ctatagtgtc acctaaattc aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa 395 accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta 455 atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat 515 gggacgcgcc ctgtagcggc gcattat 542 <210> SEQ ID NO 7 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 7 Ser Ile Arg Met Cys Arg Arg Glu Ala Gln Leu Cys Asp Pro Ile Phe 1 5 10 15 Gln Asn Cys Cys His Gly Leu Phe Cys Val Leu Val Cys Val 20 25 30 <210> SEQ ID NO 8 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 5 is Glu or gamma-carboxy-Glu; Xaa at residue 11 m ay be Pro or hydroxy-Pro <400> SEQUENCE: 8 Met Cys Arg Arg Xaa Ala Gln Leu Cys Asp Xaa Ile Phe Gln Asn Cys 1 5 10 15 Cys His Gly Leu Phe Cys Val Leu Val Cys Val 20 25 <210> SEQ ID NO 9 <211> LENGTH: 346 <212> TYPE: DNA <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (25)..(315) <400> SEQUENCE: 9 ggcattacct aaaacatcac caag atg aaa ctg acg tgc atg atg atc gtt 51 Met Lys Leu Thr Cys Met Met Ile Val 1 5 gct gtg ctg ttc ttg acc gcc tgg aca ttc gtc acg gct gat gac tcc 99 Ala Val Leu Phe Leu Thr Ala Trp Thr Phe Val Thr Ala Asp Asp Ser 10 15 20 25 aga aat gga atg gag aat ctt ttt ccg aag gca ggt cac gaa atg gag 147 Arg Asn Gly Met Glu Asn Leu Phe Pro Lys Ala Gly His Glu Met Glu 30 35 40 aac ctc gaa gac tct aaa cac agg cac cag gag aga ccg gac acc ggc 195 Asn Leu Glu Asp Ser Lys His Arg His Gln Glu Arg Pro Asp Thr Gly 45 50 55 gac aaa gaa gag atg ctg cta cag aga cag gtc aag ccg tgt cgt aaa 243 Asp Lys Glu Glu Met Leu Leu Gln Arg Gln Val Lys Pro Cys Arg Lys 60 65 70 gaa cat caa ctt tgt gat ctg att ttt caa aac tgc tgc cgt ggc tgg 291 Glu His Gln Leu Cys Asp Leu Ile Phe Gln Asn Cys Cys Arg Gly Trp 75 80 85 tat tgc gtt gtt ctg tct tgc act tgaaagctac ctgatgtgtt ctactcccat 345 Tyr Cys Val Val Leu Ser Cys Thr 90 95 c 346 <210> SEQ ID NO 10 <211> LENGTH: 97 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 10 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Met Glu Asn Leu 20 25 30 Phe Pro Lys Ala Gly His Glu Met Glu Asn Leu Glu Asp Ser Lys His 35 40 45 Arg His Gln Glu Arg Pro Asp Thr Gly Asp Lys Glu Glu Met Leu Leu 50 55 60 Gln Arg Gln Val Lys Pro Cys Arg Lys Glu His Gln Leu Cys Asp Leu 65 70 75 80 Ile Phe Gln Asn Cys Cys Arg Gly Trp Tyr Cys Val Val Leu Ser Cys 85 90 95 Thr <210> SEQ ID NO 11 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residue 1 may be Gln or pyro-Glu; Xaa at residue 4 may be Pro or hydroxy-Pro; Xaa at residue 8 may be Glu o gamma-carboxy- Glu; Xaa at residue 23 may be Trp or bromo-Trp; Xaa at residue 24 <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 11 Xaa Val Lys Xaa Cys Arg Lys Xaa His Gln Leu Cys Asp Leu Ile Phe 1 5 10 15 Gln Asn Cys Cys Arg Gly Xaa Xaa Cys Val Val Leu Ser Cys Thr 20 25 30 <210> SEQ ID NO 12 <211> LENGTH: 265 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 12 atg aaa ctg acg tgc ctg atg atc gtt gcc gtg ctg tcc ttg acc ggc 48 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Ser Leu Thr Gly 1 5 10 15 tgg aca ttc gtc acg gct gat gac tct gga aat gga ttg ggg aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn Gly Leu Gly Asn Leu 20 25 30 ttt tcg aat gca cat cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgc gtt cca cac gag ggc cct tgt aat tgg ctt aca caa 192 Asn Lys Arg Cys Val Pro His Glu Gly Pro Cys Asn Trp Leu Thr Gln 50 55 60 aac tgc tgc agt ggt tat aat tgc atc att ttt ttc tgc cta 234 Asn Cys Cys Ser Gly Tyr Asn Cys Ile Ile Phe Phe Cys Leu 65 70 75 taaaactacc gtgatgtctt ctcttcccct c 265 <210> SEQ ID NO 13 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 13 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Ser Leu Thr Gly 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn Gly Leu Gly Asn Leu 20 25 30 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Val Pro His Glu Gly Pro Cys Asn Trp Leu Thr Gln 50 55 60 Asn Cys Cys Ser Gly Tyr Asn Cys Ile Ile Phe Phe Cys Leu 65 70 75 <210> SEQ ID NO 14 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residues 3 and 7 may be Pro or hydroxy-Pro; Xaa at residue 5 may be Glu or gamma-carboxy-Glu; Xaa at residue 10 may be Trp or bromo-Trp; Xaa at residue 19 may be Tyr, 125-I-Tyr, mono-iodo- Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 14 Cys Val Xaa His Xaa Gly Xaa Cys Asn Xaa Leu Thr Gln Asn Cys Cys 1 5 10 15 Ser Gly Xaa Asn Cys Ile Ile Phe Phe Cys Leu 20 25 <210> SEQ ID NO 15 <211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(291) <400> SEQUENCE: 15 atg aaa ctg acg tgc ctg ctg atc att gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Leu Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc gga aat gga atg gag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn Gly Met Glu Asn Leu 20 25 30 ttt ccg aag gca cgt cac gaa atg gag aac ctc gaa gac tct aaa cac 144 Phe Pro Lys Ala Arg His Glu Met Glu Asn Leu Glu Asp Ser Lys His 35 40 45 agg cac cag gag aga ccg gac acg ggc gac aaa gaa gag atg ctg cta 192 Arg His Gln Glu Arg Pro Asp Thr Gly Asp Lys Glu Glu Met Leu Leu 50 55 60 cag aga cag gtc aag ccg tgt cgt aaa gaa cat caa ctt tgt gat ctg 240 Gln Arg Gln Val Lys Pro Cys Arg Lys Glu His Gln Leu Cys Asp Leu 65 70 75 80 att ttt caa aac tgc tgc cgt ggc tgg tat tgc ttg ctt cgt cct tgc 288 Ile Phe Gln Asn Cys Cys Arg Gly Trp Tyr Cys Leu Leu Arg Pro Cys 85 90 95 atc tgaaactacc gtgatgtctt ctctcccatc 321 Ile <210> SEQ ID NO 16 <211> LENGTH: 97 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 16 Met Lys Leu Thr Cys Leu Leu Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn Gly Met Glu Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Glu Asn Leu Glu Asp Ser Lys His 35 40 45 Arg His Gln Glu Arg Pro Asp Thr Gly Asp Lys Glu Glu Met Leu Leu 50 55 60 Gln Arg Gln Val Lys Pro Cys Arg Lys Glu His Gln Leu Cys Asp Leu 65 70 75 80 Ile Phe Gln Asn Cys Cys Arg Gly Trp Tyr Cys Leu Leu Arg Pro Cys 85 90 95 Ile <210> SEQ ID NO 17 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residue 1 may be Gln or pyro-Glu; Xaa at residues 4 and 29 may be Pro or hydroxy-Pro; Xaa at residue 8 may be Glu or gamma- carboxy-Glu ; Xaa at residue 23 may be Trp or bromo-Trp; <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residue 24 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-T yr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 17 Xaa Val Lys Xaa Cys Arg Lys Xaa His Gln Leu Cys Asp Leu Ile Phe 1 5 10 15 Gln Asn Cys Cys Arg Gly Xaa Xaa Cys Leu Leu Arg Xaa Cys Ile 20 25 30 <210> SEQ ID NO 18 <211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(291) <400> SEQUENCE: 18 atg aaa ctg acg tgt atg ctg atc att gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Leu Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc gga aat gga atg gag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn Gly Met Glu Asn Leu 20 25 30 ttt ccg aag gca cgt cac gaa atg gag aac ctc gaa gac tct aaa cac 144 Phe Pro Lys Ala Arg His Glu Met Glu Asn Leu Glu Asp Ser Lys His 35 40 45 agg cac cag gag aga ccg gac acg ggc gac aaa gaa gag atg ctg cta 192 Arg His Gln Glu Arg Pro Asp Thr Gly Asp Lys Glu Glu Met Leu Leu 50 55 60 cag aga cgg gtc aag ccg tgc agt gaa gaa ggt caa ctt tgt gat cca 240 Gln Arg Arg Val Lys Pro Cys Ser Glu Glu Gly Gln Leu Cys Asp Pro 65 70 75 80 ctt tct caa aac tgc tgc cgt ggc tgg cat tgc gtt ctt gtc tct tgc 288 Leu Ser Gln Asn Cys Cys Arg Gly Trp His Cys Val Leu Val Ser Cys 85 90 95 gtc tgaaactacc gtgatgtctt ctctcccatc 321 Val <210> SEQ ID NO 19 <211> LENGTH: 97 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 19 Met Lys Leu Thr Cys Met Leu Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn Gly Met Glu Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Glu Asn Leu Glu Asp Ser Lys His 35 40 45 Arg His Gln Glu Arg Pro Asp Thr Gly Asp Lys Glu Glu Met Leu Leu 50 55 60 Gln Arg Arg Val Lys Pro Cys Ser Glu Glu Gly Gln Leu Cys Asp Pro 65 70 75 80 Leu Ser Gln Asn Cys Cys Arg Gly Trp His Cys Val Leu Val Ser Cys 85 90 95 Val <210> SEQ ID NO 20 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residues 3 and 13 may be Pro or hydroxy-Pro; Xaa at residu es 6 and 7 may be Glu or gamma-carboxy-Glu ; Xaa at residue 22 may be Trp or bromo-Trp <400> SEQUENCE: 20 Val Lys Xaa Cys Ser Xaa Xaa Gly Gln Leu Cys Asp Xaa Leu Ser Gln 1 5 10 15 Asn Cys Cys Arg Gly Xaa His Cys Val Leu Val Ser Cys Val 20 25 30 <210> SEQ ID NO 21 <211> LENGTH: 406 <212> TYPE: DNA <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (14)..(247) <400> SEQUENCE: 21 aaacatcgcc aag atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg 49 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu 1 5 10 ttc ttg acc gcc tgg aca ttt gcc acg gct gat gac ccc aga aat gga 97 Phe Leu Thr Ala Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly 15 20 25 ttg ggg aat ctt ttt tcg aat gca cat cac gaa atg aag aac ccc gaa 145 Leu Gly Asn Leu Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu 30 35 40 gcc tct aaa ttg aac aag agg tgg tgc aaa caa agc ggt gaa atg tgt 193 Ala Ser Lys Leu Asn Lys Arg Trp Cys Lys Gln Ser Gly Glu Met Cys 45 50 55 60 aat ttg tta gac caa aac tgc tgc gac ggc tat tgc ata gta ctt gtc 241 Asn Leu Leu Asp Gln Asn Cys Cys Asp Gly Tyr Cys Ile Val Leu Val 65 70 75 tgc aca taaaactgcc gtgatgtctt ctcttcccct ctgtgctacc tggcttgatc 297 Cys Thr tttgattggc gcgtgtcgtt cactggttat gaaccccccc cccccccccc ccccccccct 357 tccggctctc tggaggcctc gggggttcaa catccaaata aagtgacag 406 <210> SEQ ID NO 22 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 22 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Trp Cys Lys Gln Ser Gly Glu Met Cys Asn Leu Leu Asp 50 55 60 Gln Asn Cys Cys Asp Gly Tyr Cys Ile Val Leu Val Cys Thr 65 70 75 <210> SEQ ID NO 23 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residue 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 20 may be Tyr, 125-I-Ty r, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 23 Xaa Cys Lys Gln Asp Gly Xaa Met Cys Asn Leu Leu Asp Gln Asn Cys 1 5 10 15 Cys Asp Gly Xaa Cys Ile Val Leu Val Cys Thr 20 25 <210> SEQ ID NO 24 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residue 7 may be Glu or gamma-carboxy-Glu;Xaa at residue 9 is Nle; Xaa at residue 20 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 24 Xaa Cys Lys Gln Asp Gly Xaa Xaa Cys Asn Leu Leu Asp Gln Asn Cys 1 5 10 15 Cys Asp Gly Xaa Cys Ile Val Leu Val Cys Thr 20 25 <210> SEQ ID NO 25 <211> LENGTH: 265 <212> TYPE: DNA <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 25 atg aaa ctg acg tgt gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg ggg aat ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 ttt tcg aat gca cat cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgg tgc aaa caa agc ggt gaa atg tgt aat ttg tta gac 192 Asn Lys Arg Trp Cys Lys Gln Ser Gly Glu Met Cys Asn Leu Leu Asp 50 55 60 caa aac tgc tgc gac ggc tat tgc ata gta ctt gtc tgc aca 234 Gln Asn Cys Cys Asp Gly Tyr Cys Ile Val Leu Val Cys Thr 65 70 75 taaaactgcc gtgatgtctt ctcctcccct c 265 <210> SEQ ID NO 26 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 26 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Trp Cys Lys Gln Ser Gly Glu Met Cys Asn Leu Leu Asp 50 55 60 Gln Asn Cys Cys Asp Gly Tyr Cys Ile Val Leu Val Cys Thr 65 70 75 <210> SEQ ID NO 27 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residue 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 20 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 27 Xaa Cys Lys Gln Ser Gly Xaa Met Cys Asn Leu Leu Asp Gln Asn Cys 1 5 10 15 Cys Asp Gly Xaa Cys Ile Val Leu Val Cys Thr 20 25 <210> SEQ ID NO 28 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residue 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 20 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 28 Xaa Cys Lys Gln Ser Gly Xaa Met Cys Asn Leu Leu Asp Gln Asn Cys 1 5 10 15 Cys Asp Gly Xaa Cys Ile Val Phe Val Cys Thr 20 25 <210> SEQ ID NO 29 <211> LENGTH: 265 <212> TYPE: DNA <213> ORGANISM: Conus distans <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 29 atg aaa ctg acg tgc ctg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg ggg aat ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 ttt tcg aat gca cat cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgg tgc aaa caa agc ggt gaa atg tgt aat ttg tta gac 192 Asn Lys Arg Trp Cys Lys Gln Ser Gly Glu Met Cys Asn Leu Leu Asp 50 55 60 caa aac tgc tgc gac ggc tat tgc ata gta ctt gtc tgc aca 234 Gln Asn Cys Cys Asp Gly Tyr Cys Ile Val Leu Val Cys Thr 65 70 75 taaaactgcc gtgatgtctt ctcctcccct c 265 <210> SEQ ID NO 30 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus distans <400> SEQUENCE: 30 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Trp Cys Lys Gln Ser Gly Glu Met Cys Asn Leu Leu Asp 50 55 60 Gln Asn Cys Cys Asp Gly Tyr Cys Ile Val Leu Val Cys Thr 65 70 75 <210> SEQ ID NO 31 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus distans <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residue 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 20 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 31 Xaa Cys Lys Gln Ser Gly Xaa Met Cys Asn Leu Leu Asp Gln Asn Cys 1 5 10 15 Cys Asp Gly Xaa Cys Ile Val Leu Val Cys Thr 20 25 <210> SEQ ID NO 32 <211> LENGTH: 265 <212> TYPE: DNA <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 32 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg ggg aat ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 ttt tcg aat gca cat cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgg tgc aaa caa agc ggt gaa atg tgt aat ttg tta gac 192 Asn Lys Arg Trp Cys Lys Gln Ser Gly Glu Met Cys Asn Leu Leu Asp 50 55 60 caa aac tgc tgc gag ggc tat tgc ata gta ctt gtc tgc aca 234 Gln Asn Cys Cys Glu Gly Tyr Cys Ile Val Leu Val Cys Thr 65 70 75 taaaactgcc gtgatgtctt ctcctcccct c 265 <210> SEQ ID NO 33 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 33 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Trp Cys Lys Gln Ser Gly Glu Met Cys Asn Leu Leu Asp 50 55 60 Gln Asn Cys Cys Glu Gly Tyr Cys Ile Val Leu Val Cys Thr 65 70 75 <210> SEQ ID NO 34 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residues 7 and 18 may be Glu or gamma-carboxy-Glu; Xaa at residue 20 may be Tyr,125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 34 Xaa Cys Lys Gln Ser Gly Xaa Met Cys Asn Leu Leu Asp Gln Asn Cys 1 5 10 15 Cys Xaa Gly Xaa Cys Ile Val Leu Val Cys Thr 20 25 <210> SEQ ID NO 35 <211> LENGTH: 256 <212> TYPE: DNA <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(225) <400> SEQUENCE: 35 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gcc acg gct gat gac ccc aga aat gga ttg gag aat ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 ttt ttg aag gca cat cac gaa atg aac ccc gaa gcc tct aag ttg aat 144 Phe Leu Lys Ala His His Glu Met Asn Pro Glu Ala Ser Lys Leu Asn 35 40 45 gag agg tgc ctt ggt ggt ggt gaa gtt tgt gat atc ttt ttt cca caa 192 Glu Arg Cys Leu Gly Gly Gly Glu Val Cys Asp Ile Phe Phe Pro Gln 50 55 60 tgc tgt ggc tat tgc att ctt ctt ttc tgc aca taaaactacc gtgatgtctt 245 Cys Cys Gly Tyr Cys Ile Leu Leu Phe Cys Thr 65 70 75 ctcctcccct c 256 <210> SEQ ID NO 36 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 36 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 Phe Leu Lys Ala His His Glu Met Asn Pro Glu Ala Ser Lys Leu Asn 35 40 45 Glu Arg Cys Leu Gly Gly Gly Glu Val Cys Asp Ile Phe Phe Pro Gln 50 55 60 Cys Cys Gly Tyr Cys Ile Leu Leu Phe Cys Thr 65 70 75 <210> SEQ ID NO 37 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro;Xaa at residue 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 37 Cys Leu Gly Gly Gly Xaa Val Cys Asp Ile Phe Phe Xaa Gln Cys Cys 1 5 10 15 Gly Xaa Cys Ile Leu Leu Phe Cys Thr 20 25 <210> SEQ ID NO 38 <211> LENGTH: 441 <212> TYPE: DNA <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (70)..(300) <400> SEQUENCE: 38 gcttgcacgg tgaatttggc ttcacagttt tccactgtcg tctttggcat catctgaaac 60 atcgccaag atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg 111 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg ggg 159 Thr Ala Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly 15 20 25 30 aat att ttt tcg aat gca cat cac gaa atg aag aat ccc gaa gcc tct 207 Asn Ile Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser 35 40 45 aaa ttg aac aag agg tgc cgt cta ggg gct gaa agt tgt gat gta att 255 Lys Leu Asn Lys Arg Cys Arg Leu Gly Ala Glu Ser Cys Asp Val Ile 50 55 60 tca caa aac tgc tgc caa ggc acg tgc gtt ttt ttc tgc tta cca 300 Ser Gln Asn Cys Cys Gln Gly Thr Cys Val Phe Phe Cys Leu Pro 65 70 75 tgatgtcttc tattctcctc tgtgctacct ggcttgatct ttcattagcg cgtgcctttc 360 actggttatg aaccccctga tccgactctc tggcagcctc gggggttcaa catccaaata 420 aaacgacagc acaatgacaa a 441 <210> SEQ ID NO 39 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 39 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Ile 20 25 30 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Arg Leu Gly Ala Glu Ser Cys Asp Val Ile Ser Gln 50 55 60 Asn Cys Cys Gln Gly Thr Cys Val Phe Phe Cys Leu Pro 65 70 75 <210> SEQ ID NO 40 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 26 may be Pro or hydroxy-Pro <400> SEQUENCE: 40 Cys Arg Leu Gly Ala Xaa Ser Cys Asp Val Ile Ser Gln Asn Cys Cys 1 5 10 15 Gln Gly Thr Cys Val Phe Phe Cys Leu Xaa 20 25 <210> SEQ ID NO 41 <211> LENGTH: 446 <212> TYPE: DNA <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (74)..(304) <400> SEQUENCE: 41 ggatccttgc acggtgaatt tggcttcaca gttttccact gtcgtctttc gcatcatcca 60 aaacatcacc aag atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg 109 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu 1 5 10 ttc ttg acc gcc tgg aca ttc gcc acg gct gat gac ccc aga aat gga 157 Phe Leu Thr Ala Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly 15 20 25 ttg gag aaa ctt ttt tcg aat aca cat cac gaa atg aag aac ccc gaa 205 Leu Glu Lys Leu Phe Ser Asn Thr His His Glu Met Lys Asn Pro Glu 30 35 40 gcc tct aaa ttg aac aag agg tgc aaa caa gct gat gaa tct tgt aat 253 Ala Ser Lys Leu Asn Lys Arg Cys Lys Gln Ala Asp Glu Ser Cys Asn 45 50 55 60 gta ttt tca ctt gac tgc tgc acc ggc tta tgc ttg gga ttc tgc gta 301 Val Phe Ser Leu Asp Cys Cys Thr Gly Leu Cys Leu Gly Phe Cys Val 65 70 75 tcg tgatgtcttc tactcccctc tgtgctacct ggcttgatct ttgattggcg 354 Ser tgtgcctttc attggttatg aacccccctg atccgattct ttggcggcct cgggggttca 414 acatccaaat aaagcgacag cacaataaaa aa 446 <210> SEQ ID NO 42 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 42 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Lys Leu 20 25 30 Phe Ser Asn Thr His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Lys Gln Ala Asp Glu Ser Cys Asn Val Phe Ser Leu 50 55 60 Asp Cys Cys Thr Gly Leu Cys Leu Gly Phe Cys Val Ser 65 70 75 <210> SEQ ID NO 43 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu. <400> SEQUENCE: 43 Cys Lys Gln Ala Asp Xaa Ser Cys Asn Val Phe Ser Leu Asp Cys Cys 1 5 10 15 Thr Gly Leu Cys Leu Gly Phe Cys Val Ser 20 25 <210> SEQ ID NO 44 <211> LENGTH: 242 <212> TYPE: DNA <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(225) <400> SEQUENCE: 44 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg acc acc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 tgg aca ttc gcc acg gcc atc acc agg aat gga ttg ggg aat ctt ttt 96 Trp Thr Phe Ala Thr Ala Ile Thr Arg Asn Gly Leu Gly Asn Leu Phe 20 25 30 ccg aag aat cat cac gaa atg aag aac ccc gaa gcc tct aaa ttg aac 144 Pro Lys Asn His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu Asn 35 40 45 aag agg tgc gtt cca tac gag ggc cct tgt aat tgg ctt aca caa aac 192 Lys Arg Cys Val Pro Tyr Glu Gly Pro Cys Asn Trp Leu Thr Gln Asn 50 55 60 tgc tgc gat gag cta tgc gta ttt ttc tgc cta taaaactagc ctgatgt 242 Cys Cys Asp Glu Leu Cys Val Phe Phe Cys Leu 65 70 75 <210> SEQ ID NO 45 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 45 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 Trp Thr Phe Ala Thr Ala Ile Thr Arg Asn Gly Leu Gly Asn Leu Phe 20 25 30 Pro Lys Asn His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu Asn 35 40 45 Lys Arg Cys Val Pro Tyr Glu Gly Pro Cys Asn Trp Leu Thr Gln Asn 50 55 60 Cys Cys Asp Glu Leu Cys Val Phe Phe Cys Leu 65 70 75 <210> SEQ ID NO 46 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residue 2 and 7 may be Pro or hydroxy-Pro; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 5 and 18 may be Glu or gamma-carboxy-Glu ; Xaa at residue 10 may be Trp or bromo-Trp <400> SEQUENCE: 46 Cys Val Xaa Xaa Xaa Gly Xaa Cys Asn Xaa Leu Thr Gln Asn Cys Cys 1 5 10 15 Asp Xaa Leu Cys Val Phe Phe Cys Leu 20 25 <210> SEQ ID NO 47 <211> LENGTH: 250 <212> TYPE: DNA <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(231) <400> SEQUENCE: 47 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctc ttc ttg acc gtc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Val 1 5 10 15 tgg aca ttc gcc acg gct gat gac tcc gga aat gga ttg gag aaa ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Ser Gly Asn Gly Leu Glu Lys Leu 20 25 30 ttt tcg aat gca cat cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgc aaa caa gct gat gaa cct tgt gat gta ttt tca ctt 192 Asn Lys Arg Cys Lys Gln Ala Asp Glu Pro Cys Asp Val Phe Ser Leu 50 55 60 gaa tgc tgc acc ggc ata tgt ctt gga ttc tgc acg tgg tgatgtcttc 241 Glu Cys Cys Thr Gly Ile Cys Leu Gly Phe Cys Thr Trp 65 70 75 cctcccctc 250 <210> SEQ ID NO 48 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Val 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Ser Gly Asn Gly Leu Glu Lys Leu 20 25 30 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Lys Gln Ala Asp Glu Pro Cys Asp Val Phe Ser Leu 50 55 60 Glu Cys Cys Thr Gly Ile Cys Leu Gly Phe Cys Thr Trp 65 70 75 <210> SEQ ID NO 49 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 6 and 14 may be Glu or gamma-carboxy-Glu; Xaa at residue 7 may be Pro or hydroxy-Pro; Xaa at residue 26may be Trp or bromo-Trp <400> SEQUENCE: 49 Cys Lys Gln Ala Asp Xaa Xaa Cys Asp Val Phe Ser Leu Xaa Cys Cys 1 5 10 15 Thr Gly Ile Cys Leu Gly Phe Cys Thr Xaa 20 25 <210> SEQ ID NO 50 <211> LENGTH: 434 <212> TYPE: DNA <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (71)..(295) <400> SEQUENCE: 50 gccttgcacg gtgaatttgg cttcatagtt ttccactgtc gtctttggca tcatccaaaa 60 catcaccaag atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc 109 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe 1 5 10 ttg acc gcc tgg aca ttc gcc acg gct gat gac tcc agc aat gga ttg 157 Leu Thr Ala Trp Thr Phe Ala Thr Ala Asp Asp Ser Ser Asn Gly Leu 15 20 25 gag aat ctt ttt ttg aag gca cat cac gaa atg aac ccc gaa gcc tct 205 Glu Asn Leu Phe Leu Lys Ala His His Glu Met Asn Pro Glu Ala Ser 30 35 40 45 aag ttg aac gag agg tgc ctt gat gct ggt gaa gtt tgt gat att ttt 253 Lys Leu Asn Glu Arg Cys Leu Asp Ala Gly Glu Val Cys Asp Ile Phe 50 55 60 ttt cca aca tgc tgc ggc tat tgc att ctt ctt ttc tgc gca 295 Phe Pro Thr Cys Cys Gly Tyr Cys Ile Leu Leu Phe Cys Ala 65 70 75 taaaactacc gtgatgtctt ctactcccct ctgtgctacc tggcttgatc tttgattggc 355 gcgtaccctt cactggttat gaaacccctg atccagctct ctggaggcct cgggggttca 415 acatccaaat aaagcgaca 434 <210> SEQ ID NO 51 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 51 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Ser Ser Asn Gly Leu Glu Asn Leu 20 25 30 Phe Leu Lys Ala His His Glu Met Asn Pro Glu Ala Ser Lys Leu Asn 35 40 45 Glu Arg Cys Leu Asp Ala Gly Glu Val Cys Asp Ile Phe Phe Pro Thr 50 55 60 Cys Cys Gly Tyr Cys Ile Leu Leu Phe Cys Ala 65 70 75 <210> SEQ ID NO 52 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro; Xaa at residue 18 may be Tyr, 125- I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr. <400> SEQUENCE: 52 Cys Leu Asp Ala Gly Xaa Val Cys Asp Ile Phe Phe Xaa Thr Cys Cys 1 5 10 15 Gly Xaa Cys Ile Leu Leu Phe Cys Ala 20 25 <210> SEQ ID NO 53 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3 and 9 may be Glu or gamma-carboxy-Glu; Xaa at residue 7 may be Pro or hydroxy-Pro <400> SEQUENCE: 53 Cys Ile Xaa Gln Phe Asp Xaa Cys Xaa Met Ile Arg His Thr Cys Cys 1 5 10 15 Val Gly Val Cys Phe Leu Met Ala Cys Ile 20 25 <210> SEQ ID NO 54 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3, 7 and 13 may be Pro or hydroxy-Pro; Xaa at residue 19 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 54 Cys Ala Xaa Phe Leu His Xaa Cys Thr Phe Phe Phe Xaa Asn Cys Cys 1 5 10 15 Asn Ser Xaa Cys Val Gln Phe Ile Cys Leu 20 25 <210> SEQ ID NO 55 <211> LENGTH: 260 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(240) <400> SEQUENCE: 55 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gcc acg gct gat gac ccc aga aat gga ttg gag aat ttt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Phe 20 25 30 ttt tcg aag aca caa cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Lys Thr Gln His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgc cta gca gaa cat gaa act tgt aat ata ttt aca caa 192 Asn Lys Arg Cys Leu Ala Glu His Glu Thr Cys Asn Ile Phe Thr Gln 50 55 60 aac tgc tgc gaa ggc gtg tgc att ttt atc tgc gta caa gct cca gag 240 Asn Cys Cys Glu Gly Val Cys Ile Phe Ile Cys Val Gln Ala Pro Glu 65 70 75 80 tgatgtcttc tcctcccctc 260 <210> SEQ ID NO 56 <211> LENGTH: 80 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 56 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Phe 20 25 30 Phe Ser Lys Thr Gln His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Leu Ala Glu His Glu Thr Cys Asn Ile Phe Thr Gln 50 55 60 Asn Cys Cys Glu Gly Val Cys Ile Phe Ile Cys Val Gln Ala Pro Glu 65 70 75 80 <210> SEQ ID NO 57 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 4, 6, 17 and 29 may be Glu or gamma-carboxy-Glu; Xaa at residue 28 may be Pro or hydroxy-Pro <400> SEQUENCE: 57 Cys Leu Ala Xaa His Xaa Thr Cys Asn Ile Phe Thr Gln Asn Cys Cys 1 5 10 15 Xaa Gly Val Cys Ile Phe Ile Cys Val Gln Ala Xaa Xaa 20 25 <210> SEQ ID NO 58 <211> LENGTH: 261 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(231) <400> SEQUENCE: 58 atg aaa ctg act gtc atg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Val Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gcc acg gct gaa gac ccc aga cat gga ttg gag aat ctt 96 Trp Thr Phe Ala Thr Ala Glu Asp Pro Arg His Gly Leu Glu Asn Leu 20 25 30 ttt tcg aag gca cat cac gaa atg aag aac cct gaa gac tct aaa ttg 144 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Asp Ser Lys Leu 35 40 45 gac aag agg tgc att cca cat ttt gac cct tgt gac ccg ata cgc cac 192 Asp Lys Arg Cys Ile Pro His Phe Asp Pro Cys Asp Pro Ile Arg His 50 55 60 acc tgc tgc ttt ggc ctg tgc cta cta ata gcc tgc atc taaaactgcc 241 Thr Cys Cys Phe Gly Leu Cys Leu Leu Ile Ala Cys Ile 65 70 75 gtgatgtctt ctctcccatc 261 <210> SEQ ID NO 59 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 59 Met Lys Leu Thr Val Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Glu Asp Pro Arg His Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Asp Ser Lys Leu 35 40 45 Asp Lys Arg Cys Ile Pro His Phe Asp Pro Cys Asp Pro Ile Arg His 50 55 60 Thr Cys Cys Phe Gly Leu Cys Leu Leu Ile Ala Cys Ile 65 70 75 <210> SEQ ID NO 60 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3, 7 and 10 may be Pro or hydroxy-Pro. <400> SEQUENCE: 60 Cys Ile Xaa His Phe Asp Xaa Cys Asp Xaa Ile Arg His Thr Cys Cys 1 5 10 15 Phe Gly Leu Cys Leu Leu Ile Ala Cys Ile 20 25 <210> SEQ ID NO 61 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(228) <400> SEQUENCE: 61 atg aaa ctg acg tgc gtg atg acc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gaa gac ccc aga gat gga ttg aag aat ctt 96 Trp Thr Phe Val Thr Ala Glu Asp Pro Arg Asp Gly Leu Lys Asn Leu 20 25 30 tta tca aat gca cat aac gaa atg aag aac ccc gaa gcc tct aca ttg 144 Leu Ser Asn Ala His Asn Glu Met Lys Asn Pro Glu Ala Ser Thr Leu 35 40 45 aac gag agg tgc ctt ggg ttt ggt gaa gct tgt ctt ata ctt tat tca 192 Asn Glu Arg Cys Leu Gly Phe Gly Glu Ala Cys Leu Ile Leu Tyr Ser 50 55 60 gac tgc tgc ggc tat tgc gtt ggt gct atc tgc cta taaaactacc 238 Asp Cys Cys Gly Tyr Cys Val Gly Ala Ile Cys Leu 65 70 75 gtgatgtctt ctcctcccct c 259 <210> SEQ ID NO 62 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 62 Met Lys Leu Thr Cys Val Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Glu Asp Pro Arg Asp Gly Leu Lys Asn Leu 20 25 30 Leu Ser Asn Ala His Asn Glu Met Lys Asn Pro Glu Ala Ser Thr Leu 35 40 45 Asn Glu Arg Cys Leu Gly Phe Gly Glu Ala Cys Leu Ile Leu Tyr Ser 50 55 60 Asp Cys Cys Gly Tyr Cys Val Gly Ala Ile Cys Leu 65 70 75 <210> SEQ ID NO 63 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residue m6 ay be Glu or gamma-carboxy-Glu; Xaa at residues 12 and 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 63 Cys Leu Gly Phe Gly Xaa Ala Cys Leu Ile Leu Xaa Ser Asp Cys Cys 1 5 10 15 Gly Xaa Cys Val Gly Ala Ile Cys Leu 20 25 <210> SEQ ID NO 64 <211> LENGTH: 262 <212> TYPE: DNA <213> ORGANISM: Conus aulicus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(240) <400> SEQUENCE: 64 atg aaa ctg acg tgt gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gcc acg gct gat gac ccc aga aat gga ttg gag aat ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 ttt tcg aag aca caa cac aaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Lys Thr Gln His Lys Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgc aaa gca gaa aat gaa ctt tgt aat ata ttt ata caa 192 Asn Lys Arg Cys Lys Ala Glu Asn Glu Leu Cys Asn Ile Phe Ile Gln 50 55 60 aac tgc tgc gac ggg acg tgc ctt ctt atc tgc ata caa aat cca cag 240 Asn Cys Cys Asp Gly Thr Cys Leu Leu Ile Cys Ile Gln Asn Pro Gln 65 70 75 80 tgatgtcttc tctcctaccc tc 262 <210> SEQ ID NO 65 <211> LENGTH: 80 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <400> SEQUENCE: 65 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Thr Gln His Lys Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Lys Ala Glu Asn Glu Leu Cys Asn Ile Phe Ile Gln 50 55 60 Asn Cys Cys Asp Gly Thr Cys Leu Leu Ile Cys Ile Gln Asn Pro Gln 65 70 75 80 <210> SEQ ID NO 66 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 4 and 6may be Glu or gamma-carboxy-Glu; Xaa at residue 28 may be Pro or hydroxy-Pro <400> SEQUENCE: 66 Cys Lys Ala Xaa Asn Xaa Leu Cys Asn Ile Phe Ile Gln Asn Cys Cys 1 5 10 15 Asp Gly Thr Cys Leu Leu Ile Cys Ile Gln Asn Xaa Gln 20 25 <210> SEQ ID NO 67 <211> LENGTH: 258 <212> TYPE: DNA <213> ORGANISM: Conus aulicus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(228) <400> SEQUENCE: 67 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg gat aat cgt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Asp Asn Arg 20 25 30 ttt tcg aag gca cgt cac gaa atg aat aac cgc aga gcc tct aaa ttg 144 Phe Ser Lys Ala Arg His Glu Met Asn Asn Arg Arg Ala Ser Lys Leu 35 40 45 aac aag agg tgc ctt gag ttt ggt gaa ctt tgt aat ttt ttt ttc cca 192 Asn Lys Arg Cys Leu Glu Phe Gly Glu Leu Cys Asn Phe Phe Phe Pro 50 55 60 acc tgc tgc ggc tat tgc gtt ctt ctt gtc tgc cta taaactaccg 238 Thr Cys Cys Gly Tyr Cys Val Leu Leu Val Cys Leu 65 70 75 tgatgtcttc tcttcccctc 258 <210> SEQ ID NO 68 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <400> SEQUENCE: 68 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Asp Asn Arg 20 25 30 Phe Ser Lys Ala Arg His Glu Met Asn Asn Arg Arg Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Leu Glu Phe Gly Glu Leu Cys Asn Phe Phe Phe Pro 50 55 60 Thr Cys Cys Gly Tyr Cys Val Leu Leu Val Cys Leu 65 70 75 <210> SEQ ID NO 69 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residues 3 and 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro; Xaa at residue 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 69 Cys Leu Xaa Phe Gly Xaa Leu Cys Asn Phe Phe Phe Xaa Thr Cys Cys 1 5 10 15 Gly Xaa Cys Val Leu Leu Val Cys Leu 20 25 <210> SEQ ID NO 70 <211> LENGTH: 263 <212> TYPE: DNA <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(231) <400> SEQUENCE: 70 atg aaa ctg acg tgt gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gtc atg gct gat gac tcc gga aat gga ttg gaa aat ctg 96 Trp Thr Phe Val Met Ala Asp Asp Ser Gly Asn Gly Leu Glu Asn Leu 20 25 30 ttt tcg aag gca cat cac gaa atg aag aac cct gaa gcc tct aaa ttg 144 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgc gct caa agc agt gaa tta tgt gat gcg ctg gac tca 192 Asn Lys Arg Cys Ala Gln Ser Ser Glu Leu Cys Asp Ala Leu Asp Ser 50 55 60 gac tgc tgc agt ggt gtt tgc atg gta ttt ttc tgc cta taaaactgcc 241 Asp Cys Cys Ser Gly Val Cys Met Val Phe Phe Cys Leu 65 70 75 gtgatgtctt ctctatcccc tc 263 <210> SEQ ID NO 71 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 71 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Met Ala Asp Asp Ser Gly Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Ala Gln Ser Ser Glu Leu Cys Asp Ala Leu Asp Ser 50 55 60 Asp Cys Cys Ser Gly Val Cys Met Val Phe Phe Cys Leu 65 70 75 <210> SEQ ID NO 72 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu. <400> SEQUENCE: 72 Cys Ala Gln Ser Ser Xaa Leu Cys Asp Ala Leu Asp Ser Asp Cys Cys 1 5 10 15 Ser Gly Val Cys Met Val Phe Phe Cys Leu 20 25 <210> SEQ ID NO 73 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus distans <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(228) <400> SEQUENCE: 73 atg aaa ctg acg tgc gtg atg acc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gaa gac ccc aga gat gga ttg agg aat ctt 96 Trp Thr Phe Val Thr Ala Glu Asp Pro Arg Asp Gly Leu Arg Asn Leu 20 25 30 tta tcg aat gca cgt cat gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Leu Ser Asn Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac gag agg tgc ctt ggg ttt ggt gaa gct tgt ctt atg ctt tat tca 192 Asn Glu Arg Cys Leu Gly Phe Gly Glu Ala Cys Leu Met Leu Tyr Ser 50 55 60 gac tgc tgc agc tat tgc gtt ggt gct gtc tgc cta taaaactacc 238 Asp Cys Cys Ser Tyr Cys Val Gly Ala Val Cys Leu 65 70 75 gtgatgtctt ctactcccat c 259 <210> SEQ ID NO 74 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus distans <400> SEQUENCE: 74 Met Lys Leu Thr Cys Val Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Glu Asp Pro Arg Asp Gly Leu Arg Asn Leu 20 25 30 Leu Ser Asn Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Glu Arg Cys Leu Gly Phe Gly Glu Ala Cys Leu Met Leu Tyr Ser 50 55 60 Asp Cys Cys Ser Tyr Cys Val Gly Ala Val Cys Leu 65 70 75 <210> SEQ ID NO 75 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus distans <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residues 12 and 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 75 Cys Leu Gly Phe Gly Xaa Ala Cys Leu Met Leu Xaa Ser Asp Cys Cys 1 5 10 15 Ser Xaa Cys Val Gly Ala Val Cys Leu 20 25 <210> SEQ ID NO 76 <211> LENGTH: 262 <212> TYPE: DNA <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(231) <400> SEQUENCE: 76 atg aaa ctg acg tgc ctg atg acc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gcc acg gct gaa gac ccc aga aat gga ttg gag aat ctt 96 Trp Thr Phe Ala Thr Ala Glu Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 ttt tcg aag gca cat cac gaa atg aag aac cct gaa gac tct aaa ttg 144 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Asp Ser Lys Leu 35 40 45 gac aag agg tgc gtt aaa tat ctt gac cct tgt gac atg tta cgc cac 192 Asp Lys Arg Cys Val Lys Tyr Leu Asp Pro Cys Asp Met Leu Arg His 50 55 60 acc tgc tgc ttt ggc ctg tgc gta cta ata gcc tgc atc taaaactgcc 241 Thr Cys Cys Phe Gly Leu Cys Val Leu Ile Ala Cys Ile 65 70 75 gtgatgtctt ctactcccat c 262 <210> SEQ ID NO 77 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <400> SEQUENCE: 77 Met Lys Leu Thr Cys Leu Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Glu Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Asp Ser Lys Leu 35 40 45 Asp Lys Arg Cys Val Lys Tyr Leu Asp Pro Cys Asp Met Leu Arg His 50 55 60 Thr Cys Cys Phe Gly Leu Cys Val Leu Ile Ala Cys Ile 65 70 75 <210> SEQ ID NO 78 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 7 may be Pro or hydroxy-Pro <400> SEQUENCE: 78 Cys Val Lys Xaa Leu Asp Xaa Cys Asp Met Leu Arg His Thr Cys Cys 1 5 10 15 Phe Gly Leu Cys Val Leu Ile Ala Cys Ile 20 25 <210> SEQ ID NO 79 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(228) <400> SEQUENCE: 79 atg aaa ctg acg tgt gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg ggg aat ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 ttt tcg aat gca cat cac gaa atg aag aac ccc gaa gct tct aaa ttg 144 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac gag agg tgc ctt ggg ttt ggt gaa gtt tgc aat ttc ttt ttt cca 192 Asn Glu Arg Cys Leu Gly Phe Gly Glu Val Cys Asn Phe Phe Phe Pro 50 55 60 aac tgc tgc agc tat tgc gtt gct ctt gtc tgc cta taaaactacc 238 Asn Cys Cys Ser Tyr Cys Val Ala Leu Val Cys Leu 65 70 75 gtgatgtctt ctattcccct c 259 <210> SEQ ID NO 80 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <400> SEQUENCE: 80 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Glu Arg Cys Leu Gly Phe Gly Glu Val Cys Asn Phe Phe Phe Pro 50 55 60 Asn Cys Cys Ser Tyr Cys Val Ala Leu Val Cys Leu 65 70 75 <210> SEQ ID NO 81 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro; Xaa at residue 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 81 Cys Leu Gly Phe Gly Xaa Val Cys Asn Phe Phe Phe Xaa Asn Cys Cys 1 5 10 15 Ser Xaa Cys Val Ala Leu Val Cys Leu 20 25 <210> SEQ ID NO 82 <211> LENGTH: 260 <212> TYPE: DNA <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(240) <400> SEQUENCE: 82 atg aaa ctg acg tgc gtg atg ctc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Leu Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gcc acg gct gat gac tcc agc aat gga ctg gag aat ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Ser Ser Asn Gly Leu Glu Asn Leu 20 25 30 ttt tcg aag gca cat cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgc att cca caa ttt gat cct tgt gac atg gta cgt cac 192 Asn Lys Arg Cys Ile Pro Gln Phe Asp Pro Cys Asp Met Val Arg His 50 55 60 act tgc tgc aaa ggg ttg tgc gta cta ata gcc tgc tct aaa act gcg 240 Thr Cys Cys Lys Gly Leu Cys Val Leu Ile Ala Cys Ser Lys Thr Ala 65 70 75 80 tgatgtcttc atctcccctc 260 <210> SEQ ID NO 83 <211> LENGTH: 80 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <400> SEQUENCE: 83 Met Lys Leu Thr Cys Val Met Leu Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Ser Ser Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Ile Pro Gln Phe Asp Pro Cys Asp Met Val Arg His 50 55 60 Thr Cys Cys Lys Gly Leu Cys Val Leu Ile Ala Cys Ser Lys Thr Ala 65 70 75 80 <210> SEQ ID NO 84 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 3 and 7 may be Pro or hydroxy-Pro. <400> SEQUENCE: 84 Cys Ile Xaa Gln Phe Asp Xaa Cys Asp Met Val Arg His Thr Cys Cys 1 5 10 15 Lys Gly Leu Cys Val Leu Ile Ala Cys Ser Lys Thr Ala 20 25 <210> SEQ ID NO 85 <211> LENGTH: 260 <212> TYPE: DNA <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(240) <400> SEQUENCE: 85 atg aaa ctg acg tgc ttg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gcc acg gct gat gac ccc aga aat gga ttg gag aat ttt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Phe 20 25 30 ttt tcg aag aca caa cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Lys Thr Gln His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgc aaa gca gaa agt gaa gct tgt aat ata att aca caa 192 Asn Lys Arg Cys Lys Ala Glu Ser Glu Ala Cys Asn Ile Ile Thr Gln 50 55 60 aac tgc tgc gac ggc aag tgc ctt ttt ttc tgc ata caa att cca gag 240 Asn Cys Cys Asp Gly Lys Cys Leu Phe Phe Cys Ile Gln Ile Pro Glu 65 70 75 80 tgatgtcttc tcctcccatc 260 <210> SEQ ID NO 86 <211> LENGTH: 80 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <400> SEQUENCE: 86 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Phe 20 25 30 Phe Ser Lys Thr Gln His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Lys Ala Glu Ser Glu Ala Cys Asn Ile Ile Thr Gln 50 55 60 Asn Cys Cys Asp Gly Lys Cys Leu Phe Phe Cys Ile Gln Ile Pro Glu 65 70 75 80 <210> SEQ ID NO 87 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 4, 6 and 29 may be Glu or gamma-carboxy-Glu; Xaa at residue 28 may be Pro or hydroxy-Pro <400> SEQUENCE: 87 Cys Lys Ala Xaa Ser Xaa Ala Cys Asn Ile Ile Thr Gln Asn Cys Cys 1 5 10 15 Asp Gly Lys Cys Leu Phe Phe Cys Ile Gln Ile Xaa Xaa 20 25 <210> SEQ ID NO 88 <211> LENGTH: 632 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (110)..(199) <400> SEQUENCE: 88 ggtcgacatc atcatcatca tcgatccatc tgtccatcca tccattcatt cattcgctgc 60 cagactgtca taaatattcg agtctctcct tctgtttgta tctgacaga ttg aac aag 118 Leu Asn Lys 1 agg tgc att gac ggt ggt gaa att tgt gat att ttt ttt cca aac tgc 166 Arg Cys Ile Asp Gly Gly Glu Ile Cys Asp Ile Phe Phe Pro Asn Cys 5 10 15 tgc agt ggg tgg tgc att att ctc gtc tgc gca tgaaactacc gtgatgtctt 219 Cys Ser Gly Trp Cys Ile Ile Leu Val Cys Ala 20 25 30 ctactcccct ctagtagtag taggcggccg ctctagagga tccaagctta cgtacgcgtg 279 catgcgacgt catagctctt ctatagtgtc acctaaattc aattcactgg ccgtcgtttt 339 acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc 399 ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt ccaacagttt 459 gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt 519 ggtgggtacg cgcagcgtga ccggtacact tgccagcgcc ctagcgcccg ctccttttgc 579 tttcttccct tcctttctcg ccaccgttcg cccggggttt tcccgtcaag ctc 632 <210> SEQ ID NO 89 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 89 Leu Asn Lys Arg Cys Ile Asp Gly Gly Glu Ile Cys Asp Ile Phe Phe 1 5 10 15 Pro Asn Cys Cys Ser Gly Trp Cys Ile Ile Leu Val Cys Ala 20 25 30 <210> SEQ ID NO 90 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro; Xaa at residue 19 mo-Trp <400> SEQUENCE: 90 Cys Ile Asp Gly Gly Xaa Ile Cys Asp Ile Phe Phe Xaa Asn Cys Cys 1 5 10 15 Ser Gly Xaa Cys Ile Ile Leu Val Cys Ala 20 25 <210> SEQ ID NO 91 <211> LENGTH: 650 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (107)..(196) <400> SEQUENCE: 91 ggtcgacatc atcatcatcg atccatctgt ccatccatcc attcattcat tcgctgccag 60 actgtcataa atattcgagt ctctccttct gtttgtatct gacaga ttg aac aag 115 Leu Asn Lys 1 agg tgc ctt gac ggt ggt gaa att tgt ggt att ttg ttt cca agc tgc 163 Arg Cys Leu Asp Gly Gly Glu Ile Cys Gly Ile Leu Phe Pro Ser Cys 5 10 15 tgc agt ggg tgg tgc att gtt ctc gtc tgc gca tgaaactacc gtgatgtctt 216 Cys Ser Gly Trp Cys Ile Val Leu Val Cys Ala 20 25 30 ctactcccct ctagtagtag taggcggccg ctctagagga tccaagctta cgtacgcgtg 276 catgcgacgt catagctctt ctatagtgtc acctaaattc aattcactgg ccgtcgtttt 336 acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc 396 ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacaagt 456 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 516 tggtggttac gcgcaccgtg accgctacac ttgccagcgc cctagccgcc cgctcctttc 576 gctttcttcc cttcctttct cgcacgttcg gccggctttc cccgtcaagc tctaaatcgg 636 gggcttccct ttta 650 <210> SEQ ID NO 92 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 92 Leu Asn Lys Arg Cys Leu Asp Gly Gly Glu Ile Cys Gly Ile Leu Phe 1 5 10 15 Pro Ser Cys Cys Ser Gly Trp Cys Ile Val Leu Val Cys Ala 20 25 30 <210> SEQ ID NO 93 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro; Xaa at residue 19 may be Trp or bromo-Trp <400> SEQUENCE: 93 Cys Leu Asp Gly Gly Xaa Ile Cys Gly Ile Leu Phe Xaa Ser Cys Cys 1 5 10 15 Ser Gly Xaa Cys Ile Val Leu Val Cys Ala 20 25 <210> SEQ ID NO 94 <211> LENGTH: 618 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (107)..(193) <400> SEQUENCE: 94 ggtcgacatc atcatcatcg atccatctgt ccatccatcc atccattcat tcgctgccag 60 actgtaataa atattcgagt ctctctttct gtttgtatct gacaga ttg aac aag 115 Leu Asn Lys 1 agg tgc ctt gag ttt ggt gaa gtt tgt aat ttt ttt ttc cca acc tgc 163 Arg Cys Leu Glu Phe Gly Glu Val Cys Asn Phe Phe Phe Pro Thr Cys 5 10 15 tgc ggc tat tgc gtt ctt ctt gtc tgc cta taaaactacc gtgatgtctt 213 Cys Gly Tyr Cys Val Leu Leu Val Cys Leu 20 25 ctactcccct ctagtagtag taggcggccg ctctagagga tccaagctta cgtacgcgtg 273 catgcgacgt catagctctt ctatagtgtc acctaaattc aattcactgg ccgtcgtttt 333 acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc 393 ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt 453 gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt 513 ggtggttacg cgcagcgtga ccgctacact tgcagcgccc tagcgcccgc tcctttcgct 573 ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaa 618 <210> SEQ ID NO 95 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 95 Leu Asn Lys Arg Cys Leu Glu Phe Gly Glu Val Cys Asn Phe Phe Phe 1 5 10 15 Pro Thr Cys Cys Gly Tyr Cys Val Leu Leu Val Cys Leu 20 25 <210> SEQ ID NO 96 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residues 3 and 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro; Xaa at residue 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 96 Cys Leu Xaa Phe Gly Xaa Val Cys Asn Phe Phe Phe Xaa Thr Cys Cys 1 5 10 15 Gly Xaa Cys Val Leu Leu Val Cys Leu 20 25 <210> SEQ ID NO 97 <211> LENGTH: 444 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (150)..(236) <400> SEQUENCE: 97 gaaagctggt acgcctgcag gtaccggtcc ggaattcccg ggtcgacatc atcatcatca 60 tcgatccatc tgtccatcca tccattcatt cattcgctgc cagactgtaa taaatattcg 120 agtttctcct tctgtttgta tctgacagg ttg aac aag agg tgc caa gag ttc 173 Leu Asn Lys Arg Cys Gln Glu Phe 1 5 ggt gaa gtt tgt aat ttt ttt ttc cca gac tgc tgc ggc tat tgc gtt 221 Gly Glu Val Cys Asn Phe Phe Phe Pro Asp Cys Cys Gly Tyr Cys Val 10 15 20 ctt tta ctc tgc ata taaaactacc gtgatgtctt ctcttcccat ctagtagtag 276 Leu Leu Leu Cys Ile 25 tagtagtagt aggcggccgc tctagaggat ccaagcttac gtacgcgtgc atgcgacgtc 336 atagctcttc tatagtgtca cctaaattca attcactggc cgtcgtttta caaccgtcgt 396 gactgggaaa accctggcgt tcccaactta attcgccttg cagcacat 444 <210> SEQ ID NO 98 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 98 Leu Asn Lys Arg Cys Gln Glu Phe Gly Glu Val Cys Asn Phe Phe Phe 1 5 10 15 Pro Asp Cys Cys Gly Tyr Cys Val Leu Leu Leu Cys Ile 20 25 <210> SEQ ID NO 99 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residues 3 and 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro; Xaa at residue 18may be Tyr,125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 99 Cys Gln Xaa Phe Gly Xaa Val Cys Asn Phe Phe Phe Xaa Asp Cys Cys 1 5 10 15 Gly Xaa Cys Val Leu Leu Leu Cys Ile 20 25 <210> SEQ ID NO 100 <211> LENGTH: 545 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (153)..(242) <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(545) <223> OTHER INFORMATION: n may be any nucleotide <400> SEQUENCE: 100 ttttgaagcn ggtacgcctg caggtaccgg tccggaattc ccgggtcgac atcatcatca 60 tcatcgatcc atctgtccat ccatccattc attcattcgc taccagactg taataaatat 120 tcgggtctct ctttctgttt gtatctgaca ga ttg gac aag agg tgc att cca 173 Leu Asp Lys Arg Cys Ile Pro 1 5 cat ttt gac cct tgt gac ccg ata cgc cac acc tgc tgc ttt ggc ctg 221 His Phe Asp Pro Cys Asp Pro Ile Arg His Thr Cys Cys Phe Gly Leu 10 15 20 tgc cta cta ata gcc tgc atc taaaactgcc gtgatgtctt ctcctcccct 272 Cys Leu Leu Ile Ala Cys Ile 25 30 ctagtagtag taggcggccg ctctagagga tccaagctta cgtacgcgtg catgcgacgt 332 catagctctt ctatagtgtc acctaaattc aattcactgg ccgtcgtttt acaacgtcgt 392 gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc 452 agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg 512 aatggcgaat gggacgcgcc ctgtagcggc gct 545 <210> SEQ ID NO 101 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 101 Leu Asp Lys Arg Cys Ile Pro His Phe Asp Pro Cys Asp Pro Ile Arg 1 5 10 15 His Thr Cys Cys Phe Gly Leu Cys Leu Leu Ile Ala Cys Ile 20 25 30 <210> SEQ ID NO 102 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3, 7 and 10 may be Pro or hydroxy-Pro. <400> SEQUENCE: 102 Cys Ile Xaa His Phe Asp Xaa Cys Asp Xaa Ile Arg His Thr Cys Cys 1 5 10 15 Phe Gly Leu Cys Leu Leu Ile Ala Cys Ile 20 25 <210> SEQ ID NO 103 <211> LENGTH: 534 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (140)..(226) <400> SEQUENCE: 103 ggtacgcctg caggtaccgg tccggaattc ccgggtcgac atcatcatca tcgatccatc 60 tgtccatcca tccattcttt catttgctgc cagactgtaa taaatattcg agtctctctt 120 tctgtttgta tctgacaga ttg aac aag agg tgc ctt gag ttt ggt gaa gtt 172 Leu Asn Lys Arg Cys Leu Glu Phe Gly Glu Val 1 5 10 tgt aat ttt ttt ttc cca acc tgc tgc ggc tat tgc gtt ctt ctt gtc 220 Cys Asn Phe Phe Phe Pro Thr Cys Cys Gly Tyr Cys Val Leu Leu Val 15 20 25 tgc cta taaaactacc gtgatgtctt ctcttcccct ctagtagtag taggcggccg 276 Cys Leu ctctagagga tccaagctta cgtacgcgtg catgcgacgt catagctctt ctatagtgtc 336 acctaaattc aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt 396 tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga 456 ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc 516 ctgtagcggc gcattaag 534 <210> SEQ ID NO 104 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 104 Leu Asn Lys Arg Cys Leu Glu Phe Gly Glu Val Cys Asn Phe Phe Phe 1 5 10 15 Pro Thr Cys Cys Gly Tyr Cys Val Leu Leu Val Cys Leu 20 25 <210> SEQ ID NO 105 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residues 3 and 6 may be Glu or gamma-carboxy-Glu; Xaa at residue13 may be Pro or hydroxy-Pro; Xaa at residue 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 105 Cys Leu Xaa Phe Gly Xaa Val Cys Asn Phe Phe Phe Xaa Thr Cys Cys 1 5 10 15 Gly Xaa Cys Val Leu Leu Val Cys Leu 20 25 <210> SEQ ID NO 106 <211> LENGTH: 200 <212> TYPE: DNA <213> ORGANISM: Conus obscurus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (73)..(180) <400> SEQUENCE: 106 cgatccatct gtccatccat ccattcgttc gttcgctgcc aaactgtaat aaataaccga 60 gtctctctgt tt gta tct gac aga tcg aaa aag caa tgc cgt caa aat ggt 111 Val Ser Asp Arg Ser Lys Lys Gln Cys Arg Gln Asn Gly 1 5 10 gaa gtg tgt gat gcg aat ttg gca cac tgc tgc agt ggc ccg tgt ttt 159 Glu Val Cys Asp Ala Asn Leu Ala His Cys Cys Ser Gly Pro Cys Phe 15 20 25 ctc ttc tgt cta aac cag ccg tgatgtcttc tactcccctc 200 Leu Phe Cys Leu Asn Gln Pro 30 35 <210> SEQ ID NO 107 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Conus obscurus <400> SEQUENCE: 107 Val Ser Asp Arg Ser Lys Lys Gln Cys Arg Gln Asn Gly Glu Val Cys 1 5 10 15 Asp Ala Asn Leu Ala His Cys Cys Ser Gly Pro Cys Phe Leu Phe Cys 20 25 30 Leu Asn Gln Pro 35 <210> SEQ ID NO 108 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus obscurus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(32) <223> OTHER INFORMATION: Xaa at residue 10 may be Glu or gamma-carboxy-Glu; Xaa at residues 23 and 32 may be Pro or hydroxy-Pro <400> SEQUENCE: 108 Ser Lys Lys Gln Cys Arg Gln Asn Gly Xaa Val Cys Asp Ala Asn Leu 1 5 10 15 Ala His Cys Cys Ser Gly Xaa Cys Phe Leu Phe Cys Leu Asn Gln Xaa 20 25 30 <210> SEQ ID NO 109 <211> LENGTH: 262 <212> TYPE: DNA <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(231) <400> SEQUENCE: 109 atg aaa ctg acg tgc gtg atg atc att gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gcc acg gct gat gac tcc gga aat gga ttg gaa aat ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Ser Gly Asn Gly Leu Glu Asn Leu 20 25 30 ttt tcg aag gca cat cac gaa atg aag aac ccc aaa gcc tct aaa ttg 144 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Lys Ala Ser Lys Leu 35 40 45 aac aag agg tgc act caa agc ggt gaa ctt tgt gat gtg ata gac cca 192 Asn Lys Arg Cys Thr Gln Ser Gly Glu Leu Cys Asp Val Ile Asp Pro 50 55 60 gac tgc tgc aat aat ttt tgc att ata ttt ttc tgc ata taaaactgcc 241 Asp Cys Cys Asn Asn Phe Cys Ile Ile Phe Phe Cys Ile 65 70 75 gtgatgtctt ctactcccct c 262 <210> SEQ ID NO 110 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 110 Met Lys Leu Thr Cys Val Met Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Ser Gly Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Lys Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Thr Gln Ser Gly Glu Leu Cys Asp Val Ile Asp Pro 50 55 60 Asp Cys Cys Asn Asn Phe Cys Ile Ile Phe Phe Cys Ile 65 70 75 <210> SEQ ID NO 111 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro <400> SEQUENCE: 111 Cys Thr Gln Ser Gly Xaa Leu Cys Asp Val Ile Asp Xaa Asp Cys Cys 1 5 10 15 Asn Asn Phe Cys Ile Ile Phe Phe Cys Ile 20 25 <210> SEQ ID NO 112 <211> LENGTH: 286 <212> TYPE: DNA <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (25)..(255) <400> SEQUENCE: 112 ggcattacct aaaacatcac caaa atg aaa ctg acg tgc atg atg atc gtt 51 Met Lys Leu Thr Cys Met Met Ile Val 1 5 gct gtg ctg ttc ttg acc gcc tgg aca ttc gcc acg gct gat gac tcc 99 Ala Val Leu Phe Leu Thr Ala Trp Thr Phe Ala Thr Ala Asp Asp Ser 10 15 20 25 gga aat gga ttg gag aaa ctt ttt tcg aat gca cat cac gaa atg aag 147 Gly Asn Gly Leu Glu Lys Leu Phe Ser Asn Ala His His Glu Met Lys 30 35 40 aac ccc gaa gcc tct aat ttg aac aag agg tgc gct cct ttt ctt cac 195 Asn Pro Glu Ala Ser Asn Leu Asn Lys Arg Cys Ala Pro Phe Leu His 45 50 55 ctt tgt acc ttt ttc ttc cca aac tgc tgc aac ggc tat tgc gtt caa 243 Leu Cys Thr Phe Phe Phe Pro Asn Cys Cys Asn Gly Tyr Cys Val Gln 60 65 70 ttt atc tgc cta taaaactact gtgatgtctt ctattcccct c 286 Phe Ile Cys Leu 75 <210> SEQ ID NO 113 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 113 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Ser Gly Asn Gly Leu Glu Lys Leu 20 25 30 Phe Ser Asn Ala His His Glu Met Lys Asn Pro Glu Ala Ser Asn Leu 35 40 45 Asn Lys Arg Cys Ala Pro Phe Leu His Leu Cys Thr Phe Phe Phe Pro 50 55 60 Asn Cys Cys Asn Gly Tyr Cys Val Gln Phe Ile Cys Leu 65 70 75 <210> SEQ ID NO 114 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3 and 13 may be Pro or hydroxy-Pro; Xaa at residue 19 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 114 Cys Ala Xaa Phe Leu His Leu Cys Thr Phe Phe Phe Xaa Asn Cys Cys 1 5 10 15 Asn Gly Xaa Cys Val Gln Phe Ile Cys Leu 20 25 <210> SEQ ID NO 115 <211> LENGTH: 484 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (74)..(304) <400> SEQUENCE: 115 ggatcctagc acagtgaatt tggcttcaca gttttccact gtcgtctttg gcatcatcca 60 aacatcacc aag atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg 109 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu 1 5 10 ttc ttg acc gcc tgg aca ttt gcc acg gct gat gac ccc aga aat gga 157 Phe Leu Thr Ala Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly 15 20 25 ttg gag aat ctt ttt tcg aag gca cat cac gaa atg aag aac ccc aaa 205 Leu Glu Asn Leu Phe Ser Lys Ala His His Glu Met Lys Asn Pro Lys 30 35 40 gac tct aaa ttg aac aag agg tgc ctt gac gct ggt gaa atg tgt gat 253 Asp Ser Lys Leu Asn Lys Arg Cys Leu Asp Ala Gly Glu Met Cys Asp 45 50 55 60 ctt ttt aat tca aaa tgc tgc agt ggg tgg tgc att att ctc ttc tgc 301 Leu Phe Asn Ser Lys Cys Cys Ser Gly Trp Cys Ile Ile Leu Phe Cys 65 70 75 gca taaaactacc gtgatgtctt ctactcccct ctgtgctacc tggcttgatc 354 Ala tttgattggc gcgtgccctt cactggttat gaacccccct gatccgactc tctggcggcc 414 tcgggggttc aacatccaaa taaagccgac acgatactga cgtagaaaaa aaaaaaaaaa 474 aaaaaaaaaa 484 <210> SEQ ID NO 116 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 116 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Lys Asp Ser Lys Leu 35 40 45 Asn Lys Arg Cys Leu Asp Ala Gly Glu Met Cys Asp Leu Phe Asn Ser 50 55 60 Lys Cys Cys Ser Gly Trp Cys Ile Ile Leu Phe Cys Ala 65 70 75 <210> SEQ ID NO 117 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 19 may be Trp or bromo-Trp <400> SEQUENCE: 117 Cys Leu Asp Ala Gly Xaa Met Cys Asp Leu Phe Asn Ser Lys Cys Cys 1 5 10 15 Ser Gly Xaa Cys Ile Ile Leu Phe Cys Ala 20 25 <210> SEQ ID NO 118 <211> LENGTH: 427 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (19)..(249) <400> SEQUENCE: 118 gccgaaaaca tcaccaag atg aaa ctg acg agc atg atg atc gtt gct gtg 51 Met Lys Leu Thr Ser Met Met Ile Val Ala Val 1 5 10 ctg ttc ttg acc gcc tgg aca ttc gtc acg gct gac gac tcc gga aat 99 Leu Phe Leu Thr Ala Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn 15 20 25 gga ttg gag aat ctt ttt tcg aag gca cat cac gag atg aag aac ccc 147 Gly Leu Glu Asn Leu Phe Ser Lys Ala His His Glu Met Lys Asn Pro 30 35 40 aaa gac tct aaa ttg aac aag agg tgc ctt gac ggt ggt gaa att tgt 195 Lys Asp Ser Lys Leu Asn Lys Arg Cys Leu Asp Gly Gly Glu Ile Cys 45 50 55 ggt att ttg ttt cca agc tgc tgc agt ggg tgg tgc att gtt ctc gtc 243 Gly Ile Leu Phe Pro Ser Cys Cys Ser Gly Trp Cys Ile Val Leu Val 60 65 70 75 tgc gca tgaaactacc gtgatgtctt ctactcccct ctgtgctacc tggcttgatc 299 Cys Ala tttgattggc gcgtgccctt cactggttat gaacccccct gatccgactc tctggcggcc 359 tcgggggttc aacatccaaa taaagcgaca cgacaatgac aaaaaaaaaa aaaaaaaaaa 419 aaaaaaaa 427 <210> SEQ ID NO 119 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 119 Met Lys Leu Thr Ser Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Gly Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Lys Asp Ser Lys Leu 35 40 45 Asn Lys Arg Cys Leu Asp Gly Gly Glu Ile Cys Gly Ile Leu Phe Pro 50 55 60 Ser Cys Cys Ser Gly Trp Cys Ile Val Leu Val Cys Ala 65 70 75 <210> SEQ ID NO 120 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 13 may be Pro or hydroxy-Pro; Xaa at residue 19 may be Trp or bromo-Trp <400> SEQUENCE: 120 Cys Leu Asp Gly Gly Xaa Ile Cys Gly Ile Leu Phe Xaa Ser Cys Cys 1 5 10 15 Ser Gly Xaa Cys Ile Val Leu Val Cys Ala 20 25 <210> SEQ ID NO 121 <211> LENGTH: 470 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (70)..(303) <400> SEQUENCE: 121 gctagcacag tgaatttggc ttcacagttt tccactgtcg tctttggcat catccaaaac 60 atcaccaag atg aaa ctg acg tgc atg atg atc gaa gca gag ctg ttc ttg 111 Met Lys Leu Thr Cys Met Met Ile Glu Ala Glu Leu Phe Leu 1 5 10 acc gcc tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg gag 159 Thr Ala Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu 15 20 25 30 aat ctt ttt tcg aag gca cat cac gaa atg aag aac ccc gaa gcc tct 207 Asn Leu Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser 35 40 45 aaa ttg aac aag agg tgc cct aac act ggt gaa tta tgt gat gtg gtt 255 Lys Leu Asn Lys Arg Cys Pro Asn Thr Gly Glu Leu Cys Asp Val Val 50 55 60 gaa caa aac tgc tgc tat acc tat tgc ttt att gta gtc tgc cct ata 303 Glu Gln Asn Cys Cys Tyr Thr Tyr Cys Phe Ile Val Val Cys Pro Ile 65 70 75 taactaccgt gatgtcttct actcccctct gtgctgcctg gcttgatctt tgattggcgc 363 gtgcccttca ctggttatga acccccctga tccgactctc ttgcggcctc aggggttcaa 423 catccaaata aagcgacacg aaaatgaaaa aaaaaaaaaa aaaaaaa 470 <210> SEQ ID NO 122 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 122 Met Lys Leu Thr Cys Met Met Ile Glu Ala Glu Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Pro Asn Thr Gly Glu Leu Cys Asp Val Val Glu Gln 50 55 60 Asn Cys Cys Tyr Thr Tyr Cys Phe Ile Val Val Cys Pro Ile 65 70 75 <210> SEQ ID NO 123 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residues 2 and 26 may be Pro or hydroxy-Pro; Xaa at residues 6 and 12 may be Glu or gamma-carboxy-Glu; Xaa at residues 17 and 19 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 123 Cys Xaa Asn Thr Gly Xaa Leu Cys Asp Val Val Xaa Gln Asn Cys Cys 1 5 10 15 Xaa Thr Xaa Cys Phe Ile Val Val Cys Xaa Ile 20 25 <210> SEQ ID NO 124 <211> LENGTH: 470 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (67)..(312) <400> SEQUENCE: 124 ttgcacggtg aatttcgctt atatttttct actgtcgtct ttggcatcat ccaaaacatc 60 accaag atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg 108 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc acg gct gtg cct cac tcc agc gat gta ttg 156 Thr Ala Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asp Val Leu 15 20 25 30 gag aat ctt tat ctg aag gca ctt cac gaa acg gaa aac cac gaa gcc 204 Glu Asn Leu Tyr Leu Lys Ala Leu His Glu Thr Glu Asn His Glu Ala 35 40 45 tct aaa ttg aac gtg aga gac gac gag tgc gaa cct cct gga gat ttt 252 Ser Lys Leu Asn Val Arg Asp Asp Glu Cys Glu Pro Pro Gly Asp Phe 50 55 60 tgt ggc ttt ttt aaa att ggg ccg cct tgc tgc agt ggc tgg tgc ttc 300 Cys Gly Phe Phe Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe 65 70 75 ctc tgg tgc gcc taaaactgcc gtgatgtctt ctattcccct ctgtgctacc 352 Leu Trp Cys Ala 80 tggcttgatc tttgattggc gcgtgccctt cagtggttat gaacccccct gatccgactc 412 tctgggggcc tcgggggttc aacatccaaa taaagctgac aacacaataa aaaaaaaa 470 <210> SEQ ID NO 125 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 125 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asp Val Leu Glu Asn 20 25 30 Leu Tyr Leu Lys Ala Leu His Glu Thr Glu Asn His Glu Ala Ser Lys 35 40 45 Leu Asn Val Arg Asp Asp Glu Cys Glu Pro Pro Gly Asp Phe Cys Gly 50 55 60 Phe Phe Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Leu Trp 65 70 75 80 Cys Ala <210> SEQ ID NO 126 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residues 3 and 5 may be Glu or gamma-carboxy-Glu; Xaa at residues 6, 7, 18 and 19 may be Pro or hydroxy-Pro; Xaa at residues 24 and 28 may be Trp or bromo-Trp <400> SEQUENCE: 126 Asp Asp Xaa Cys Xaa Xaa Xaa Gly Asp Phe Cys Gly Phe Phe Lys Ile 1 5 10 15 Gly Xaa Xaa Cys Cys Ser Gly Xaa Cys Phe Leu Xaa Cys Ala 20 25 30 <210> SEQ ID NO 127 <211> LENGTH: 277 <212> TYPE: DNA <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 127 atg aaa ctg acg tgt gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gtg cct cac tcc agc gat gca ttg gag aat 96 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asp Ala Leu Glu Asn 20 25 30 ctt tat ctg aag gca ctt cac gaa acg gaa aac cac gaa gcc tct aaa 144 Leu Tyr Leu Lys Ala Leu His Glu Thr Glu Asn His Glu Ala Ser Lys 35 40 45 ttg aac gtg aga gac gac gag tgc gaa cct cct gga gat ttt tgt ggc 192 Leu Asn Val Arg Asp Asp Glu Cys Glu Pro Pro Gly Asp Phe Cys Gly 50 55 60 ttt ttt aaa att ggg ccg cct tgc tgc agt ggc tgg tgc ttc ctc tgg 240 Phe Phe Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Leu Trp 65 70 75 80 tgc gca taaaactgcc gtgatgtctt ctcctcccct c 277 Cys Ala <210> SEQ ID NO 128 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 128 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asp Ala Leu Glu Asn 20 25 30 Leu Tyr Leu Lys Ala Leu His Glu Thr Glu Asn His Glu Ala Ser Lys 35 40 45 Leu Asn Val Arg Asp Asp Glu Cys Glu Pro Pro Gly Asp Phe Cys Gly 50 55 60 Phe Phe Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Leu Trp 65 70 75 80 Cys Ala <210> SEQ ID NO 129 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residues 3 and 5 may be Glu or gamma-carboxy-Glu; Xaa at residues 6, 7, 18 and 19 may be Pro or hydroxy-Pro; Xaa at residues 24 and 28 may be Trp or bromo-Trp <400> SEQUENCE: 129 Asp Asp Xaa Cys Xaa Xaa Xaa Gly Asp Phe Cys Gly Phe Phe Lys Ile 1 5 10 15 Gly Xaa Xaa Cys Cys Ser Gly Xaa Cys Phe Leu Xaa Cys Ala 20 25 30 <210> SEQ ID NO 130 <211> LENGTH: 277 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 130 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gtg cct cac tcc agc aat gca ttg gaa aat 96 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asn Ala Leu Glu Asn 20 25 30 ctt tat ctg aag gca cgt cac gaa atg gaa aac ccc gaa gcc tct aaa 144 Leu Tyr Leu Lys Ala Arg His Glu Met Glu Asn Pro Glu Ala Ser Lys 35 40 45 ttg aac acg aga gac gac gat tgc gaa cct cct gga aat ttt tgt ggc 192 Leu Asn Thr Arg Asp Asp Asp Cys Glu Pro Pro Gly Asn Phe Cys Gly 50 55 60 atg ata aaa att ggg ccg cct tgc tgc agt ggc tgg tgc ttt ttc gcc 240 Met Ile Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Phe Ala 65 70 75 80 tgc gcc taaaactgcc gtgatgtctt ctcctcccct c 277 Cys Ala <210> SEQ ID NO 131 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 131 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asn Ala Leu Glu Asn 20 25 30 Leu Tyr Leu Lys Ala Arg His Glu Met Glu Asn Pro Glu Ala Ser Lys 35 40 45 Leu Asn Thr Arg Asp Asp Asp Cys Glu Pro Pro Gly Asn Phe Cys Gly 50 55 60 Met Ile Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Phe Ala 65 70 75 80 Cys Ala <210> SEQ ID NO 132 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residue 5 may be Glu or gamma-carboxy-Glu; Xaa at residues 6, 7, 18 and 19 may be Pro or hydroxy-Pro; Xaa at residue 24 maybe Trp or bromo-Trp <400> SEQUENCE: 132 Asp Asp Asp Cys Xaa Xaa Xaa Gly Asn Phe Cys Gly Met Ile Lys Ile 1 5 10 15 Gly Xaa Xaa Cys Cys Ser Gly Xaa Cys Phe Phe Ala Cys Ala 20 25 30 <210> SEQ ID NO 133 <211> LENGTH: 277 <212> TYPE: DNA <213> ORGANISM: Conus aulicus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 133 atg aaa ctg acg tgc ctg atg ata gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gtg cct cac tcc agc aat gca ttg gag aat 96 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asn Ala Leu Glu Asn 20 25 30 ctt tat ctg aag gca cgt cac gaa atg gaa aac ccc gaa gcc tct aaa 144 Leu Tyr Leu Lys Ala Arg His Glu Met Glu Asn Pro Glu Ala Ser Lys 35 40 45 ttg aac acg aga gac tac gat tgc gaa cct cct gga aat ttt tgt ggc 192 Leu Asn Thr Arg Asp Tyr Asp Cys Glu Pro Pro Gly Asn Phe Cys Gly 50 55 60 atg ata aaa att ggg ccg cct tgc tgc agt ggc tgg tgc ttt ttc gcc 240 Met Ile Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Phe Ala 65 70 75 80 tgc gcc taaaactgcc gtgatgtctt ctcctcccct c 277 Cys Ala <210> SEQ ID NO 134 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <400> SEQUENCE: 134 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asn Ala Leu Glu Asn 20 25 30 Leu Tyr Leu Lys Ala Arg His Glu Met Glu Asn Pro Glu Ala Ser Lys 35 40 45 Leu Asn Thr Arg Asp Tyr Asp Cys Glu Pro Pro Gly Asn Phe Cys Gly 50 55 60 Met Ile Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Phe Ala 65 70 75 80 Cys Ala <210> SEQ ID NO 135 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residue 2 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 5 may be Glu or gamma-carboxy-Glu; Xaa at residues 6, 7, 18 and 19 may be Pro or hydroxy-Pro; Xaa at residue 24 may be Trp or bromo-Trp <400> SEQUENCE: 135 Asp Xaa Asp Cys Xaa Xaa Xaa Gly Asn Phe Cys Gly Met Ile Lys Ile 1 5 10 15 Gly Xaa Xaa Cys Cys Ser Gly Xaa Cys Phe Phe Ala Cys Ala 20 25 30 <210> SEQ ID NO 136 <211> LENGTH: 685 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (111)..(212) <400> SEQUENCE: 136 ggtcgacatc atcatcatca tcgatccatc tgtccatcca tctattcatt cattcgtggc 60 caaactgtaa taaataatgc aagtctctct ttctgtttgt atctgacaga ttg aac 116 Leu Asn 1 acg aga gac gac gat tgc gaa cct cct gga aat ttt tgt ggc atg ata 164 Thr Arg Asp Asp Asp Cys Glu Pro Pro Gly Asn Phe Cys Gly Met Ile 5 10 15 aaa att ggg ccg cct tgc tgc agt ggc tgg tgc ttt ttc gcc tgc gcc 212 Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Phe Ala Cys Ala 20 25 30 taaaactgcc gtgatgtctt ctcttcccct ctagtagtag taggcggccg ctctagagga 272 tccaagctta cgtacgcgtg catgcgacgt catagctctt ctatagtgtc acctaaattc 332 aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt 392 aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc 452 gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc 512 gcattaagcg cggcgggtgt ggtggttacg ccgcagccgt gacccgctac acttgccagc 572 gccctagcgc ccgctccttt cgctttcttc cttcctttct cgccacgttc gccggctttt 632 cccgtcaagc tctaaatcgg gggctccttt agggtccgat ttaagtgctt tac 685 <210> SEQ ID NO 137 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 137 Leu Asn Thr Arg Asp Asp Asp Cys Glu Pro Pro Gly Asn Phe Cys Gly 1 5 10 15 Met Ile Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Phe Ala 20 25 30 Cys Ala <210> SEQ ID NO 138 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residue 5 may be Glu or gamma-carboxy-Glu; Xaa at residues 6, 7, 18 and 19 may be Pro or hydroxy-Pro; Xaa at residue 24 maybe Trp or bromo-Trp <400> SEQUENCE: 138 Asp Asp Asp Cys Xaa Xaa Xaa Gly Asn Phe Cys Gly Met Ile Lys Ile 1 5 10 15 Gly Xaa Xaa Cys Cys Ser Gly Xaa Cys Phe Phe Ala Cys Ala 20 25 30 <210> SEQ ID NO 139 <211> LENGTH: 126 <212> TYPE: DNA <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(96) <400> SEQUENCE: 139 ttg aac cag aga gac tgc ctt agt aaa aac gct ttc tgt gcc tgg ccg 48 Leu Asn Gln Arg Asp Cys Leu Ser Lys Asn Ala Phe Cys Ala Trp Pro 1 5 10 15 ata ctt gga cca ctg tgc tgc agt ggc tgg tgc tta tac gtc tgc atg 96 Ile Leu Gly Pro Leu Cys Cys Ser Gly Trp Cys Leu Tyr Val Cys Met 20 25 30 taaaactgcc gtgatgtctt ctatcccctc 126 <210> SEQ ID NO 140 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus regius <400> SEQUENCE: 140 Leu Asn Gln Arg Asp Cys Leu Ser Lys Asn Ala Phe Cys Ala Trp Pro 1 5 10 15 Ile Leu Gly Pro Leu Cys Cys Ser Gly Trp Cys Leu Tyr Val Cys Met 20 25 30 <210> SEQ ID NO 141 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Xaa at residues 11 and 22 may be Trp or bromo-Trp; Xaa at residues 12 and 16 may be Pro or hydroxy-Pro; Xaa at residue 25 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phos pho-Tyr <400> SEQUENCE: 141 Asp Cys Leu Ser Lys Asn Ala Phe Cys Ala Xaa Xaa Ile Leu Gly Xaa 1 5 10 15 Leu Cys Cys Ser Gly Xaa Cys Leu Xaa Val Cys Met 20 25 <210> SEQ ID NO 142 <211> LENGTH: 133 <212> TYPE: DNA <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (2)..(103) <400> SEQUENCE: 142 a ttg aac aag aaa ggt gat gac tgc ctt gct gtt aaa aaa aat tgt ggc 49 Leu Asn Lys Lys Gly Asp Asp Cys Leu Ala Val Lys Lys Asn Cys Gly 1 5 10 15 ttt cca aaa ctt gga ggg cca tgc tgc agt ggc ttg tgc ttt ttc gtc 97 Phe Pro Lys Leu Gly Gly Pro Cys Cys Ser Gly Leu Cys Phe Phe Val 20 25 30 tgc gcc taaaactgcc gtgatgtctt ctcctcccct 133 Cys Ala <210> SEQ ID NO 143 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 143 Leu Asn Lys Lys Gly Asp Asp Cys Leu Ala Val Lys Lys Asn Cys Gly 1 5 10 15 Phe Pro Lys Leu Gly Gly Pro Cys Cys Ser Gly Leu Cys Phe Phe Val 20 25 30 Cys Ala <210> SEQ ID NO 144 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residues 14 and 19 may be Pro or hydroxy-Pro. <400> SEQUENCE: 144 Gly Asp Asp Cys Leu Ala Val Lys Lys Asn Cys Gly Phe Xaa Lys Leu 1 5 10 15 Gly Gly Xaa Cys Cys Ser Gly Leu Cys Phe Phe Val Cys Ala 20 25 30 <210> SEQ ID NO 145 <211> LENGTH: 127 <212> TYPE: DNA <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(96) <400> SEQUENCE: 145 ttg aat cag agc gac tgc ctt cct aga gac aca ttc tgt gcc ttg ccg 48 Leu Asn Gln Ser Asp Cys Leu Pro Arg Asp Thr Phe Cys Ala Leu Pro 1 5 10 15 caa ctt gga cta ctg tgc tgc agt ggc cgg tgc tta ctc ttc tgc gtg 96 Gln Leu Gly Leu Leu Cys Cys Ser Gly Arg Cys Leu Leu Phe Cys Val 20 25 30 taaaactgcc gtgatgtctt ctcctcccct c 127 <210> SEQ ID NO 146 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus regius <400> SEQUENCE: 146 Leu Asn Gln Ser Asp Cys Leu Pro Arg Asp Thr Phe Cys Ala Leu Pro 1 5 10 15 Gln Leu Gly Leu Leu Cys Cys Ser Gly Arg Cys Leu Leu Phe Cys Val 20 25 30 <210> SEQ ID NO 147 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Xaa at residues 4 and 12 may be Pro or hydroxy-Pro. <400> SEQUENCE: 147 Asp Cys Leu Xaa Arg Asp Thr Phe Cys Ala Leu Xaa Gln Leu Gly Leu 1 5 10 15 Leu Cys Cys Ser Gly Arg Cys Leu Leu Phe Cys Val 20 25 <210> SEQ ID NO 148 <211> LENGTH: 345 <212> TYPE: DNA <213> ORGANISM: Conus aurisiacus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 148 atg aaa ctg acg tgc gtg atg acc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga aat gga ctg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Lys Asn Leu 20 25 30 ttt ccg aag gca cgt cat gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag aga gat ggg tgc tct aat gct ggt gca ttt tgt ggc atc cat 192 Asn Lys Arg Asp Gly Cys Ser Asn Ala Gly Ala Phe Cys Gly Ile His 50 55 60 cca gga ctc tgc tgc agc gag att tgc att gtt tgg tgc aca 234 Pro Gly Leu Cys Cys Ser Glu Ile Cys Ile Val Trp Cys Thr 65 70 75 tgagtcgtat tctgctggta cattttgtgg cttcaacgga ggactctgct gcagcaacct 294 ttgcttattt ttcgtgtgct taacatattc gtgatgtctt ctactcccat c 345 <210> SEQ ID NO 149 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 149 Met Lys Leu Thr Cys Val Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Lys Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Asp Gly Cys Ser Asn Ala Gly Ala Phe Cys Gly Ile His 50 55 60 Pro Gly Leu Cys Cys Ser Glu Ile Cys Ile Val Trp Cys Thr 65 70 75 <210> SEQ ID NO 150 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 14 may be Pro or hydroxy-Pro; Xaa at residue 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 25 may be Trp or bromo-Trp <400> SEQUENCE: 150 Asp Gly Cys Ser Asn Ala Gly Ala Phe Cys Gly Ile His Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Ile Cys Ile Val Xaa Cys Thr 20 25 <210> SEQ ID NO 151 <211> LENGTH: 412 <212> TYPE: DNA <213> ORGANISM: Conus purpurascens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(243) <400> SEQUENCE: 151 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg act gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aaa aat gga ctg gag aat cat 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Lys Asn Gly Leu Glu Asn His 20 25 30 ttt tgg aag gca cgt gac gaa atg aag aac cgc gaa gcc tct aaa ttg 144 Phe Trp Lys Ala Arg Asp Glu Met Lys Asn Arg Glu Ala Ser Lys Leu 35 40 45 gac aaa aag gaa gcc tgc tat gcg cct ggt act ttt tgt ggc ata aag 192 Asp Lys Lys Glu Ala Cys Tyr Ala Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 ccc ggg cta tgc tgc agt gag ttt tgt ctc ccg ggc gtc tgc ttc ggt 240 Pro Gly Leu Cys Cys Ser Glu Phe Cys Leu Pro Gly Val Cys Phe Gly 65 70 75 80 ggt taactgccgt gatgtcttct actcccctct gtgctacctg gcttgatctt 293 Gly tgatcggcgt gtgcccttca ctggttatga acccactgat cttacctctc ttgaaggacc 353 tctggggtcc agcatccaaa taagcgacat cccaatgaaa aaaaaaaaaa aaaaaaaaa 412 <210> SEQ ID NO 152 <211> LENGTH: 81 <212> TYPE: PRT <213> ORGANISM: Conus purpurascens <400> SEQUENCE: 152 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Lys Asn Gly Leu Glu Asn His 20 25 30 Phe Trp Lys Ala Arg Asp Glu Met Lys Asn Arg Glu Ala Ser Lys Leu 35 40 45 Asp Lys Lys Glu Ala Cys Tyr Ala Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 Pro Gly Leu Cys Cys Ser Glu Phe Cys Leu Pro Gly Val Cys Phe Gly 65 70 75 80 Gly <210> SEQ ID NO 153 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus purpurascens <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 1 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 6, 14 and 24 may be Pro or hydroxy-Pro <400> SEQUENCE: 153 Xaa Ala Cys Xaa Ala Xaa Gly Thr Phe Cys Gly Ile Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Leu Xaa Gly Val Cys Phe Gly 20 25 <210> SEQ ID NO 154 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus purpurascens <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 1 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 6, 14 and 24 may be Pro or hydroxy-Pro <400> SEQUENCE: 154 Xaa Ala Cys Xaa Ala Xaa Gly Thr Ala Cys Gly Ile Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Leu Xaa Gly Val Cys Phe Gly 20 25 <210> SEQ ID NO 155 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus purpurascens <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 1 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 6, 14 and 24 may be Pro or hydroxy-Pro <400> SEQUENCE: 155 Xaa Ala Cys Xaa Ala Xaa Gly Thr Phe Cys Gly Ala Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Leu Xaa Gly Val Cys Phe Gly 20 25 <210> SEQ ID NO 156 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus purpurascens <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 1 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 6, 14 and 24 may be Pro or hydroxy-Pro <400> SEQUENCE: 156 Xaa Ala Cys Xaa Ala Xaa Gly Ala Phe Cys Gly Ile Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Leu Xaa Gly Val Cys Phe Gly 20 25 <210> SEQ ID NO 157 <211> LENGTH: 289 <212> TYPE: DNA <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(252) <400> SEQUENCE: 157 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg acc acc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga tat gga ttg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 ttt ccg aag gca cgt cat gaa atg aag aac cct gaa gcc tct aaa ttg 144 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag aga gat ggg tgc tat aat gct ggt aca ttt tgt ggc atc cgt 192 Asn Lys Arg Asp Gly Cys Tyr Asn Ala Gly Thr Phe Cys Gly Ile Arg 50 55 60 cca gga ctc tgc tgc agc gag ttt tgc ttt tta tgg tgc ata aca ttt 240 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 gtt gat tct ggc taacagtgtg cgttggttag tgtcttctcc tcccctc 289 Val Asp Ser Gly <210> SEQ ID NO 158 <211> LENGTH: 84 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 158 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Asp Gly Cys Tyr Asn Ala Gly Thr Phe Cys Gly Ile Arg 50 55 60 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 Val Asp Ser Gly <210> SEQ ID NO 159 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(32) <223> OTHER INFORMATION: Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 14 may be Pro or hydroxy-Pro; Xaa at residue 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 25 may be Trp or bromo-Trp <400> SEQUENCE: 159 Asp Gly Cys Xaa Asn Ala Gly Thr Phe Cys Gly Ile Arg Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Phe Leu Xaa Cys Ile Thr Phe Val Asp Ser 20 25 30 <210> SEQ ID NO 160 <211> LENGTH: 273 <212> TYPE: DNA <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(249) <400> SEQUENCE: 160 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg acc acc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga tat gga ttg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 ttt ccg aag gca cgt cat gaa atg aag aac cct gaa gcc tct aaa ttg 144 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag aga gat gaa tgc tat cct cct ggt aca ttt tgt ggc atc aaa 192 Asn Lys Arg Asp Glu Cys Tyr Pro Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 cca gga ctt tgc tgc agc gcg ata tgc tta tcg ttt gtc tgc ata tca 240 Pro Gly Leu Cys Cys Ser Ala Ile Cys Leu Ser Phe Val Cys Ile Ser 65 70 75 80 ttt gat ttt tgattgatgt cttctcctcc cctc 273 Phe Asp Phe <210> SEQ ID NO 161 <211> LENGTH: 83 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 161 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Asp Glu Cys Tyr Pro Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 Pro Gly Leu Cys Cys Ser Ala Ile Cys Leu Ser Phe Val Cys Ile Ser 65 70 75 80 Phe Asp Phe <210> SEQ ID NO 162 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(32) <223> OTHER INFORMATION: Xaa at residue 2 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 5, 6and 14 may be Pro or hydro xy-Pro <400> SEQUENCE: 162 Asp Xaa Cys Xaa Xaa Xaa Gly Thr Phe Cys Gly Ile Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Ala Ile Cys Leu Ser Phe Val Cys Ile Ser Phe Asp Phe 20 25 30 <210> SEQ ID NO 163 <211> LENGTH: 289 <212> TYPE: DNA <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(252) <400> SEQUENCE: 163 atg aaa ctg acg tgc gtg atg atc gtt gct gta ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga tat gga ctg aag gat ctg 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asp Leu 20 25 30 ttt ccg aag gaa cgt cat gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Pro Lys Glu Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac cag aga gaa gcc tgc tat aat gct ggt tca ttt tgt ggc atc cat 192 Asn Gln Arg Glu Ala Cys Tyr Asn Ala Gly Ser Phe Cys Gly Ile His 50 55 60 cca gga ctc tgc tgc agc gag ttt tgc att ctt tgg tgc ata aca ttt 240 Pro Gly Leu Cys Cys Ser Glu Phe Cys Ile Leu Trp Cys Ile Thr Phe 65 70 75 80 gtt gat tct ggc taactgtgtg cgttggttga tgtcttctcc tcccatc 289 Val Asp Ser Gly <210> SEQ ID NO 164 <211> LENGTH: 84 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 164 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asp Leu 20 25 30 Phe Pro Lys Glu Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Gln Arg Glu Ala Cys Tyr Asn Ala Gly Ser Phe Cys Gly Ile His 50 55 60 Pro Gly Leu Cys Cys Ser Glu Phe Cys Ile Leu Trp Cys Ile Thr Phe 65 70 75 80 Val Asp Ser Gly <210> SEQ ID NO 165 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(32) <223> OTHER INFORMATION: Xaa at residues 1 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 14 may be Pro or hydroxy-Pro; Xaa at residue 25 may be Trp or bromo-Trp <400> SEQUENCE: 165 Xaa Ala Cys Xaa Asn Ala Gly Ser Phe Cys Gly Ile His Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Ile Leu Xaa Cys Ile Thr Phe Val Asp Ser 20 25 30 <210> SEQ ID NO 166 <211> LENGTH: 271 <212> TYPE: DNA <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(249) <400> SEQUENCE: 166 atg aaa ctg acg tgc atg atg atc gtt gct gta ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga tat gga ctg aag gat ctg 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asp Leu 20 25 30 ttt ccg aag gaa cgt cat gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Pro Lys Glu Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac cag aga gaa gcc tgc tat aat gct ggt aca ttt tgt ggc atc aaa 192 Asn Gln Arg Glu Ala Cys Tyr Asn Ala Gly Thr Phe Cys Gly Ile Lys 50 55 60 cca gga ctt tgc tgc agc gcg ata tgc tta tcg ttt gtc tgc ata tca 240 Pro Gly Leu Cys Cys Ser Ala Ile Cys Leu Ser Phe Val Cys Ile Ser 65 70 75 80 ttt gat ttg attgatgtct tctcctcccc tc 271 Phe Asp Leu <210> SEQ ID NO 167 <211> LENGTH: 83 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 167 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asp Leu 20 25 30 Phe Pro Lys Glu Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Gln Arg Glu Ala Cys Tyr Asn Ala Gly Thr Phe Cys Gly Ile Lys 50 55 60 Pro Gly Leu Cys Cys Ser Ala Ile Cys Leu Ser Phe Val Cys Ile Ser 65 70 75 80 Phe Asp Leu <210> SEQ ID NO 168 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(32) <223> OTHER INFORMATION: Xaa at residue 1 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 14 may be Pro or hydroxy-Pro <400> SEQUENCE: 168 Xaa Ala Cys Xaa Asn Ala Gly Thr Phe Cys Gly Ile Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Ala Ile Cys Leu Ser Phe Val Cys Ile Ser Phe Asp Phe 20 25 30 <210> SEQ ID NO 169 <211> LENGTH: 272 <212> TYPE: DNA <213> ORGANISM: Conus ermineus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(243) <400> SEQUENCE: 169 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg act gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aaa aat gga ctg gag aat cat 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Lys Asn Gly Leu Glu Asn His 20 25 30 ttt tgg aag gca cgt gac gaa atg aag aac cgc gaa gcc tct aaa ttg 144 Phe Trp Lys Ala Arg Asp Glu Met Lys Asn Arg Glu Ala Ser Lys Leu 35 40 45 gac aaa aag gaa gcc tgc tat ccg cct ggt act ttt tgt ggc ata aag 192 Asp Lys Lys Glu Ala Cys Tyr Pro Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 ccc ggg cta tgc tgc agt gag ttg tgt tta ccg gcc gtc tgc gtc ggt 240 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Pro Ala Val Cys Val Gly 65 70 75 80 ggt taactgccgt gatgtcttct cctcccctc 272 Gly <210> SEQ ID NO 170 <211> LENGTH: 81 <212> TYPE: PRT <213> ORGANISM: Conus ermineus <400> SEQUENCE: 170 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Lys Asn Gly Leu Glu Asn His 20 25 30 Phe Trp Lys Ala Arg Asp Glu Met Lys Asn Arg Glu Ala Ser Lys Leu 35 40 45 Asp Lys Lys Glu Ala Cys Tyr Pro Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Pro Ala Val Cys Val Gly 65 70 75 80 Gly <210> SEQ ID NO 171 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus ermineus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 1 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 5, 6, 14 and 24 may be Pro or hydroxy-Pro <400> SEQUENCE: 171 Xaa Ala Cys Xaa Xaa Xaa Gly Thr Phe Cys Gly Ile Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Leu Cys Leu Xaa Ala Val Cys Val Gly 20 25 <210> SEQ ID NO 172 <211> LENGTH: 272 <212> TYPE: DNA <213> ORGANISM: Conus purpurascens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(243) <400> SEQUENCE: 172 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg act gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aaa aat gga ctg gag aat cat 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Lys Asn Gly Leu Glu Asn His 20 25 30 ttt tgg aag gca cgt gac gaa atg aag aac cgc gaa gcc tct aaa ttg 144 Phe Trp Lys Ala Arg Asp Glu Met Lys Asn Arg Glu Ala Ser Lys Leu 35 40 45 gac aaa aag gaa gcc tgc tat ccg cct ggt act ttt tgt ggc ata aag 192 Asp Lys Lys Glu Ala Cys Tyr Pro Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 ccc ggg cta tgc tgc agt gag ttg tgt tta ccg gcc gtc tgc gtc ggt 240 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Pro Ala Val Cys Val Gly 65 70 75 80 ggt taactgccgt gatgtcttct cctcccctc 272 Gly <210> SEQ ID NO 173 <211> LENGTH: 81 <212> TYPE: PRT <213> ORGANISM: Conus purpurascens <400> SEQUENCE: 173 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Lys Asn Gly Leu Glu Asn His 20 25 30 Phe Trp Lys Ala Arg Asp Glu Met Lys Asn Arg Glu Ala Ser Lys Leu 35 40 45 Asp Lys Lys Glu Ala Cys Tyr Pro Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Pro Ala Val Cys Val Gly 65 70 75 80 Gly <210> SEQ ID NO 174 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus purpurascens <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 1 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 14 and 24 may be Pro orhydroxy-Pro <400> SEQUENCE: 174 Xaa Ala Cys Xaa Xaa Xaa Gly Thr Phe Cys Gly Ile Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Leu Cys Leu Xaa Ala Val Cys Val Gly 20 25 <210> SEQ ID NO 175 <211> LENGTH: 266 <212> TYPE: DNA <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 175 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg acc act 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga tat gga ttg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 ttt ccg aag gca cgt cat gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag aga gaa ggg tgc tct agt ggt ggt aca ttt tgt ggc atc cat 192 Asn Lys Arg Glu Gly Cys Ser Ser Gly Gly Thr Phe Cys Gly Ile His 50 55 60 cca gga ctc tgc tgc agc gag ttt tgc ttt ctt tgg tgc ata aca ttt 240 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 att gat tgatgtcttc tcctcccctc 266 Ile Asp <210> SEQ ID NO 176 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 176 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Glu Gly Cys Ser Ser Gly Gly Thr Phe Cys Gly Ile His 50 55 60 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 Ile Asp <210> SEQ ID NO 177 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residues 1 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 14 may be Pro or hydroxy-Pro; Xaa at residue 25 may be Trp or bromo-Trp <400> SEQUENCE: 177 Xaa Gly Cys Ser Ser Gly Gly Thr Phe Cys Gly Ile His Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Phe Leu Xaa Cys Ile Thr Phe Ile Asp 20 25 30 <210> SEQ ID NO 178 <211> LENGTH: 266 <212> TYPE: DNA <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 178 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg acc act 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga tat gga ttg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 ttt ccg aag gca cgt cat gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag aga gat ggg tgc tct agt ggt ggt aca ttt tgt ggc atc cat 192 Asn Lys Arg Asp Gly Cys Ser Ser Gly Gly Thr Phe Cys Gly Ile His 50 55 60 cca gga ctc tgc tgc agc gag ttt tgc ttt ctt tgg tgc ata aca ttt 240 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 att gat tgatgtcttc tcctcccctc 266 Ile Asp <210> SEQ ID NO 179 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 179 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Asp Gly Cys Ser Ser Gly Gly Thr Phe Cys Gly Ile His 50 55 60 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 Ile Asp <210> SEQ ID NO 180 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residue 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 14 may be Pro or hydroxy-Pro; Xaa at residue 25 may be Trp or bromo-Trp <400> SEQUENCE: 180 Asp Gly Cys Ser Ser Gly Gly Thr Phe Cys Gly Ile His Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Phe Leu Xaa Cys Ile Thr Phe Ile Asp 20 25 30 <210> SEQ ID NO 181 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residues 6 and 14 may be Pro or hydroxy-Pro; Xaa at residue 31may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 181 Ser Lys Cys Phe Ser Xaa Gly Thr Phe Cys Gly Ile Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Val Arg Cys Phe Ser Leu Phe Cys Ile Ser Phe Xaa 20 25 30 <210> SEQ ID NO 182 <211> LENGTH: 345 <212> TYPE: DNA <213> ORGANISM: Conus catus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 182 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga aat gga ctg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Lys Asn Leu 20 25 30 ttt ccg aag gca cgt cat gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag aga tat ggg tgc tct aat gct ggt gca ttt tgt ggc atc cat 192 Asn Lys Arg Tyr Gly Cys Ser Asn Ala Gly Ala Phe Cys Gly Ile His 50 55 60 cca gga ctc tgc tgc agc gag ctt tgc ctg gtt tgg tgc aca 234 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Val Trp Cys Thr 65 70 75 tgagtgctat tcttctggta cattttgtgg cttcaacgga ggactctgct gcagcaacct 294 ttgcttattt tcgtgtgctt aacatttcgt gatgtcttct ctattcccct c 345 <210> SEQ ID NO 183 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus catus <400> SEQUENCE: 183 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Lys Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Tyr Gly Cys Ser Asn Ala Gly Ala Phe Cys Gly Ile His 50 55 60 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Val Trp Cys Thr 65 70 75 <210> SEQ ID NO 184 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus catus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 14 may be Pro or hydroxy-Pro; Xaa at residue 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 25 may be Trp or bromo-Trp <400> SEQUENCE: 184 Xaa Gly Cys Ser Asn Ala Gly Ala Phe Cys Gly Ile His Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Leu Cys Leu Val Xaa Cys Thr 20 25 <210> SEQ ID NO 185 <211> LENGTH: 345 <212> TYPE: DNA <213> ORGANISM: Conus catus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 185 atg aaa ctg acg tgt atg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga tat gga ctg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 ttt ccg aag gca cgt cat gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag aga tat ggg tgc tct aat gct ggt gca ttt tgt ggc atc cat 192 Asn Lys Arg Tyr Gly Cys Ser Asn Ala Gly Ala Phe Cys Gly Ile His 50 55 60 cca gga ctc tgc tgc agc gag ctt tgc ctg ggt tgg tgc aca 234 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Gly Trp Cys Thr 65 70 75 tgagtgctat tctactggta cattttgtgg cttcaacgga ggactctgct gcagcaacct 294 ttgcttattt tcgtgtgctt aacatttcgt gatgtcttct ctattcccct c 345 <210> SEQ ID NO 186 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus catus <400> SEQUENCE: 186 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Tyr Gly Cys Ser Asn Ala Gly Ala Phe Cys Gly Ile His 50 55 60 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Gly Trp Cys Thr 65 70 75 <210> SEQ ID NO 187 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus catus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 14 may be Pro or hydroxy-Pro; Xaa at residue 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 25 may be Trp or bromo-Trp <400> SEQUENCE: 187 Xaa Gly Cys Ser Asn Ala Gly Ala Phe Cys Gly Ile His Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Leu Cys Leu Gly Xaa Cys Thr 20 25 <210> SEQ ID NO 188 <211> LENGTH: 266 <212> TYPE: DNA <213> ORGANISM: Conus distans <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 188 atg aaa ctg acg tgt ctg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga aat gga ttg gag aat ctc 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 tct ccg aag gca cct cac gaa atg aag aac ccc gaa gcc tct aaa tcg 144 Ser Pro Lys Ala Pro His Glu Met Lys Asn Pro Glu Ala Ser Lys Ser 35 40 45 aac aag aga tat gag tgc tat cta ctg gta cat ttt tgt ggc atc aac 192 Asn Lys Arg Tyr Glu Cys Tyr Leu Leu Val His Phe Cys Gly Ile Asn 50 55 60 gga gga ctc tgc tgc agc aac ctt tgc tta ttt ttc gtg tgc tta aca 240 Gly Gly Leu Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr 65 70 75 80 ttt tcg tgatgtcttc tcctcccatc 266 Phe Ser <210> SEQ ID NO 189 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus distans <400> SEQUENCE: 189 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 Ser Pro Lys Ala Pro His Glu Met Lys Asn Pro Glu Ala Ser Lys Ser 35 40 45 Asn Lys Arg Tyr Glu Cys Tyr Leu Leu Val His Phe Cys Gly Ile Asn 50 55 60 Gly Gly Leu Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr 65 70 75 80 Phe Ser <210> SEQ ID NO 190 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus distans <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residues 1 and 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 2 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 190 Xaa Xaa Cys Xaa Leu Leu Val His Phe Cys Gly Ile Asn Gly Gly Leu 1 5 10 15 Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr Phe Ser 20 25 30 <210> SEQ ID NO 191 <211> LENGTH: 113 <212> TYPE: DNA <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(93) <400> SEQUENCE: 191 ttg agc aag aga gac tgc ctt cct gac tac acg att tgt gcc ttc aat 48 Leu Ser Lys Arg Asp Cys Leu Pro Asp Tyr Thr Ile Cys Ala Phe Asn 1 5 10 15 atg ggt ctg tgc tgc agc gac aag tgc atg ctc gtc tgc ctg ccg 93 Met Gly Leu Cys Cys Ser Asp Lys Cys Met Leu Val Cys Leu Pro 20 25 30 tgatgtcttc tcctcccctc 113 <210> SEQ ID NO 192 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus regius <400> SEQUENCE: 192 Leu Ser Lys Arg Asp Cys Leu Pro Asp Tyr Thr Ile Cys Ala Phe Asn 1 5 10 15 Met Gly Leu Cys Cys Ser Asp Lys Cys Met Leu Val Cys Leu Pro 20 25 30 <210> SEQ ID NO 193 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residues 5 and 27 may be Pro or hydroxy-Pro; Xaa at residue 7 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 193 Asp Cys Leu Xaa Asp Xaa Thr Ile Cys Ala Phe Asn Met Gly Leu Cys 1 5 10 15 Cys Ser Asp Lys Cys Met Leu Val Cys Leu Xaa 20 25 <210> SEQ ID NO 194 <211> LENGTH: 116 <212> TYPE: DNA <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(96) <400> SEQUENCE: 194 ttg aac aag aga atc atc tgc ttt cct gac tac atg ttt tgt ggc gtc 48 Leu Asn Lys Arg Ile Ile Cys Phe Pro Asp Tyr Met Phe Cys Gly Val 1 5 10 15 aat gtg ttt ctg tgc tgc agt ggc aac tgc ctt ctc atc tgc gtg ccg 96 Asn Val Phe Leu Cys Cys Ser Gly Asn Cys Leu Leu Ile Cys Val Pro 20 25 30 tgatgtcttc tactcccctc 116 <210> SEQ ID NO 195 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus regius <400> SEQUENCE: 195 Leu Asn Lys Arg Ile Ile Cys Phe Pro Asp Tyr Met Phe Cys Gly Val 1 5 10 15 Asn Val Phe Leu Cys Cys Ser Gly Asn Cys Leu Leu Ile Cys Val Pro 20 25 30 <210> SEQ ID NO 196 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Xaa at residues 5 and 28 may be Pro or hydroxy-Pro; Xaa at residue 7 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 196 Ile Ile Cys Gly Xaa Asp Xaa Met Phe Cys Gly Val Asn Val Phe Leu 1 5 10 15 Cys Cys Ser Gly Asn Cys Leu Leu Ile Cys Val Xaa 20 25 <210> SEQ ID NO 197 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(228) <400> SEQUENCE: 197 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gtg cct cac tcc agc aat gcg ttg gag aat 96 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asn Ala Leu Glu Asn 20 25 30 ctt tat ctg aag gca cat cat gaa atg aac aac ccc gaa gac tct gaa 144 Leu Tyr Leu Lys Ala His His Glu Met Asn Asn Pro Glu Asp Ser Glu 35 40 45 ttg aac aag agg tgc tat gat ggt ggg aca ggt tgt gac tct gga aac 192 Leu Asn Lys Arg Cys Tyr Asp Gly Gly Thr Gly Cys Asp Ser Gly Asn 50 55 60 caa tgc tgc agt ggc tgg tgc att ttc gcc tgc ctc taaaactgtc 238 Gln Cys Cys Ser Gly Trp Cys Ile Phe Ala Cys Leu 65 70 75 gtgatgtctt ctcctcccct c 259 <210> SEQ ID NO 198 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 198 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asn Ala Leu Glu Asn 20 25 30 Leu Tyr Leu Lys Ala His His Glu Met Asn Asn Pro Glu Asp Ser Glu 35 40 45 Leu Asn Lys Arg Cys Tyr Asp Gly Gly Thr Gly Cys Asp Ser Gly Asn 50 55 60 Gln Cys Cys Ser Gly Trp Cys Ile Phe Ala Cys Leu 65 70 75 <210> SEQ ID NO 199 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 2 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 18 may be Trp or bromo-Trp <400> SEQUENCE: 199 Cys Xaa Asp Gly Gly Thr Gly Cys Asp Ser Gly Asn Gln Cys Cys Ser 1 5 10 15 Gly Xaa Cys Ile Phe Ala Cys Leu 20 <210> SEQ ID NO 200 <211> LENGTH: 258 <212> TYPE: DNA <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(228) <400> SEQUENCE: 200 atg aaa ctg acg tgc att atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Ile Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gtg cct cac tcc agc aat gcg ttg gag aat 96 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asn Ala Leu Glu Asn 20 25 30 ctt tat ctg aag gca cat cat gaa atg aac aac ccc gag gac tct gaa 144 Leu Tyr Leu Lys Ala His His Glu Met Asn Asn Pro Glu Asp Ser Glu 35 40 45 ttg aac aag agg tgc tat gat ggt ggg aca ggt tgt gac tct gga aac 192 Leu Asn Lys Arg Cys Tyr Asp Gly Gly Thr Gly Cys Asp Ser Gly Asn 50 55 60 caa tgc tgc agt ggc tgg tgc att ttc gtc tgc ctc taaaactgcc 238 Gln Cys Cys Ser Gly Trp Cys Ile Phe Val Cys Leu 65 70 75 gtgatgtctt ctctcccatc 258 <210> SEQ ID NO 201 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 201 Met Lys Leu Thr Cys Ile Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asn Ala Leu Glu Asn 20 25 30 Leu Tyr Leu Lys Ala His His Glu Met Asn Asn Pro Glu Asp Ser Glu 35 40 45 Leu Asn Lys Arg Cys Tyr Asp Gly Gly Thr Gly Cys Asp Ser Gly Asn 50 55 60 Gln Cys Cys Ser Gly Trp Cys Ile Phe Val Cys Leu 65 70 75 <210> SEQ ID NO 202 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 2 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 18 may be Trp or bromo-Trp <400> SEQUENCE: 202 Cys Xaa Asp Gly Gly Thr Gly Cys Asp Ser Gly Asn Gln Cys Cys Ser 1 5 10 15 Gly Xaa Cys Ile Phe Val Cys Leu 20 <210> SEQ ID NO 203 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(228) <400> SEQUENCE: 203 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca gtc gtc acg gct gtg cct cac tcc aac aag cgg ttg gcg aat 96 Trp Thr Val Val Thr Ala Val Pro His Ser Asn Lys Arg Leu Ala Asn 20 25 30 ctt tat ctg aag gca cgt cac gaa atg aaa aac ccc gaa gcc tct aat 144 Leu Tyr Leu Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Asn 35 40 45 gtg gac aag agg tgc ttt gag agt tgg gta gct tgt gag tct cca aaa 192 Val Asp Lys Arg Cys Phe Glu Ser Trp Val Ala Cys Glu Ser Pro Lys 50 55 60 cga tgc tgc agt cac gtg tgc ctt ttc gtc tgc acc tgaaactgcc 238 Arg Cys Cys Ser His Val Cys Leu Phe Val Cys Thr 65 70 75 gtgatgtctt ctcctcccct c 259 <210> SEQ ID NO 204 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <400> SEQUENCE: 204 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Val Val Thr Ala Val Pro His Ser Asn Lys Arg Leu Ala Asn 20 25 30 Leu Tyr Leu Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Asn 35 40 45 Val Asp Lys Arg Cys Phe Glu Ser Trp Val Ala Cys Glu Ser Pro Lys 50 55 60 Arg Cys Cys Ser His Val Cys Leu Phe Val Cys Thr 65 70 75 <210> SEQ ID NO 205 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residues 3 and 9 may be Glu or gamma-carboxy-Glu; Xaa at residue 5 may be Trp or bromo-Trp; Xaa at residue 11 may be Pro or hydroxy-Pro <400> SEQUENCE: 205 Cys Phe Xaa Ser Xaa Val Ala Cys Xaa Ser Xaa Lys Arg Cys Cys Ser 1 5 10 15 His Val Cys Leu Phe Val Cys Thr 20 <210> SEQ ID NO 206 <211> LENGTH: 253 <212> TYPE: DNA <213> ORGANISM: Conus distans <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(228) <400> SEQUENCE: 206 atg aaa ctg acg tgt atg ttg atc atc gct gtg ctg ttc ctg acg gcc 48 Met Lys Leu Thr Cys Met Leu Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgt caa ctc tct aca aat gcg agt tac gcc aga agt aag cag aag cat 96 Cys Gln Leu Ser Thr Asn Ala Ser Tyr Ala Arg Ser Lys Gln Lys His 20 25 30 cgt gtt ctg agg tcg act gac aaa aac tcc aag ttg acc cag cgt tgc 144 Arg Val Leu Arg Ser Thr Asp Lys Asn Ser Lys Leu Thr Gln Arg Cys 35 40 45 aat gaa gct caa gaa cat tgc act caa aat cct gac tgc tgc agt gag 192 Asn Glu Ala Gln Glu His Cys Thr Gln Asn Pro Asp Cys Cys Ser Glu 50 55 60 tct tgc aat aag ttt gtc ggc aga tgc ttg tca gac tgatctgatg 238 Ser Cys Asn Lys Phe Val Gly Arg Cys Leu Ser Asp 65 70 75 tcttctcctc ccatc 253 <210> SEQ ID NO 207 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus distans <400> SEQUENCE: 207 Met Lys Leu Thr Cys Met Leu Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Cys Gln Leu Ser Thr Asn Ala Ser Tyr Ala Arg Ser Lys Gln Lys His 20 25 30 Arg Val Leu Arg Ser Thr Asp Lys Asn Ser Lys Leu Thr Gln Arg Cys 35 40 45 Asn Glu Ala Gln Glu His Cys Thr Gln Asn Pro Asp Cys Cys Ser Glu 50 55 60 Ser Cys Asn Lys Phe Val Gly Arg Cys Leu Ser Asp 65 70 75 <210> SEQ ID NO 208 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus distans <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 3, 6 and 17 may be Glu or gamma-carboxy-Glu; Xaa at residue 12 may be Pro or hydroxy-Pro <400> SEQUENCE: 208 Cys Asn Xaa Ala Gln Xaa His Cys Thr Gln Asn Xaa Asp Cys Cys Ser 1 5 10 15 Xaa Ser Cys Asn Lys Phe Val Gly Arg Cys Leu Ser Asp 20 25 <210> SEQ ID NO 209 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(228) <400> SEQUENCE: 209 atg aaa ctg acg tgc ctg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gtg cct gac tcc agc aat gcg ttg gag aat 96 Trp Thr Phe Val Thr Ala Val Pro Asp Ser Ser Asn Ala Leu Glu Asn 20 25 30 ctt tat ctg aag gca cat cat gaa atg aac aac ccc gaa gac tct gaa 144 Leu Tyr Leu Lys Ala His His Glu Met Asn Asn Pro Glu Asp Ser Glu 35 40 45 ttg aac aag agg tgc tat gat ggt ggg aca agt tgt aac act gga aac 192 Leu Asn Lys Arg Cys Tyr Asp Gly Gly Thr Ser Cys Asn Thr Gly Asn 50 55 60 caa tgc tgc agt ggc tgg tgc att ttc ctc tgc ctc taaaactgcc 238 Gln Cys Cys Ser Gly Trp Cys Ile Phe Leu Cys Leu 65 70 75 gtgatgtctt ctcttcccct c 259 <210> SEQ ID NO 210 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 210 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Val Pro Asp Ser Ser Asn Ala Leu Glu Asn 20 25 30 Leu Tyr Leu Lys Ala His His Glu Met Asn Asn Pro Glu Asp Ser Glu 35 40 45 Leu Asn Lys Arg Cys Tyr Asp Gly Gly Thr Ser Cys Asn Thr Gly Asn 50 55 60 Gln Cys Cys Ser Gly Trp Cys Ile Phe Leu Cys Leu 65 70 75 <210> SEQ ID NO 211 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 2 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 18 may be Trp or bromo-Trp <400> SEQUENCE: 211 Cys Xaa Asp Gly Gly Thr Ser Cys Asn Thr Gly Asn Gln Cys Cys Ser 1 5 10 15 Gly Xaa Cys Ile Phe Leu Cys Leu 20 <210> SEQ ID NO 212 <211> LENGTH: 286 <212> TYPE: DNA <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (25)..(255) <400> SEQUENCE: 212 ggcattacct aaaacatcac caag atg aaa ctg acg tgc atg atg atc gtt 51 Met Lys Leu Thr Cys Met Met Ile Val 1 5 gct gtg ctg ttc ttg acc gcc tgg aca ttc gtc acg gct gcg cct cac 99 Ala Val Leu Phe Leu Thr Ala Trp Thr Phe Val Thr Ala Ala Pro His 10 15 20 25 tcc agc aat gcg ttg gag aat ctt tat ctg aag gca cat cat gaa atg 147 Ser Ser Asn Ala Leu Glu Asn Leu Tyr Leu Lys Ala His His Glu Met 30 35 40 aac aac ccc gaa gcc tct gaa ttg aac aag agg tgc tat gat agt ggg 195 Asn Asn Pro Glu Ala Ser Glu Leu Asn Lys Arg Cys Tyr Asp Ser Gly 45 50 55 aca agt tgt aac act gga aac caa tgc tgc agt ggc tgg tgc att ttc 243 Thr Ser Cys Asn Thr Gly Asn Gln Cys Cys Ser Gly Trp Cys Ile Phe 60 65 70 gtc tct tgc ctc taaaactacc gtgatgtctt ctcctcccct c 286 Val Ser Cys Leu 75 <210> SEQ ID NO 213 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 213 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Ala Pro His Ser Ser Asn Ala Leu Glu Asn 20 25 30 Leu Tyr Leu Lys Ala His His Glu Met Asn Asn Pro Glu Ala Ser Glu 35 40 45 Leu Asn Lys Arg Cys Tyr Asp Ser Gly Thr Ser Cys Asn Thr Gly Asn 50 55 60 Gln Cys Cys Ser Gly Trp Cys Ile Phe Val Ser Cys Leu 65 70 75 <210> SEQ ID NO 214 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residue 2 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 18 may be Trp or bromo-Trp <400> SEQUENCE: 214 Cys Xaa Asp Ser Gly Thr Ser Cys Asn Thr Gly Asn Gln Cys Cys Ser 1 5 10 15 Gly Xaa Cys Ile Phe Val Ser Cys Leu 20 25 <210> SEQ ID NO 215 <211> LENGTH: 272 <212> TYPE: DNA <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(252) <400> SEQUENCE: 215 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ctg aca gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg acg cta gtc atg gct gat gac tcc aac aat gga ctg gcg aat ctt 96 Trp Thr Leu Val Met Ala Asp Asp Ser Asn Asn Gly Leu Ala Asn Leu 20 25 30 ttt tcg aaa tca cgt gac gaa atg gag gac ccc gaa gct tct aaa ttg 144 Phe Ser Lys Ser Arg Asp Glu Met Glu Asp Pro Glu Ala Ser Lys Leu 35 40 45 gag aaa agg gat tgc caa gca cta tgg gat tat tgt cca gta ccg ctc 192 Glu Lys Arg Asp Cys Gln Ala Leu Trp Asp Tyr Cys Pro Val Pro Leu 50 55 60 ttg tca tcg ggt gat tgc tgc tat ggc tta atc tgt ggc cct ttc gtc 240 Leu Ser Ser Gly Asp Cys Cys Tyr Gly Leu Ile Cys Gly Pro Phe Val 65 70 75 80 tgc att gga tgg tgatgtcttc tactcccatc 272 Cys Ile Gly Trp <210> SEQ ID NO 216 <211> LENGTH: 84 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 216 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Leu Val Met Ala Asp Asp Ser Asn Asn Gly Leu Ala Asn Leu 20 25 30 Phe Ser Lys Ser Arg Asp Glu Met Glu Asp Pro Glu Ala Ser Lys Leu 35 40 45 Glu Lys Arg Asp Cys Gln Ala Leu Trp Asp Tyr Cys Pro Val Pro Leu 50 55 60 Leu Ser Ser Gly Asp Cys Cys Tyr Gly Leu Ile Cys Gly Pro Phe Val 65 70 75 80 Cys Ile Gly Trp <210> SEQ ID NO 217 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(33) <223> OTHER INFORMATION: Xaa at residues 6 and 33 may be Trp or bromo-Trp; Xaa at residues 8 and 21 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 10, 12 and 27 may be Pro or hydroxy-Pro <400> SEQUENCE: 217 Asp Cys Gln Ala Leu Xaa Asp Xaa Cys Xaa Val Xaa Leu Leu Ser Ser 1 5 10 15 Gly Asp Cys Cys Xaa Gly Leu Ile Cys Gly Xaa Phe Val Cys Ile Gly 20 25 30 Xaa <210> SEQ ID NO 218 <211> LENGTH: 275 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(249) <400> SEQUENCE: 218 atg aaa ctg acg tgc ctg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc atg gct gat gac tcc aac aat gga ctg gca aat ctt 96 Trp Thr Phe Val Met Ala Asp Asp Ser Asn Asn Gly Leu Ala Asn Leu 20 25 30 ttc tcg aaa tca cgt gac gaa atg gag gat acc gat cct tct aaa ttg 144 Phe Ser Lys Ser Arg Asp Glu Met Glu Asp Thr Asp Pro Ser Lys Leu 35 40 45 gag aac aga aaa act tgc caa aga agg tgg gat ttt tgt cca gga tcg 192 Glu Asn Arg Lys Thr Cys Gln Arg Arg Trp Asp Phe Cys Pro Gly Ser 50 55 60 ctc gtt gga gtg ata act tgc tgc ggt ggc tta atc tgt ttt ctg ttc 240 Leu Val Gly Val Ile Thr Cys Cys Gly Gly Leu Ile Cys Phe Leu Phe 65 70 75 80 ttc tgc gtt tgatagtgat gctcttctcc tcccct 275 Phe Cys Val <210> SEQ ID NO 219 <211> LENGTH: 83 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 219 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Met Ala Asp Asp Ser Asn Asn Gly Leu Ala Asn Leu 20 25 30 Phe Ser Lys Ser Arg Asp Glu Met Glu Asp Thr Asp Pro Ser Lys Leu 35 40 45 Glu Asn Arg Lys Thr Cys Gln Arg Arg Trp Asp Phe Cys Pro Gly Ser 50 55 60 Leu Val Gly Val Ile Thr Cys Cys Gly Gly Leu Ile Cys Phe Leu Phe 65 70 75 80 Phe Cys Val <210> SEQ ID NO 220 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(32) <223> OTHER INFORMATION: Xaa at residue 7 may be Trp or bromo-Trp; Xaa at residue 10 may be Pro or hydroxy-Pro <400> SEQUENCE: 220 Lys Thr Cys Gln Arg Arg Xaa Asp Phe Cys Xaa Gly Ser Leu Val Gly 1 5 10 15 Val Ile Thr Cys Cys Gly Gly Leu Ile Cys Phe Leu Phe Phe Cys Val 20 25 30 <210> SEQ ID NO 221 <211> LENGTH: 274 <212> TYPE: DNA <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 221 atg aaa ctg acg tgt gtg atg atc gtt gct gtg ctg ttc ctg aca gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg acg cta gtc atg gct gat gac tcc aac aat gga ctg gcg aat ctt 96 Trp Thr Leu Val Met Ala Asp Asp Ser Asn Asn Gly Leu Ala Asn Leu 20 25 30 ttt tcg aaa tta cgt gac gaa atg gag gac ccc gaa ggt tct aaa ttg 144 Phe Ser Lys Leu Arg Asp Glu Met Glu Asp Pro Glu Gly Ser Lys Leu 35 40 45 gag aaa aag gat tgc caa gaa aaa tgg gat tat tgt cca gta ccg ttc 192 Glu Lys Lys Asp Cys Gln Glu Lys Trp Asp Tyr Cys Pro Val Pro Phe 50 55 60 ttg gga tcg agg tat tgc tgc gat ggc ttt atc tgt cca tct ttc ttc 240 Leu Gly Ser Arg Tyr Cys Cys Asp Gly Phe Ile Cys Pro Ser Phe Phe 65 70 75 80 tgc gct tgatagtgat gtcttctcta ttcccctc 274 Cys Ala <210> SEQ ID NO 222 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 222 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Leu Val Met Ala Asp Asp Ser Asn Asn Gly Leu Ala Asn Leu 20 25 30 Phe Ser Lys Leu Arg Asp Glu Met Glu Asp Pro Glu Gly Ser Lys Leu 35 40 45 Glu Lys Lys Asp Cys Gln Glu Lys Trp Asp Tyr Cys Pro Val Pro Phe 50 55 60 Leu Gly Ser Arg Tyr Cys Cys Asp Gly Phe Ile Cys Pro Ser Phe Phe 65 70 75 80 Cys Ala <210> SEQ ID NO 223 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residue 4 may be Glu or gamma-carboxy-Glu; Xaa at residue 6 may be Trp or bromo-Trp; Xaa at residues 8 and 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 10, 12 and 26 may be Pro or hydroxy-Pro <400> SEQUENCE: 223 Asp Cys Gln Xaa Lys Xaa Asp Xaa Cys Xaa Val Xaa Phe Leu Gly Ser 1 5 10 15 Arg Xaa Cys Cys Asp Gly Phe Ile Cys Xaa Ser Phe Phe Cys Ala 20 25 30 <210> SEQ ID NO 224 <211> LENGTH: 271 <212> TYPE: DNA <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(252) <400> SEQUENCE: 224 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ttg ttc ctg aca gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg acg cta gtc atg gct gat gac tcc aac aat gga ctg gcg aat cat 96 Trp Thr Leu Val Met Ala Asp Asp Ser Asn Asn Gly Leu Ala Asn His 20 25 30 ttt tgg aaa tca cgt gac gaa atg gag gac cct gaa gct tct aaa ttg 144 Phe Trp Lys Ser Arg Asp Glu Met Glu Asp Pro Glu Ala Ser Lys Leu 35 40 45 gag aaa agg gat tgc caa ggc gaa tgg gag ttt tgt ata gta ccg gtc 192 Glu Lys Arg Asp Cys Gln Gly Glu Trp Glu Phe Cys Ile Val Pro Val 50 55 60 ctt gga ttt gtg tat tgc tgc ccc tgg ctt atc tgt ggc cct ttc gtc 240 Leu Gly Phe Val Tyr Cys Cys Pro Trp Leu Ile Cys Gly Pro Phe Val 65 70 75 80 tgc gtt gat atc tgatgtcttc tatcccctc 271 Cys Val Asp Ile <210> SEQ ID NO 225 <211> LENGTH: 84 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 225 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Leu Val Met Ala Asp Asp Ser Asn Asn Gly Leu Ala Asn His 20 25 30 Phe Trp Lys Ser Arg Asp Glu Met Glu Asp Pro Glu Ala Ser Lys Leu 35 40 45 Glu Lys Arg Asp Cys Gln Gly Glu Trp Glu Phe Cys Ile Val Pro Val 50 55 60 Leu Gly Phe Val Tyr Cys Cys Pro Trp Leu Ile Cys Gly Pro Phe Val 65 70 75 80 Cys Val Asp Ile <210> SEQ ID NO 226 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(33) <223> OTHER INFORMATION: Xaa at residues 5 and 7 may be Glu or gamma-carboxy-Glu; Xaa at residues 6 and 22 may be Trp or bromo-Trp; Xaa at residues 12, 21 and 27 may be Pro or hydroxy-Pro; <221> NAME/KEY: SITE <222> LOCATION: (1)..(33) <223> OTHER INFORMATION: Xaa at residue 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 226 Asp Cys Gln Gly Xaa Xaa Xaa Phe Cys Ile Val Xaa Val Leu Gly Phe 1 5 10 15 Val Xaa Cys Cys Xaa Xaa Leu Ile Cys Gly Xaa Phe Val Cys Val Asp 20 25 30 Ile <210> SEQ ID NO 227 <211> LENGTH: 265 <212> TYPE: DNA <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 227 atg aaa ctg acg tgc ctg atg atc att gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Met Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc atg gct gat gac ccc aga gat gaa ccg gag gca cgt 96 Trp Thr Phe Val Met Ala Asp Asp Pro Arg Asp Glu Pro Glu Ala Arg 20 25 30 gac gaa atg aac ccc gca gcc tct aaa ttg aac gag aga ggc tgc ctt 144 Asp Glu Met Asn Pro Ala Ala Ser Lys Leu Asn Glu Arg Gly Cys Leu 35 40 45 gaa gtt gat tat ttt tgc ggc ata ccg ttt gtg aac aac ggg cta tgc 192 Glu Val Asp Tyr Phe Cys Gly Ile Pro Phe Val Asn Asn Gly Leu Cys 50 55 60 tgc agt ggc aat tgt gtt ttt gtc tgc aca ccc caa ggg aag 234 Cys Ser Gly Asn Cys Val Phe Val Cys Thr Pro Gln Gly Lys 65 70 75 taaaactgct gtgatgtctt ctcttcccat c 265 <210> SEQ ID NO 228 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <400> SEQUENCE: 228 Met Lys Leu Thr Cys Leu Met Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Met Ala Asp Asp Pro Arg Asp Glu Pro Glu Ala Arg 20 25 30 Asp Glu Met Asn Pro Ala Ala Ser Lys Leu Asn Glu Arg Gly Cys Leu 35 40 45 Glu Val Asp Tyr Phe Cys Gly Ile Pro Phe Val Asn Asn Gly Leu Cys 50 55 60 Cys Ser Gly Asn Cys Val Phe Val Cys Thr Pro Gln Gly Lys 65 70 75 <210> SEQ ID NO 229 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residue 4 may be Glu or gamma-carboxy-Glu; Xaa at residue 7 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 12 and 30 may be Pro or hydroxy-Pro <400> SEQUENCE: 229 Gly Cys Leu Xaa Val Asp Xaa Phe Cys Gly Ile Xaa Phe Val Asn Asn 1 5 10 15 Gly Leu Cys Cys Ser Gly Asn Cys Val Phe Val Cys Thr Xaa Gln 20 25 30 <210> SEQ ID NO 230 <211> LENGTH: 428 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (122)..(229) <400> SEQUENCE: 230 ggtcgacatc atcatcatcg atccatctgt ccatccatct gtccatccat ccattcattc 60 attcactgcc aaactgtcat aaatatttga gtctctcttt ctgtttttat ctgacagatt 120 g aac gag aga gac tgc ctt aat gtt gat tat ttt tgc ggc ata ccg ttt 169 Asn Glu Arg Asp Cys Leu Asn Val Asp Tyr Phe Cys Gly Ile Pro Phe 1 5 10 15 gtg aac aac ggg cta tgc tgc agt ggc aat tgt gtt ttt gtc tgc aca 217 Val Asn Asn Gly Leu Cys Cys Ser Gly Asn Cys Val Phe Val Cys Thr 20 25 30 ccc caa ggg aag taaaactgcc gtgatgtctt ctcttcccct ctagtagtag 269 Pro Gln Gly Lys 35 taggcggccg ctctagagga tccaagctta cgtacgcgtg catgcgacgt catagctctt 329 ctatagtgtc acctaaattc aattcactgg ccgtccgttt tacaacgtcg tgactgggaa 389 aaccctggcg ttacccaact taatcgcctt gcagcacat 428 <210> SEQ ID NO 231 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 231 Asn Glu Arg Asp Cys Leu Asn Val Asp Tyr Phe Cys Gly Ile Pro Phe 1 5 10 15 Val Asn Asn Gly Leu Cys Cys Ser Gly Asn Cys Val Phe Val Cys Thr 20 25 30 Pro Gln Gly Lys 35 <210> SEQ ID NO 232 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residue 6 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 11 and 29 may be Pro or hydroxy-Pro <400> SEQUENCE: 232 Cys Leu Asn Val Asp Xaa Phe Cys Gly Ile Xaa Phe Val Asn Asn Gly 1 5 10 15 Leu Cys Cys Ser Gly Asn Cys Val Phe Val Cys Thr Xaa Gln 20 25 30 <210> SEQ ID NO 233 <211> LENGTH: 227 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (105)..(224) <400> SEQUENCE: 233 tcgacatcat catcatcgat ccatctgtcc atccatccat tcattcattc gctgccaaac 60 tgtcataaat atttgagtct ctctttctgt ttttatctga caga ttg gac aag aga 116 Leu Asp Lys Arg 1 gag tgc ctg gaa gct gat tat tat tgc gtc tta ccg ttt gtg ggc aac 164 Glu Cys Leu Glu Ala Asp Tyr Tyr Cys Val Leu Pro Phe Val Gly Asn 5 10 15 20 ggg atg tgc tgc agt ggc att tgt gtt ttt gtc tgc ata gcc caa cgc 212 Gly Met Cys Cys Ser Gly Ile Cys Val Phe Val Cys Ile Ala Gln Arg 25 30 35 ttt aaa acc gtc tga 227 Phe Lys Thr Val 40 <210> SEQ ID NO 234 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 234 Leu Asp Lys Arg Glu Cys Leu Glu Ala Asp Tyr Tyr Cys Val Leu Pro 1 5 10 15 Phe Val Gly Asn Gly Met Cys Cys Ser Gly Ile Cys Val Phe Val Cys 20 25 30 Ile Ala Gln Arg Phe Lys Thr Val 35 40 <210> SEQ ID NO 235 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(36) <223> OTHER INFORMATION: Xaa at residues 1 and 4 may be Glu or gamma-carboxy-Glu; Xaa at residues 7 and 8 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 12 may be Pro or hydroxy-Pro <400> SEQUENCE: 235 Xaa Cys Leu Xaa Ala Asp Xaa Xaa Cys Val Leu Xaa Phe Val Gly Asn 1 5 10 15 Gly Met Cys Cys Ser Gly Ile Cys Val Phe Val Cys Ile Ala Gln Arg 20 25 30 Phe Lys Thr Val 35 <210> SEQ ID NO 236 <211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (131)..(241) <400> SEQUENCE: 236 gtaccggtcc ggaattcccg ggtcgacatc atcatcatcg atccatctgt ccatccatcc 60 atccattcat tcattcgctg ccaaactgtc ataaacattt gagtctctct ttctgttttt 120 atctgacaga ttg aac gag aga gac tgc ctt gaa cct gat tat gtt tgc 169 Leu Asn Glu Arg Asp Cys Leu Glu Pro Asp Tyr Val Cys 1 5 10 ggc ata ccg ttt gtg ttc aac ggg cta tgc tgc agt gga att tgt gtt 217 Gly Ile Pro Phe Val Phe Asn Gly Leu Cys Cys Ser Gly Ile Cys Val 15 20 25 ttt atc tgc ata gcc caa aag tat taaaacgccg tgatgtcttc tattcccatc 271 Phe Ile Cys Ile Ala Gln Lys Tyr 30 35 tagtagtagt aggcggccgc tctagaggat ccaagcttac gtacgcgtgc atgcgacgtc 331 atagctcttc tatagtgtca cctaaattca attcactggc cgtcgtttta caacgtcgtg 391 actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca 451 gctggcgtaa tagccgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg 511 aatggcgaat gggg 525 <210> SEQ ID NO 237 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 237 Leu Asn Glu Arg Asp Cys Leu Glu Pro Asp Tyr Val Cys Gly Ile Pro 1 5 10 15 Phe Val Phe Asn Gly Leu Cys Cys Ser Gly Ile Cys Val Phe Ile Cys 20 25 30 Ile Ala Gln Lys Tyr 35 <210> SEQ ID NO 238 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(33) <223> OTHER INFORMATION: Xaa at residue 4 may be Glu or gamma-carboxy-Glu; Xaa at residues 5 and 12 may be Pro or hydroxy-Pro; Xaa at residues 7 and 33 maybe Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 238 Asp Cys Leu Xaa Xaa Asp Xaa Val Cys Gly Ile Xaa Phe Val Phe Asn 1 5 10 15 Gly Leu Cys Cys Ser Gly Ile Cys Val Phe Ile Cys Ile Ala Gln Lys 20 25 30 Xaa <210> SEQ ID NO 239 <211> LENGTH: 537 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (146)..(247) <400> SEQUENCE: 239 ggtacgcctg caggtaccgg tccggaattc ccgggtcgac atcatcatca tcatcgatcc 60 atctgtccat ccatctattc attcattcgc tgtcaaactg taatacatat tagaatctct 120 ctttctgttt gtatctgaca gattg gag aaa agg gcg tgc agc aaa aaa tgg 172 Glu Lys Arg Ala Cys Ser Lys Lys Trp 1 5 gaa tat tgt ata gta ccg atc ctt gga ttc gta tat tgc tgc cct ggc 220 Glu Tyr Cys Ile Val Pro Ile Leu Gly Phe Val Tyr Cys Cys Pro Gly 10 15 20 25 tta atc tgt ggt cct ttc gtc tgc gtt tgatagtgat gtcttctcct 267 Leu Ile Cys Gly Pro Phe Val Cys Val 30 cccatctagt agtagtaggc ggccgctcta gaggatccaa gcttacgtac gcgtgcatgc 327 gacgtcatag ctcttctata gtgtcaccta aattcaattc actggccgtc gttttacaac 387 gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt 447 tcgccagctg gcgtaataag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc 507 agcctgaatg gcgaaatggg acgcgccctg 537 <210> SEQ ID NO 240 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 240 Glu Lys Arg Ala Cys Ser Lys Lys Trp Glu Tyr Cys Ile Val Pro Ile 1 5 10 15 Leu Gly Phe Val Tyr Cys Cys Pro Gly Leu Ile Cys Gly Pro Phe Val 20 25 30 Cys Val <210> SEQ ID NO 241 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residue 6 may be Trp or bromo-Trp; Xaa at residue 7 may be Glu or gamma-carboxy-Glu; Xaa at residues 8 and 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 12, 21 and 27 may be Pro or hydroxy-Pro <400> SEQUENCE: 241 Ala Cys Ser Lys Lys Xaa Xaa Xaa Cys Ile Val Xaa Ile Leu Gly Phe 1 5 10 15 Val Xaa Cys Cys Xaa Gly Leu Ile Cys Gly Xaa Phe Val Cys Val 20 25 30 <210> SEQ ID NO 242 <211> LENGTH: 552 <212> TYPE: DNA <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (149)..(271) <400> SEQUENCE: 242 aaagccggta cgcctgcagg taccggtccg gaattcccgg gtcgacatca tcatcatcat 60 cgatccatct gtccatccat ccattcattc attcactgcc aaactgtcat aaatatttga 120 gtctctcttt ctgtttttat ctgacaga ttg aac gag aga gac tgc ctt aat 172 Leu Asn Glu Arg Asp Cys Leu Asn 1 5 gtt gat tat ttt tgt ggc ata ccg ttt gtg aac aac ggg cta tgc tgc 220 Val Asp Tyr Phe Cys Gly Ile Pro Phe Val Asn Asn Gly Leu Cys Cys 10 15 20 agt ggc aat tgt gtt ttt tgt ctg cac acc cca agg gaa gta aaa ctg 268 Ser Gly Asn Cys Val Phe Cys Leu His Thr Pro Arg Glu Val Lys Leu 25 30 35 40 ccg tgatgtcttc tcttcccctc tagtagtagt aggcggccgc tctagaggat 321 Pro ccaagcttac gtacgcgtgc atgcgacgtc atagctcttc tatagtgtca cctaaattca 381 attcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta 441 atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg 501 atcgcccttc ccaacagttg cgcagcctga atggcgaatg ggacgcgccc t 552 <210> SEQ ID NO 243 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 243 Leu Asn Glu Arg Asp Cys Leu Asn Val Asp Tyr Phe Cys Gly Ile Pro 1 5 10 15 Phe Val Asn Asn Gly Leu Cys Cys Ser Gly Asn Cys Val Phe Cys Leu 20 25 30 His Thr Pro Arg Glu Val Lys Leu Pro 35 40 <210> SEQ ID NO 244 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(37) <223> OTHER INFORMATION: Xaa at residue 7 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 12, 31 and 37 may be Pro or hydroxy-Pro; Xaa at residue 33 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 244 Asp Cys Leu Asn Val Asp Xaa Phe Cys Gly Ile Xaa Phe Val Asn Asn 1 5 10 15 Gly Leu Cys Cys Ser Gly Asn Cys Val Phe Cys Leu His Thr Xaa Arg 20 25 30 Xaa Val Lys Leu Xaa 35 <210> SEQ ID NO 245 <211> LENGTH: 212 <212> TYPE: DNA <213> ORGANISM: Conus obscurus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (86)..(181) <400> SEQUENCE: 245 cgatccatct gtccatccat ccattcattc attcattgcc aaactgtaac aaatattcaa 60 gtctctcttt ctgtttgtgt ctgac aga tcg aaa cgg tgc ctt gtt tac ggt 112 Arg Ser Lys Arg Cys Leu Val Tyr Gly 1 5 aca cct tgt gac tgg ctg acc att gcg ggt atg gag tgc tgc agt aaa 160 Thr Pro Cys Asp Trp Leu Thr Ile Ala Gly Met Glu Cys Cys Ser Lys 10 15 20 25 aag tgc ttt atg atg tgc tgg taaaactgcc gtgatgtctt ctactcccct c 212 Lys Cys Phe Met Met Cys Trp 30 <210> SEQ ID NO 246 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus obscurus <400> SEQUENCE: 246 Arg Ser Lys Arg Cys Leu Val Tyr Gly Thr Pro Cys Asp Trp Leu Thr 1 5 10 15 Ile Ala Gly Met Glu Cys Cys Ser Lys Lys Cys Phe Met Met Cys Trp 20 25 30 <210> SEQ ID NO 247 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Conus obscurus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 7 may be Pro or hydroxy-Pro; Xaa at residues 10 and 28 may be Trp or bromo-Trp; Xaa at residue 17 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 247 Cys Leu Val Xaa Gly Thr Xaa Cys Asp Xaa Leu Thr Ile Ala Gly Met 1 5 10 15 Xaa Cys Cys Ser Lys Lys Cys Phe Met Met Cys Xaa 20 25 <210> SEQ ID NO 248 <211> LENGTH: 139 <212> TYPE: DNA <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (2)..(109) <400> SEQUENCE: 248 attg aac cag aga gac tgc cat gaa gtt ggt gaa ttt tgt ggc tta ccg 49 Leu Asn Gln Arg Asp Cys His Glu Val Gly Glu Phe Cys Gly Leu Pro 1 5 10 15 tta ata aag aac ggg cta tgc tgc agt cag att tgt tta ggt gtc tgc 97 Leu Ile Lys Asn Gly Leu Cys Cys Ser Gln Ile Cys Leu Gly Val Cys 20 25 30 gca aaa gtg ttt taaaactgcc gtgatgtctt ctactcccat 139 Ala Lys Val Phe 35 <210> SEQ ID NO 249 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 249 Leu Asn Gln Arg Asp Cys His Glu Val Gly Glu Phe Cys Gly Leu Pro 1 5 10 15 Leu Ile Lys Asn Gly Leu Cys Cys Ser Gln Ile Cys Leu Gly Val Cys 20 25 30 Ala Lys Val Phe 35 <210> SEQ ID NO 250 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(32) <223> OTHER INFORMATION: Xaa at residues 4 and 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 12 may be Pro or hydroxy-Pro <400> SEQUENCE: 250 Asp Cys His Xaa Val Gly Xaa Phe Cys Gly Leu Xaa Leu Ile Lys Asn 1 5 10 15 Gly Leu Cys Cys Ser Gln Ile Cys Leu Gly Val Cys Ala Lys Val Phe 20 25 30 <210> SEQ ID NO 251 <211> LENGTH: 133 <212> TYPE: DNA <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (2)..(100) <400> SEQUENCE: 251 a tta gac aag aaa gag tgc act gcc aat ggt gaa ttt tgt ggc ata tcg 49 Leu Asp Lys Lys Glu Cys Thr Ala Asn Gly Glu Phe Cys Gly Ile Ser 1 5 10 15 gtc ttt gga agc tac cta tgc tgc agt ggc cgg tgt gta ttc gtc tgc 97 Val Phe Gly Ser Tyr Leu Cys Cys Ser Gly Arg Cys Val Phe Val Cys 20 25 30 atc tagttgaact gccgtgatgt cttctactcc cct 133 Ile <210> SEQ ID NO 252 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 252 Leu Asp Lys Lys Glu Cys Thr Ala Asn Gly Glu Phe Cys Gly Ile Ser 1 5 10 15 Val Phe Gly Ser Tyr Leu Cys Cys Ser Gly Arg Cys Val Phe Val Cys 20 25 30 Ile <210> SEQ ID NO 253 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 1 and 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 17 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 253 Xaa Cys Thr Ala Asn Gly Xaa Phe Cys Gly Ile Ser Val Phe Gly Ser 1 5 10 15 Xaa Leu Cys Cys Ser Gly Arg Cys Val Phe Val Cys Ile 20 25 <210> SEQ ID NO 254 <211> LENGTH: 133 <212> TYPE: DNA <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (2)..(100) <400> SEQUENCE: 254 a ttg gac aag aaa gag tgc act acc aat ggt gaa ttt tgt ggc ata tcg 49 Leu Asp Lys Lys Glu Cys Thr Thr Asn Gly Glu Phe Cys Gly Ile Ser 1 5 10 15 gtc ttt gca agc ttc cta tgc tgc agt ggc ctg tgt gta ttc gtc tgc 97 Val Phe Ala Ser Phe Leu Cys Cys Ser Gly Leu Cys Val Phe Val Cys 20 25 30 atc tagctgaact gccgtgatgt cttctcttcc cct 133 Ile <210> SEQ ID NO 255 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 255 Leu Asp Lys Lys Glu Cys Thr Thr Asn Gly Glu Phe Cys Gly Ile Ser 1 5 10 15 Val Phe Ala Ser Phe Leu Cys Cys Ser Gly Leu Cys Val Phe Val Cys 20 25 30 Ile <210> SEQ ID NO 256 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 1 and 7 may be Glu or gamma-carboxy-Glu. <400> SEQUENCE: 256 Xaa Cys Thr Thr Asn Gly Xaa Phe Cys Gly Ile Ser Val Phe Ala Ser 1 5 10 15 Phe Leu Cys Cys Ser Gly Leu Cys Val Phe Val Cys Ile 20 25 <210> SEQ ID NO 257 <211> LENGTH: 133 <212> TYPE: DNA <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (2)..(100) <400> SEQUENCE: 257 a ttg gac aag aga aaa tgc ttt ccc aaa aat cat ttt tgt ggc ttt gtg 49 Leu Asp Lys Arg Lys Cys Phe Pro Lys Asn His Phe Cys Gly Phe Val 1 5 10 15 gtg atg ctg aac tac cta tgc tgc agt ggc cgg tgt ata ttc gtc tgc 97 Val Met Leu Asn Tyr Leu Cys Cys Ser Gly Arg Cys Ile Phe Val Cys 20 25 30 gtc tagttgaact gccgtgatgt cttctactcc cat 133 Val <210> SEQ ID NO 258 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 258 Leu Asp Lys Arg Lys Cys Phe Pro Lys Asn His Phe Cys Gly Phe Val 1 5 10 15 Val Met Leu Asn Tyr Leu Cys Cys Ser Gly Arg Cys Ile Phe Val Cys 20 25 30 Val <210> SEQ ID NO 259 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residue 4 may be Pro or hydroxy-Pro; Xaa at residue 17 maybe Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 259 Lys Cys Phe Xaa Lys Asn His Phe Cys Gly Phe Val Val Met Leu Asn 1 5 10 15 Xaa Leu Cys Cys Ser Gly Arg Cys Ile Phe Val Cys Val 20 25 <210> SEQ ID NO 260 <211> LENGTH: 130 <212> TYPE: DNA <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(99) <400> SEQUENCE: 260 ttg aac aag aga agc tgc ctt cct cta gac tgg ttt tgt ggc ttc aat 48 Leu Asn Lys Arg Ser Cys Leu Pro Leu Asp Trp Phe Cys Gly Phe Asn 1 5 10 15 ata att gga gcg ttt ctg tgc tgt agt ggc tac tgc ctt gtc gtc tgc 96 Ile Ile Gly Ala Phe Leu Cys Cys Ser Gly Tyr Cys Leu Val Val Cys 20 25 30 atg taaaactgcc gtgatgtctt ctcctcccct c 130 Met <210> SEQ ID NO 261 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Conus regius <400> SEQUENCE: 261 Leu Asn Lys Arg Ser Cys Leu Pro Leu Asp Trp Phe Cys Gly Phe Asn 1 5 10 15 Ile Ile Gly Ala Phe Leu Cys Cys Ser Gly Tyr Cys Leu Val Val Cys 20 25 30 Met <210> SEQ ID NO 262 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus regius <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residue 4 may be Pro or hydroxy-Pro; Xaa at residue 7 maybe Trp or bromo-Trp; Xaa at residue 23 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 262 Ser Cys Leu Xaa Leu Asp Xaa Phe Cys Gly Phe Asn Ile Ile Gly Ala 1 5 10 15 Phe Leu Cys Cys Ser Gly Xaa Cys Leu Val Val Cys Met 20 25 <210> SEQ ID NO 263 <211> LENGTH: 319 <212> TYPE: DNA <213> ORGANISM: Conus delessertii <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(285) <400> SEQUENCE: 263 atg aaa ctg acg tgt ctg ctg atc gtt gct gtg ctg gtc ttg gca gcc 48 Met Lys Leu Thr Cys Leu Leu Ile Val Ala Val Leu Val Leu Ala Ala 1 5 10 15 tgt cag ttc atc gta gct ggc gac tcg agt gat ggc cag gag aat cct 96 Cys Gln Phe Ile Val Ala Gly Asp Ser Ser Asp Gly Gln Glu Asn Pro 20 25 30 gct ctg agg tca cct agc gat tcc tct ggg aaa atg tca tca atg aag 144 Ala Leu Arg Ser Pro Ser Asp Ser Ser Gly Lys Met Ser Ser Met Lys 35 40 45 cgc ttc cag aca cgg ctg atg gtg ggg caa tct gca tcg aaa aga cca 192 Arg Phe Gln Thr Arg Leu Met Val Gly Gln Ser Ala Ser Lys Arg Pro 50 55 60 agc aag agg gac tgc atc ccc ggc ggc gaa aat tgt gat gta ttc cga 240 Ser Lys Arg Asp Cys Ile Pro Gly Gly Glu Asn Cys Asp Val Phe Arg 65 70 75 80 cca tac cgg tgc tgc agt gga tat tgc ata cta ctc ctt tgc gca 285 Pro Tyr Arg Cys Cys Ser Gly Tyr Cys Ile Leu Leu Leu Cys Ala 85 90 95 tgataaagct gccttgatgt cttctcctcc cctc 319 <210> SEQ ID NO 264 <211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM: Conus delessertii <400> SEQUENCE: 264 Met Lys Leu Thr Cys Leu Leu Ile Val Ala Val Leu Val Leu Ala Ala 1 5 10 15 Cys Gln Phe Ile Val Ala Gly Asp Ser Ser Asp Gly Gln Glu Asn Pro 20 25 30 Ala Leu Arg Ser Pro Ser Asp Ser Ser Gly Lys Met Ser Ser Met Lys 35 40 45 Arg Phe Gln Thr Arg Leu Met Val Gly Gln Ser Ala Ser Lys Arg Pro 50 55 60 Ser Lys Arg Asp Cys Ile Pro Gly Gly Glu Asn Cys Asp Val Phe Arg 65 70 75 80 Pro Tyr Arg Cys Cys Ser Gly Tyr Cys Ile Leu Leu Leu Cys Ala 85 90 95 <210> SEQ ID NO 265 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Conus delessertii <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Xaa at residues 4 and 14 may be Pro or hydroxy-Pro; Xaa at residue 7 may be Glu or gamma-carboxy-Glu; Xaa at residues 15 and 21 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 265 Asp Cys Ile Xaa Gly Gly Xaa Asn Cys Asp Val Phe Arg Xaa Xaa Arg 1 5 10 15 Cys Cys Ser Gly Xaa Cys Ile Leu Leu Leu Cys Ala 20 25 <210> SEQ ID NO 266 <211> LENGTH: 1009 <212> TYPE: DNA <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (147)..(233) <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(1009) <223> OTHER INFORMATION: n may ba any nucleotide <400> SEQUENCE: 266 gctggttcgc ctgcaggtac cggtccggaa ttcccgggtc gacatcatca tcatcgatcc 60 atctgtccat ccatctattc attcattcat tcgctgccaa actgtattaa atattcaagt 120 ctctctttct gtttgtgtct aacaga ttg aga tgg tgc att cct agt ggt gaa 173 Leu Arg Trp Cys Ile Pro Ser Gly Glu 1 5 ctt tgt ttc cgc tcg gat cac ata gga tgc tgc agt ggc aag tgc gca 221 Leu Cys Phe Arg Ser Asp His Ile Gly Cys Cys Ser Gly Lys Cys Ala 10 15 20 25 ttc gtc tgc ttg taaaactgcc gtgatgtctt ctcctcccat ctagtagtag 273 Phe Val Cys Leu taggcggccg ctctagagga tccaagctta cgtacgcgtg catgcgacgt catagctctt 333 ctatagtgtc acctaaattc aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa 393 accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta 453 atagcgaaga ggcccgcacc gatcgccctt cccaacagtt tgcgcagcct gaatggcgaa 513 tgggacgcgc cctgtagcgg cgcattaaac cgcggcgggt gtgggtgggt tacgcccacg 573 tgacccgcta cacttgccag cgccctancg ccccgctcct ttcgctttct ttcccttcct 633 ttctcgncac gtttcggccg nttttccccg tcaagctctt aaatcggggg gcttcccttt 693 aagggttncc gaattantgc tttaccggna cccttgaccc ccaaaaaaac ttggantaag 753 gggngatggn tcncgtaant gggggccatc ncccctgaan agaacggttt ttcncccctt 813 ttgacngttg ggngttccnc ggtttttaaa aaangggacc ttttntttcc aaaactggga 873 ananacctaa accctatttt tggggctatt tttttgantt tnaaanggga ttttgcccca 933 ttttnggccc tnttggggta aaaaaaagag ccggttttaa aaaaaatttt accccaaatt 993 ttaacaaaaa tttttt 1009 <210> SEQ ID NO 267 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 267 Leu Arg Trp Cys Ile Pro Ser Gly Glu Leu Cys Phe Arg Ser Asp His 1 5 10 15 Ile Gly Cys Cys Ser Gly Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 268 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residue3 may be Trp or bromo-Trp; Xaa at residue 6 may be Pro or hydroxy-Pro; Xaa at residue 9 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 268 Leu Arg Xaa Cys Ile Xaa Ser Gly Xaa Leu Cys Phe Arg Ser Asp His 1 5 10 15 Ile Gly Cys Cys Ser Gly Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 269 <211> LENGTH: 90 <212> TYPE: DNA <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(87) <400> SEQUENCE: 269 ttg aga tgg tgc att cct agt ggt gat ctt tgt ttc cgc tcg gat cac 48 Leu Arg Trp Cys Ile Pro Ser Gly Asp Leu Cys Phe Arg Ser Asp His 1 5 10 15 ata gga tgc tgc agt ggc aag tgc gca ttc gtc tgc ttg taa 90 Ile Gly Cys Cys Ser Gly Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 270 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 270 Leu Arg Trp Cys Ile Pro Ser Gly Asp Leu Cys Phe Arg Ser Asp His 1 5 10 15 Ile Gly Cys Cys Ser Gly Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 271 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residue 4 may be Pro or hydroxy-Pro <400> SEQUENCE: 271 Xaa Cys Ile Xaa Ser Gly Asp Leu Cys Phe Arg Ser Asp His Ile Gly 1 5 10 15 Cys Cys Ser Gly Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 272 <211> LENGTH: 90 <212> TYPE: DNA <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(87) <400> SEQUENCE: 272 ttg aga tgg tgc att cct agt ggt gat ctt tgt ttc cgc tcg gat cac 48 Leu Arg Trp Cys Ile Pro Ser Gly Asp Leu Cys Phe Arg Ser Asp His 1 5 10 15 ata caa tgc tgc agt ggc aag tgc gca ttc gtc tgc ttg taa 90 Ile Gln Cys Cys Ser Gly Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 273 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 273 Leu Arg Trp Cys Ile Pro Ser Gly Asp Leu Cys Phe Arg Ser Asp His 1 5 10 15 Ile Gln Cys Cys Ser Gly Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 274 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue1 may be Trp or bromo-Trp; Xaa at residue 4 may be Pro or hydroxy-Pro <400> SEQUENCE: 274 Xaa Cys Ile Xaa Ser Gly Asp Leu Cys Phe Arg Ser Asp His Ile Gln 1 5 10 15 Cys Cys Ser Gly Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 275 <211> LENGTH: 206 <212> TYPE: DNA <213> ORGANISM: Conus obscurus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (77)..(175) <400> SEQUENCE: 275 cgatccatct gtccatccat ccattcagtc attcgctgcc aaactgtaac aaatattcaa 60 gtcttgcttt ctgttt gtg tct gac aga ttg aga tgg tgc gtt cct agc ggt 112 Val Ser Asp Arg Leu Arg Trp Cys Val Pro Ser Gly 1 5 10 gaa gtt tgt cgc cgc tat gaa ttc gtg gga tgc tgc agt ggc aag tgc 160 Glu Val Cys Arg Arg Tyr Glu Phe Val Gly Cys Cys Ser Gly Lys Cys 15 20 25 ttc ttc gtc tgc tcg taaaactgtt gtgatgtctt ctcctcccct c 206 Phe Phe Val Cys Ser 30 <210> SEQ ID NO 276 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Conus obscurus <400> SEQUENCE: 276 Val Ser Asp Arg Leu Arg Trp Cys Val Pro Ser Gly Glu Val Cys Arg 1 5 10 15 Arg Tyr Glu Phe Val Gly Cys Cys Ser Gly Lys Cys Phe Phe Val Cys 20 25 30 Ser <210> SEQ ID NO 277 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus obscurus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residue 3 may be Trp or bromo-Trp; Xaa at residue 6 may be Pro or hydroxy-Pro; Xaa at residues 9 and 15 may be Glu or gamma-carboxy-Glu; Xaa at residue 14 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 277 Leu Arg Xaa Cys Val Xaa Ser Gly Xaa Val Cys Arg Arg Xaa Xaa Phe 1 5 10 15 Val Gly Cys Cys Ser Gly Lys Cys Phe Phe Val Cys Ser 20 25 <210> SEQ ID NO 278 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (22)..(117) <400> SEQUENCE: 278 ctctctctct ctctgctgga c agg tcg act cgc tgc ttg cct gac gga acg 51 Arg Ser Thr Arg Cys Leu Pro Asp Gly Thr 1 5 10 tct tgc ctt ttt agt agg atc aga tgc tgc ggt act tgc agt tca atc 99 Ser Cys Leu Phe Ser Arg Ile Arg Cys Cys Gly Thr Cys Ser Ser Ile 15 20 25 tta aag tca tgt gtg agc tgatccggcg gttgatcttc ctccctctgt 147 Leu Lys Ser Cys Val Ser 30 gctccatcct tttctgcctg agtcctcctt acctgagagt ggtcatgaac cactcatcac 207 ctactcctct ggaggcttca gaggagctac attgaaataa aagccgcatt gc 259 <210> SEQ ID NO 279 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 279 Arg Ser Thr Arg Cys Leu Pro Asp Gly Thr Ser Cys Leu Phe Ser Arg 1 5 10 15 Ile Arg Cys Cys Gly Thr Cys Ser Ser Ile Leu Lys Ser Cys Val Ser 20 25 30 <210> SEQ ID NO 280 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Xaa at residue 3 may be Pro or hydroxy-Pro. <400> SEQUENCE: 280 Cys Leu Xaa Asp Gly Thr Ser Cys Leu Phe Ser Arg Ile Arg Cys Cys 1 5 10 15 Gly Thr Cys Ser Ser Ile Leu Lys Ser Cys Val Ser 20 25 <210> SEQ ID NO 281 <211> LENGTH: 478 <212> TYPE: DNA <213> ORGANISM: Conus geographus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (73)..(318) <400> SEQUENCE: 281 ggatcttgca cggtgaattt cgcttcatat ttttctactg tcgtctttgg catcatccaa 60 aacatcacca ag atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc 111 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe 1 5 10 ttg acc gcc tgg aca ttc gtc acg gct gtg cct cac tcc agc gat gta 159 Leu Thr Ala Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asp Val 15 20 25 ttg gag aat ctt tat ctg aag gca ctt cac gaa acg gaa aac cac gaa 207 Leu Glu Asn Leu Tyr Leu Lys Ala Leu His Glu Thr Glu Asn His Glu 30 35 40 45 gcc tct aaa ttg aac gtg aga gac gac gag tgc gaa cct cct gga gat 255 Ala Ser Lys Leu Asn Val Arg Asp Asp Glu Cys Glu Pro Pro Gly Asp 50 55 60 ttt tgt ggc ttt ttt aaa att ggg ccg cct tgc tgc agt ggc tgg tgc 303 Phe Cys Gly Phe Phe Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys 65 70 75 ttc ctc tgg tgc gcc taaaactgcc gtgatgtctt ctattcccct ctgtgctacc 358 Phe Leu Trp Cys Ala 80 tggcttgatc tttgattggc gcgtgccctt cagtggttat gaacccccct gagccgactc 418 tctgggggcc tcgggggttc aacatccaaa taaagcgaca acacaatcac aagtaaaaaa 478 <210> SEQ ID NO 282 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus geographus <400> SEQUENCE: 282 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Val Pro His Ser Ser Asp Val Leu Glu Asn 20 25 30 Leu Tyr Leu Lys Ala Leu His Glu Thr Glu Asn His Glu Ala Ser Lys 35 40 45 Leu Asn Val Arg Asp Asp Glu Cys Glu Pro Pro Gly Asp Phe Cys Gly 50 55 60 Phe Phe Lys Ile Gly Pro Pro Cys Cys Ser Gly Trp Cys Phe Leu Trp 65 70 75 80 Cys Ala <210> SEQ ID NO 283 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus geographus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residues 3and 5 may be Glu or gamma-carboxy-Glu; Xaa at residues 6, 7, 18 and 19 may be Pro or hydroxy-Pro; Xaa at residues 24 and 28 may be Trp or bromo-Trp <400> SEQUENCE: 283 Asp Asp Xaa Cys Xaa Xaa Xaa Gly Asp Phe Cys Gly Phe Phe Lys Ile 1 5 10 15 Gly Xaa Xaa Cys Cys Ser Gly Xaa Cys Phe Leu Xaa Cys Ala 20 25 30 <210> SEQ ID NO 284 <211> LENGTH: 318 <212> TYPE: DNA <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (3)..(164) <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(318) <223> OTHER INFORMATION: n may be any nucleotide <400> SEQUENCE: 284 gc tgc agg tcg act cta gag gcg ttg gag aat ctt tat ctg aag gca 47 Cys Arg Ser Thr Leu Glu Ala Leu Glu Asn Leu Tyr Leu Lys Ala 1 5 10 15 cat cat gaa atg aac aac ccc gaa gac tct gaa ttg aac aag agg tgc 95 His His Glu Met Asn Asn Pro Glu Asp Ser Glu Leu Asn Lys Arg Cys 20 25 30 tat gat agt ggg aca agt tgt aac act gga aac caa tgc tgc agt ggc 143 Tyr Asp Ser Gly Thr Ser Cys Asn Thr Gly Asn Gln Cys Cys Ser Gly 35 40 45 tgg tgc att ttc gtc tgc ctc taaaactgcc gtgatgtctt ctactcccct 194 Trp Cys Ile Phe Val Cys Leu 50 ctgtgctacc tacctggctt gatctttgat tggcgcgtgc ccttcactgg ttatgaaccc 254 ctctgatccg actctctggg ggcctcgggg atccaacatc aaaatanagc gacagcacaa 314 tcac 318 <210> SEQ ID NO 285 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 285 Cys Arg Ser Thr Leu Glu Ala Leu Glu Asn Leu Tyr Leu Lys Ala His 1 5 10 15 His Glu Met Asn Asn Pro Glu Asp Ser Glu Leu Asn Lys Arg Cys Tyr 20 25 30 Asp Ser Gly Thr Ser Cys Asn Thr Gly Asn Gln Cys Cys Ser Gly Trp 35 40 45 Cys Ile Phe Val Cys Leu 50 <210> SEQ ID NO 286 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 2 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 18 may be Trp or bromo-Trp <400> SEQUENCE: 286 Cys Xaa Asp Ser Gly Thr Ser Cys Asn Thr Gly Asn Gln Cys Cys Ser 1 5 10 15 Gly Xaa Cys Ile Phe Val Cys Leu 20 <210> SEQ ID NO 287 <211> LENGTH: 480 <212> TYPE: DNA <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (52)..(333) <400> SEQUENCE: 287 gcttcgtatt tctccgctgt cttccttggc atcacccaaa acatcaccaa g atg aaa 57 Met Lys 1 ctg acg tgc atg atg atc gtt gct ctg ctg ttc ttg acc gcc tgg aca 105 Leu Thr Cys Met Met Ile Val Ala Leu Leu Phe Leu Thr Ala Trp Thr 5 10 15 ttc gtc acg gct gtt gac tcc aaa aat gaa ctg gag aac aga gga gga 153 Phe Val Thr Ala Val Asp Ser Lys Asn Glu Leu Glu Asn Arg Gly Gly 20 25 30 tgg ggg cag gca gga gga tgg ggg aaa ctt ttt ccg atg gca cgc gac 201 Trp Gly Gln Ala Gly Gly Trp Gly Lys Leu Phe Pro Met Ala Arg Asp 35 40 45 50 gaa atg aaa aac agc gaa gtc tct aaa ttg gac aat aag aga aag tgc 249 Glu Met Lys Asn Ser Glu Val Ser Lys Leu Asp Asn Lys Arg Lys Cys 55 60 65 gct gca gcc ggt gaa gct tgc gta ata cct atc att gga aac gta ttt 297 Ala Ala Ala Gly Glu Ala Cys Val Ile Pro Ile Ile Gly Asn Val Phe 70 75 80 tgc tgc aaa ggc tac tgt ctt ttc gtc tgc att agt taaactgctg 343 Cys Cys Lys Gly Tyr Cys Leu Phe Val Cys Ile Ser 85 90 tgatgccttc tactcacctc tgtgctacct ggcttgatct ttgattggcg tgtgcccttc 403 actggttatg agctcgtctg atcctactct ctggagacct ctgtggtcca acatccaaat 463 aaagcggcat cccaatg 480 <210> SEQ ID NO 288 <211> LENGTH: 94 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <400> SEQUENCE: 288 Met Lys Leu Thr Cys Met Met Ile Val Ala Leu Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Val Asp Ser Lys Asn Glu Leu Glu Asn Arg 20 25 30 Gly Gly Trp Gly Gln Ala Gly Gly Trp Gly Lys Leu Phe Pro Met Ala 35 40 45 Arg Asp Glu Met Lys Asn Ser Glu Val Ser Lys Leu Asp Asn Lys Arg 50 55 60 Lys Cys Ala Ala Ala Gly Glu Ala Cys Val Ile Pro Ile Ile Gly Asn 65 70 75 80 Val Phe Cys Cys Lys Gly Tyr Cys Leu Phe Val Cys Ile Ser 85 90 <210> SEQ ID NO 289 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residue 11 may be Pro or hydroxy-Pro; Xaa at residue 22 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 289 Cys Ala Ala Ala Gly Xaa Ala Cys Val Ile Xaa Ile Ile Gly Asn Val 1 5 10 15 Phe Cys Cys Lys Gly Xaa Cys Leu Phe Val Cys Ile Ser 20 25 <210> SEQ ID NO 290 <211> LENGTH: 410 <212> TYPE: DNA <213> ORGANISM: Conus leopardus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 290 atg aaa ctg acg tgc gtg gtg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg ata ttc atc acg gct gat gac tcc aca aat gga ctg gag aat cgt 96 Trp Ile Phe Ile Thr Ala Asp Asp Ser Thr Asn Gly Leu Glu Asn Arg 20 25 30 ttt agg aag gca cgt gac aac atg aag aac gcc aaa gcc tct aca tta 144 Phe Arg Lys Ala Arg Asp Asn Met Lys Asn Ala Lys Ala Ser Thr Leu 35 40 45 gcc gag aag aaa gcg tgt gtt gaa ctt ggt gag att tgt gcc aca ggc 192 Ala Glu Lys Lys Ala Cys Val Glu Leu Gly Glu Ile Cys Ala Thr Gly 50 55 60 ttc ttc cta gac gag gaa tgc tgc act ggt tca tgc cat gtc ttc tgc 240 Phe Phe Leu Asp Glu Glu Cys Cys Thr Gly Ser Cys His Val Phe Cys 65 70 75 80 gta cta tagttaaact gctgtgatgt cttcttctct cctccgtgct acctggcttg 296 Val Leu atctttgatt ggtgcctgtc cttcagtggt tgtgaaaccc tctgatccta ctctctggac 356 gcctctgagg cccaacatcc aaataaagcg acatcctaat gccaaaaaaa aaaa 410 <210> SEQ ID NO 291 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus leopardus <400> SEQUENCE: 291 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Ile Phe Ile Thr Ala Asp Asp Ser Thr Asn Gly Leu Glu Asn Arg 20 25 30 Phe Arg Lys Ala Arg Asp Asn Met Lys Asn Ala Lys Ala Ser Thr Leu 35 40 45 Ala Glu Lys Lys Ala Cys Val Glu Leu Gly Glu Ile Cys Ala Thr Gly 50 55 60 Phe Phe Leu Asp Glu Glu Cys Cys Thr Gly Ser Cys His Val Phe Cys 65 70 75 80 Val Leu <210> SEQ ID NO 292 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus leopardus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residues 4, 7, 17 and 18 may be Glu or gamma-carboxy-Glu. <400> SEQUENCE: 292 Ala Cys Val Xaa Leu Gly Xaa Ile Cys Ala Thr Gly Phe Phe Leu Asp 1 5 10 15 Xaa Xaa Cys Cys Thr Gly Ser Cys His Val Phe Cys Val Leu 20 25 30 <210> SEQ ID NO 293 <211> LENGTH: 336 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(231) <400> SEQUENCE: 293 atg aaa ctg acg tgc gtg gtg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg gag aat ctt 96 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 ttt tcg aag gca cat cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag agg tgc cct aac act ggt gaa tta tgt gat gtg gtt gaa caa 192 Asn Lys Arg Cys Pro Asn Thr Gly Glu Leu Cys Asp Val Val Glu Gln 50 55 60 aac tgc tgc tat acc tat tgc ttt att gta gtc tgc cta taaaactacc 241 Asn Cys Cys Tyr Thr Tyr Cys Phe Ile Val Val Cys Leu 65 70 75 gtgatgtctt ctactcccct ctgtgctgcc tggcttgatc tttgattggc gcgtgccctt 301 cactggttat gacccccctg atccgacctc tgggg 336 <210> SEQ ID NO 294 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 294 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Pro Asn Thr Gly Glu Leu Cys Asp Val Val Glu Gln 50 55 60 Asn Cys Cys Tyr Thr Tyr Cys Phe Ile Val Val Cys Leu 65 70 75 <210> SEQ ID NO 295 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 2 may be Pro or hydroxy-Pro; Xaa at residues 6 and 12 may be Glu or gamma-carboxy-Glu; Xaa at residues 17 and 19 maybe Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 295 Cys Xaa Asn Thr Gly Xaa Leu Cys Asp Val Val Xaa Gln Asn Cys Cys 1 5 10 15 Xaa Thr Xaa Cys Phe Ile Val Val Cys Leu 20 25 <210> SEQ ID NO 296 <211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(240) <400> SEQUENCE: 296 ggatcc atg aaa ctg acg tgt atg gtg atc gtt gct gtg cta ttc ttg 48 Met Lys Leu Thr Cys Met Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tcg gct gat gac tcc aga aat gga ttc gag aat cga aat gga 96 Thr Ala Ser Ala Asp Asp Ser Arg Asn Gly Phe Glu Asn Arg Asn Gly 15 20 25 30 gaa cga aac gaa aac gaa atg aag aac ctc gaa gcc tct aaa ttg aac 144 Glu Arg Asn Glu Asn Glu Met Lys Asn Leu Glu Ala Ser Lys Leu Asn 35 40 45 agg aga gac ggc gat tgc gtt gat ggt ggt gaa ttt tgt ggc ttt ccg 192 Arg Arg Asp Gly Asp Cys Val Asp Gly Gly Glu Phe Cys Gly Phe Pro 50 55 60 aaa att gga ggg cca tgc tgt agt ggc tgg tgc ttt ttc gtc tgc tta 240 Lys Ile Gly Gly Pro Cys Cys Ser Gly Trp Cys Phe Phe Val Cys Leu 65 70 75 taaaactgcc atgatgtctt ctacccccct ctgtgctacc tgacttgatc tttgattggc 300 gtgtgccctt cactggttat gaacccctct gatccgactc tctggaggcc tcgggggtcc 360 aacatccaaa taaagcgaca gcaaaaaaaa aaaaaaaaaa aa 402 <210> SEQ ID NO 297 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <400> SEQUENCE: 297 Met Lys Leu Thr Cys Met Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Ser Ala Asp Asp Ser Arg Asn Gly Phe Glu Asn Arg Asn Gly Glu Arg 20 25 30 Asn Glu Asn Glu Met Lys Asn Leu Glu Ala Ser Lys Leu Asn Arg Arg 35 40 45 Asp Gly Asp Cys Val Asp Gly Gly Glu Phe Cys Gly Phe Pro Lys Ile 50 55 60 Gly Gly Pro Cys Cys Ser Gly Trp Cys Phe Phe Val Cys Leu 65 70 75 <210> SEQ ID NO 298 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residue 9 may be Glu or gamma-carboxy-Glu; Xaa at residues 14 and 19may be Pro or hydroxy-Pro; Xaa at residue 24 may be Trp or bromo-Trp <400> SEQUENCE: 298 Asp Gly Asp Cys Val Asp Gly Gly Xaa Phe Cys Gly Phe Xaa Lys Ile 1 5 10 15 Gly Gly Xaa Cys Cys Ser Gly Xaa Cys Phe Phe Val Cys Leu 20 25 30 <210> SEQ ID NO 299 <211> LENGTH: 274 <212> TYPE: DNA <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(216) <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(274) <223> OTHER INFORMATION: n may be any nucleotide <400> SEQUENCE: 299 ggatcc atg aaa ctg acg tgc gtg gtg atc gtt gct gtg cta ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc ttg gct gat gac tcc aga aat gga ttg gag aat cga aat gaa 96 Thr Ala Leu Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Arg Asn Glu 15 20 25 30 caa gaa cga aac gaa aac gaa atg agg gac cgc cgg gac tgc caa gat 144 Gln Glu Arg Asn Glu Asn Glu Met Arg Asp Arg Arg Asp Cys Gln Asp 35 40 45 agt ggt gta gtt tgt ggc ttt ccg aaa cct gaa cca cac tgc tgc agt 192 Ser Gly Val Val Cys Gly Phe Pro Lys Pro Glu Pro His Cys Cys Ser 50 55 60 ggc tgg tgc ctt ttc gtc tgc gcc taaaactgcc gtgatgtcaa ataaagcgac 246 Gly Trp Cys Leu Phe Val Cys Ala 65 70 agacaatnaa aaaaaaaaaa aaaaaaaa 274 <210> SEQ ID NO 300 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <400> SEQUENCE: 300 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Leu Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Arg Asn Glu Gln Glu 20 25 30 Arg Asn Glu Asn Glu Met Arg Asp Arg Arg Asp Cys Gln Asp Ser Gly 35 40 45 Val Val Cys Gly Phe Pro Lys Pro Glu Pro His Cys Cys Ser Gly Trp 50 55 60 Cys Leu Phe Val Cys Ala 65 70 <210> SEQ ID NO 301 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Xaa at residues 12, 14 and 16 may be Pro or hydroxy-Pro; Xaa at residue15 may be Glu or gamma-carboxy-Glu; Xaa at residue 22 may b e Trp or bromo-Trp <400> SEQUENCE: 301 Asp Cys Gln Asp Ser Gly Val Val Cys Gly Phe Xaa Lys Xaa Xaa Xaa 1 5 10 15 His Cys Cys Ser Gly Xaa Cys Leu Phe Val Cys Ala 20 25 <210> SEQ ID NO 302 <211> LENGTH: 340 <212> TYPE: DNA <213> ORGANISM: Conus arenatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(246) <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(340) <223> OTHER INFORMATION: n may be any nucleotide <400> SEQUENCE: 302 ggatcc atg aaa ctg acg tgt gtg gtg atc gtt gct gtg ctg ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc acg gct gac tcc ata cgt gca ctg gag gat 96 Thr Ala Trp Thr Phe Val Thr Ala Asp Ser Ile Arg Ala Leu Glu Asp 15 20 25 30 ttt ttt gcg aag gca cgt gac gaa atg gaa aac agc gga gct tct cca 144 Phe Phe Ala Lys Ala Arg Asp Glu Met Glu Asn Ser Gly Ala Ser Pro 35 40 45 ttg aac gag aga gac tgc cga cct gta ggt caa tat tgt ggc ata ccg 192 Leu Asn Glu Arg Asp Cys Arg Pro Val Gly Gln Tyr Cys Gly Ile Pro 50 55 60 tat aag cac aac tgg cga tgc tgc agt cag ctt tgt gca att atc tgt 240 Tyr Lys His Asn Trp Arg Cys Cys Ser Gln Leu Cys Ala Ile Ile Cys 65 70 75 gtt tcc taacccctct gatcctactc tctgaagacc tccgggattc aacatccaaa 296 Val Ser 80 taaagcgaca tcccgatnaa aaaaaangaa aaaaaaaaaa aaaa 340 <210> SEQ ID NO 303 <211> LENGTH: 80 <212> TYPE: PRT <213> ORGANISM: Conus arenatus <400> SEQUENCE: 303 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Ser Ile Arg Ala Leu Glu Asp Phe Phe 20 25 30 Ala Lys Ala Arg Asp Glu Met Glu Asn Ser Gly Ala Ser Pro Leu Asn 35 40 45 Glu Arg Asp Cys Arg Pro Val Gly Gln Tyr Cys Gly Ile Pro Tyr Lys 50 55 60 His Asn Trp Arg Cys Cys Ser Gln Leu Cys Ala Ile Ile Cys Val Ser 65 70 75 80 <210> SEQ ID NO 304 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus arenatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residues 4 and 12 may be Pro orhydroxy-Pro; Xaa at residues 8 and 13 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 17 may be Trp or bromo-Trp <400> SEQUENCE: 304 Asp Cys Arg Xaa Val Gly Gln Xaa Cys Gly Ile Xaa Xaa Lys His Asn 1 5 10 15 Xaa Arg Cys Cys Ser Gln Leu Cys Ala Ile Ile Cys Val Ser 20 25 30 <210> SEQ ID NO 305 <211> LENGTH: 281 <212> TYPE: DNA <213> ORGANISM: Conus arenatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(234) <400> SEQUENCE: 305 ggatcc atg aaa ctg acg tgt gtg gtg atc gtt gtt gtg ctg ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Val Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc aag gct gat gac tcc ata aat gga ttg gag 96 Thr Ala Trp Thr Phe Val Lys Ala Asp Asp Ser Ile Asn Gly Leu Glu 15 20 25 30 aat ctt ttt ccg aag gca cgt cac gaa atg aag aac ccc gaa gcc tct 144 Asn Leu Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser 35 40 45 aaa ttg aac gag agg tgc ctt gaa aag ggt gta ctt tgt gat ccg agt 192 Lys Leu Asn Glu Arg Cys Leu Glu Lys Gly Val Leu Cys Asp Pro Ser 50 55 60 gct gga aac tgc tgt agt ggc gaa tgc gtt tta gtc tgc ctc 234 Ala Gly Asn Cys Cys Ser Gly Glu Cys Val Leu Val Cys Leu 65 70 75 taaaactacc gtgatgtctt ctactcccat ctgtgctacc cctcgag 281 <210> SEQ ID NO 306 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus arenatus <400> SEQUENCE: 306 Met Lys Leu Thr Cys Val Val Ile Val Val Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Lys Ala Asp Asp Ser Ile Asn Gly Leu Glu Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Glu Arg Cys Leu Glu Lys Gly Val Leu Cys Asp Pro Ser Ala Gly 50 55 60 Asn Cys Cys Ser Gly Glu Cys Val Leu Val Cys Leu 65 70 75 <210> SEQ ID NO 307 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus arenatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residues 3 and 19 may be Glu or gamma-carboxy-Glu; Xaa at residue 10 may be Pro or hydroxy-Pro <400> SEQUENCE: 307 Cys Leu Xaa Lys Gly Val Leu Cys Asp Xaa Ser Ala Gly Asn Cys Cys 1 5 10 15 Ser Gly Xaa Cys Val Leu Val Cys Leu 20 25 <210> SEQ ID NO 308 <211> LENGTH: 287 <212> TYPE: DNA <213> ORGANISM: Conus arenatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(240) <400> SEQUENCE: 308 ggatcc atg aaa ctg acg tgc atg gtg atc gtt act gtg ttg ttc ttg 48 Met Lys Leu Thr Cys Met Val Ile Val Thr Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc acg gct gat gac tcc aga aat gaa ttg gag 96 Thr Ala Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Glu Leu Glu 15 20 25 30 aat ctt ttt ctg aag gca tat cac gaa atg aac tcc gaa gcc tct aaa 144 Asn Leu Phe Leu Lys Ala Tyr His Glu Met Asn Ser Glu Ala Ser Lys 35 40 45 ttg gac aag aaa gag tgc gtt gct ggt agt cac ttt tgt ggt ttt ccg 192 Leu Asp Lys Lys Glu Cys Val Ala Gly Ser His Phe Cys Gly Phe Pro 50 55 60 aaa att gga ggg cca tgc tgc agt ggc tgg tgc ttt ttc gtc tgc ttg 240 Lys Ile Gly Gly Pro Cys Cys Ser Gly Trp Cys Phe Phe Val Cys Leu 65 70 75 taaacctgcc gtgatgtctt ctactcccat ctgtgctacc cctcgag 287 <210> SEQ ID NO 309 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus arenatus <400> SEQUENCE: 309 Met Lys Leu Thr Cys Met Val Ile Val Thr Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Glu Leu Glu Asn Leu 20 25 30 Phe Leu Lys Ala Tyr His Glu Met Asn Ser Glu Ala Ser Lys Leu Asp 35 40 45 Lys Lys Glu Cys Val Ala Gly Ser His Phe Cys Gly Phe Pro Lys Ile 50 55 60 Gly Gly Pro Cys Cys Ser Gly Trp Cys Phe Phe Val Cys Leu 65 70 75 <210> SEQ ID NO 310 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Conus arenatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Xaa at residue 1 may be Glu or gamma-carboxy-Glu; Xaa at residues 12 and 17 may be Pro or hydroxy-Pro; Xaa at residue 22 may be Trp or bromo-Trp <400> SEQUENCE: 310 Xaa Cys Val Ala Gly Ser His Phe Cys Gly Phe Xaa Lys Ile Gly Gly 1 5 10 15 Xaa Cys Cys Ser Gly Xaa Cys Phe Phe Val Cys Leu 20 25 <210> SEQ ID NO 311 <211> LENGTH: 400 <212> TYPE: DNA <213> ORGANISM: Conus tessulatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(243) <400> SEQUENCE: 311 ggatcc atg aaa ctg acg tgt gtg gtg atc gtt gct gtg atg ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Met Phe Leu 1 5 10 acc gcc tgg aca ttc atc acg gct gat gac tcc ata aat gga ctg gag 96 Thr Ala Trp Thr Phe Ile Thr Ala Asp Asp Ser Ile Asn Gly Leu Glu 15 20 25 30 gat aga ggc ata tgg ggg gaa cct ttg tcg aag gca cgt gac gaa atg 144 Asp Arg Gly Ile Trp Gly Glu Pro Leu Ser Lys Ala Arg Asp Glu Met 35 40 45 aac ccc gaa gtc tct aaa cgg gat tgc tgg cct caa tat tgg ttt tgt 192 Asn Pro Glu Val Ser Lys Arg Asp Cys Trp Pro Gln Tyr Trp Phe Cys 50 55 60 ggc cta cag agg gga tgc tgc cca ggg act act tgc ttc ttc ctt tgc 240 Gly Leu Gln Arg Gly Cys Cys Pro Gly Thr Thr Cys Phe Phe Leu Cys 65 70 75 ttt tagtgatctc ttcgactccc ttctgtgcta cctggcttga cctttgattg 293 Phe gcgcgtgccc ttcactggtt ataaacccct ctgttcctcc tctctggacg cttcggggtg 353 tccagcatcc aaataaagcg acgtccccaa aaaaaaaaaa aaaaaaa 400 <210> SEQ ID NO 312 <211> LENGTH: 79 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <400> SEQUENCE: 312 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Met Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ile Thr Ala Asp Asp Ser Ile Asn Gly Leu Glu Asp Arg 20 25 30 Gly Ile Trp Gly Glu Pro Leu Ser Lys Ala Arg Asp Glu Met Asn Pro 35 40 45 Glu Val Ser Lys Arg Asp Cys Trp Pro Gln Tyr Trp Phe Cys Gly Leu 50 55 60 Gln Arg Gly Cys Cys Pro Gly Thr Thr Cys Phe Phe Leu Cys Phe 65 70 75 <210> SEQ ID NO 313 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3 and 7 may be Trp or bromo-Trp; Xaa at residues 4 and 17 may be Pro or hydroxy-Pro; Xaa at residue 6 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 313 Asp Cys Xaa Xaa Gln Xaa Xaa Phe Cys Gly Leu Gln Arg Gly Cys Cys 1 5 10 15 Xaa Gly Thr Thr Cys Phe Phe Leu Cys Phe 20 25 <210> SEQ ID NO 314 <211> LENGTH: 419 <212> TYPE: DNA <213> ORGANISM: Conus tessulatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(249) <400> SEQUENCE: 314 ggatcc atg aaa ctg acg tgc gtg gtg gtc gtt gct gtg ctg ttc ttg 48 Met Lys Leu Thr Cys Val Val Val Val Ala Val Leu Phe Leu 1 5 10 aac gcc tgg aca ttc gcc acg gct gtt gac tcc aaa cat gca ctg gcg 96 Asn Ala Trp Thr Phe Ala Thr Ala Val Asp Ser Lys His Ala Leu Ala 15 20 25 30 aaa ctt ttt atg aag gca cgt gac gaa atg tat aac ccc gat gcc act 144 Lys Leu Phe Met Lys Ala Arg Asp Glu Met Tyr Asn Pro Asp Ala Thr 35 40 45 aaa ttg gac gat aag aga tgg tgc gct tta gat ggt gaa ctt tgt atc 192 Lys Leu Asp Asp Lys Arg Trp Cys Ala Leu Asp Gly Glu Leu Cys Ile 50 55 60 ata ccg gtc att ggg tcc ata ttt tgc tgc cat ggc ata tgt atg atc 240 Ile Pro Val Ile Gly Ser Ile Phe Cys Cys His Gly Ile Cys Met Ile 65 70 75 tac tgc gtc tagttgaact gccgtgatgt cttctactcc cctctgtgct 289 Tyr Cys Val 80 acccctggtt tgatctttga ttgccctgtg cccttcactg attatgaatc cctctgatcc 349 tactctctga agacctcttg gggtccaaca tccaaataaa gcgacatccc aaaaaaaaaa 409 aaaaaaaaaa 419 <210> SEQ ID NO 315 <211> LENGTH: 81 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <400> SEQUENCE: 315 Met Lys Leu Thr Cys Val Val Val Val Ala Val Leu Phe Leu Asn Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Val Asp Ser Lys His Ala Leu Ala Lys Leu 20 25 30 Phe Met Lys Ala Arg Asp Glu Met Tyr Asn Pro Asp Ala Thr Lys Leu 35 40 45 Asp Asp Lys Arg Trp Cys Ala Leu Asp Gly Glu Leu Cys Ile Ile Pro 50 55 60 Val Ile Gly Ser Ile Phe Cys Cys His Gly Ile Cys Met Ile Tyr Cys 65 70 75 80 Val <210> SEQ ID NO 316 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residue 7 maybe Glu or gamma-carboxy-Glu; Xaa at residue 12 may be Pro or hydroxy-Pro; Xaa at residue 27 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 316 Xaa Cys Ala Leu Asp Gly Xaa Leu Cys Ile Ile Xaa Val Ile Gly Ser 1 5 10 15 Ile Phe Cys Cys His Gly Ile Cys Met Ile Xaa Cys Val 20 25 <210> SEQ ID NO 317 <211> LENGTH: 408 <212> TYPE: DNA <213> ORGANISM: Conus imperialis <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(240) <400> SEQUENCE: 317 ggatcc atg aaa ctg acg tgc gtg gtg ttc gtt gct gtg ccg ttc ttg 48 Met Lys Leu Thr Cys Val Val Phe Val Ala Val Pro Phe Leu 1 5 10 acc gcc tcg gta ttc atc acg gct gat gac tcc aga aat gga atc gag 96 Thr Ala Ser Val Phe Ile Thr Ala Asp Asp Ser Arg Asn Gly Ile Glu 15 20 25 30 aat ctt cct cgg atg aga cgt cac gaa atg aag aac ccc aaa gcc tct 144 Asn Leu Pro Arg Met Arg Arg His Glu Met Lys Asn Pro Lys Ala Ser 35 40 45 aag ttg aac aag aga cag tgc cgt gta gaa ggt gaa att tgt ggc atg 192 Lys Leu Asn Lys Arg Gln Cys Arg Val Glu Gly Glu Ile Cys Gly Met 50 55 60 ctg ttt gaa gca caa tgc tgc gat ggc tgg tgc ttt ttc gtc tgc atg 240 Leu Phe Glu Ala Gln Cys Cys Asp Gly Trp Cys Phe Phe Val Cys Met 65 70 75 taaaactgcc gtgatgtctt ctactctcct ctgtgctacc tgccctgatc tttgattggc 300 tcgcgccctt cattggttat gaacccctct gatcctactc tctggaggcc tcaggggtcc 360 agcatctaaa taaagcgaca tcacaatcaa aaaaaaaaaa aaaaaaaa 408 <210> SEQ ID NO 318 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus imperialis <400> SEQUENCE: 318 Met Lys Leu Thr Cys Val Val Phe Val Ala Val Pro Phe Leu Thr Ala 1 5 10 15 Ser Val Phe Ile Thr Ala Asp Asp Ser Arg Asn Gly Ile Glu Asn Leu 20 25 30 Pro Arg Met Arg Arg His Glu Met Lys Asn Pro Lys Ala Ser Lys Leu 35 40 45 Asn Lys Arg Gln Cys Arg Val Glu Gly Glu Ile Cys Gly Met Leu Phe 50 55 60 Glu Ala Gln Cys Cys Asp Gly Trp Cys Phe Phe Val Cys Met 65 70 75 <210> SEQ ID NO 319 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus imperialis <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Gln or pyro-Glu; Xaa at residues 5, 7 and 14 may be Glu or gamma-carboxy-Glu; Xaa at residue 21 may be Trp or bromo-Trp <400> SEQUENCE: 319 Xaa Cys Arg Val Xaa Gly Xaa Ile Cys Gly Met Leu Phe Xaa Ala Gln 1 5 10 15 Cys Cys Asp Gly Xaa Cys Phe Phe Val Cys Met 20 25 <210> SEQ ID NO 320 <211> LENGTH: 281 <212> TYPE: DNA <213> ORGANISM: Conus caracteristicus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(234) <400> SEQUENCE: 320 ggatcc atg aaa ctg acg tgt gtg gtg atc gtt gct gtg ctg ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc acg gct gat gac tcc aga aat gga ttg gag 96 Thr Ala Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu 15 20 25 30 aat ctt ttt ccg aag gca cgt cac gaa atg aag aac ccc gaa gcc tct 144 Asn Leu Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser 35 40 45 aaa ttg aac aag agg tgc gtt gac cct ggt gaa ttt tgt ggt ccg gga 192 Lys Leu Asn Lys Arg Cys Val Asp Pro Gly Glu Phe Cys Gly Pro Gly 50 55 60 ttt gga gat tgc tgc act ggc ttc tgc ctt tta gtc tgc atc 234 Phe Gly Asp Cys Cys Thr Gly Phe Cys Leu Leu Val Cys Ile 65 70 75 taaaactgcc gtgatgtctt ctactcccat ctgtgctacc cctcgag 281 <210> SEQ ID NO 321 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 321 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Val Asp Pro Gly Glu Phe Cys Gly Pro Gly Phe Gly 50 55 60 Asp Cys Cys Thr Gly Phe Cys Leu Leu Val Cys Ile 65 70 75 <210> SEQ ID NO 322 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residues 4 and 10 may be Pro or hydroxy-Pro; Xaa at residue 6 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 322 Cys Val Asp Xaa Gly Xaa Phe Cys Gly Xaa Gly Phe Gly Asp Cys Cys 1 5 10 15 Thr Gly Phe Cys Leu Leu Val Cys Ile 20 25 <210> SEQ ID NO 323 <211> LENGTH: 287 <212> TYPE: DNA <213> ORGANISM: Conus miliaris <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(240) <400> SEQUENCE: 323 ggatcc atg aaa ctg acg tgc gtg gtg atc gtt gct gtg ttg ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc atg gct gat gac tcc aga aat gat ttg gag 96 Thr Ala Trp Thr Phe Val Met Ala Asp Asp Ser Arg Asn Asp Leu Glu 15 20 25 30 aat ctt ttt ctg aag gca cgt cat gaa atg aag aac ccc gaa gct tct 144 Asn Leu Phe Leu Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser 35 40 45 aaa ttg aac aag aga tgc ctt cca aat ggt gta ctt tgt gat ctg gga 192 Lys Leu Asn Lys Arg Cys Leu Pro Asn Gly Val Leu Cys Asp Leu Gly 50 55 60 tct cca cca tac tgc tgc agt ggc tgg tgc gcg atc gtc gtc tgc atc 240 Ser Pro Pro Tyr Cys Cys Ser Gly Trp Cys Ala Ile Val Val Cys Ile 65 70 75 taaaactgtc gtcatgtctt ctactcccat ctgtgctacc cctcgag 287 <210> SEQ ID NO 324 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus miliaris <400> SEQUENCE: 324 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Met Ala Asp Asp Ser Arg Asn Asp Leu Glu Asn Leu 20 25 30 Phe Leu Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Leu Pro Asn Gly Val Leu Cys Asp Leu Gly Ser Pro 50 55 60 Pro Tyr Cys Cys Ser Gly Trp Cys Ala Ile Val Val Cys Ile 65 70 75 <210> SEQ ID NO 325 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus miliaris <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residues 3, 13 and 14 may be Pro or hydroxy-Pro; Xaa at residue 15 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 20 may be Trp or bromo-Trp <400> SEQUENCE: 325 Cys Leu Xaa Asn Gly Val Leu Cys Asp Leu Gly Ser Xaa Xaa Xaa Cys 1 5 10 15 Cys Ser Gly Xaa Cys Ala Ile Val Val Cys Ile 20 25 <210> SEQ ID NO 326 <211> LENGTH: 287 <212> TYPE: DNA <213> ORGANISM: Conus atlanticus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(240) <400> SEQUENCE: 326 ggatcc atg aaa ctg acg tgc gtg gtg atc gtt gct gtg ctg ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc acg gct gat gac tcc ata aat ggg ttg gag 96 Thr Ala Trp Thr Phe Val Thr Ala Asp Asp Ser Ile Asn Gly Leu Glu 15 20 25 30 aat ctt ttt ccg aag gca cgt cac gaa atg agg aaa ccc gaa gcc tct 144 Asn Leu Phe Pro Lys Ala Arg His Glu Met Arg Lys Pro Glu Ala Ser 35 40 45 aga tcg aga ggg agg tgc cgt cct cgt ggt atg ttc tgt ggc ttt ccg 192 Arg Ser Arg Gly Arg Cys Arg Pro Arg Gly Met Phe Cys Gly Phe Pro 50 55 60 aaa cct gga cca tac tgc tgc aat ggc tgg tgc ttt ttc gtc tgc atc 240 Lys Pro Gly Pro Tyr Cys Cys Asn Gly Trp Cys Phe Phe Val Cys Ile 65 70 75 taaaactgcc gtgatgtgtt ctactcccat ctgtgctacc cctcgag 287 <210> SEQ ID NO 327 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus atlanticus <400> SEQUENCE: 327 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Ile Asn Gly Leu Glu Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Arg Lys Pro Glu Ala Ser Arg Ser 35 40 45 Arg Gly Arg Cys Arg Pro Arg Gly Met Phe Cys Gly Phe Pro Lys Pro 50 55 60 Gly Pro Tyr Cys Cys Asn Gly Trp Cys Phe Phe Val Cys Ile 65 70 75 <210> SEQ ID NO 328 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus atlanticus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residues 3, 11, 13 and 15 may be Pro or hydroxy-Pro; Xaa at residue16 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 21 may be Trp or bromo-Trp <400> SEQUENCE: 328 Cys Arg Xaa Arg Gly Met Phe Cys Gly Phe Xaa Lys Xaa Gly Xaa Xaa 1 5 10 15 Cys Cys Asn Gly Xaa Cys Phe Phe Val Cys Ile 20 25 <210> SEQ ID NO 329 <211> LENGTH: 284 <212> TYPE: DNA <213> ORGANISM: Conus lividus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(237) <400> SEQUENCE: 329 ggatcc atg aaa ctg acg tgc gtg gtg atc gtt gct gtg ctg ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg gag 96 Thr Ala Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu 15 20 25 30 aat ctt ttt tcg aag gca cat cac gaa atg aag aac ccc gaa gcc tct 144 Asn Leu Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser 35 40 45 aaa ttg aac aag agg tgc cct aac act ggt gaa tta tgt gat gtg gtt 192 Lys Leu Asn Lys Arg Cys Pro Asn Thr Gly Glu Leu Cys Asp Val Val 50 55 60 gaa caa aac tgc tgc tat acc tat tgc ttt att gta gtc tgc cta 237 Glu Gln Asn Cys Cys Tyr Thr Tyr Cys Phe Ile Val Val Cys Leu 65 70 75 taaaactacc gtgatgtctt ctactcccat ctgtgctacc cctcgag 284 <210> SEQ ID NO 330 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus lividus <400> SEQUENCE: 330 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Glu Asn Leu 20 25 30 Phe Ser Lys Ala His His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Pro Asn Thr Gly Glu Leu Cys Asp Val Val Glu Gln 50 55 60 Asn Cys Cys Tyr Thr Tyr Cys Phe Ile Val Val Cys Leu 65 70 75 <210> SEQ ID NO 331 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus lividus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 2 may be Pro or hydroxy-Pro; Xaa at residues 6 and 12 may be Glu or gamma-carboxy-Glu; Xaa at residues 17 and 19 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 331 Cys Xaa Asn Thr Gly Xaa Leu Cys Asp Val Val Xaa Gln Asn Cys Cys 1 5 10 15 Xaa Thr Xaa Cys Phe Ile Val Val Cys Leu 20 25 <210> SEQ ID NO 332 <211> LENGTH: 281 <212> TYPE: DNA <213> ORGANISM: Conus pulicarius <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(234) <400> SEQUENCE: 332 ggatcc atg aaa ctg acg tgc atg gtg atc gtt gct gtg ctg ttc ttg 48 Met Lys Leu Thr Cys Met Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc aag gct gat gac tcc aga aat gga ttg gag 96 Thr Ala Trp Thr Phe Val Lys Ala Asp Asp Ser Arg Asn Gly Leu Glu 15 20 25 30 aat ctt ttt ccg aag gca cgt cac gaa atg aag aac tcc aaa gcc tct 144 Asn Leu Phe Pro Lys Ala Arg His Glu Met Lys Asn Ser Lys Ala Ser 35 40 45 aaa tta aac aag agg tgc gtt gaa gat ggt gat ttt tgt ggt ccg gga 192 Lys Leu Asn Lys Arg Cys Val Glu Asp Gly Asp Phe Cys Gly Pro Gly 50 55 60 tat gaa gag tgc tgc agt ggc ttc tgc ctt tac gtc tgc atc 234 Tyr Glu Glu Cys Cys Ser Gly Phe Cys Leu Tyr Val Cys Ile 65 70 75 taaaactgcc gtgatgtctt ctactcccat ctgtgctacc cctcgag 281 <210> SEQ ID NO 333 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 333 Met Lys Leu Thr Cys Met Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Lys Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Ser Lys Ala Ser Lys Leu 35 40 45 Asn Lys Arg Cys Val Glu Asp Gly Asp Phe Cys Gly Pro Gly Tyr Glu 50 55 60 Glu Cys Cys Ser Gly Phe Cys Leu Tyr Val Cys Ile 65 70 75 <210> SEQ ID NO 334 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residues 3, 13 and 14 may be Glu or gamma-carboxy-Glu; Xaa at residue 10 may be Pro or hydroxy-Pro; Xaa at residues 12 and 22 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 334 Cys Val Xaa Asp Gly Asp Phe Cys Gly Xaa Gly Xaa Xaa Xaa Cys Cys 1 5 10 15 Ser Gly Phe Cys Leu Xaa Val Cys Ile 20 25 <210> SEQ ID NO 335 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Conus generalis <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(249) <400> SEQUENCE: 335 ggatcc atg aaa ctg acg tgt gtg gtg atc gtt gct gtg cta ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc acg gct gat gac acc aga tat aaa ctg gag 96 Thr Ala Trp Thr Phe Val Thr Ala Asp Asp Thr Arg Tyr Lys Leu Glu 15 20 25 30 aat cct ttt ctg aag gca cgc aac gaa ctg cag aaa cac gaa gcc tct 144 Asn Pro Phe Leu Lys Ala Arg Asn Glu Leu Gln Lys His Glu Ala Ser 35 40 45 caa ctg aac gag aga ggc tgc ctt gac cca ggt tac ttc tgt ggg acg 192 Gln Leu Asn Glu Arg Gly Cys Leu Asp Pro Gly Tyr Phe Cys Gly Thr 50 55 60 ccg ttt ctt gga gca tac tgc tgc ggt ggc att tgc ctt att gtc tgc 240 Pro Phe Leu Gly Ala Tyr Cys Cys Gly Gly Ile Cys Leu Ile Val Cys 65 70 75 ata gaa acg taaaggcttg atgtcttcta ctcccatctg tgctacccct cgag 293 Ile Glu Thr 80 <210> SEQ ID NO 336 <211> LENGTH: 81 <212> TYPE: PRT <213> ORGANISM: Conus generalis <400> SEQUENCE: 336 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Thr Arg Tyr Lys Leu Glu Asn Pro 20 25 30 Phe Leu Lys Ala Arg Asn Glu Leu Gln Lys His Glu Ala Ser Gln Leu 35 40 45 Asn Glu Arg Gly Cys Leu Asp Pro Gly Tyr Phe Cys Gly Thr Pro Phe 50 55 60 Leu Gly Ala Tyr Cys Cys Gly Gly Ile Cys Leu Ile Val Cys Ile Glu 65 70 75 80 Thr <210> SEQ ID NO 337 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Conus generalis <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(30) <223> OTHER INFORMATION: Xaa at residues 5 and 12 may be Pro or hydroxy-Pro; Xaa at residues 7 and 17 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 337 Gly Cys Leu Asp Xaa Gly Xaa Phe Cys Gly Thr Xaa Phe Leu Gly Ala 1 5 10 15 Xaa Cys Cys Gly Gly Ile Cys Leu Ile Val Cys Ile Xaa Thr 20 25 30 <210> SEQ ID NO 338 <211> LENGTH: 400 <212> TYPE: DNA <213> ORGANISM: Conus episcopatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(234) <400> SEQUENCE: 338 ggatcc atg aaa ctg acg tgc gtg gtg atc gtt gct gtg ctg ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttt gcc acg gct gat gac ccc aga aat gga ttg ggg 96 Thr Ala Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly 15 20 25 30 aat ctt ttt tcg aat gta cat cac gaa atg aag aac ctc gaa gac tct 144 Asn Leu Phe Ser Asn Val His His Glu Met Lys Asn Leu Glu Asp Ser 35 40 45 aaa ttg gac aag aag tgc ctt ggg ttt ggt gaa gct tgt ctt atg ctt 192 Lys Leu Asp Lys Lys Cys Leu Gly Phe Gly Glu Ala Cys Leu Met Leu 50 55 60 tat tca gac tgc tgc agc tat tgc gtt gct ctt gtc tgc cta 234 Tyr Ser Asp Cys Cys Ser Tyr Cys Val Ala Leu Val Cys Leu 65 70 75 taaaactacc gtgacgtctt ctactcccct ctgtgctacc tggcttgatc tttgattggc 294 gtgtgcgctt cactggttat gaacccctct gatcctactc tctgaagacc tctggggtcc 354 aacatccaaa taaagcgaca tcacaaaaaa aaaaaaaaaa aaaaaa 400 <210> SEQ ID NO 339 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 339 Met Lys Leu Thr Cys Val Val Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Ala Thr Ala Asp Asp Pro Arg Asn Gly Leu Gly Asn Leu 20 25 30 Phe Ser Asn Val His His Glu Met Lys Asn Leu Glu Asp Ser Lys Leu 35 40 45 Asp Lys Lys Cys Leu Gly Phe Gly Glu Ala Cys Leu Met Leu Tyr Ser 50 55 60 Asp Cys Cys Ser Tyr Cys Val Ala Leu Val Cys Leu 65 70 75 <210> SEQ ID NO 340 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(25) <223> OTHER INFORMATION: Xaa at residue 6 may be Glu or gamma-carboxy-Glu; Xaa at residues 12 and 18 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-s ulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 340 Cys Leu Gly Phe Gly Xaa Ala Cys Leu Met Leu Xaa Ser Asp Cys Cys 1 5 10 15 Ser Xaa Cys Val Ala Leu Val Cys Leu 20 25 <210> SEQ ID NO 341 <211> LENGTH: 404 <212> TYPE: DNA <213> ORGANISM: Conus episcopatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (7)..(240) <400> SEQUENCE: 341 ggatcc atg aaa ctg acg tgc gtg gtg atc att gct gtg ctg ttc ttg 48 Met Lys Leu Thr Cys Val Val Ile Ile Ala Val Leu Phe Leu 1 5 10 acc gcc tgg aca ttc gtc atg gct gat gac ccc aga gat gaa ccg gag 96 Thr Ala Trp Thr Phe Val Met Ala Asp Asp Pro Arg Asp Glu Pro Glu 15 20 25 30 gca cgt gac gaa atg aac ccc gca gcc tct aaa ttg aac gag aga ggc 144 Ala Arg Asp Glu Met Asn Pro Ala Ala Ser Lys Leu Asn Glu Arg Gly 35 40 45 tgc ctt gca gtt gat tat ttt tgc ggc ata ccg ttt gtg agc aac ggg 192 Cys Leu Ala Val Asp Tyr Phe Cys Gly Ile Pro Phe Val Ser Asn Gly 50 55 60 cta tgc tgc agt ggc aat tgt gtt ttt gtc tgc aca ccc caa ggg aag 240 Leu Cys Cys Ser Gly Asn Cys Val Phe Val Cys Thr Pro Gln Gly Lys 65 70 75 taaaactgcc gtgacgtctt ctactcccct ctgtgctacc tggcttgatc tttgattggc 300 gtgtgcactt cactggttat gaacccctct gatcctactc tctgaagacc tctggggtcc 360 aacatccaaa taaagcgaca tcccaaaaaa aaaaaaaaaa aaaa 404 <210> SEQ ID NO 342 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 342 Met Lys Leu Thr Cys Val Val Ile Ile Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Met Ala Asp Asp Pro Arg Asp Glu Pro Glu Ala Arg 20 25 30 Asp Glu Met Asn Pro Ala Ala Ser Lys Leu Asn Glu Arg Gly Cys Leu 35 40 45 Ala Val Asp Tyr Phe Cys Gly Ile Pro Phe Val Ser Asn Gly Leu Cys 50 55 60 Cys Ser Gly Asn Cys Val Phe Val Cys Thr Pro Gln Gly Lys 65 70 75 <210> SEQ ID NO 343 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residue 7 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 12 and 30 may be Pro or hydroxy-Pro <400> SEQUENCE: 343 Gly Cys Leu Ala Val Asp Xaa Phe Cys Gly Ile Xaa Phe Val Ser Asn 1 5 10 15 Gly Leu Cys Cys Ser Gly Asn Cys Val Phe Val Cys Thr Xaa Gln 20 25 30 <210> SEQ ID NO 344 <211> LENGTH: 202 <212> TYPE: DNA <213> ORGANISM: Conus achatinus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (85)..(171) <400> SEQUENCE: 344 cgatcctctg tcctccatct attattattc gctgccaaac tgtgttaaat attcaagtct 60 ctctttctgt ttgtgtctaa cagg ttg aga tgg tgc att cct aga ggt gat 111 Leu Arg Trp Cys Ile Pro Arg Gly Asp 1 5 ctt tgt ttc ccc tcg gat cgc ata caa tgc tgc agt ggc aag tgc aca 159 Leu Cys Phe Pro Ser Asp Arg Ile Gln Cys Cys Ser Gly Lys Cys Thr 10 15 20 25 ttc gtc tgc atg taaaactgcc gtgatgtctt ctcctcccct c 202 Phe Val Cys Met <210> SEQ ID NO 345 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus achatinus <400> SEQUENCE: 345 Leu Arg Trp Cys Ile Pro Arg Gly Asp Leu Cys Phe Pro Ser Asp Arg 1 5 10 15 Ile Gln Cys Cys Ser Gly Lys Cys Thr Phe Val Cys Met 20 25 <210> SEQ ID NO 346 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus achatinus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residues 4 and 11 may be Pro or hydroxy-Pro <400> SEQUENCE: 346 Xaa Cys Ile Xaa Arg Gly Asp Leu Cys Phe Xaa Ser Asp Arg Ile Gln 1 5 10 15 Cys Cys Ser Gly Lys Cys Thr Phe Val Cys Met 20 25 <210> SEQ ID NO 347 <211> LENGTH: 202 <212> TYPE: DNA <213> ORGANISM: Conus achatinus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (85)..(171) <400> SEQUENCE: 347 cgatcctctg tcctcctcct tcattcattc gctgccaaac tgtattaaat attcgaatct 60 ctctttctgt ttgtgtctga caga ttg aga ggg tgc gtt cct agt ggt gaa 111 Leu Arg Gly Cys Val Pro Ser Gly Glu 1 5 att tgt tac ttc atg gat cac ata gga tgc tgc agt ggc aag tgc aca 159 Ile Cys Tyr Phe Met Asp His Ile Gly Cys Cys Ser Gly Lys Cys Thr 10 15 20 25 ttc gtc tgc atg taaaactgcc gtgatgtctt ctcctcccat c 202 Phe Val Cys Met <210> SEQ ID NO 348 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus achatinus <400> SEQUENCE: 348 Leu Arg Gly Cys Val Pro Ser Gly Glu Ile Cys Tyr Phe Met Asp His 1 5 10 15 Ile Gly Cys Cys Ser Gly Lys Cys Thr Phe Val Cys Met 20 25 <210> SEQ ID NO 349 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus achatinus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 4 may be Pro or hydroxy-Pro; Xaa at residue 7 may be Glu or gamma-carboxy-Glu; Xaa at residue 10 may be Tyr, 125-I- Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 349 Gly Cys Val Xaa Ser Gly Xaa Ile Cys Xaa Phe Met Asp His Ile Gly 1 5 10 15 Cys Cys Ser Gly Lys Cys Thr Phe Val Cys Met 20 25 <210> SEQ ID NO 350 <211> LENGTH: 264 <212> TYPE: DNA <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 350 atg aaa ctg acg tgc gtg atg atc gtt act gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Thr Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aca tat gga ttg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Thr Tyr Gly Leu Lys Asn Leu 20 25 30 ttg ccg aac gga cgt cat gaa atg atg aac ccc gaa gcc cct aaa ttg 144 Leu Pro Asn Gly Arg His Glu Met Met Asn Pro Glu Ala Pro Lys Leu 35 40 45 aac aag aaa gat gaa tgc tct gct cct ggt gca ttt tgt ctc atc agg 192 Asn Lys Lys Asp Glu Cys Ser Ala Pro Gly Ala Phe Cys Leu Ile Arg 50 55 60 cca gga ctc tgc tgc agc gag ttc tgc ttc ttt gcg tgt ttt 234 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Phe Ala Cys Phe 65 70 75 tagtgacggt tgatgtcttc tactcccctc 264 <210> SEQ ID NO 351 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 351 Met Lys Leu Thr Cys Val Met Ile Val Thr Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Thr Tyr Gly Leu Lys Asn Leu 20 25 30 Leu Pro Asn Gly Arg His Glu Met Met Asn Pro Glu Ala Pro Lys Leu 35 40 45 Asn Lys Lys Asp Glu Cys Ser Ala Pro Gly Ala Phe Cys Leu Ile Arg 50 55 60 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Phe Ala Cys Phe 65 70 75 <210> SEQ ID NO 352 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residues 2 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residues 6 and 14 may be Pro or hydroxy-Pro <400> SEQUENCE: 352 Asp Xaa Cys Ser Ala Xaa Gly Ala Phe Cys Leu Ile Arg Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Phe Phe Ala Cys Phe 20 25 <210> SEQ ID NO 353 <211> LENGTH: 276 <212> TYPE: DNA <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 353 atg aaa ctg acg tgc gtg atg atc gtt act gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Thr Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga gac gct ccg gat agt gca 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asp Ala Pro Asp Ser Ala 20 25 30 gaa gga tgg gag aaa ctt ttc tcg gag gca cgt gac gaa atg aag aac 144 Glu Gly Trp Glu Lys Leu Phe Ser Glu Ala Arg Asp Glu Met Lys Asn 35 40 45 cgc aaa gac ttt gaa ttg aga ggg tgc ctt cct agg tgg gaa ttt tgt 192 Arg Lys Asp Phe Glu Leu Arg Gly Cys Leu Pro Arg Trp Glu Phe Cys 50 55 60 ccc atc ttt aaa aaa aac gat tgc tgc agt ggc ata tgc ata agc atc 240 Pro Ile Phe Lys Lys Asn Asp Cys Cys Ser Gly Ile Cys Ile Ser Ile 65 70 75 80 tgc ttg taaaactccg tgatgtcttc tcttcccatc 276 Cys Leu <210> SEQ ID NO 354 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 354 Met Lys Leu Thr Cys Val Met Ile Val Thr Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asp Ala Pro Asp Ser Ala 20 25 30 Glu Gly Trp Glu Lys Leu Phe Ser Glu Ala Arg Asp Glu Met Lys Asn 35 40 45 Arg Lys Asp Phe Glu Leu Arg Gly Cys Leu Pro Arg Trp Glu Phe Cys 50 55 60 Pro Ile Phe Lys Lys Asn Asp Cys Cys Ser Gly Ile Cys Ile Ser Ile 65 70 75 80 Cys Leu <210> SEQ ID NO 355 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residues 4 and 10 may be Pro or hydroxy-Pro; Xaa at residue 6 may be Trp or bromo-Trp; Xaa at residue 7 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 355 Gly Cys Leu Xaa Arg Xaa Xaa Phe Cys Xaa Ile Phe Lys Lys Asn Asp 1 5 10 15 Cys Cys Ser Gly Ile Cys Ile Ser Ile Cys Leu 20 25 <210> SEQ ID NO 356 <211> LENGTH: 268 <212> TYPE: DNA <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(237) <400> SEQUENCE: 356 atg aaa ctg acg tgc atg atg att gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg ata ttt gta atg gct gat gac tcc aga aat gga ttg gag aat ctt 96 Trp Ile Phe Val Met Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 cct cag act aca cgt cac gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Pro Gln Thr Thr Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac cag aca gac tgc ctt gct aaa gac gct ttc tgt gcc tgg ccg ata 192 Asn Gln Thr Asp Cys Leu Ala Lys Asp Ala Phe Cys Ala Trp Pro Ile 50 55 60 ctt gga cca ctg tgc tgc agt cgc ttg tgc tta tac gtc tgc atg 237 Leu Gly Pro Leu Cys Cys Ser Arg Leu Cys Leu Tyr Val Cys Met 65 70 75 taaaactgcc gtgatgtctt ctactcccct c 268 <210> SEQ ID NO 357 <211> LENGTH: 79 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <400> SEQUENCE: 357 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Ile Phe Val Met Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 Pro Gln Thr Thr Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Gln Thr Asp Cys Leu Ala Lys Asp Ala Phe Cys Ala Trp Pro Ile 50 55 60 Leu Gly Pro Leu Cys Cys Ser Arg Leu Cys Leu Tyr Val Cys Met 65 70 75 <210> SEQ ID NO 358 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Xaa at residue 11 may be Trp or bromo-Trp; Xaa at residues 12 and 16 may be Pro or hydroxy-Pro; Xaa at residue 25 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr. <400> SEQUENCE: 358 Asp Cys Leu Ala Lys Asp Ala Phe Cys Ala Xaa Xaa Ile Leu Gly Xaa 1 5 10 15 Leu Cys Cys Ser Arg Leu Cys Leu Xaa Val Cys Met 20 25 <210> SEQ ID NO 359 <211> LENGTH: 266 <212> TYPE: DNA <213> ORGANISM: Conus consors <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 359 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga aat gga ttg gag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 tct ccg aag gca cgt cac gaa atg aag aac ccc gaa gcc tct aaa tcg 144 Ser Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Ser 35 40 45 aac aag aga tat gag tgc tat tct act ggt aca ttt tgt ggc atc aac 192 Asn Lys Arg Tyr Glu Cys Tyr Ser Thr Gly Thr Phe Cys Gly Ile Asn 50 55 60 gga gga ctc tgc tgc agc aac ctt tgc tta ttt ttc gtg tgc tta aca 240 Gly Gly Leu Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr 65 70 75 80 ttt tcg tgatgtcttc tcctcccctc 266 Phe Ser <210> SEQ ID NO 360 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus consors <400> SEQUENCE: 360 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 Ser Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Ser 35 40 45 Asn Lys Arg Tyr Glu Cys Tyr Ser Thr Gly Thr Phe Cys Gly Ile Asn 50 55 60 Gly Gly Leu Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr 65 70 75 80 Phe Ser <210> SEQ ID NO 361 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus consors <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residues 1 and 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 2 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 361 Xaa Xaa Cys Xaa Ser Thr Gly Thr Phe Cys Gly Ile Asn Gly Gly Leu 1 5 10 15 Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr Phe Ser 20 25 30 <210> SEQ ID NO 362 <211> LENGTH: 289 <212> TYPE: DNA <213> ORGANISM: Conus consors <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(252) <400> SEQUENCE: 362 atg aaa ctg acg tgc ctg atg atc gtt gct gtg ctg ttc ttg acc acc 48 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga tat gga ttg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 ttt ccg aag gca cgt cat gaa atg aag aac cct gaa gcc tct aaa ttg 144 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag aga gat ggg tgc tat aat gct ggt aca ttt tgt ggc atc cgt 192 Asn Lys Arg Asp Gly Cys Tyr Asn Ala Gly Thr Phe Cys Gly Ile Arg 50 55 60 cca gga ctc tgc tgc agc gag ttt tgc ttt tta tgg tgc ata aca ttt 240 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 gtt gat tct ggc taacagtgtg cgttggttga tgtcttctac tcccctc 289 Val Asp Ser Gly <210> SEQ ID NO 363 <211> LENGTH: 84 <212> TYPE: PRT <213> ORGANISM: Conus consors <400> SEQUENCE: 363 Met Lys Leu Thr Cys Leu Met Ile Val Ala Val Leu Phe Leu Thr Thr 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Tyr Gly Leu Lys Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Asp Gly Cys Tyr Asn Ala Gly Thr Phe Cys Gly Ile Arg 50 55 60 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 Val Asp Ser Gly <210> SEQ ID NO 364 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Conus consors <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(32) <223> OTHER INFORMATION: Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 14 may be Pro or hydroxy-Pro; Xaa at residue 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 25 may be Trp or bromo-Trp <400> SEQUENCE: 364 Asp Gly Cys Xaa Asn Ala Gly Thr Phe Cys Gly Ile Arg Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Phe Leu Xaa Cys Ile Thr Phe Val Asp Ser 20 25 30 <210> SEQ ID NO 365 <211> LENGTH: 205 <212> TYPE: DNA <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (83)..(175) <400> SEQUENCE: 365 cgatccatct gtccatccat ctattcattc attcgctgcc aaactgtatt aaatattcaa 60 gtctctcttt ctgtttgtgt ct aac aga ttg agt agg tgc att cct agt ggt 112 Asn Arg Leu Ser Arg Cys Ile Pro Ser Gly 1 5 10 gat ctt tgt ttc ccc tcg gat cac ata caa tgc tgc aat gcc aag tgc 160 Asp Leu Cys Phe Pro Ser Asp His Ile Gln Cys Cys Asn Ala Lys Cys 15 20 25 gca ttc gtc tgc ttg taaaactgcc gtgatgtctt ctcttccctc 205 Ala Phe Val Cys Leu 30 <210> SEQ ID NO 366 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 366 Asn Arg Leu Ser Arg Cys Ile Pro Ser Gly Asp Leu Cys Phe Pro Ser 1 5 10 15 Asp His Ile Gln Cys Cys Asn Ala Lys Cys Ala Phe Val Cys Leu 20 25 30 <210> SEQ ID NO 367 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3 and 10 may be Pro or hydroxy-Pro. <400> SEQUENCE: 367 Cys Ile Xaa Ser Gly Asp Leu Cys Phe Xaa Ser Asp His Ile Gln Cys 1 5 10 15 Cys Asn Ala Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 368 <211> LENGTH: 206 <212> TYPE: DNA <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (83)..(175) <400> SEQUENCE: 368 cgatccatct gtccatccat ctattcattc attcgctgtc aaactgtatt aaatattcaa 60 gtctctcttt ctgtttgtgt ct aac aga ttg agt tgg tgc att cct agt ggt 112 Asn Arg Leu Ser Trp Cys Ile Pro Ser Gly 1 5 10 gat ctt tgt ttc ccc tcg gat cac ata caa tgc tgc agt gcc aag tgc 160 Asp Leu Cys Phe Pro Ser Asp His Ile Gln Cys Cys Ser Ala Lys Cys 15 20 25 gca ttc gtc tgc ttg taaaactgcc gtgatgtctt ctactcccct c 206 Ala Phe Val Cys Leu 30 <210> SEQ ID NO 369 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 369 Asn Arg Leu Ser Trp Cys Ile Pro Ser Gly Asp Leu Cys Phe Pro Ser 1 5 10 15 Asp His Ile Gln Cys Cys Ser Ala Lys Cys Ala Phe Val Cys Leu 20 25 30 <210> SEQ ID NO 370 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residues 4 and 11 may be Pro or hydroxy-Pro <400> SEQUENCE: 370 Xaa Cys Ile Xaa Ser Gly Asp Leu Cys Phe Xaa Ser Asp His Ile Gln 1 5 10 15 Cys Cys Ser Ala Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 371 <211> LENGTH: 206 <212> TYPE: DNA <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (83)..(175) <400> SEQUENCE: 371 cgatccatct gtccatccat ctattcattc attcgctgtc aaactgtatt aaatattcaa 60 gtctctcttt ctgtttgtgt ct aac aga ttg agt agg tgc att cct agt ggt 112 Asn Arg Leu Ser Arg Cys Ile Pro Ser Gly 1 5 10 gat ctt tgt ttc ccc tcg gat cac ata caa tgc tgc agt gcc aag tgc 160 Asp Leu Cys Phe Pro Ser Asp His Ile Gln Cys Cys Ser Ala Lys Cys 15 20 25 gca ttc gtc tgc ttg taaaactgcc gtgatgtctt ctcctcccct c 206 Ala Phe Val Cys Leu 30 <210> SEQ ID NO 372 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 372 Asn Arg Leu Ser Arg Cys Ile Pro Ser Gly Asp Leu Cys Phe Pro Ser 1 5 10 15 Asp His Ile Gln Cys Cys Ser Ala Lys Cys Ala Phe Val Cys Leu 20 25 30 <210> SEQ ID NO 373 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3 and 10 may be Pro or hydroxy-Pro. <400> SEQUENCE: 373 Cys Ile Xaa Ser Gly Asp Leu Cys Phe Xaa Ser Asp His Ile Gln Cys 1 5 10 15 Cys Ser Ala Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 374 <211> LENGTH: 206 <212> TYPE: DNA <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (83)..(175) <400> SEQUENCE: 374 cgatccatct gtccatccat ctattcattc attcgctgcc aaactgtatt aaatattcaa 60 gtctctcttt ctgtttgtgt ct aac aga ttg agt agg tgc att cct agt ggt 112 Asn Arg Leu Ser Arg Cys Ile Pro Ser Gly 1 5 10 gat ctt tgt ttc ccc tcg gat cac ata caa tgc tgc aat gcc gag tgc 160 Asp Leu Cys Phe Pro Ser Asp His Ile Gln Cys Cys Asn Ala Glu Cys 15 20 25 gca ttc gtc tgc ttg taaaactgcc gtgatgtctt ctcctcccct c 206 Ala Phe Val Cys Leu 30 <210> SEQ ID NO 375 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 375 Asn Arg Leu Ser Arg Cys Ile Pro Ser Gly Asp Leu Cys Phe Pro Ser 1 5 10 15 Asp His Ile Gln Cys Cys Asn Ala Glu Cys Ala Phe Val Cys Leu 20 25 30 <210> SEQ ID NO 376 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3 and 10 may be Pro or hydroxy-Pro; Xaa at residue 20 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 376 Cys Ile Xaa Ser Gly Asp Leu Cys Phe Xaa Ser Asp His Ile Gln Cys 1 5 10 15 Cys Asn Ala Xaa Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 377 <211> LENGTH: 206 <212> TYPE: DNA <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (83)..(175) <400> SEQUENCE: 377 cgatccatct gtccatccat ctattcattc attcgctgtc aaactgtatt aaatattcaa 60 gtctctcttt ctgtttgtgt ct aac aga ttg agt tgg tgc att cct agt ggt 112 Asn Arg Leu Ser Trp Cys Ile Pro Ser Gly 1 5 10 gat ctt tgt ttc ccc tcg gat cac ata cga tgc tgc agt gcc aag tgc 160 Asp Leu Cys Phe Pro Ser Asp His Ile Arg Cys Cys Ser Ala Lys Cys 15 20 25 gca ttc gtc tgc ttg taaaactgcc gtgatgtctt ctcttcccat c 206 Ala Phe Val Cys Leu 30 <210> SEQ ID NO 378 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 378 Asn Arg Leu Ser Trp Cys Ile Pro Ser Gly Asp Leu Cys Phe Pro Ser 1 5 10 15 Asp His Ile Arg Cys Cys Ser Ala Lys Cys Ala Phe Val Cys Leu 20 25 30 <210> SEQ ID NO 379 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residues 4 and 11 may be Pro or hydroxy-Pro <400> SEQUENCE: 379 Xaa Cys Ile Xaa Ser Gly Asp Leu Cys Phe Xaa Ser Asp His Ile Arg 1 5 10 15 Cys Cys Ser Ala Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 380 <211> LENGTH: 206 <212> TYPE: DNA <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (83)..(175) <400> SEQUENCE: 380 cgatccatct gtccatccat ctattcattc attcgctgcc aaactgtatt aaatattcaa 60 gtctctcttt ctgtttgtgt ct aac aga ttg agt agg tgc att cct agt ggt 112 Asn Arg Leu Ser Arg Cys Ile Pro Ser Gly 1 5 10 gat ctt tgt ttc ccc tcg gat cac ata caa tgc tgc aat gcc aag tgc 160 Asp Leu Cys Phe Pro Ser Asp His Ile Gln Cys Cys Asn Ala Lys Cys 15 20 25 gca ttc gcc tgc ttg taaaactgcc gtgatgtctt ctcttcccct c 206 Ala Phe Ala Cys Leu 30 <210> SEQ ID NO 381 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 381 Asn Arg Leu Ser Arg Cys Ile Pro Ser Gly Asp Leu Cys Phe Pro Ser 1 5 10 15 Asp His Ile Gln Cys Cys Asn Ala Lys Cys Ala Phe Ala Cys Leu 20 25 30 <210> SEQ ID NO 382 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residues 3 and 10 may be Pro or hydroxy-Pro. <400> SEQUENCE: 382 Cys Ile Xaa Ser Gly Asp Leu Cys Phe Xaa Ser Asp His Ile Gln Cys 1 5 10 15 Cys Asn Ala Lys Cys Ala Phe Ala Cys Leu 20 25 <210> SEQ ID NO 383 <211> LENGTH: 206 <212> TYPE: DNA <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (83)..(175) <400> SEQUENCE: 383 cgatccatct gtccatccat ctattcattc attcgctgcc aaactgtatt aaatattcaa 60 gtctctcttt ctgtttgtgt ct aac aga ttg agt tgg tgc att cct agt ggt 112 Asn Arg Leu Ser Trp Cys Ile Pro Ser Gly 1 5 10 gat ctt tgt ttc ccc tcg gat cac ata caa tgc tgc aat gcc aag tgc 160 Asp Leu Cys Phe Pro Ser Asp His Ile Gln Cys Cys Asn Ala Lys Cys 15 20 25 gca ttc gtc tgc ttg taaaactgcc gtgatgtctt ctactcccct c 206 Ala Phe Val Cys Leu 30 <210> SEQ ID NO 384 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 384 Asn Arg Leu Ser Trp Cys Ile Pro Ser Gly Asp Leu Cys Phe Pro Ser 1 5 10 15 Asp His Ile Gln Cys Cys Asn Ala Lys Cys Ala Phe Val Cys Leu 20 25 30 <210> SEQ ID NO 385 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residues 4 and 11 may be Pro or hydroxy-Pro <400> SEQUENCE: 385 Xaa Cys Ile Xaa Ser Gly Asp Leu Cys Phe Xaa Ser Asp His Ile Gln 1 5 10 15 Cys Cys Asn Ala Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 386 <211> LENGTH: 200 <212> TYPE: DNA <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (77)..(169) <400> SEQUENCE: 386 cgatcctctg tcctcctcta ttattattcg ctgccaactg tattaaatat tcaagtctct 60 ctttctgttt gtgtct aac aga ttg agt tgg tgc att cct act ggt gat ctt 112 Asn Arg Leu Ser Trp Cys Ile Pro Thr Gly Asp Leu 1 5 10 tgt ttc ccc tcg gat cac ata caa tgc tgc agt ggc aag tgc aca ttc 160 Cys Phe Pro Ser Asp His Ile Gln Cys Cys Ser Gly Lys Cys Thr Phe 15 20 25 gtc tgc atg taaaactgcc gtgatgtctt ctcctcccct c 200 Val Cys Met 30 <210> SEQ ID NO 387 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 387 Asn Arg Leu Ser Trp Cys Ile Pro Thr Gly Asp Leu Cys Phe Pro Ser 1 5 10 15 Asp His Ile Gln Cys Cys Ser Gly Lys Cys Thr Phe Val Cys Met 20 25 30 <210> SEQ ID NO 388 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue1 may be Trp or bromo-Trp; Xaa at residues 4 and 11 may be Pro or hydroxy-Pro <400> SEQUENCE: 388 Xaa Cys Ile Xaa Thr Gly Asp Leu Cys Phe Xaa Ser Asp His Ile Gln 1 5 10 15 Cys Cys Ser Gly Lys Cys Thr Phe Val Cys Met 20 25 <210> SEQ ID NO 389 <211> LENGTH: 266 <212> TYPE: DNA <213> ORGANISM: Conus monachus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 389 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga aat gga ttg gag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 tct ccg aag gca cgt cac gaa atg aag aac ccc gaa gcc tct aaa tcg 144 Ser Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Ser 35 40 45 aac aag aga tat gag tgc tat tct act ggt aca ttt tgt ggc atc aac 192 Asn Lys Arg Tyr Glu Cys Tyr Ser Thr Gly Thr Phe Cys Gly Ile Asn 50 55 60 gga gga ctc tgc tgc agc aac ctt tgc tta ttt ttc gtg tgc tta aca 240 Gly Gly Leu Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr 65 70 75 80 ttt tcg tgatgtcttc tcctcccctc 266 Phe Ser <210> SEQ ID NO 390 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus monachus <400> SEQUENCE: 390 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 Ser Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Ser 35 40 45 Asn Lys Arg Tyr Glu Cys Tyr Ser Thr Gly Thr Phe Cys Gly Ile Asn 50 55 60 Gly Gly Leu Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr 65 70 75 80 Phe Ser <210> SEQ ID NO 391 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus monachus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residues 1 and 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 2 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 391 Xaa Xaa Cys Xaa Ser Thr Gly Thr Phe Cys Gly Ile Asn Gly Gly Leu 1 5 10 15 Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr Phe Ser 20 25 30 <210> SEQ ID NO 392 <211> LENGTH: 277 <212> TYPE: DNA <213> ORGANISM: Conus stercusmuscarum <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 392 atg aaa ctg acg tgc atg atg atc gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc aca gct gat gac tcc ata aat gga ccg gag aat aga 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Ile Asn Gly Pro Glu Asn Arg 20 25 30 cga ata tgg gag aaa ctt ttg ttg aag gca cgt gac gaa atg aag aac 144 Arg Ile Trp Glu Lys Leu Leu Leu Lys Ala Arg Asp Glu Met Lys Asn 35 40 45 ccc gaa gcc tct caa ttg aga tgg tgc att cct agt ggt gaa ctt tgt 192 Pro Glu Ala Ser Gln Leu Arg Trp Cys Ile Pro Ser Gly Glu Leu Cys 50 55 60 ttc cgc tcg gat cac ata caa tgc tgc agt gcc aag tgc gca ttc gtc 240 Phe Arg Ser Asp His Ile Gln Cys Cys Ser Ala Lys Cys Ala Phe Val 65 70 75 80 tgc ttg taaaactacc gtgatgtctt ctcctcccat c 277 Cys Leu <210> SEQ ID NO 393 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 393 Met Lys Leu Thr Cys Met Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Ile Asn Gly Pro Glu Asn Arg 20 25 30 Arg Ile Trp Glu Lys Leu Leu Leu Lys Ala Arg Asp Glu Met Lys Asn 35 40 45 Pro Glu Ala Ser Gln Leu Arg Trp Cys Ile Pro Ser Gly Glu Leu Cys 50 55 60 Phe Arg Ser Asp His Ile Gln Cys Cys Ser Ala Lys Cys Ala Phe Val 65 70 75 80 Cys Leu <210> SEQ ID NO 394 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 1 may be Trp or bromo-Trp; Xaa at residue 4 may be Pro or hydroxy-Pro; Xaa at residue 7 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 394 Xaa Cys Ile Xaa Ser Gly Xaa Leu Cys Pro Arg Ser Asp His Ile Gln 1 5 10 15 Cys Cys Ser Ala Lys Cys Ala Phe Val Cys Leu 20 25 <210> SEQ ID NO 395 <211> LENGTH: 266 <212> TYPE: DNA <213> ORGANISM: Conus stercusmuscarum <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 395 atg aaa ctg acg tgt gtg atg atc gtt gct gtg ctg ttc ttg atc gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Ile Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga aat gga ttg aag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Lys Asn Leu 20 25 30 ttt ccg aag gca cgt cat gaa atg aag aac ccc gaa gcc tct aaa ttg 144 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 aac aag aga gat ggg tgc tct agt ggt ggt aca ttt tgt ggc atc cgt 192 Asn Lys Arg Asp Gly Cys Ser Ser Gly Gly Thr Phe Cys Gly Ile Arg 50 55 60 cca gga ctc tgc tgc agc gag ttt tgc ttt ctt tgg tgc ata aca ttt 240 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 att gat tgatgtcttc tattcccctc 266 Ile Asp <210> SEQ ID NO 396 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 396 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Ile Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Lys Asn Leu 20 25 30 Phe Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Leu 35 40 45 Asn Lys Arg Asp Gly Cys Ser Ser Gly Gly Thr Phe Cys Gly Ile Arg 50 55 60 Pro Gly Leu Cys Cys Ser Glu Phe Cys Phe Leu Trp Cys Ile Thr Phe 65 70 75 80 Ile Asp <210> SEQ ID NO 397 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residue 14 may be Pro or hydroxy-Pro; Xaa at residue 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 25 may be Trp or bromo-Trp <400> SEQUENCE: 397 Asp Gly Cys Ser Ser Gly Gly Thr Phe Cys Gly Ile Arg Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Phe Cys Phe Leu Xaa Cys Ile Thr Phe Ile Asp 20 25 30 <210> SEQ ID NO 398 <211> LENGTH: 265 <212> TYPE: DNA <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(234) <400> SEQUENCE: 398 atg aaa ctg acg tgc ata atg acc gtt gct gtg ctg ttc ttg acc gct 48 Met Lys Leu Thr Cys Ile Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aga aat gga ttg gag aat ctt 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 ctt ctg aag aca cgt cac gaa gtg gaa aac ccc aaa gcc tct agg tcg 144 Leu Leu Lys Thr Arg His Glu Val Glu Asn Pro Lys Ala Ser Arg Ser 35 40 45 ggc ggt agg tgc cgt cct ggt ggt acg gtt tgt ggc ttt ccg aaa cct 192 Gly Gly Arg Cys Arg Pro Gly Gly Thr Val Cys Gly Phe Pro Lys Pro 50 55 60 gga cca tac tgc tgc agt ggc tgg tgc ttt ttt gtc tgc gcc 234 Gly Pro Tyr Cys Cys Ser Gly Trp Cys Phe Phe Val Cys Ala 65 70 75 taaacctgcc gtgatgtctt ctcctcccat c 265 <210> SEQ ID NO 399 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <400> SEQUENCE: 399 Met Lys Leu Thr Cys Ile Met Thr Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 Leu Leu Lys Thr Arg His Glu Val Glu Asn Pro Lys Ala Ser Arg Ser 35 40 45 Gly Gly Arg Cys Arg Pro Gly Gly Thr Val Cys Gly Phe Pro Lys Pro 50 55 60 Gly Pro Tyr Cys Cys Ser Gly Trp Cys Phe Phe Val Cys Ala 65 70 75 <210> SEQ ID NO 400 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residues 3, 11, 13 and 15 may be Pro or hydroxy-Pro; Xaa at residue 16 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 21 may be Trp or bromo-Trp <400> SEQUENCE: 400 Cys Arg Xaa Gly Gly Thr Val Cys Gly Phe Xaa Lys Xaa Gly Xaa Xaa 1 5 10 15 Cys Cys Ser Gly Xaa Cys Phe Phe Val Cys Ala 20 25 <210> SEQ ID NO 401 <211> LENGTH: 272 <212> TYPE: DNA <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(243) <400> SEQUENCE: 401 atg aaa ctg acg tgc gtg atg atc gtt gct gtg ctg ttc ttg act gcc 48 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 tgg aca ttc gtc acg gct gat gac tcc aaa aat gga ctg gag aat cat 96 Trp Thr Phe Val Thr Ala Asp Asp Ser Lys Asn Gly Leu Glu Asn His 20 25 30 ttt tgg aag gca cgt gac gaa atg aag aac cgc gaa gcc tct aaa ttg 144 Phe Trp Lys Ala Arg Asp Glu Met Lys Asn Arg Glu Ala Ser Lys Leu 35 40 45 gac aaa aag gaa gcc tgc tat ccg cct ggt act ttt tgt ggc ata aag 192 Asp Lys Lys Glu Ala Cys Tyr Pro Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 ccc ggg cta tgc tgc agt gag ttg tgt tta ccg gcc gtc tgc gtc ggt 240 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Pro Ala Val Cys Val Gly 65 70 75 80 ggt taactgccgt gatgtcttct attcccctc 272 Gly <210> SEQ ID NO 402 <211> LENGTH: 81 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <400> SEQUENCE: 402 Met Lys Leu Thr Cys Val Met Ile Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Trp Thr Phe Val Thr Ala Asp Asp Ser Lys Asn Gly Leu Glu Asn His 20 25 30 Phe Trp Lys Ala Arg Asp Glu Met Lys Asn Arg Glu Ala Ser Lys Leu 35 40 45 Asp Lys Lys Glu Ala Cys Tyr Pro Pro Gly Thr Phe Cys Gly Ile Lys 50 55 60 Pro Gly Leu Cys Cys Ser Glu Leu Cys Leu Pro Ala Val Cys Val Gly 65 70 75 80 Gly <210> SEQ ID NO 403 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Xaa at residues 1 and 20 may be Glu or gamma-carboxy-Glu; Xaa at residue 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residues 5, 6, 14 and 24 may be Pro or hydroxy-Pro <400> SEQUENCE: 403 Xaa Ala Cys Xaa Xaa Xaa Gly Thr Phe Cys Gly Ile Lys Xaa Gly Leu 1 5 10 15 Cys Cys Ser Xaa Leu Cys Leu Xaa Ala Val Cys Val Gly 20 25 <210> SEQ ID NO 404 <211> LENGTH: 265 <212> TYPE: DNA <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(246) <400> SEQUENCE: 404 atg aaa ctg acg tgt ctg atg gct gtt gct gtg ctg ttc ttg acc gcc 48 Met Lys Leu Thr Cys Leu Met Ala Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 cgg aca ttc gtc acg gct gat gac tcc aga aat gga ttg gag aat ctt 96 Arg Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 tct ccg aag gca cgt cac gaa atg aag aac ccc gaa gcc tct aaa tcg 144 Ser Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Ser 35 40 45 aac aag aga tat gag tgc tat tct act ggt aca ttt tgt ggc atc aac 192 Asn Lys Arg Tyr Glu Cys Tyr Ser Thr Gly Thr Phe Cys Gly Ile Asn 50 55 60 gga gga ctc tgc tgc agc aac ctt tgc tta ttt ttc gtg tgc tta aca 240 Gly Gly Leu Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr 65 70 75 80 ttt tcg tgatgtcttc tatcccctc 265 Phe Ser <210> SEQ ID NO 405 <211> LENGTH: 82 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <400> SEQUENCE: 405 Met Lys Leu Thr Cys Leu Met Ala Val Ala Val Leu Phe Leu Thr Ala 1 5 10 15 Arg Thr Phe Val Thr Ala Asp Asp Ser Arg Asn Gly Leu Glu Asn Leu 20 25 30 Ser Pro Lys Ala Arg His Glu Met Lys Asn Pro Glu Ala Ser Lys Ser 35 40 45 Asn Lys Arg Tyr Glu Cys Tyr Ser Thr Gly Thr Phe Cys Gly Ile Asn 50 55 60 Gly Gly Leu Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr 65 70 75 80 Phe Ser <210> SEQ ID NO 406 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(31) <223> OTHER INFORMATION: Xaa at residues 1 and 4 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 2 may be Glu or gamma-carboxy-Glu <400> SEQUENCE: 406 Xaa Xaa Cys Xaa Ser Thr Gly Thr Phe Cys Gly Ile Asn Gly Gly Leu 1 5 10 15 Cys Cys Ser Asn Leu Cys Leu Phe Phe Val Cys Leu Thr Phe Ser 20 25 30 <210> SEQ ID NO 407 <211> LENGTH: 287 <212> TYPE: DNA <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(231) <400> SEQUENCE: 407 atg aaa ctg acg tgt atg gtg atc gtc gcc gtg ctg ctc ctg acg acc 48 Met Lys Leu Thr Cys Met Val Ile Val Ala Val Leu Leu Leu Thr Thr 1 5 10 15 tgt cat ctc atc aca gct gat gac tcc aga ggt acg cag aag cat cgt 96 Cys His Leu Ile Thr Ala Asp Asp Ser Arg Gly Thr Gln Lys His Arg 20 25 30 tcc ctg agg tcg act acc aaa gtc tcc aag tcg act agc tgc atg aaa 144 Ser Leu Arg Ser Thr Thr Lys Val Ser Lys Ser Thr Ser Cys Met Lys 35 40 45 gcc ggg tct tat tgc gtc gct act acg aga atc tgc tgc ggt tat tgc 192 Ala Gly Ser Tyr Cys Val Ala Thr Thr Arg Ile Cys Cys Gly Tyr Cys 50 55 60 gct tat ttc ggc aaa ata tgt att ggc tat ccc aaa aac tgatcctccc 241 Ala Tyr Phe Gly Lys Ile Cys Ile Gly Tyr Pro Lys Asn 65 70 75 cctactgtgc tctatccttt tctgcctgat gtcttctcct cccctc 287 <210> SEQ ID NO 408 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <400> SEQUENCE: 408 Met Lys Leu Thr Cys Met Val Ile Val Ala Val Leu Leu Leu Thr Thr 1 5 10 15 Cys His Leu Ile Thr Ala Asp Asp Ser Arg Gly Thr Gln Lys His Arg 20 25 30 Ser Leu Arg Ser Thr Thr Lys Val Ser Lys Ser Thr Ser Cys Met Lys 35 40 45 Ala Gly Ser Tyr Cys Val Ala Thr Thr Arg Ile Cys Cys Gly Tyr Cys 50 55 60 Ala Tyr Phe Gly Lys Ile Cys Ile Gly Tyr Pro Lys Asn 65 70 75 <210> SEQ ID NO 409 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Conus striolatus <220> FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (1)..(35) <223> OTHER INFORMATION: Xaa at residues 10, 21, 24 and 32 may be Tyr, 125-I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr; Xaa at residue 33 may be Pro or hydroxy-Pro <400> SEQUENCE: 409 Ser Thr Ser Cys Met Lys Ala Gly Ser Xaa Cys Val Ala Thr Thr Arg 1 5 10 15 Ile Cys Cys Gly Xaa Cys Ala Xaa Phe Gly Lys Ile Cys Ile Gly Xaa 20 25 30 Xaa Lys Asn 35 

What is claimed is:
 1. A substantially pure O-Superfamily conopeptide selected from the peptides set forth in Table
 2. 2. A substantially pure conotoxin peplide selected from the group consisting of the mature toxin peptide sequences disclosed in Table 1 except the peptides Di6.2, Af6.9, KK1, KK2, δ-GmVIA, M6.4, δ-PVIA, δ-PVIA-OH, δ-NgVIA, δ-TxVIA, and Israel TxVIA.
 3. The substantially pure conotoxin peptide of claim 2, wherein Xaa₁ is Glu.
 4. The substantially pure conotoxin peptide of claim 2, wherein Xaa₅ is Tyr.
 5. The substantially pure conotoxin peptide of claim 2, wherein Xaa₄ is Trp.
 6. The substantially pure conotoxin peptide of claim 2, wherein Xaa₂ is Gln.
 7. The substantially pure conotoxin peptide of claim 2, wherein Xaa₃ is Pro.
 8. The substantially pure conotoxin peptide of claim 2, wherein Xaa₃ is hydroxy-Pro.
 9. The substantially pure conotoxin peptide of claim 2, wherein Xaa₅ is ¹²⁵I-Tyr, mono-iodo-Tyr or di-iodo-Tyr.
 10. The substantially pure conotoxin peptide of claim 2, wherein Xaa₄ is 6-bromo-Trp.
 11. The substantially pure conotoxin peptide of claim 2, wherein Xaa₁ is Gla.
 12. The substantially pure conotoxin peptide of claim 2, wherein Xaa₂ is pyro-Glu.
 13. An isolated nucleic acid comprising a nucleic acid coding for an O-Superfamily conotoxin precursor comprising an amino acid sequence selected from the group of amino acid sequences set forth in Table
 1. 14. The nucleic acid of claim 13 wherein the nucleic acid comprises a nucleotide sequence selected from the group of nucleotide sequences set forth in Table 1 or their complements.
 15. A substantially pure conotoxin protein precursor comprising an amino acid sequence selected from the group of amino acid sequences set forth in Table
 1. 16. A pharmaceutical composition comprising a conotoxin peptide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, said conotoxin peptide being the conotoxin peptide of claim
 1. 17. A pharmaceutical composition comprising a conotoxin peptide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, said conotoxin peptide selected from the group consisting of the conotoxin peptides of claim
 2. 18. A method for regulating the flow of sodium through sodium channels in an individual in need thereof which comprises administering a therapeutically effective amount of a conotoxin peptide of claim 1 or a pharmaceutically acceptible salt thereof.
 19. A method for treating or preventing disorders associated with voltage gated ion channel disorders in which comprises administering to a patient in need thereof a therapeutically effective amount of a conotoxin peptide of claim 1 or a pharmaceutically acceptible salt thereof.
 20. The method of claim 18, wherein said individual in need thereof suffers from a disorder selected from the group consisting of multiple sclerosis, other demyelinating diseases (such as acute disseminated encephalomyelitis, optic neuromyelitis, adrenoleukodystrophy, acute transverse myelitis, progressive multifocal leukoencephalopathy), sub-acute sclerosing panencephalomyelitis (SSPE), metachromatic leukodystrophy, Pelizaeus-Merzbacher disease, spinal cord injury, botulinum toxin poisoning, Huntington's chorea, compression and entrapment neurophathies (such as carpal tunnel syndrome, ulnar nerve palsy), cardiovascular disorders (such as cardiac arrhythmias, congestive heart failure), reactive gliosis, hyperglycemia, immunosuppression, cocaine addiction, cancer, cognitive dysfunction, disorders resulting from defects in neurotransmitter release (such as Eaton-Lambert syndrome), and reversal of the actions of curare and other neuromuscular blocking drugs.
 21. The method of claim 19, wherein said disorder is a neurologic disorder.
 22. The method of claim 19, wherein said neurologic disorder is a seizure.
 23. The method of claim 22, wherein said seizure is seizure is associated with epilepsy.
 24. The method of claim 21, wherein said neurologic disorder is a neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia.
 25. The method of claim 24, wherein said neurotoxic injury is associated with stroke, cerebrovascular accident, brain or spinal cord trauma, myocardial infarct, physical trauma, drownings, suffocation, perinatal asphyxia, or hypoglycemic events.
 26. The method of claim 19, wherein said disorder is pain.
 27. The method of claim 26, wherein said pain is migraine, acute pain, persistent pain, neuropathic pain or nociceptive pain.
 28. The method of claim 19, wherein said disorder is inflammation.
 29. The method of claim 19, wherein said disorder is a cardiovascular disorder.
 30. A method of alleviating pain which comprises administering to a mammal that is either exhibiting pain or is about to be subjected to a pain-causing event a pain-alleviating amount of an active agent comprising a conotoxin peptide of claim 1 or a pharmaceutically acceptible salt thereof.
 31. A method for treating disorders associated with radical depolarization of excitable membranes by activating a K_(ATP) channel which comprises administering to an individual in need thereof an effective amount of an active agent comprising a conotoxin peptide of claim 1 or a pharmaceutically acceptible salt thereof.
 32. The method of claim 31, wherein said disorder is cardiac ischemia.
 33. The method of claim 31, wherein said disorder is cerebral ischemia.
 34. The method of claim 31, wherein said disorder is asthma.
 35. The method of claim 31, wherein said disorder is ocular ischemia.
 36. A method of identifying compounds that mimic the therapeutic activity of a O-Superfamily conotoxin, comprising the steps of: (a) conducting a biological assay on a test compound to deterimine the therapeutic activity; and (b) comparing the results obtained from the biological assay of the test compound to the results obtained from the biological assay of a O-Superfamily conotoxin.
 37. A substantially pure O-superfamily-conotoxin peptide derivative comprising a permutant of the peptide of claim
 1. 38. A substantially pure O-superfamily-conotoxin peptide derivative comprising a permutant of the peptide of claim
 2. 